LOCUS       NM_001270413            4792 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus KN motif and ankyrin repeat domains 2 (Kank2),
            mRNA.
ACCESSION   NM_001270413 XM_002729875
VERSION     NM_001270413.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4792)
  AUTHORS   Li,L., Li,Z.B., Jia,M. and Chu,H.T.
  TITLE     Therapeutic effects of KANK2 in myocardial infarction rats might be
            associated with the NF-kappaB p65 inhibition
  JOURNAL   Int Immunopharmacol 86, 106687 (2020)
   PUBMED   32570033
  REMARK    GeneRIF: Therapeutic effects of KANK2 in myocardial infarction rats
            might be associated with the NF-kappaB p65 inhibition.
REFERENCE   2  (bases 1 to 4792)
  AUTHORS   Jurewicz,E., Miazga,K., Fabczak,H., Slawinska,U. and Filipek,A.
  TITLE     CacyBP/SIP in the rat spinal cord in norm and after transection -
            Influence on the phosphorylation state of ERK1/2 and p38 kinases
  JOURNAL   Neurochem Int 138, 104757 (2020)
   PUBMED   32544715
  REMARK    GeneRIF: CacyBP/SIP in the rat spinal cord in norm and after
            transection - Influence on the phosphorylation state of ERK1/2 and
            p38 kinases.
REFERENCE   3  (bases 1 to 4792)
  AUTHORS   Gee,H.Y., Zhang,F., Ashraf,S., Kohl,S., Sadowski,C.E.,
            Vega-Warner,V., Zhou,W., Lovric,S., Fang,H., Nettleton,M.,
            Zhu,J.Y., Hoefele,J., Weber,L.T., Podracka,L., Boor,A.,
            Fehrenbach,H., Innis,J.W., Washburn,J., Levy,S., Lifton,R.P.,
            Otto,E.A., Han,Z. and Hildebrandt,F.
  TITLE     KANK deficiency leads to podocyte dysfunction and nephrotic
            syndrome
  JOURNAL   J Clin Invest 125 (6), 2375-2384 (2015)
   PUBMED   25961457
  REMARK    GeneRIF: In rats, KANK1, KANK2, and KANK4 all localized to
            podocytes in glomeruli, and KANK1 partially colocalized with
            synaptopodin.
REFERENCE   4  (bases 1 to 4792)
  AUTHORS   Ramot,Y., Molho-Pessach,V., Meir,T., Alper-Pinus,R., Siam,I.,
            Tams,S., Babay,S. and Zlotogorski,A.
  TITLE     Mutation in KANK2, encoding a sequestering protein for steroid
            receptor coactivators, causes keratoderma and woolly hair
  JOURNAL   J Med Genet 51 (6), 388-394 (2014)
   PUBMED   24671081
REFERENCE   5  (bases 1 to 4792)
  AUTHORS   Wang,D., Liang,J., Zhang,Y., Gui,B., Wang,F., Yi,X., Sun,L., Yao,Z.
            and Shang,Y.
  TITLE     Steroid receptor coactivator-interacting protein (SIP) inhibits
            caspase-independent apoptosis by preventing apoptosis-inducing
            factor (AIF) from being released from mitochondria
  JOURNAL   J Biol Chem 287 (16), 12612-12621 (2012)
   PUBMED   22371500
REFERENCE   6  (bases 1 to 4792)
  AUTHORS   Zhang,Y., Zhang,H., Liang,J., Yu,W. and Shang,Y.
  TITLE     SIP, a novel ankyrin repeat containing protein, sequesters steroid
            receptor coactivators in the cytoplasm
  JOURNAL   EMBO J 26 (11), 2645-2657 (2007)
   PUBMED   17476305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 4, 2012 this sequence version replaced XM_002729875.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760386, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000008.1  28616913-28616993   c
            82-196              JAXUCZ010000008.1  28614539-28614653   c
            197-1417            JAXUCZ010000008.1  28612957-28614177   c
            1418-1546           JAXUCZ010000008.1  28600878-28601006   c
            1547-1649           JAXUCZ010000008.1  28600684-28600786   c
            1650-1886           JAXUCZ010000008.1  28600003-28600239   c
            1887-1974           JAXUCZ010000008.1  28596481-28596568   c
            1975-2194           JAXUCZ010000008.1  28595415-28595634   c
            2195-2337           JAXUCZ010000008.1  28593752-28593894   c
            2338-2538           JAXUCZ010000008.1  28591135-28591335   c
            2539-2628           JAXUCZ010000008.1  28590671-28590760   c
            2629-4792           JAXUCZ010000008.1  28587770-28589933   c
FEATURES             Location/Qualifiers
     source          1..4792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..4792
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /note="KN motif and ankyrin repeat domains 2"
                     /db_xref="GeneID:100361376"
                     /db_xref="RGD:2320289"
     exon            1..81
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            82..196
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2682
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 2"
                     /protein_id="NP_001257342.1"
                     /db_xref="GeneID:100361376"
                     /db_xref="RGD:2320289"
                     /translation="MAQVLHVPAPFPGTPGQASSAAFPNKEPDPPYSVETPYGYRLDL
                     DFLKYVDDIEKGHTLRRVPVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSY
                     CGRGFYPQYGALETRSGTNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSS
                     LAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKL
                     SVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAVLETRSVGTWVRER
                     DLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRV
                     VEGPREVEVAASTAAGAPAQRAQSLEPYGAGLKALATSAENTLVFRSHEVVETMCPLP
                     TASTSNMHTAKKISITERNCTGAARMAEPSPSSPYPAAEPENPAPAAQDTTDRELTRP
                     VASQDSQAAEGAGGASLGVQSALKRKEVPADPDVHQRNLQFVGINGGYESSSEDSSTA
                     ENSEHESTENEAPEPPVRVLSTAEGPQLRPLGPAVGKTSQDERQLSQESQRVPEAKVA
                     PGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSD
                     AHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCQ
                     VDKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLGNVNAKASQAGQTALMLAVSHGR
                     VDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTA
                     LMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE"
     exon            197..1417
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1546
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1649
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1886
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1974
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2194
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2337
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2538
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2628
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..4792
                     /gene="Kank2"
                     /gene_synonym="RGD1563532"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgcgttgg ctccacaggc ttggggcgac tgaggcggag cgggcaggac gcttgggacg
       61 gcggaggctg cagcgcgcca ggttagcctc agctgtccga aggctgttgg ggagactcgg
      121 ttccctgagt gacatctgag gagcaactgc agagagagga tggcccaggt cctgcatgtg
      181 cccgccccat tcccaggaac ccctggccaa gcctcctcag cggccttccc caacaaggag
      241 ccagacccgc catactcggt ggagacgccc tatggctacc gcctggacct ggactttctt
      301 aagtacgtgg atgacattga gaagggccac acactgcgca gggtgccggt gcagcgccgg
      361 ccacgcctgg gctccctgcc acgtggcccg ggctcctggt ggacgtccac agagtcgctg
      421 tgctctgacg ccagtgggga cagccggcac tcggcctact cctactgtgg ccgcggcttc
      481 tacccacagt acggagcctt ggagacccgc agcggcacca acccacgcgt ggaacgcacg
      541 ctgctggatg cgcggcgccg actggaggac caggcggctg ccccatcatc gggtggcctg
      601 ggctctctga cgcccagcgc tgcgggctcc accagctccc tggcaggcgt gggcctgctg
      661 ccccccacac ctcgcagctc tggcttgtcc accccagtgg cacccagcgc tggtcacctg
      721 gcccacgtgc gcgaacagat ggctggagcc ctgcgcaagc tgcgccagct ggaggagcag
      781 gtcaagctga tccccgtgct ccaggtcaag ctgtcggtgc tccaggagga aaaaagacag
      841 ctcaccgtgc agctcaagag ccagaagttt ctaggccacc cctcagggac aaggagccgg
      901 agcgagctct gcctggacct tccggaggcc cccgacgacc ctgctgtgct agagactcgc
      961 tcggtgggca cctgggttcg agaaagggat ttgggcattc cagatggtga agctgccctg
     1021 gtagctaaag tggccgtgtt ggagacccag ctcaaaaaag cgctgcagga gctgcgggcg
     1081 gctcagaccc agcaggtcga cctccagccc caagcctggc caccaccaga cacccaggtc
     1141 cgcgtggaca ccgtgcgagt tgtggagggt ccccgggaag tggaggtggc agccagcacg
     1201 gcagccgggg ctcctgcaca gcgagctcag agtctggaac cctatggagc agggctgaag
     1261 gccctggcca catctgcgga gaacaccctt gtgttccgaa gtcatgaggt ggtggagacc
     1321 atgtgtcccc tgcccacagc ttccaccagc aacatgcaca cagccaagaa gatcagtatt
     1381 acagaacgga attgcactgg tgcggccagg atggcagagc cttccccctc tagtccatac
     1441 cctgctgcag agcctgagaa ccctgcccca gctgcccagg acaccacgga cagggagctc
     1501 accaggcctg tggcatcgca ggactcacaa gcggccgagg gagcaggcgg agcctccttg
     1561 ggagtccaat cagccttgaa gaggaaagag gtccctgcag accctgacgt ccaccagagg
     1621 aaccttcagt ttgtgggcat caatggcggg tatgagtcct cctcggaaga ctccagcaca
     1681 gcagagaact cggaacacga gagcacagag aacgaggccc cagagcctcc ggtgagggtt
     1741 ctgagcacag ctgaaggccc tcagctcagg cctctggggc ctgcagtggg caagaccagt
     1801 caggacgagc gtcagctctc tcaggaatcc cagcgtgtgc ccgaagccaa ggtggcccca
     1861 ggacctgacc ccgaggagga gattcggatg gatctgagcc ctgacctcat atcagcatgc
     1921 ttggccctgg agaaatactt ggagaacccc aatgccctca cggagcgaga actgaaagtg
     1981 gcttatacca cggtgcttca ggagtggctg cgcctggcct gccgcagtga tgcacaccct
     2041 gagcttgtac ggcgacatct ggtcaccttc agggccatgt ctgcccggct gctggactat
     2101 gtggtcaaca tcgctgacag caatggtaac actgccctgc actactccgt gtcacatgcc
     2161 aacttccctg tggttcggca gttgctggac agcggcgtgt gtcaggtgga caagctaaac
     2221 cgtgctggct acagcccgat aatgctcact gctttggcca ccctgaagac ccaggatgac
     2281 attgacacca tccttcaact cttccgcctt gggaatgtca acgccaaagc cagccaggca
     2341 ggacagacgg ccctgatgct ggcggtcagc cacgggcggg tggatgtggt gaaagcgctg
     2401 ttggcctgtg aggtggatgt taacatgcag gatgaggacg gctccacggc cctgatgtgt
     2461 gcgtgtgagc acggacacaa ggagatcacc gggctcctgc tggctgtgcc tagctgtgac
     2521 atctcactca ccgaccgcga tggaagcaca gcgctgatgg tagccctcga cgctgggcag
     2581 agcgagatcg catctatgct gtactcacgc atgaacatca agtgctcctt cgctcccatg
     2641 tcagactacg agagtccggc ttcgtcttca gctgaagagt gaatacaggg aaccagtgag
     2701 tccccaggac ccaccagcca caagccatgg caaaccgtcc gtcctcaatc cctgtccctt
     2761 tctgccttgg cattcctcag ccctgttctc cacagcaaac cccctgcact tccctaaggg
     2821 agctctgaca tctaccagac tccagccttt cccagcaccg tgggttcaaa gccagaaagc
     2881 caagctacat tctcctccca gttggcgcca gttggcgacg cccgggtgtg ggtttcttat
     2941 gaagaacaga gagaacaatc agccggcaat tatgggagga gtgggggcaa gaggggaaaa
     3001 tactgtattc ttgagtcatt gttaggggat gggaggggtc agaattcagt tgctaaattt
     3061 gaatgtcact ggaatgttac agtgtccttt gtctcaacac tacagcaggt ctccacaaag
     3121 cccgctcaac accctttgtc acctcttttc attgtctagt gtacaatagg gttttgtcca
     3181 ctgccctcca cctctagacg gtttctttag ggccaggggt gtctctcaaa ataagactct
     3241 gtcatcactt agccatctgc ctcccgccag aaagcagtgt tttcctttca ctgtcacaca
     3301 cacacacaca cacacacaca cacacacacg tacacacaca tgcatgcaca cacggggctt
     3361 gtcaccctgc agctgatgtt cttgctgtga cttggaaatg actacttaca aggagaggtt
     3421 atgcagacct ccctattccc cacagggagg gcttgggaca ggagaatgct cctagaaaac
     3481 ctttcaaacc tacatacaga cacaaaaaga aaaaaatttc ggagcggctc ccagcatccc
     3541 aggcagagcc tccctcctca gagcgtaaac agaggatgtg atactgacca agaacgggct
     3601 ctcgctcgga agcccatgtg ttcctgatta agagctggct ggcctcagag cactcccaga
     3661 actaagctta aagtgccagg ctttgccgaa atccaaaggg acaaatgagt agttttatgt
     3721 ttgtgtgttt gtttttaatg ccctagagct cctgctggtg acagggtaca gacaggctgc
     3781 acttttctct tactgggttt cctttctgtc cccagaatct cagcgtggtt catagggggg
     3841 ttggatcttg ttgtttttcc ttgtttcttt tctagatgtg ccttgtgatg gggaggacat
     3901 gtcctctcaa gtctccctgt gttatccagg tcacagctgg acccactggg ccttggagcc
     3961 aaacctcagg agggcagagt tgaggctcat gaactaaagg aaagtgttcg tttctcttct
     4021 agacaagtag gtctcttggt ttgatggagt cttactccgc ttgacttttg taggaggggt
     4081 ttgactaagg catagaggct tggttggcat gagaaaataa gatggatggg tggatggatg
     4141 gatggacgga cagacggatg gatggatggg tgggtggaca gacagacgga tggacagacg
     4201 gatggatggg tggatggatg gatggatgga tgagtggctg gatacatgac tagatggatg
     4261 gctacttaat ggatgggtag atgagtccgt ggacagatga atgaggagtg gttggatgaa
     4321 taaatgagca atggatgaga gactaggcgg ggctggtgga cggatgtcat gatggagtct
     4381 ttgcacgtgt ataaaacaga aaaccaaact gtaggacagc cgctggtgtc tccggacgct
     4441 cacagcctag ggtacattca taaggctgtg ctctgagctg agccccgagt tccagccttg
     4501 tagccagcaa gggagtttat ttaaggttct ggaagcatca gctatgaccc caaagcacac
     4561 actcctcaga aaagcccctg tctgtttctg ccactgctgc tttctgtgtc tctgtgaggg
     4621 ggccaccagg gccaaacacc ggtctctcct ctcctttcct gtatactcat gttgtatttc
     4681 tactccgtga ccacggtacg tccatgaaga cagtgttaca cgtaaatgaa gtattctttt
     4741 cttgtaatca tgttttagaa agtaaaggga cttaataaag ctgcaaacaa gc
//
