LOCUS       NM_001037197            5170 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus KN motif and ankyrin repeat domains 1 (Kank1),
            mRNA.
ACCESSION   NM_001037197 XM_219925
VERSION     NM_001037197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5170)
  AUTHORS   Gee,H.Y., Zhang,F., Ashraf,S., Kohl,S., Sadowski,C.E.,
            Vega-Warner,V., Zhou,W., Lovric,S., Fang,H., Nettleton,M.,
            Zhu,J.Y., Hoefele,J., Weber,L.T., Podracka,L., Boor,A.,
            Fehrenbach,H., Innis,J.W., Washburn,J., Levy,S., Lifton,R.P.,
            Otto,E.A., Han,Z. and Hildebrandt,F.
  TITLE     KANK deficiency leads to podocyte dysfunction and nephrotic
            syndrome
  JOURNAL   J Clin Invest 125 (6), 2375-2384 (2015)
   PUBMED   25961457
  REMARK    GeneRIF: In rats, KANK1, KANK2, and KANK4 all localized to
            podocytes in glomeruli, and KANK1 partially colocalized with
            synaptopodin.
REFERENCE   2  (bases 1 to 5170)
  AUTHORS   Li,C.C., Kuo,J.C., Waterman,C.M., Kiyama,R., Moss,J. and Vaughan,M.
  TITLE     Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG)
            1 and KANK1 proteins on cell polarity and directed migration during
            wound healing
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19228-19233 (2011)
   PUBMED   22084092
REFERENCE   3  (bases 1 to 5170)
  AUTHORS   Kakinuma,N. and Kiyama,R.
  TITLE     A major mutation of KIF21A associated with congenital fibrosis of
            the extraocular muscles type 1 (CFEOM1) enhances translocation of
            Kank1 to the membrane
  JOURNAL   Biochem Biophys Res Commun 386 (4), 639-644 (2009)
   PUBMED   19559006
REFERENCE   4  (bases 1 to 5170)
  AUTHORS   Roy,B.C., Kakinuma,N. and Kiyama,R.
  TITLE     Kank attenuates actin remodeling by preventing interaction between
            IRSp53 and Rac1
  JOURNAL   J Cell Biol 184 (2), 253-267 (2009)
   PUBMED   19171758
REFERENCE   5  (bases 1 to 5170)
  AUTHORS   Kakinuma,N., Roy,B.C., Zhu,Y., Wang,Y. and Kiyama,R.
  TITLE     Kank regulates RhoA-dependent formation of actin stress fibers and
            cell migration via 14-3-3 in PI3K-Akt signaling
  JOURNAL   J Cell Biol 181 (3), 537-549 (2008)
   PUBMED   18458160
REFERENCE   6  (bases 1 to 5170)
  AUTHORS   Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
  TITLE     Kank proteins: a new family of ankyrin-repeat domain-containing
            proteins
  JOURNAL   Biochim Biophys Acta 1780 (2), 128-133 (2008)
   PUBMED   17996375
REFERENCE   7  (bases 1 to 5170)
  AUTHORS   Wang,Y., Kakinuma,N., Zhu,Y. and Kiyama,R.
  TITLE     Nucleo-cytoplasmic shuttling of human Kank protein accompanies
            intracellular translocation of beta-catenin
  JOURNAL   J Cell Sci 119 (Pt 19), 4002-4010 (2006)
   PUBMED   16968744
REFERENCE   8  (bases 1 to 5170)
  AUTHORS   Sarkar,S., Roy,B.C., Hatano,N., Aoyagi,T., Gohji,K. and Kiyama,R.
  TITLE     A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a
            growth suppressor of renal cell carcinoma
  JOURNAL   J Biol Chem 277 (39), 36585-36591 (2002)
   PUBMED   12133830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 10, 2008 this sequence version replaced NM_001037197.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000001.1  232381720-232381813
            95-206              JAXUCZ010000001.1  232445658-232445769
            207-212             JAXUCZ010000001.1  232456543-232456548
            213-2891            JAXUCZ010000001.1  232475711-232478389
            2892-3083           JAXUCZ010000001.1  232488383-232488574
            3084-3192           JAXUCZ010000001.1  232489218-232489326
            3193-3444           JAXUCZ010000001.1  232490419-232490670
            3445-3532           JAXUCZ010000001.1  232492069-232492156
            3533-3752           JAXUCZ010000001.1  232494126-232494345
            3753-3895           JAXUCZ010000001.1  232496376-232496518
            3896-4096           JAXUCZ010000001.1  232497038-232497238
            4097-4195           JAXUCZ010000001.1  232499226-232499324
            4196-5170           JAXUCZ010000001.1  232499860-232500834
FEATURES             Location/Qualifiers
     source          1..5170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..5170
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /note="KN motif and ankyrin repeat domains 1"
                     /db_xref="GeneID:309429"
                     /db_xref="RGD:1307714"
     exon            1..94
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            95..206
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..4258
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /note="ankyrin repeat domain 15"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 1"
                     /protein_id="NP_001032274.2"
                     /db_xref="GeneID:309429"
                     /db_xref="RGD:1307714"
                     /translation="MAYTTKVNGCAPENADGVLNGDRNKEKKDPYFVETPYGFQLDLD
                     FVKYVDDIQKGNTIKKLNIQKRRKPSGPCAEVRAIPGPQGVWTSTESLSSSNSDDSKQ
                     CPSFLLARSHVTSTPIPRPPAPLETSPTFAISENRQLLPPPSPQLPRHNLHVTKTLME
                     TRRRLEQERVTMQMAPGEFRRPRLASFGGMGSTSSLPSFMGSGNHSSAMHQLQNGYQG
                     NGDYSSYVPAVPTTSSMGSSVRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKE
                     LEEQVRTIPVLQVKISVLQEEKRQLASQLKNQRAASQNEACGVRKRSYSAGNASQLEL
                     LSRARRGGGELYIDYEEEEMESVEQSTQRIREFRQLTADMQALEQKIQDSSCEATPEL
                     RENGQCASRERKSVAVGSDENMNDIVVYHRDFRSRKDTAVGTVTETRNFGISVTEAML
                     GVITEADKEIELQQQTIEALKEKIYRLEVQLKETTHDQEMTKLKQELQAAGSRKKVDK
                     AIMAQPLVFSKLVEALVPTREQMVGSHVDTMDSCVGTSVQTSSVGTSCHPDRKNQVVG
                     PELPMNWWVVKERVGTHDRCVGRSVETCNRSVGVEVSVCETGSNTEASGSDLTLLKTN
                     LNLKDVRSIGCGDCSVDVIVCLPKECTSRSMNTEAVGQGEAAVMAVPHTTDQHTSTNL
                     ERVDQGTNTEVTTLVESCTNTLLSTLDKQTSTQNVEMRTVAIGEGRVRDINPSTKTRS
                     VGVGTVLSGSSDFDKPCAVKTKESGVGQINIHDNYLVGLKMRTIACGPPQLTVGLIGS
                     RRSVGVGNEPVGDLLEDPLQPQVPSGMMTGLDHYIERVQKLLAEQQTLLAENYSELAE
                     AFGEPHSQIGSLNSQLISTLSSINSVMKSASTEELRNPDFQKSSLGKIAGNHLECTCK
                     CGGLRSGGLVNVQTSQPEVETETTEGKRGCEQFLTQGNTLPPVNLTDDQIATGLYVCP
                     NNENTLKSIMKKSDGNKDSNGAKKNLQFIGVNGGYETTSSDDSSSGGSSSSESDDECD
                     TNGYPPEEEEEEEEEEEDHDTRGMAEGRHAVNIEGFQSARVEDEVQVPECEPEKEEIR
                     ERYELSEKMLSACSLLKYNINDPKALASKDMRICLNTLQHEWFRVSSQKSAVPAMVGD
                     YIAAFEAVSPDVLRYIINMADGNGNTALHYSVSHSNFQIVKLLLDADVCNVDHQNKAG
                     YTPIMLAALAAVEAEKDMQVVEELFSCGDVNAKASQAGQTALMLAVSHGRIDMVKGLL
                     ACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCSGHLEDNDGSTALSIALEAG
                     HKDIAVLLYAHLNFSKAQSPSTPRLGRKTSPGPTHRGSFD"
     exon            207..212
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            213..2891
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3083
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3192
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3444
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3532
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3752
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..3895
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4096
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..4195
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..5170
                     /gene="Kank1"
                     /gene_synonym="Ankrd15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctactgaatt ttatccgcct tctggccatg ctacaaagtt gtctgtggag ttgaaatgtt
       61 tattgcaata acctctgacc ttacatgatt taaggttgaa cctttgggaa cgtgctgtat
      121 gccattcacg caagtcctca ccgtttgccg tgtccatcct tggatttgaa ccagcatggc
      181 ttataccaca aaagttaatg gctgtgctcc agaaaacgca gatggagttc tgaatggaga
      241 ccgtaacaag gaaaagaaag acccgtattt tgtggaaacc ccgtacggtt ttcagctaga
      301 cttagatttc gtcaagtacg tggatgacat acagaaggga aacaccatca agaaactaaa
      361 catccagaag aggcgaaagc catccgggcc atgtgcagaa gtcagggcca tacccggtcc
      421 tcaaggtgtg tggacttcca ctgagtccct gtcatcctcc aacagtgatg acagcaagca
      481 gtgtcccagc ttcctcctag ccagaagcca cgtcacgtcg accccaatcc cacggccacc
      541 tgccccgcta gagacctcgc ccacttttgc tatctcagaa aaccgacagc tgctgccccc
      601 tccctcgccc caactcccca ggcacaacct ccatgtcacc aagacgttga tggagacccg
      661 gagaaggctt gaacaggaga gagtcaccat gcagatggca ccgggtgagt tccgaaggcc
      721 caggctggcc agttttggag gcatgggctc cacgagctcc ctcccatcct tcatgggttc
      781 tggcaaccac agttctgcaa tgcaccagct tcagaatgga taccaaggca atggcgatta
      841 tagcagctat gtcccagcgg tgcctacgac ttcttccatg ggaagctccg tccgtcacag
      901 cccgctgagt tcagggatct ccaccccggt gaccaacgtg agccccatgc acctgcagca
      961 catccgcgag cagatggcca ttgccttaaa gcgcctgaag gagcttgagg agcaggtgcg
     1021 aaccatccct gtgctccagg tcaagatctc ggtcttgcaa gaagagaaaa ggcaattggc
     1081 ctcgcagctg aagaaccaga gggccgcgtc ccagaacgag gcgtgtggtg tgaggaagcg
     1141 ctcctacagc gcaggcaatg cctcccagct ggaattgctt tcccgagccc gaagaggtgg
     1201 cggggaatta tacatcgact acgaggagga agaaatggag agcgtggagc agagcacaca
     1261 gaggatcagg gagttccggc agctcacggc tgacatgcag gcgctggagc agaagattca
     1321 ggatagcagc tgtgaagcca cgccggagct cagggagaac gggcagtgcg cgtctcggga
     1381 gcgcaagtct gtggcggtgg gcagcgatga gaacatgaat gacatcgttg tataccacag
     1441 ggacttcagg tcccgcaagg atacagctgt ggggacagtc actgagacga ggaattttgg
     1501 catcagcgtg acagaagcca tgcttggggt tattactgag gctgacaaag agatcgaact
     1561 gcagcagcag accatagagg ccttaaagga gaagatttac cgcctggaag tacagcttaa
     1621 agaaaccacc catgaccagg agatgactaa gctcaagcag gaactacagg ctgccggatc
     1681 caggaaaaaa gttgacaagg ccataatggc ccagccactt gtcttcagca agttggtgga
     1741 ggcgctagtg ccaaccagag aacaaatggt cggcagtcac gtggacacaa tggattcgtg
     1801 tgttgggacc tccgtgcaaa ctagtagcgt aggcacctcc tgccatcctg accgcaagaa
     1861 ccaagtcgtg gggcccgagc tgcctatgaa ttggtgggtc gtaaaggaga gggtggggac
     1921 tcacgaccga tgcgtaggga ggtctgttga gacttgtaac cggagtgtgg gtgtagaagt
     1981 cagtgtctgt gaaacaggca gcaacacaga ggcttctggg agcgacctga ccctcctgaa
     2041 gacaaacttg aacctcaaag acgtgcggtc cattggctgt ggagactgtt ctgttgatgt
     2101 gattgtctgc ttgcccaagg agtgcacctc ccgaagcatg aacacagagg ctgtaggtca
     2161 gggggaagct gctgtcatgg cggtgcccca taccacagac cagcacacca gcacgaatct
     2221 ggagcgggtg gaccagggca ctaacacgga ggtaaccacc ctggtggagt cctgcaccaa
     2281 cactctcctc agcactctgg acaagcagac cagcacccag aatgtggaga tgcgaacggt
     2341 ggccatcgga gaaggccgag tcagagacat caacccctcc acaaagactc ggtctgttgg
     2401 ggtcgggaca gtgctgtctg gcagttctga ctttgacaag ccatgtgctg tgaagaccaa
     2461 agagtcgggt gtgggacaga taaatattca cgacaactat ctagttggtc tcaaaatgag
     2521 gaccatagcg tgcgggcctc cacagttgac tgtgggactc ataggcagca ggaggagcgt
     2581 gggtgttggg aacgagcctg taggggatct cctggaggat cctcttcagc ctcaggttcc
     2641 atctggaatg atgactggct tggatcacta cattgagcgc gtgcagaagc tgctggcaga
     2701 gcagcagacg ttgctggctg agaactacag tgagctggcg gaggctttcg gggagcctca
     2761 ttcacagatc ggctccctca attcacaact catcagcacc ctgtcgtcca tcaattccgt
     2821 catgaagtct gcaagcacag aagagctcag gaaccctgac ttccagaaaa gcagtctggg
     2881 taaaattgca ggaaatcact tggaatgtac ctgtaagtgt ggaggccttc ggtcgggagg
     2941 actagtaaat gtacaaacat cccagcctga ggtggagaca gagacaacag aaggcaagcg
     3001 gggctgtgag cagttcctca cacagggaaa tactctgccc ccggtgaacc tgacagatga
     3061 ccagatagcc accggtctct atgtatgtcc aaataatgaa aacacactga aatccatcat
     3121 gaagaaaagc gatgggaata aagattcgaa cggagccaaa aagaatcttc agttcattgg
     3181 tgttaacggc gggtatgaga caacttcaag tgatgattcc agctcgggtg gaagctcttc
     3241 ttccgagtca gatgacgagt gtgacaccaa tgggtatcct cccgaggaag aggaggagga
     3301 ggaagaggag gaggaggacc acgacactcg gggaatggcg gaagggcgcc acgcagttaa
     3361 tattgaaggt ttccagtctg ccagggtgga agatgaagtg caggttccag aatgtgaacc
     3421 tgagaaggag gaaatcagag agaggtatga attaagtgaa aagatgctgt ctgcctgcag
     3481 cttattgaaa tataacataa atgatcccaa agctttggcc agcaaagata tgaggatctg
     3541 tctgaacacc ctccagcatg agtggttccg agtgtccagt cagaagtccg ctgtgccagc
     3601 catggtgggt gactacatcg ccgcgttcga ggctgtctcc ccggacgtgc tccggtacat
     3661 catcaacatg gcggacggca acgggaacac cgccctccac tacagcgtgt cccactccaa
     3721 cttccagatc gtcaagctgc ttctggatgc agacgtgtgt aacgtagatc atcagaacaa
     3781 ggcagggtac acgcccatca tgctggcagc cctcgcagcc gtggaggcag agaaggacat
     3841 gcaggtcgta gaagaactct tcagctgtgg agatgtgaat gccaaggcca gtcaggcagg
     3901 acagacagcc ctcatgctgg ccgtcagtca tgggcggata gacatggtga agggcctact
     3961 ggcctgtggg gctgacgtca acatccagga tgacgagggt tctactgccc tgatgtgtgc
     4021 cagcgaacat gggcatgtgg agatcgtgaa gctgctgctg gcccagccag gctgcagtgg
     4081 ccacctggag gacaatgacg gcagcaccgc tctctccata gctttggaag caggacacaa
     4141 ggacattgct gtgcttctgt atgcccacct caacttctcg aaagcccagt ctccgagcac
     4201 cccgaggctt ggaagaaaga cctctcctgg tcccactcac cgaggttcct ttgactgatt
     4261 atgtaacaca gccctgtgta ccaccgtgaa gctgctagtt attcctgtcg gggtgacaga
     4321 tactgaatgt atacggacca tgccaggctg accagcaaac agaagagtaa aggaacaagc
     4381 tgaaggctga tgcttttgca ggaaaggcag agtcctgcca ggaaatggcc aagctaggtg
     4441 caggccacct ctctggccct ctgctcttag aggacttggc cccagttctg tggctgctga
     4501 actggttccg ttacttgcag tggtaggaaa tggtggtccc gcctggccag gctgtctcta
     4561 ccatgcaagc atatgtcaga ttctccatga cattgtagct ttggagtttt ccacaaatac
     4621 ttactaaatg tggggccatt gagaagccct tccagtatcc cactccaggg tgcttctgtc
     4681 cacttctctt ttgtctttta aaataagaac cttgagggag aggactttga gcagcagcag
     4741 cttggcaccc ccaggctgat aatttcccga ttaacaatag aagagcggaa ctctcaaacc
     4801 atttaaactt acaagaaata ttttcagttg gtttatctag gtggatgtat tatacgcctt
     4861 tttttatata aaagacttct atatgaaatc gacaacagta ttttcagctt ttatattcca
     4921 cagtacagtc ataaagagct acgtgtaacg taacggttta agcaactgcc caaccgtgtc
     4981 tgtgtctggt gacaaaggtt tgaattgggt tagaggactg ggttccagat ttgcgtctag
     5041 ggaggcagag tgtagttctc cgtgtattgc taccgtgccg cggcatttac ttgggtcctg
     5101 tatatgtatt taaatgtttg aagtgcctta gactcttgcc atattttcaa aataaaaatt
     5161 tcattaagct
//
