LOCUS       NM_031047               3463 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus junction plakoglobin (Jup), mRNA.
ACCESSION   NM_031047
VERSION     NM_031047.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3463)
  AUTHORS   Hou,S., Fang,M., Zhu,Q., Liu,Y., Liu,L. and Li,X.
  TITLE     MicroRNA-939 governs vascular integrity and angiogenesis through
            targeting gamma-catenin in endothelial cells
  JOURNAL   Biochem Biophys Res Commun 484 (1), 27-33 (2017)
   PUBMED   28115160
REFERENCE   2  (bases 1 to 3463)
  AUTHORS   Dubash,A.D., Kam,C.Y., Aguado,B.A., Patel,D.M., Delmar,M.,
            Shea,L.D. and Green,K.J.
  TITLE     Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic
            gene expression in cardiomyocytes
  JOURNAL   J Cell Biol 212 (4), 425-438 (2016)
   PUBMED   26858265
REFERENCE   3  (bases 1 to 3463)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3463)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   5  (bases 1 to 3463)
  AUTHORS   Yim,J.H., Baek,J.H., Lee,C.W., Kim,M.J., Yun,H.S., Hong,E.H.,
            Lee,S.J., Park,J.K., Um,H.D. and Hwang,S.G.
  TITLE     Identification of HDAC4 as a target of gamma-catenin that regulates
            the oncogenic K-Ras-mediated malignant phenotype of Rat2 cells
  JOURNAL   Biochem Biophys Res Commun 436 (3), 436-442 (2013)
   PUBMED   23747726
  REMARK    GeneRIF: gamma-Catenin regulates expression of HDAC4, but not HDAC1
            and HDAC2 in Rat-K-Ras cells.
REFERENCE   6  (bases 1 to 3463)
  AUTHORS   Sacco,P.A., McGranahan,T.M., Wheelock,M.J. and Johnson,K.R.
  TITLE     Identification of plakoglobin domains required for association with
            N-cadherin and alpha-catenin
  JOURNAL   J Biol Chem 270 (34), 20201-20206 (1995)
   PUBMED   7650039
REFERENCE   7  (bases 1 to 3463)
  AUTHORS   Aberle,H., Bierkamp,C., Torchard,D., Serova,O., Wagner,T., Natt,E.,
            Wirsching,J., Heidkamper,C., Montagna,M., Lynch,H.T. et al.
  TITLE     The human plakoglobin gene localizes on chromosome 17q21 and is
            subjected to loss of heterozygosity in breast and ovarian cancers
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6384-6388 (1995)
   PUBMED   7604000
REFERENCE   8  (bases 1 to 3463)
  AUTHORS   Rubinfeld,B., Souza,B., Albert,I., Munemitsu,S. and Polakis,P.
  TITLE     The APC protein and E-cadherin form similar but independent
            complexes with alpha-catenin, beta-catenin, and plakoglobin
  JOURNAL   J Biol Chem 270 (10), 5549-5555 (1995)
   PUBMED   7890674
REFERENCE   9  (bases 1 to 3463)
  AUTHORS   Knudsen,K.A. and Wheelock,M.J.
  TITLE     Plakoglobin, or an 83-kD homologue distinct from beta-catenin,
            interacts with E-cadherin and N-cadherin
  JOURNAL   J Cell Biol 118 (3), 671-679 (1992)
   PUBMED   1639850
REFERENCE   10 (bases 1 to 3463)
  AUTHORS   Franke,W.W., Goldschmidt,M.D., Zimbelmann,R., Mueller,H.M.,
            Schiller,D.L. and Cowin,P.
  TITLE     Molecular cloning and amino acid sequence of human plakoglobin, the
            common junctional plaque protein
  JOURNAL   Proc Natl Acad Sci U S A 86 (11), 4027-4031 (1989)
   PUBMED   2726765
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC065580.1.
            
            On Feb 1, 2004 this sequence version replaced NM_031047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3463
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..3463
                     /gene="Jup"
                     /note="junction plakoglobin"
                     /db_xref="GeneID:81679"
                     /db_xref="RGD:620412"
     exon            1..386
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            387..599
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..2629
                     /gene="Jup"
                     /note="gamma-catenin (plakoglobin)"
                     /codon_start=1
                     /product="junction plakoglobin"
                     /protein_id="NP_112309.2"
                     /db_xref="GeneID:81679"
                     /db_xref="RGD:620412"
                     /translation="MEVMNLIEQPIKVTEWQQTYTYDSGIHSGVNTCVPSVSSKGLLD
                     EDDTCGRQYTLKKTTTYTQGVPQSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLL
                     ATQVEGQTTNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVT
                     KAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREG
                     LLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPL
                     LNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRV
                     LKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLENV
                     LKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDD
                     ITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNL
                     ALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGA
                     LHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAE
                     GASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEA
                     AQSMIPINEPYADDMDATYRPMYSSDVPLDPLDMHMDMDGDYPMDTYSDGLRPPYPAA
                     DHMLA"
     exon            600..859
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1098
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1300
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1445
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1549
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1888
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2044
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2164
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2315
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2437
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2477
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2647
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..3439
                     /gene="Jup"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccctcca ggctcggtga accgcaggtc tgagaagggc ggggaggaac tagggcaggt
       61 gcctcggagt tcgcgcctcc cccagggccc gcggagcttg cccgacgcgg cgtcgctgac
      121 tctcccctgg agctgaccgg gcagactttg acccgctccg cctggtccca gatcccacgg
      181 tgacaggaat ttaccgctcg ggaaacttgc tgcctagtct ctttggggcc accctcaccc
      241 caccccacgc gtcatcctcg ctttccctcc ctccctactc ccccaggcct gggtggggcc
      301 ctattgtctg cgcccagctt acccaactgt gggggccgag tgcacatttt cccagagacg
      361 cgattcccac ctgctgagca gagcagccac gatggaggtg atgaacctta ttgaacagcc
      421 catcaaggtg acggagtggc agcagacgta cacctatgac tcgggcatcc actccggtgt
      481 caatacctgt gtgccctctg tcagcagcaa gggcctcctc gatgaggatg acacctgcgg
      541 cagacagtac acactcaaga aaactaccac ctacacacaa ggggtgccac agagccaagg
      601 cgacctggag taccagatgt ccaccacggc cagagccaag cgggtgcggg aggccatgtg
      661 cccaggtgtc tcaggcgagg acagttctct cctcctggcc acccaggtgg aggggcagac
      721 gaccaacctg cagcgactgg ccgaaccatc ccagctactc aagtcggcca ttgtacatct
      781 catcaactac caggacgacg cagagctggc cacccgggct ctgcctgagc tcaccaagct
      841 gctcaacgat gaggacccgg tagtggtcac caaggcggct atgatcgtga accagctgtc
      901 caagaaggag gcatcccgcc gtgccctgat gggctcgccc cagctggtgg cggctgtggt
      961 gcggaccatg cagaacacca gtgacctgga tactgcccgc tgtaccacca gcatcctgca
     1021 caacctctcc caccaccgag aggggctgct tgctatcttc aagtctggag gcatccccgc
     1081 cctggtccga atgctcagtt cccccgtaga gtctgtcctg ttctacgcca tcaccacact
     1141 gcacaacctg ctgctctacc aggagggcgc caagatggcg gtgcgtctgg cagacggact
     1201 gcagaagatg gtgcccctac ttaacaagaa caaccccaaa ttcctggcca tcaccaccga
     1261 ctgcctgcag ctcctggcct atggcaacca ggagagcaag ctgatcatcc tggccaatgg
     1321 gggaccccag ggtcttgtgc agatcatgag gaactacagc tacgagaagc ttctgtggac
     1381 caccagccgg gtgctcaagg tgctctccgt gtgccccagc aacaagcctg ccatcgtgga
     1441 ggctggtggg atgcaggctc taggcaagca cttgacaagc aacagccccc gcctggtgca
     1501 gaactgcctg tggactctgc gcaatctctc ggatgtggcc accaagcagg agggcctgga
     1561 gaacgtgctg aagatcctgg tcaatcagct gagcgtggat gatgtcaacg tcctcacctg
     1621 tgccacgggc accctctcca acctgacctg caacaacagc aaaaacaaga cgctggtgac
     1681 gcagaacagt ggcgtggagg cgctcatcca cgccatcctc agagccggag acaaggacga
     1741 catcacagag cccgccgttt gcgccctgcg ccaccttacc agccgccacc ctgaggctga
     1801 gatggcccag aactctgtgc gcctcaacta tggaatcccg gccattgtga aactgctcaa
     1861 ccagccgaac cagtggccac tggtcaaggc aactatcggc ctgatccgga acctggctct
     1921 gtgccccgcc aatcatgccc cgctgcagga ggccgcggtc attccccgcc tcgttcagct
     1981 gctggtcaag gcccaccagg atgcccagcg acatgtagct gcgggcaccc agcagcccta
     2041 cacggatggt gtgaggatgg aggagatcgt ggagggctgc accggagccc tgcacatcct
     2101 cgcccgagat cccatgaacc gcatggagat cttccggctc aacaccattc ccctgtttgt
     2161 ccagctcctg tattcctctg tggagaacat ccagcgtgtg gctgccggag tgctgtgcga
     2221 gctggcccag gacaaggagg ctgccgatgc catagacgcg gagggcgcct ctgcccctct
     2281 catggaactg ctccactccc gcaatgaggg gaccgcgacc tacgctgctg ctgtcctgtt
     2341 ccgcatctcc gaggacaaga acccagatta ccgtaagcga gtgtctgtgg aactcaccaa
     2401 ctcgctcttc aagcatgacc cagctgcctg ggaggctgcc cagagcatga tcccgatcaa
     2461 cgaaccctat gcagacgaca tggatgcaac ctaccgcccc atgtactcca gcgatgtgcc
     2521 tctggacccc ctggatatgc acatggacat ggatggcgac taccccatgg acacctacag
     2581 cgacggcctg agacctccct accccgctgc agaccacatg ctggcctagc tggctccacc
     2641 tcactcagag ctgtttctca cctggaaagc tctccagagc agactgtggg acgagacagt
     2701 acctaagccc cgggagccag cctggacttc ctgctgcaca cgcgctccag agagttcctc
     2761 cgtagggatt ttgggatggt gtctgctccc gcttttctgt cctgggctgg ggatccaggc
     2821 tcagtacttt ctccccctcc ccactatggc tatgaccact aaagctttag actcggcctg
     2881 tgtccctgta cagcagccct ctctgctgac tccagctgcc tggacccccc agggcttcct
     2941 ttgtttttcc ggggccagtt ttctcaatga actaaagcat ccaactgccc tgacctcctg
     3001 ggatatccaa gacacaggtt caaggcccaa acccttcaca tccaaagctt cttttgaaaa
     3061 gttcagggac cttcttgggg gtagcgggag agagtggaga ctttttaagt gcccctgcta
     3121 ggacctgccc ttctcttcag gatgctaagt ctgccttgcc cctcccaagg gtgaagctcc
     3181 ctctcacact gctccacact ggcccatctg acctgcagaa gtgctctagc tcacccctct
     3241 ggtgtgtggt gaggggcttt cttctcccac tcctttttga ctcccaccac ctcctgcaca
     3301 tgggtttggg gaggactgaa atggaagtcc cctcagagag tcttattatc aacactttat
     3361 gttttggtta ttggtttttc tttccttttt gtttttgtat agaccaaagc aaagaaaata
     3421 aaataacaca gagatccaaa aaaaaaaaaa aaaaaaaaaa aaa
//
