LOCUS       NM_138875               1679 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus JunD proto-oncogene, AP-1 transcription factor
            subunit (Jund), transcript variant 1, mRNA.
ACCESSION   NM_138875 XM_579658
VERSION     NM_138875.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Costantino,S., Akhmedov,A., Melina,G., Mohammed,S.A., Othman,A.,
            Ambrosini,S., Wijnen,W.J., Sada,L., Ciavarella,G.M., Liberale,L.,
            Tanner,F.C., Matter,C.M., Hornemann,T., Volpe,M.,
            Mechta-Grigoriou,F., Camici,G.G., Sinatra,R., Luscher,T.F. and
            Paneni,F.
  TITLE     Obesity-induced activation of JunD promotes myocardial lipid
            accumulation and metabolic cardiomyopathy
  JOURNAL   Eur Heart J 40 (12), 997-1008 (2019)
   PUBMED   30629164
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Gupta,S., Kumar,P., Kaur,H., Sharma,N., Saluja,D., Bharti,A.C. and
            Das,B.C.
  TITLE     Selective participation of c-Jun with Fra-2/c-Fos promotes
            aggressive tumor phenotypes and poor prognosis in tongue cancer
  JOURNAL   Sci Rep 5, 16811 (2015)
   PUBMED   26581505
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Zou,T., Rao,J.N., Liu,L., Xiao,L., Chung,H.K., Li,Y., Chen,G.,
            Gorospe,M. and Wang,J.Y.
  TITLE     JunD enhances miR-29b levels transcriptionally and
            posttranscriptionally to inhibit proliferation of intestinal
            epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 308 (10), C813-C824 (2015)
   PUBMED   25788572
  REMARK    GeneRIF: JunD activates miR-29b by enhancing its transcription and
            processing, which contribute to the inhibitory effect of JunD
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Yao,S.T., Gouraud,S.S., Qiu,J., Cunningham,J.T., Paton,J.F. and
            Murphy,D.
  TITLE     Selective up-regulation of JunD transcript and protein expression
            in vasopressinergic supraoptic nucleus neurones in water-deprived
            rats
  JOURNAL   J Neuroendocrinol 24 (12), 1542-1552 (2012)
   PUBMED   22827527
  REMARK    GeneRIF: JunD is highly co-expressed with c-Fos in magnocellular
            neurons of the supraoptic nucleus following dehydration.
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Short,J.D. and Pfarr,C.M.
  TITLE     Translational regulation of the JunD messenger RNA
  JOURNAL   J Biol Chem 277 (36), 32697-32705 (2002)
   PUBMED   12105216
  REMARK    GeneRIF: Translation initiation from alternative AUG and non-AUG
            sites in human, mouse and rat.
REFERENCE   7  (bases 1 to 1679)
  AUTHORS   Prabhakar,N.R., Shenoy,B.C., Simonson,M.S. and Cherniack,N.S.
  TITLE     Cell selective induction and transcriptional activation of
            immediate early genes by hypoxia
  JOURNAL   Brain Res 697 (1-2), 266-270 (1995)
   PUBMED   8593588
REFERENCE   8  (bases 1 to 1679)
  AUTHORS   Yamada,T., Nakao,S., Osada,S., Imagawa,M. and Nishihara,T.
  TITLE     Sequence analysis of the rat jun-D gene
  JOURNAL   Gene 153 (2), 285-286 (1995)
   PUBMED   7875605
REFERENCE   9  (bases 1 to 1679)
  AUTHORS   Berger,I. and Shaul,Y.
  TITLE     Structure and function of human jun-D
  JOURNAL   Oncogene 6 (4), 561-566 (1991)
   PUBMED   1903194
REFERENCE   10 (bases 1 to 1679)
  AUTHORS   Hirai,S.I., Ryseck,R.P., Mechta,F., Bravo,R. and Yaniv,M.
  TITLE     Characterization of junD: a new member of the jun proto-oncogene
            family
  JOURNAL   EMBO J 8 (5), 1433-1439 (1989)
   PUBMED   2504580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138875.4.
            
            Summary: The protein encoded by this intronless gene is a member of
            the JUN family, and a functional component of the AP1 transcription
            factor complex. This protein has been proposed to protect cells
            from p53-dependent senescence and apoptosis. Alternative
            translation initiation site usage results in the production of
            different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) encodes two isoforms resulting
            from the use of alternative in-frame translation initiation codons.
            The longer isoform (JunD-FL) is derived from an upstream AUG (S1
            ORF, PMID:12105216), while the shorter isoform (deltaJunD) is
            derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq
            represents the longer isoform (JunD-FL).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC062053.1, SRR22582416.235404.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1679              JAXUCZ010000016.1  18768093-18769771   c
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1679
                     /gene="Jund"
                     /note="JunD proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:24518"
                     /db_xref="RGD:2945"
     exon            1..1679
                     /gene="Jund"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1133
                     /gene="Jund"
                     /note="isoform JunD-FL is encoded by transcript variant 1;
                     transcription factor jun-D; jun D proto-oncogene;
                     transcription factor AP-1 subunit JunD; transcription
                     factor JunD"
                     /codon_start=1
                     /product="transcription factor JunD isoform JunD-FL"
                     /protein_id="NP_620230.1"
                     /db_xref="GeneID:24518"
                     /db_xref="RGD:2945"
                     /translation="METPFYGEEALSGLAAGASSVAGAAGAPGGGGFAPPGRAFPGAP
                     PTSSMLKKDALTLSLAEQGAAGLKPGSATAPSALRPDGAPDGLLASPDLGLLKLASPE
                     LERLIIQSNGLVTTTPTSTQFLYPKVAASEEQEFAEGFVKALEDLHKQSQLGAATAAT
                     SGAPAPPAPADLAATPGATETPVYANLSSFAGGAGPPGGAATVAFAAEPVPFPPPPGA
                     LGPPPPPHPPRLAALKDEPQTVPDVPSFGDSPPLSPIDMDTQERIKAERKRLRNRIAA
                     SKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLP
                     QHQVPAY"
ORIGIN      
        1 tcggagccgg tctgtacggg cagcggactg gggggcatac ggggcccccc ggggaggccg
       61 cggccactcc ccccgccccg gggccgagcg cggcggggga ggcggggatg gaaacgccct
      121 tctatggcga ggaggcgctg agcggcctgg ctgcgggtgc gtcgagcgtc gctggtgctg
      181 ctggggcccc cggcggtggt ggcttcgcgc ccccgggccg cgctttcccc ggggcgcccc
      241 caacgagcag catgctgaag aaagacgcgc tgacgctcag cctggcggag cagggagcgg
      301 cgggattgaa accagggtcg gccactgcac cttctgcatt gcgccccgac ggcgcccccg
      361 acgggctgct ggcttcgccg gatcttgggc tgctcaaact cgcgtcgccg gagctggaaa
      421 ggctgatcat ccagtccaac gggctggtga ccaccacccc gaccagtacg cagttcctct
      481 accctaaggt ggcggccagc gaggagcagg agttcgccga aggcttcgtc aaggcgctgg
      541 aggacctgca caagcagagc cagctgggtg cggccaccgc ggccacctca ggggctcccg
      601 cgccccccgc gcccgcggac ctggcagcca cccccggggc cacggagacc ccggtctacg
      661 ccaacctgag cagtttcgcg ggtggcgccg ggccccctgg gggcgcggcc acagtggcct
      721 tcgccgcgga gccagtgccc ttcccgccgc ccccgggcgc gctggggccg ccgccacctc
      781 cgcatccacc gcgtctggcc gcgctcaagg acgagccgca gaccgtgccg gacgtgccga
      841 gcttcggcga cagccctcca ctgtcgccca tcgacatgga cacgcaggaa cgcatcaagg
      901 cggagcgcaa gaggctgcgc aaccgcatcg ccgcttccaa atgccgcaag cgcaagctgg
      961 agcgtatctc gcgcctggag gagaaagtca agaccctcaa aagccagaac accgagctgg
     1021 cgtccaccgc gagcctgctg cgcgagcagg tggcgcagct caaacagaaa gtcctcagcc
     1081 acgtcaacag cggctgccag ctgctgcccc agcaccaggt ccccgcgtat tgagcccgag
     1141 cgcgggacgc atgcgcggac tagatgcggt ggggggggcg ccccggactc tttcgagact
     1201 cggtgccccc ggactcgaca agctggaccc ccctttactc tggatgggga ccccgagcgc
     1261 acgatccccg ccctcgcgcc gcctctgtac ccccagtcct acgcgtggct gcccctttgt
     1321 acctccgagt aggggctcta aggggcgcgc agcctcacgc tctgccttta tttctttttt
     1381 tttttttttt ttttgccttt tggaagagag aacgggagtg tccgatttcg ccctatttat
     1441 gtttctactc gggaacaaac gttggttgcg tgttgcgtgt gtgtttcctt gtgttggttt
     1501 tttaaagaaa cgggaagaag aaaaaaaaaa tcctcccccc ttatcccccg cgctctctcc
     1561 tcctcccgac accatcccct ctctttttgt ttggttttgt tttgctacga gtccacattc
     1621 ctgttccgta atccttggtt cgccggtttt gtgttttcag taaagtcttc gttacgcca
//
