LOCUS       NM_021836               1822 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus JunB proto-oncogene, AP-1 transcription factor
            subunit (Junb), mRNA.
ACCESSION   NM_021836
VERSION     NM_021836.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Sun,Y., Wang,J., Pan,S., Yang,T., Sun,X., Wang,Y., Shi,X., Zhao,X.,
            Guo,J. and Zhang,X.
  TITLE     LINC00657 played oncogenic roles in esophageal squamous cell
            carcinoma by targeting miR-615-3p and JunB
  JOURNAL   Biomed Pharmacother 108, 316-324 (2018)
   PUBMED   30227324
  REMARK    Erratum:[Biomed Pharmacother. 2019 Mar;111:1507. doi:
            10.1016/j.biopha.2018.12.032.. PMID: 30600121]
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Yan,M., Yang,S., Meng,F., Zhao,Z., Tian,Z. and Yang,P.
  TITLE     MicroRNA 199a-5p induces apoptosis by targeting JunB
  JOURNAL   Sci Rep 8 (1), 6699 (2018)
   PUBMED   29703907
  REMARK    GeneRIF: Based on these findings, miR-199a-5p induces apoptosis by
            targeting JunB.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Pei,H., Guo,Z., Wang,Z., Dai,Y., Zheng,L., Zhu,L., Zhang,J., Hu,W.,
            Nie,J., Mao,W., Jia,X., Li,B., Hei,T.K. and Zhou,G.
  TITLE     RAC2 promotes abnormal proliferation of quiescent cells by enhanced
            JUNB expression via the MAL-SRF pathway
  JOURNAL   Cell Cycle 17 (9), 1115-1123 (2018)
   PUBMED   29895215
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Kong,X., Kuilman,T., Shahrabi,A., Boshuizen,J., Kemper,K.,
            Song,J.Y., Niessen,H.W.M., Rozeman,E.A., Geukes Foppen,M.H.,
            Blank,C.U. and Peeper,D.S.
  TITLE     Cancer drug addiction is relayed by an ERK2-dependent phenotype
            switch
  JOURNAL   Nature 550 (7675), 270-274 (2017)
   PUBMED   28976960
REFERENCE   5  (bases 1 to 1822)
  AUTHORS   Verma,G., Vishnoi,K., Tyagi,A., Jadli,M., Singh,T., Goel,A.,
            Sharma,A., Agarwal,K., Prasad,S.C., Pandey,D., Sharma,S.,
            Mehrotra,R., Singh,S.M. and Bharti,A.C.
  TITLE     Characterization of key transcription factors as molecular
            signatures of HPV-positive and HPV-negative oral cancers
  JOURNAL   Cancer Med 6 (3), 591-604 (2017)
   PUBMED   28155253
REFERENCE   6  (bases 1 to 1822)
  AUTHORS   Schorpp-Kistner,M., Wang,Z.Q., Angel,P. and Wagner,E.F.
  TITLE     JunB is essential for mammalian placentation
  JOURNAL   EMBO J 18 (4), 934-948 (1999)
   PUBMED   10022836
REFERENCE   7  (bases 1 to 1822)
  AUTHORS   Urakami,S., Tsuchiya,H., Orimoto,K., Kobayashi,T., Igawa,M. and
            Hino,O.
  TITLE     Overexpression of members of the AP-1 transcriptional factor family
            from an early stage of renal carcinogenesis and inhibition of cell
            growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene
            mutant (Eker) rat model
  JOURNAL   Biochem Biophys Res Commun 241 (1), 24-30 (1997)
   PUBMED   9405228
REFERENCE   8  (bases 1 to 1822)
  AUTHORS   Prabhakar,N.R., Shenoy,B.C., Simonson,M.S. and Cherniack,N.S.
  TITLE     Cell selective induction and transcriptional activation of
            immediate early genes by hypoxia
  JOURNAL   Brain Res 697 (1-2), 266-270 (1995)
   PUBMED   8593588
REFERENCE   9  (bases 1 to 1822)
  AUTHORS   Kitabayashi,I., Kawakami,Z., Matsuoka,T., Chiu,R., Gachelin,G. and
            Yokoyama,K.
  TITLE     Two cis-regulatory elements that mediate different signaling
            pathways for serum-dependent activation of the junB gene
  JOURNAL   J Biol Chem 268 (19), 14482-14489 (1993)
   PUBMED   8314805
REFERENCE   10 (bases 1 to 1822)
  AUTHORS   Kawakami,Z., Kitabayashi,I., Matsuoka,T., Gachelin,G. and
            Yokoyama,K.
  TITLE     Conserved structural motifs among mammalian junB genes
  JOURNAL   Nucleic Acids Res 20 (4), 914 (1992)
   PUBMED   1542584
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061862.1.
            
            On Dec 20, 2003 this sequence version replaced NM_021836.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061862.1, SRR8487226.221786.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1822
                     /gene="Junb"
                     /note="JunB proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:24517"
                     /db_xref="RGD:2944"
     exon            1..1785
                     /gene="Junb"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1305
                     /gene="Junb"
                     /note="transcription factor jun-B; Jun-B oncogene; jun B
                     proto-oncogene; transcription factor AP-1 subunit JunB"
                     /codon_start=1
                     /product="transcription factor JunB"
                     /protein_id="NP_068608.2"
                     /db_xref="GeneID:24517"
                     /db_xref="RGD:2944"
                     /translation="MCTKMEQPFYHDDSYAAAGYGRSPGSLSLHDYKLLKPTLALNLA
                     DPYRGLKGPGARGPGPEGSGAGSYFSGQGSDTGASLKLASTELERLIVPNSNGVITTT
                     PTPPGQYFYPRGGGSGGGTGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGASG
                     GPQAGPGGVYAGPEPPPVYTNLSSYSPASAPSGGSGTAVGTGSSYPTATISYLPHAPP
                     FAGGHPAQLGLSRGASAFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNR
                     LAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQ
                     LLLGVKGHAF"
ORIGIN      
        1 aggccagctt tggatcctgc agggagcggg gagctgagag aagagacgct gagaaagcgg
       61 gcgcaccacg gagggagaga aaagctccag aagccgggca gcgcttttac gcacagctac
      121 caactggccg ctgccgaccg tctccagctc ccgaggacgc gcgaccggac gccgggtccc
      181 gccacagccg aggacagctc gccggtcgcc gcagcgaggc ccggagcggc ccttcagggg
      241 gacctttccc agatcgccca ggccgcccgg atgtgcacga aaatggaaca gcctttctat
      301 cacgacgact catacgcagc ggcaggatac ggtcggagcc ctggcagtct ttctcttcac
      361 gactacaaac tcctgaaacc caccttagcg ctcaacctgg cagatcctta tcggggtctc
      421 aagggtcctg gggcgcgggg tccaggccca gagggcagtg gggcaggcag ctacttttcg
      481 ggtcagggat cagacacagg cgcatctctg aagctagcct ccacggaact ggagcgcttg
      541 atcgtcccca acagcaacgg cgtgatcacg acgacgccca cgcctccggg acagtacttt
      601 tacccccgtg ggggcggcag cggcggaggt acagggggcg gcgtcaccga ggagcaggag
      661 ggctttgcgg acggttttgt caaagccctg gacgacctgc acaagatgaa ccacgtgacg
      721 ccccccaacg tgtctctggg cgccagcggg ggtccccagg ccgggcctgg gggcgtctat
      781 gctggtccgg agccgcctcc ggtctacacc aacctcagca gttactcccc agcctctgca
      841 ccctctggag gttccgggac cgccgtcggg actgggagct catacccgac ggccaccatc
      901 agctacctcc cacatgcacc accctttgcg ggcggccacc cggcgcagct gggcttgagt
      961 cgcggcgctt ccgcctttaa agaggaaccg cagaccgtac cggaggcacg cagccgcgac
     1021 gccacgccgc ctgtgtcccc catcaacatg gaagaccagg agcgcatcaa agtggagcga
     1081 aagcggctgc ggaacaggct ggcggccacc aaatgccgga agcggaagct ggagcgcatc
     1141 gcgcgcctgg aggacaaggt gaagacactc aaggctgaga acgcggggct gtcaagtact
     1201 gccggcctcc tacgggagca agtggcgcag ctcaagcaga aggtcatgac ccacgtcagc
     1261 aacggctgcc agttgctgct aggggtcaag ggacacgcct tctgagagcc tcccttgctc
     1321 catacggaca cccccagcct tgaaggctgg gcgcccgccc cccactgggg tgaggggggc
     1381 aggcgatggg cactcgccca gaggtctggg gcgcagctca cacactggac tctggcctgc
     1441 ccgcctgcgc ccagtccttc cacctcgagg tttacatggc ccccttccag cgtattttgt
     1501 atgttttttt tttctggaaa gagactgaat tcatattgaa tataatatat ttgtgtattt
     1561 aacagggagg ggagaagggg gttgtcgcgg cggagctggc cccgccgcct ggtactcagc
     1621 ctgtggggat actagggagg aacctccgcc ccctgccctc cccctctgca cagtactgtg
     1681 gagaagaaac acgcacttcg tgtctaaagt ctattttaag atgtgtttgt gtgtgtgttt
     1741 gactttttat tgaatctatt taagtaaaaa aaaagtcttt attaaaaaaa aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aa
//
