LOCUS       NM_021835               3107 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Jun proto-oncogene, AP-1 transcription factor
            subunit (Jun), mRNA.
ACCESSION   NM_021835
VERSION     NM_021835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3107)
  AUTHORS   Li,Q., Li,S., Xu,C., Zhao,J., Hou,L., Jiang,F., Zhu,Z., Wang,Y. and
            Tian,L.
  TITLE     microRNA-149-5p mediates the PM2.5-induced inflammatory response by
            targeting TAB2 via MAPK and NF-kappaB signaling pathways in vivo
            and in vitro
  JOURNAL   Cell Biol Toxicol 39 (3), 703-717 (2023)
   PUBMED   34331613
REFERENCE   2  (bases 1 to 3107)
  AUTHORS   Shi,H., Duan,L., Lan,Y., He,Q., Pu,P. and Tang,H.
  TITLE     RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis
  JOURNAL   Oxid Med Cell Longev 2023, 7872193 (2023)
   PUBMED   36713029
  REMARK    GeneRIF: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3107)
  AUTHORS   Ramesh,R., Manurung,Y., Ma,K.H., Blakely,T. Jr., Won,S.,
            Moreno-Ramos,O.A., Wyatt,E., Awatramani,R. and Svaren,J.
  TITLE     JUN Regulation of Injury-Induced Enhancers in Schwann Cells
  JOURNAL   J Neurosci 42 (34), 6506-6517 (2022)
   PUBMED   35906072
  REMARK    GeneRIF: JUN Regulation of Injury-Induced Enhancers in Schwann
            Cells.
REFERENCE   4  (bases 1 to 3107)
  AUTHORS   Alam,M. and Mishra,R.
  TITLE     Bcl-xL expression and regulation in the progression, recurrence,
            and cisplatin resistance of oral cancer
  JOURNAL   Life Sci 280, 119705 (2021)
   PUBMED   34111459
REFERENCE   5  (bases 1 to 3107)
  AUTHORS   Tan,Y., Cao,H., Li,Q. and Sun,J.
  TITLE     The role of transcription factor Ap1 in the activation of the
            Nrf2/ARE pathway through TET1 in diabetic nephropathy
  JOURNAL   Cell Biol Int 45 (8), 1654-1665 (2021)
   PUBMED   33760331
  REMARK    GeneRIF: The role of transcription factor Ap1 in the activation of
            the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
REFERENCE   6  (bases 1 to 3107)
  AUTHORS   Pravenec,M., Gauguier,D., Schott,J.J., Buard,J., Kren,V., Bila,V.,
            Szpirer,C., Szpirer,J., Wang,J.M., Huang,H. et al.
  TITLE     Mapping of quantitative trait loci for blood pressure and cardiac
            mass in the rat by genome scanning of recombinant inbred strains
  JOURNAL   J Clin Invest 96 (4), 1973-1978 (1995)
   PUBMED   7560090
REFERENCE   7  (bases 1 to 3107)
  AUTHORS   Kitabayashi,I., Kawakami,Z., Chiu,R., Ozawa,K., Matsuoka,T.,
            Toyoshima,S., Umesono,K., Evans,R.M., Gachelin,G. and Yokoyama,K.
  TITLE     Transcriptional regulation of the c-jun gene by retinoic acid and
            E1A during differentiation of F9 cells
  JOURNAL   EMBO J 11 (1), 167-175 (1992)
   PUBMED   1310930
REFERENCE   8  (bases 1 to 3107)
  AUTHORS   Kitabayashi,I., Saka,F., Gachelin,G. and Yokoyama,K.
  TITLE     Nucleotide sequence of rat c-jun protooncogene
  JOURNAL   Nucleic Acids Res 18 (11), 3400 (1990)
   PUBMED   2113275
REFERENCE   9  (bases 1 to 3107)
  AUTHORS   Sakai,M., Okuda,A., Hatayama,I., Sato,K., Nishi,S. and Muramatsu,M.
  TITLE     Structure and expression of the rat c-jun messenger RNA: tissue
            distribution and increase during chemical hepatocarcinogenesis
  JOURNAL   Cancer Res 49 (20), 5633-5637 (1989)
   PUBMED   2507134
REFERENCE   10 (bases 1 to 3107)
  AUTHORS   Mermod,N., Williams,T.J. and Tjian,R.
  TITLE     Enhancer binding factors AP-4 and AP-1 act in concert to activate
            SV40 late transcription in vitro
  JOURNAL   Nature 332 (6164), 557-561 (1988)
   PUBMED   2833704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB740532.1, BE113912.1, BC078738.1, CK475341.1 and BF414978.1.
            
            On Nov 17, 2005 this sequence version replaced NM_021835.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               CB740532.1         98-429
            333-763             BE113912.1         32-462              c
            764-2433            BC078738.1         1-1670
            2434-2823           CK475341.1         294-683
            2824-3107           BF414978.1         1-284               c
FEATURES             Location/Qualifiers
     source          1..3107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3107
                     /gene="Jun"
                     /note="Jun proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:24516"
                     /db_xref="RGD:2943"
     exon            1..3094
                     /gene="Jun"
                     /inference="alignment:Splign:2.1.0"
     CDS             859..1863
                     /gene="Jun"
                     /note="transcription factor AP-1; AP1; activator protein
                     1; proto-oncogene c-jun; V-jun avian sarcoma virus 17
                     oncogene homolog; v-jun sarcoma virus 17 oncogene homolog;
                     Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun
                     oncogene; transcription factor AP-1 subunit Jun"
                     /codon_start=1
                     /product="transcription factor Jun"
                     /protein_id="NP_068607.1"
                     /db_xref="GeneID:24516"
                     /db_xref="RGD:2943"
                     /translation="MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLAD
                     PVGNLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKN
                     VTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYS
                     ASLHSEPPVYANLSNFNPGALSSGGGAPSYGATGLAFPSQPQQQQQPPQPPHHLPQQI
                     PVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRK
                     LERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
                     "
ORIGIN      
        1 ggacggactc ggctaacctg gtcgtccgcg gactccgggc tgttcatctg tttgtcttca
       61 ttttctgacc aactgcctgg atccagcgcc cgcagctcct gcaccggtgt tttggggagc
      121 acttggagag tcccttctcc cgcttttccc ggagaagaag ctcacaagtc ccggcactgc
      181 tgacagcatc gagaacggct ccggaccgcg cgaggaaata ggcgagcggc taccggccag
      241 caactttcct gacccagagg accgggaaca agtggcccgg agcgaacttt tgcaaaacct
      301 cttctgcgcc taaggctgcc accgagaccg taaagaaaag ggagaagagg aacctatact
      361 cataccagct cgcacaggcg gctgaagttg ggcgagtgct agccgcggct gcctagcgtc
      421 cccctccccc tcacagcgga ggaggggaca gttgtcggag gccgggcggc agagcccgat
      481 cgcgggcttc caccaagaat tccgtgacga ctggtctgcg ccgccggaga acctctgtcg
      541 ctggggctgg tccgcgggct ccgaggaacc gctgcttccc gagagcgctc cgtgagtgac
      601 cgcgactttt caaagctccg gatcgcgcgg gagccaacca acgtgagtgc aagcggtgtc
      661 ttaaccctgc gctccctgga gcgaactggg gaggagggcg caggggggag cactgcggtc
      721 tggagcgcac gctcctaaac aaactttgtt actgaagcgg ggacgcgcgg gtatcccccg
      781 cttcccggcg cgctgttgcg gccccgaaac ttctgcgcac agcccaggct aaccccgcgt
      841 gaagtgaccg actgttctat gactgcaaag atggaaacga ccttctacga cgatgccctc
      901 aacgcctcgt tcctccagtc cgagagtggc gcctacggct acagtaaccc taagattctg
      961 aagcagagca tgaccttgaa cctggccgac ccggtgggca atctgaagcc gcacctccga
     1021 gccaagaact cggaccttct cacgtcgccc gacgtcgggc tgctcaagct ggcgtcgccg
     1081 gagctggagc gcctgatcat ccagtccagc aatgggcaca tcaccactac accgaccccc
     1141 actcagttct tgtgccccaa gaacgtgacc gacgagcagg agggcttcgc cgaaggcttc
     1201 gtgcgcgccc tagctgaact gcatagccag aatacgctgc ccagtgtcac ctccgcggca
     1261 caacctgtca gtggggcggg catggtcgct cccgctgtgg cctcagtagc tggcgctggc
     1321 ggcggcggcg gctacagcgc cagcctgcac agtgagcctc cggtctacgc caacctcagc
     1381 aacttcaacc cgggtgcgct gagcagcggc ggtggggcgc cctcctatgg cgcgaccggg
     1441 ctggcctttc catcgcagcc ccagcagcag cagcagccgc ctcagccgcc gcaccacttg
     1501 ccccaacaga tcccggtgca gcacccgcgg ctgcaggcgc tgaaggaaga gccgcagacg
     1561 gtgccggaga tgccgggaga gacgccgccc ttgtccccca tcgacatgga gtctcaggag
     1621 cggatcaagg cggagaggaa gcgcatgagg aaccgcatcg ctgcctccaa gtgccggaaa
     1681 aggaagctgg agcggatcgc ccggctagag gaaaaagtga aaaccttgaa agcgcaaaac
     1741 tccgagctgg cgtccacggc caacatgctc agggaacagg tggcacagct taaacagaaa
     1801 gtcatgaacc acgttaacag tgggtgccaa ctcatgctaa cgcagcagtt gcaaacgttt
     1861 tgaggacaga ctgtcagggc tgaggggcag tggaagaaaa aaataacaga gataaacttg
     1921 agaacttgac tggttgcgac agagaaaaaa aagtgtccga gtactgaagc caagggtaca
     1981 caagatggac tgggttgcga cctgacggcg cccccagtgt gctggagtgg gaaggacgtg
     2041 gcgcgcctgg ctttggcgag gagccagaga gcagcggcct gttggccgcc acgctttgcg
     2101 aacgggctgt gcccgcgcga ccagaacgat ggacttttcg ttaacattga ccaagaactg
     2161 catggaccta acattcgatc tcattcagta ttaagggggg tgggtggggg cttacaaact
     2221 gcaatagaga ctgtagattg cttctgtagt gctccgtaag aacacaaagc agggagggct
     2281 gggaagggga gggaggcttg tgagtaccag gctagattgc ggatgaactc ccctggcctg
     2341 cctctctcaa ctatgtatgt acatatattt ttttttaatt tgatgaaagc tgattactgt
     2401 ctataataaa cagcttcctg cctttgtaag ttattccatg tttgtttgtt tgggtgtcct
     2461 acccagtgtt tgtaaataag agatttgaag cattctgagt ttaccatttg taataaagta
     2521 tataattttt ttatgttttg tttctgaaaa ttttcagaaa ggatatttaa gaaaacacaa
     2581 taaaccattg agaagtagcc cccaacctct ctgctgcatt atcgatagat aatgagagct
     2641 aggtgaaatg acagctgagt gtctgtatgc tggggtgaga gcctgtagtc cctcccgtct
     2701 ggttgtagga atagacaccc tgcatgctat cattggctca tactctctct ctccccagca
     2761 acccacaagt ccagactgtt gaccagaaga tggtgcagtg tttcttaagg ctggaagaag
     2821 agggtgttgc aaggggagag ggacagccca ctgggaaagc agacgcttga gttgagagcc
     2881 atatcaagta gcatgcgctg tgatcgttta taataataat aaagacttca gcaattagat
     2941 gtttatctca aagcagggac ccatggaagg ttttacaaaa ggtgtctcct tccaacttgg
     3001 attctgacga ctcctagaaa aagatgacct ttgcttgtgc atatttataa tagttcgtat
     3061 cacaataaat gtattcaaat aatggtttta aaaaaaaaaa aaaaaaa
//
