LOCUS       NM_001037974            2127 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Rattus norvegicus junctophilin 2 (Jph2), mRNA.
ACCESSION   NM_001037974 XM_230853
VERSION     NM_001037974.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2127)
  AUTHORS   Zhou,J., Liu,H., Lin,Y. and Zhao,J.
  TITLE     Membrane occupation and recognition nexus (MORN) motif controls
            protein localization and function
  JOURNAL   FEBS Lett 596 (14), 1839-1850 (2022)
   PUBMED   35568981
  REMARK    Review article
REFERENCE   2  (bases 1 to 2127)
  AUTHORS   Poulet,C., Sanchez-Alonso,J., Swiatlowska,P., Mouy,F.,
            Lucarelli,C., Alvarez-Laviada,A., Gross,P., Terracciano,C.,
            Houser,S. and Gorelik,J.
  TITLE     Junctophilin-2 tethers T-tubules and recruits functional L-type
            calcium channels to lipid rafts in adult cardiomyocytes
  JOURNAL   Cardiovasc Res 117 (1), 149-161 (2021)
   PUBMED   32053184
  REMARK    GeneRIF: Junctophilin-2 tethers T-tubules and recruits functional
            L-type calcium channels to lipid rafts in adult cardiomyocytes.
REFERENCE   3  (bases 1 to 2127)
  AUTHORS   Luo,T., Li,L., Peng,Y., Xie,R., Yan,N., Fan,H. and Zhang,Q.
  TITLE     The MORN domain of Junctophilin2 regulates functional interactions
            with small-conductance Ca2+ -activated potassium channel subtype2
            (SK2)
  JOURNAL   Biofactors 47 (1), 69-79 (2021)
   PUBMED   31904168
  REMARK    GeneRIF: The MORN domain of Junctophilin2 regulates functional
            interactions with small-conductance Ca(2+) -activated potassium
            channel subtype2 (SK2).
REFERENCE   4  (bases 1 to 2127)
  AUTHORS   Chan,B.Y.H., Roczkowsky,A., Cho,W.J., Poirier,M., Lee,T.Y.T.,
            Mahmud,Z. and Schulz,R.
  TITLE     Junctophilin-2 is a target of matrix metalloproteinase-2 in
            myocardial ischemia-reperfusion injury
  JOURNAL   Basic Res Cardiol 114 (6), 42 (2019)
   PUBMED   31506724
  REMARK    GeneRIF: Degradation of junctophilin-2 by MMP-2 is an early
            consequence of myocardial IR injury which may initiate a cascade of
            sequelae leading to impaired contractile function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2127)
  AUTHORS   Guo,A., Wang,Y., Chen,B., Wang,Y., Yuan,J., Zhang,L., Hall,D.,
            Wu,J., Shi,Y., Zhu,Q., Chen,C., Thiel,W.H., Zhan,X., Weiss,R.M.,
            Zhan,F., Musselman,C.A., Pufall,M., Zhu,W., Au,K.F., Hong,J.,
            Anderson,M.E., Grueter,C.E. and Song,L.S.
  TITLE     E-C coupling structural protein junctophilin-2 encodes a
            stress-adaptive transcription regulator
  JOURNAL   Science 362 (6421) (2018)
   PUBMED   30409805
REFERENCE   6  (bases 1 to 2127)
  AUTHORS   Jayasinghe,I., Baddeley,D., Kong,C.H., Wehrens,X.H., Cannell,M.B.
            and Soeller,C.
  TITLE     Nanoscale organization of junctophilin-2 and ryanodine receptors
            within peripheral couplings of rat ventricular cardiomyocytes
  JOURNAL   Biophys J 102 (5), L19-L21 (2012)
   PUBMED   22404946
  REMARK    GeneRIF: JPH2 is dispersed throughout RyR clusters and that the
            packing of JPH2 into junctions and the assembly of RyR clusters are
            tightly linked
REFERENCE   7  (bases 1 to 2127)
  AUTHORS   Wei,S., Guo,A., Chen,B., Kutschke,W., Xie,Y.P., Zimmerman,K.,
            Weiss,R.M., Anderson,M.E., Cheng,H. and Song,L.S.
  TITLE     T-tubule remodeling during transition from hypertrophy to heart
            failure
  JOURNAL   Circ Res 107 (4), 520-531 (2010)
   PUBMED   20576937
REFERENCE   8  (bases 1 to 2127)
  AUTHORS   Woo,J.S., Hwang,J.H., Ko,J.K., Weisleder,N., Kim,D.H., Ma,J. and
            Lee,E.H.
  TITLE     S165F mutation of junctophilin 2 affects Ca2+ signalling in
            skeletal muscle
  JOURNAL   Biochem J 427 (1), 125-134 (2010)
   PUBMED   20095964
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2127)
  AUTHORS   Minamisawa,S., Oshikawa,J., Takeshima,H., Hoshijima,M., Wang,Y.,
            Chien,K.R., Ishikawa,Y. and Matsuoka,R.
  TITLE     Junctophilin type 2 is associated with caveolin-3 and is
            down-regulated in the hypertrophic and dilated cardiomyopathies
  JOURNAL   Biochem Biophys Res Commun 325 (3), 852-856 (2004)
   PUBMED   15541368
REFERENCE   10 (bases 1 to 2127)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ304564.1.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001037974.2.
            
            On Dec 23, 2005 this sequence version replaced XM_230853.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ304564.1, FQ223967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2127
                     /gene="Jph2"
                     /note="junctophilin 2"
                     /db_xref="GeneID:296345"
                     /db_xref="RGD:1305196"
     exon            1..419
                     /gene="Jph2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2119
                     /gene="Jph2"
                     /note="JP-2; junctophilin type 2"
                     /codon_start=1
                     /product="junctophilin-2"
                     /protein_id="NP_001033063.1"
                     /db_xref="GeneID:296345"
                     /db_xref="RGD:1305196"
                     /translation="MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNF
                     GFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNS
                     GAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLR
                     TSLSSLRSEHSNGTVAPDSPAADGPTLPLPPVPRGGFALSLLATAEAARPPGLFTRGA
                     LLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDAD
                     IDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGK
                     YRHNVLVKGTKRRVLPLKSNKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKA
                     EAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPRERG
                     PGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGSSKDGLLSPGAWNGE
                     PGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSREPEVALYRGYHSYAVRT
                     GPPEPPPLEDEPEPEPEVPRSDSEPPSPVSATVQEEESPAPRSRVPAKPATLEPKPIV
                     PKAEPKAKARKTEARGLSKAGAKKKGRKEVAQEAEAEVEVEEVPNTVLICMVILLNIG
                     LAILFVHLLT"
     exon            420..1191
                     /gene="Jph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1310
                     /gene="Jph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..2038
                     /gene="Jph2"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2127
                     /gene="Jph2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagctggag gacggaggag ttgtcaggag cgaggatgag atgagcgggg gccgctttga
       61 ctttgatgat ggcggggcgt attgtggggg ctgggaaggg gggaaggcac atgggcacgg
      121 actgtgcacc ggccctaagg gccaaggtga atactcgggc tcctggaatt ttggctttga
      181 agtggcaggc gtctacacct ggcccagtgg gaataccttt gagggatatt ggagccaggg
      241 caaacgacat ggacttggca tagagaccaa ggggcgatgg ctctacaagg gggagtggac
      301 acatggcttc aaggggcgct acggaatccg gcagagcaca aacagtggtg ccaagtacga
      361 gggcacttgg aataacggcc tacaggatgg ttatggcacg gagacctatg cagacggagg
      421 gacctaccaa ggccaattca ccaacggcat gcggcatggc tacggcgtgc gccaaagcgt
      481 gccctacggg atggcagtgg tggtgcgctc cccgctgcgc acctcgctgt cctcgctgcg
      541 cagcgagcac agcaatggca cagtggctcc agactcgccg gcggcagacg ggcccacgct
      601 gcccttgccc ccggtgccgc gtggtggctt cgcgctcagc ctactggcca cggccgaggc
      661 tgcgcgtccc ccagggctgt tcacacgagg cgcactgctg ggtcgactgc gacgctcaga
      721 gtcacgcacg tcgctgggca gccagcgcag ccgcttgagc ttcctcaaga gcgagctgag
      781 ctcaggagcc agcgatgccg cgtccaccgg cagcctggcc gaaggcgccg agggccctga
      841 cgacgcggct gcacccttcg acgccgacat cgacgccacc accacggaga cctacatggg
      901 cgagtggaag aacgacaaac gctcgggctt cggtgtgagc gaacgttcca gcggccttcg
      961 ctacgagggc gagtggctgg acaacctgcg ccacggttac ggtcgcacca cgctgcccga
     1021 cggccaccgc gaggagggca agtaccgcca caatgtgctg gtcaagggca ccaagcgccg
     1081 cgtgctgccg ctcaagagca acaaggttcg ccagaaggtg gagcatgggg tcgagggtgc
     1141 gcaacgcgca gcagccattg cgcgccagaa ggctgagatt gctgcctcca ggacaagcca
     1201 tgccaaagcc aaggccgagg cagcagaaca ggctgccctg gctgccaacc aggagtccaa
     1261 cattgcccgt acattggcca aggagctggc tccagacttc taccagccag gtccggagta
     1321 tcagaagcgt cggctgctcc aggagatcct ggagaactca gagagcctgc tggagccccg
     1381 ggagcggggc ccgggcaccg gcctccccga acggccccgg gaaagcccac agctgcatga
     1441 gcgcgagacc ccgcagccgg agggcggacc cccttccccg gccggaacgc ccccgcaacc
     1501 caagagaccc cggccgggat cgtcaaagga cggtctgctg agtccgggtg cctggaacgg
     1561 cgagcccggt ggagagggca gccggcccgc cacgccatcg gatggcgccg gccgtcgtag
     1621 ccccgcgcgt ccggcttcgg agcacatggc catcgaggcg ctgcagccac cgcccgcgcc
     1681 ctcgcgggag cctgaggtgg cactgtaccg cggttaccac agctacgctg tgcgcaccgg
     1741 gccacccgag cccccgccct tggaggatga gcccgagccc gagcccgagg tcccgcgatc
     1801 cgactcggag cccccgtccc ccgtctccgc cacggtccag gaagaggagt cccctgcgcc
     1861 gcgaagccgg gtgcccgcca agcccgccac cttggagccc aagcccatag tccccaaagc
     1921 cgagcccaag gccaaggcgc gcaagacaga ggcccgcggg ctgagcaagg cgggtgccaa
     1981 gaagaagggc cggaaagaag tggcacagga ggccgaggcc gaggtggagg tagaggaggt
     2041 ccccaacacc gtcctcatct gtatggtgat cctgctgaac atcggcctgg ctatcctatt
     2101 cgttcacctc ctgacttgac cctcatc
//
