LOCUS       NM_001106630            2461 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), mRNA.
ACCESSION   NM_001106630 XM_001059299 XM_232578
VERSION     NM_001106630.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2461)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 2461)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 2461)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 2461)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 2461)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 2461)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            [WARNING] On Mar 18, 2025 this sequence was replaced by
            NM_001106630.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059299.1, XM_232578.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..2461
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..573
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2177
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001100100.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     exon            574..1333
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1452
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2096
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2192
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2461
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggtggtg gcgaccgcga gagaggaggg gaggacgggg gcagcgtcgg actggagccg
       61 atcggcggtg cgagctgccc ggggcgcagt cgtgagctcg cccgctgggt ccccacccac
      121 gagctacacc ctgcagtgcc cagctctgcc cgcgtacgtg cccccgcggg gagcgcgcag
      181 gggctgtccc ccgaatgacg ggcggaaggt tcgacttcga cgatggcggc acctactgcg
      241 gcggctggga ggagggcaag gcgcacgggc atggcatctg cacggggccc aagggccagg
      301 gcgagtactc tggctcctgg tcgcacggct tcgaggtggt tggaggctac acctggccca
      361 gcggcaacac ctaccagggc tattgggcgc agggcaagcg gcatgggctg ggggtggaga
      421 cgaagggcaa gtggatgtac cggggggagt ggtcacatgg tttcaagggg cgctacgggg
      481 tccgacagag cctgtgcacc cccgcccgct acgaggggac ctggagtaac gggctgcagg
      541 acgggtacgg cgtggagacc tacggggatg gaggtaccta ccagggccag tgggctggag
      601 gcatgcggca tggctacggt gtacgccaga gtgtgcccta tggcatggcc acggtgatcc
      661 gctccccgct gcgcacctcc ctggcctcac tgcgcagtga gcagagcaat ggcagcgtgc
      721 tgcatgaagc tgcagccgca gctgcagata acccggccgg cacaagaggt ggcttcgtgc
      781 tcaacttcca tgcggacaca gagctgggca agaagaagag tggcctcttc cgtcggggct
      841 ctcttctcgg cagcatgaaa ctccgcaagt ccgaatccaa gtcttccatc tccagcaagc
      901 gcagctcggt ccgcagtgat gcagccatga gcagaatcag ttctagcgat gccaactcca
      961 ccatcagctt cggtgacgtg gactgtgact tttgccctgt ggaagatcat gtggatgcca
     1021 ccaccacgga aacctacatg ggcgagtgga aaaacgataa gcgcaatggc ttcggcatca
     1081 gcgaacgctc caacggcatg aagtacgaag gcgagtgggc caataacaag aggcatgggt
     1141 acggctgcac tgtgtttccc gacggctcta aggaagaggg gaaatacaaa aataatatcc
     1201 tggtccgtgg aataaggaag cagcttatac caataagaaa tacaaaaact agggagaagg
     1261 tggatagagc cattgaaggt gcacaaaggg cagcggccat ggccagaacc aaagtggaaa
     1321 tagcaaactc aaggactgca catgccagag caaaagctga tgctgctgat caagctgcag
     1381 tggctgctcg ccaggagtgc gacattgcga gagctgtggc cagagagctg tcacctgatt
     1441 tctaccaacc aggtcctgat tatatcaaac aaagatttca agagggggta gatattaaag
     1501 aaaatccaga agaaaaggtc ccagaaaagc ctccatcacc aaaggaatcg cctcattttt
     1561 atcgcaaagg tacaacaccc cccaggtctc ccgaggcaag tcccaaacag agccactctc
     1621 cccagccttc ctccccaaag tccatgaaga aacagaaccc cagctcaggg gcaagactca
     1681 gtcacgataa aaggaacacg gctgaggaac aagtggtagc cattgtcaat aagcccttga
     1741 tgtcaaaggc tccttcaaag gaactgggag caaccgtgtc caagtactct ggccgccact
     1801 atgtccccaa ccccagcaat ggggagctgc actctcagta tcacggctac tatgttaaac
     1861 tgaacacgcc ccagcatcct ccagaagaca gggaggatga cagcggagtt ggccagtctt
     1921 cctcagcatt ggtacctaga ccgtcaccta acaagtggag tccccctaaa tctgtgacaa
     1981 aaccagttgc caaagaaagc aaaactgagc caaaagcaaa gaagtctgaa cttgctatac
     2041 caaagaatac agcaagcaat gatacctgcc ctcctttaga aaaagaagcc aattccggcc
     2101 ctaattccat catgattgtc ctggtcatgt tgttgaatat tgggttggcc attctttttg
     2161 ttcactttct cacttgattg gaattaggaa agggtcattt ccaaagtttg gccatcatga
     2221 atagagcagc agtgaacatg gtagagcaag tgcctctgtg gtaagaggaa atgtcccttg
     2281 ggcacatccc taagtgtggt atagcaggat cccacagaag atcacttgcc atcttttaag
     2341 taagtatcat gctgattccc atattgactt tctcaggcaa acgtaaaaat gtgaagaata
     2401 ttgagtattc agcaaaatcc atttttctcc cccaaaaagt aataaaggcc tatttcagga
     2461 c
//
