LOCUS       NM_001012143            1730 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus jumonji domain containing 6, arginine demethylase
            and lysine hydroxylase (Jmjd6), mRNA.
ACCESSION   NM_001012143 XM_340941
VERSION     NM_001012143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Wen,C., Xu,M., Mo,C., Cheng,Z., Guo,Q. and Zhu,X.
  TITLE     JMJD6 exerts function in neuropathic pain by regulating NF-kappaB
            following peripheral nerve injury in rats
  JOURNAL   Int J Mol Med 42 (1), 633-642 (2018)
   PUBMED   29620141
  REMARK    GeneRIF: JMJD6 may exert its therapeutic function in neuropathic
            pain by regulating NFkappaB following chronic constriction injury.
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Konuma,T., Yu,D., Zhao,C., Ju,Y., Sharma,R., Ren,C., Zhang,Q.,
            Zhou,M.M. and Zeng,L.
  TITLE     Structural Mechanism of the Oxygenase JMJD6 Recognition by the
            Extraterminal (ET) Domain of BRD4
  JOURNAL   Sci Rep 7 (1), 16272 (2017)
   PUBMED   29176719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Poulard,C., Rambaud,J., Hussein,N., Corbo,L. and Le Romancer,M.
  TITLE     JMJD6 regulates ERalpha methylation on arginine
  JOURNAL   PLoS One 9 (2), e87982 (2014)
   PUBMED   24498420
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Liu,W., Ma,Q., Wong,K., Li,W., Ohgi,K., Zhang,J., Aggarwal,A. and
            Rosenfeld,M.G.
  TITLE     Brd4 and JMJD6-associated anti-pause enhancers in regulation of
            transcriptional pause release
  JOURNAL   Cell 155 (7), 1581-1595 (2013)
   PUBMED   24360279
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Han,G., Li,J., Wang,Y., Li,X., Mao,H., Liu,Y. and Chen,C.D.
  TITLE     The hydroxylation activity of Jmjd6 is required for its
            homo-oligomerization
  JOURNAL   J Cell Biochem 113 (5), 1663-1670 (2012)
   PUBMED   22189873
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Kunisaki,Y., Masuko,S., Noda,M., Inayoshi,A., Sanui,T., Harada,M.,
            Sasazuki,T. and Fukui,Y.
  TITLE     Defective fetal liver erythropoiesis and T lymphopoiesis in mice
            lacking the phosphatidylserine receptor
  JOURNAL   Blood 103 (9), 3362-3364 (2004)
   PUBMED   14715629
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Cui,P., Qin,B., Liu,N., Pan,G. and Pei,D.
  TITLE     Nuclear localization of the phosphatidylserine receptor protein via
            multiple nuclear localization signals
  JOURNAL   Exp Cell Res 293 (1), 154-163 (2004)
   PUBMED   14729065
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Bose,J., Gruber,A.D., Helming,L., Schiebe,S., Wegener,I.,
            Hafner,M., Beales,M., Kontgen,F. and Lengeling,A.
  TITLE     The phosphatidylserine receptor has essential functions during
            embryogenesis but not in apoptotic cell removal
  JOURNAL   J Biol 3 (4), 15 (2004)
   PUBMED   15345036
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Li,M.O., Sarkisian,M.R., Mehal,W.Z., Rakic,P. and Flavell,R.A.
  TITLE     Phosphatidylserine receptor is required for clearance of apoptotic
            cells
  JOURNAL   Science 302 (5650), 1560-1563 (2003)
   PUBMED   14645847
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Fadok,V.A., Bratton,D.L., Rose,D.M., Pearson,A., Ezekewitz,R.A. and
            Henson,P.M.
  TITLE     A receptor for phosphatidylserine-specific clearance of apoptotic
            cells
  JOURNAL   Nature 405 (6782), 85-90 (2000)
   PUBMED   10811223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079012.1, BM391923.1 and CB789826.1.
            
            On Feb 16, 2007 this sequence version replaced NM_001012143.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132272,
                              SAMD00132298 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1190              BC079012.1         1-1190
            1191-1201           BM391923.1         611-621             c
            1202-1349           CB789826.1         213-360             c
            1350-1730           BC079012.1         1312-1692
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..1730
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /note="jumonji domain containing 6, arginine demethylase
                     and lysine hydroxylase"
                     /db_xref="GeneID:360665"
                     /db_xref="RGD:1305395"
     exon            1..416
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1499
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /EC_number="1.14.11.-"
                     /note="lysyl-hydroxylase JMJD6; jmjC domain-containing
                     protein 6; histone arginine demethylase JMJD6;
                     peptide-lysine 5-dioxygenase JMJD6; jumonji
                     domain-containing protein 6; phosphatidylserine receptor;
                     arginine demethylase and lysine hydroxylase"
                     /codon_start=1
                     /product="bifunctional arginine demethylase and
                     lysyl-hydroxylase JMJD6"
                     /protein_id="NP_001012143.2"
                     /db_xref="GeneID:360665"
                     /db_xref="RGD:1305395"
                     /translation="MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLSPAAVPD
                     NVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCG
                     EDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDL
                     FQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELI
                     KVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVL
                     NLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADAVDLQE
                     STGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTTHRRKKRRTCSMVGNGDTTSQD
                     DCVSKERSSSR"
     exon            417..805
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1092
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1228
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1367
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1700
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
     polyA_site      1700
                     /gene="Jmjd6"
                     /gene_synonym="Ptdsr"
ORIGIN      
        1 gaccttccca acatggcgcc caattggcgc gcgtgaaggc ggacctggca agtcgctgag
       61 gccaatggcg gaccgcatga ggcggtgggg cggggaggac ggctgctgtt cgcccaaccc
      121 gaagctccgg tggtggctgg ggagtgaatt ttctggaagg cgactttaaa ggcgccgggc
      181 cggagcgaag ggcgtttcgg tgccgcgcca gctggggagg gcgcacttgg tggcaggaag
      241 cgagtcgcgt cgaggtcgtg gcggaaccgg acgactaccc gctcacgatg aaccacaaga
      301 gcaagaagcg catccgcgag gccaagcgga gtgcgcggcc cgagctcaag gactcgcttg
      361 actggacgcg acacaattac tatgagagct acccgctgag ccctgcggcc gtgccggata
      421 acgtggagag agctgatgct ttgcagctgt cggtgaaaga atttgtagag cggtatgaaa
      481 gaccttacaa gcccgtggtt ctgctgaatg cacaagaggg ctggtccgca caggagaaat
      541 ggactctgga gcgtctcaaa aggaaatacc ggaaccagaa gttcaaatgc ggtgaggata
      601 atgacggcta ctcggtgaag atgaaaatga aatattacat cgagtacatg gagagcaccc
      661 gcgatgacag tcccctttac atctttgata gcagctatgg tgaacacccc aaaagaagga
      721 aacttttgga agactataag gtgcccaagt ttttcacaga tgatcttttc caatatgcgg
      781 gggagaagcg cagaccccct tacaggtggt ttgtgatggg gccaccacgt tctggaactg
      841 ggattcacat tgaccctctg gggaccagtg cctggaatgc cttagttcag ggtcacaagc
      901 ggtggtgcct gttcccaaca aacacacccc gagaactcat caaggtgacc cgagaagaag
      961 gaggaaacca acaggatgaa gcaattacct ggtttaatgt catttatccc cggacacagc
     1021 ttccaacctg gccacccgaa ttcaaacccc tggagatatt gcagaaacca ggagaaactg
     1081 tctttgtacc agggggctgg tggcacgtcg tcctcaatct tgacaccacc attgccatca
     1141 cccagaactt tgccagcagc accaacttcc ctgttgtgtg gcacaagacg gtaagagggc
     1201 ggccaaagtt atccaggaag tggtatagga tcttgaagca ggagcaccct gagctggcag
     1261 tgcttgccga cgctgttgac ctccaagagt ccacaggcat cgcctctgac agctccagtg
     1321 actcttctag ctcctccagc tccagctcgt cggactcaga ctcggagtgt gaatctgggt
     1381 cagaaggtga tgggacaaca catcgcagga agaagaggag aacttgcagc atggtgggaa
     1441 atggggacac tacctcacag gatgactgcg tgagcaaaga gcgcagttcc tccaggtgac
     1501 cacatgtggc cgctgtctgt gcaaggctgt gcttgcagca aggcttagga gggctgacac
     1561 ccagagaaca aggacactga gatgggagtt ggtagcattt ggtacagtgg cttttctcca
     1621 tggtcatatc ttaggggcaa aggtgtgtgg atggtgccaa cgaaaccctt tacctattta
     1681 ataaagacga atacatttta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
