LOCUS       NM_001191719            8363 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus jumonji domain containing 1C (Jmjd1c), mRNA.
ACCESSION   NM_001191719 XM_228122
VERSION     NM_001191719.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8363)
  AUTHORS   Zhang,S., Lu,Y. and Jiang,C.
  TITLE     Inhibition of histone demethylase JMJD1C attenuates cardiac
            hypertrophy and fibrosis induced by angiotensin II
  JOURNAL   J Recept Signal Transduct Res 40 (4), 339-347 (2020)
   PUBMED   32122211
  REMARK    GeneRIF: Inhibition of histone demethylase JMJD1C attenuates
            cardiac hypertrophy and fibrosis induced by angiotensin II.
REFERENCE   2  (bases 1 to 8363)
  AUTHORS   Kuroki,S., Akiyoshi,M., Tokura,M., Miyachi,H., Nakai,Y., Kimura,H.,
            Shinkai,Y. and Tachibana,M.
  TITLE     JMJD1C, a JmjC domain-containing protein, is required for long-term
            maintenance of male germ cells in mice
  JOURNAL   Biol Reprod 89 (4), 93 (2013)
   PUBMED   24006281
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8363)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   4  (bases 1 to 8363)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001191719.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000020.1  21461553-21461717   c
            166-330             JAXUCZ010000020.1  21435574-21435738   c
            331-444             JAXUCZ010000020.1  21401113-21401226   c
            445-550             JAXUCZ010000020.1  21375318-21375423   c
            551-675             JAXUCZ010000020.1  21373462-21373586   c
            676-819             JAXUCZ010000020.1  21372267-21372410   c
            820-1012            JAXUCZ010000020.1  21371980-21372172   c
            1013-2688           JAXUCZ010000020.1  21370030-21371705   c
            2689-2861           JAXUCZ010000020.1  21366258-21366430   c
            2862-5032           JAXUCZ010000020.1  21363726-21365896   c
            5033-5234           JAXUCZ010000020.1  21359536-21359737   c
            5235-5449           JAXUCZ010000020.1  21357459-21357673   c
            5450-5602           JAXUCZ010000020.1  21356367-21356519   c
            5603-5692           JAXUCZ010000020.1  21351270-21351359   c
            5693-5820           JAXUCZ010000020.1  21350598-21350725   c
            5821-6031           JAXUCZ010000020.1  21350092-21350302   c
            6032-6246           JAXUCZ010000020.1  21349429-21349643   c
            6247-6525           JAXUCZ010000020.1  21348661-21348939   c
            6526-6694           JAXUCZ010000020.1  21345515-21345683   c
            6695-6785           JAXUCZ010000020.1  21344597-21344687   c
            6786-6916           JAXUCZ010000020.1  21343710-21343840   c
            6917-7039           JAXUCZ010000020.1  21343189-21343311   c
            7040-7179           JAXUCZ010000020.1  21339217-21339356   c
            7180-7356           JAXUCZ010000020.1  21337798-21337974   c
            7357-7488           JAXUCZ010000020.1  21332451-21332582   c
            7489-8363           JAXUCZ010000020.1  21330990-21331864   c
FEATURES             Location/Qualifiers
     source          1..8363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..8363
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /note="jumonji domain containing 1C"
                     /db_xref="GeneID:171120"
                     /db_xref="RGD:708458"
     CDS             1..7578
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /EC_number="1.14.11.65"
                     /codon_start=1
                     /product="probable JmjC domain-containing histone
                     demethylation protein 2C"
                     /protein_id="NP_001178648.3"
                     /db_xref="GeneID:171120"
                     /db_xref="RGD:708458"
                     /translation="MAVETRPELVGKRFLCVAAGEDARPERGQSGCGRGWRAGVIRAV
                     SHRDRGHPDLAVYVEFDDLEWDKREWVKVYEDFSTFLVEYHLIWAKRKDPSQTQGSKS
                     RQIQWPALTFKPLVENSIPSSVTAVEFLIDKQVDFLTEESAFQLYQDDIDSLKPELRD
                     NPQLHAEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRT
                     MIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRASQNISTVHGHY
                     TRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPSKRKGSDSSAPDEERMKGDKYDYG
                     SRGENPKGKNKHMVTKRRKPEEDEKRLTMKRLRTDNASDASESSDSENSSKRITENSS
                     EQTPEYELKNKITSKINGEDGQPQAAEKAGEEILIDTRPHWDQMQEDKNHEEGEKLKS
                     MDSHLQDKITLRASEQATDADPNSNDSVLQECNMENQRTVELPSKDRVVSRTPTPKCA
                     MDIKNDTHSERAAQEKSNTFGLQIPENMDSNVSDSKHSNAKYLEAAKKDCDQSWVSDV
                     VKVDLTQSSTTNTPSGNDNREMEKERNHYVSYMSSLSTVSVTEDQLHKRSPPPETIRS
                     KLTTSVDTQKTKSSSSPEVFKPKVTHSPDSVKSRAAYGNSQAAGERRQASKAEHELSR
                     GSFHAAPTRGSALETTKSPLIIDKNEHFTVYRDPALIGSEAGANHISPFLSQHPFPLH
                     SSSHRTCLNPGSHHPALTPGPHLLAGSSSQTPLPTINTHPLTSGPHHPVHHPHLLPTV
                     LPGVPTASLLGGHPRLESAHTGSLSHLALAHQQQQLLQHQSPHLLGQAHPSASYNQLG
                     LYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQPTPVTSADG
                     IGLLSHIPVRPSSAEPPRPHKMTVHSSPPLTKTLADHHKEELERKAFMEPLRSNASTS
                     VKGDLDLNRSQAGKDCHLHRHFVGPRLPPETGERLNKYKEEHRRILQESIDVAPFTTK
                     IKGHEVERENYSRVVPSSSSPKSHAIKPDKDMDRSVSELYKMKHSVSQSLPQSNYFTT
                     LSNSVLNEPPRSYPSKEVSSIHTEKQNSNLSAAANPQTLSFISSLSKPPPLIKHQPES
                     ESLVGKVPDHLPHQSASHSVTTFRSDCRSPTHLTVCSTNALRSMPALHRAPVFHPPIH
                     HSLERKESSYSSLSPPTLTPVMPVNAGGKAQESQKPPTLIPEPKDSQADLKSSDQSLV
                     EVWRSNNLSKEKAEWPVEKNSGKSQAAVASVIVRPPSSTKVDSVPSGPLAAKDRVCER
                     ASSGANKTDYLKPEAGETGRILLPNVNLESAHVKSEKNFEAASQGSVPVSVMSAVNVV
                     SATQTDVLTSAGPTTSVSSLAGSEATYSLSNIISASTPLECPSSKSVSQSVAQAKGCK
                     VSTPVPVTLACSKTANAVQPGSGFSGTTDFIHLKKHKAALAAAQYKNSNVSEAELNTV
                     RNQTAAASLPLDSTMTCAASNKAVSVGNGPAAQPSQPNYHTKLKKAWLTRHSEEDKNT
                     NKMENSGTCVSEMIKPCSVNLIASTSSDIQNSVDGRVTVDKYGRDEKASRRKAKRTYE
                     SGSESADSDGSESKAEQRTKRQPKPTYKKKQNDLQKRKGEIEEDLKPNGVLSRSAKEK
                     SKLKLQNSSTGVPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSK
                     KGEESTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDDID
                     VETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNV
                     HWVCRKCGFVACLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLT
                     DLLDAMHVLREKYGIKSHCHCANRQNLQGGNVPTMNGVSQVLQNALHHSNKTSACPPE
                     SQQQSTPQRAQANGSSSPGSASTDSRLTPPESQSPLHWLADLAEQKSREEKQENKEFT
                     LEKEIKEDEEQDTPDSPNGSTSPPASQNSEQGSTLRDLLTTTAGKLRVGSTDAGIAFA
                     PVYSMGASSGKGGRTMPNILDDIIASVVENKIPPNKTSKINVKSEPNEEPKESRQSAT
                     NESNKFYRDIPHTWICDQHVLWLKDYKNSNNWKLFKECWKQGQPAVVSGVHKKMNVSL
                     WKAESISLDFGDHQADLLNCKDSIVSNANVKEFWDGFEEVSKRQKNKGGETVVLKLKD
                     CPSGEDFKTMMPARYEDFLRSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYG
                     VAAAKDHDIGTTNLHIEASDVVNVLVYVGIAKGNGVLSKAGILKKFEEEELDDILRKR
                     LKDSSEIPGALWHIYAGKDVDKIREFLQKVSKEQGLEVLPEHDPVRDQGWYVNRRLRQ
                     RLLEEYGVRACTLVQFLGDAIVLPAGTLHQVQNFHSCIQVTEDFVSPEHLVQSFHLTQ
                     ELRLLKEEINYDDKLQVKNILYHAVKEMVRALKMHEDEVEDMEDT"
     exon            1..165
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            166..330
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..444
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..550
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..675
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..819
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1012
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..2688
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2861
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..5032
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5234
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..5449
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5450..5602
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5603..5692
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5693..5820
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5821..6031
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6032..6246
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6247..6525
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6526..6694
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6695..6785
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6786..6916
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6917..7039
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7040..7179
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7180..7356
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7357..7488
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7489..8363
                     /gene="Jmjd1c"
                     /gene_synonym="Pr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggtgg agacccggcc cgagctagtg ggaaagcggt tcctgtgcgt ggcggccggc
       61 gaggacgcgc gtcccgagcg cgggcagagc ggctgcgggc gcggctggcg ggcgggggtc
      121 atccgagccg tgtcccaccg cgaccgcggc cacccggacc tggcggtcta cgtggaattt
      181 gatgaccttg aatgggataa acgggagtgg gttaaagttt atgaagattt ttcaactttc
      241 ttggtggaat atcacttaat ctgggccaaa aggaaggacc ctagccagac tcagggatca
      301 aagagcagac agattcagtg gcctgcgctg accttcaaac cattggttga aaatagtata
      361 ccaagttctg tcactgcggt agagttcctt atcgataagc aagtggattt tttaacagaa
      421 gagagtgcct ttcagctata ccaggacgac atagacagcc taaagcccga actcagggac
      481 aacccacagc tgcatgcgga agtgaaagtc tgggtgaagg aacagaaggt tcaggagatt
      541 tttatgcaag gtccttattc attaaatgga tacagagtga gagtctatag acaagattct
      601 gccacccagt ggtttactgg cataattact catcatgacc tcttcacccg caccatgatc
      661 gttatgaatg atcaggtact agaaccacag aatgtcgatc cttctatggt tcaaatgacc
      721 tttctagatg atgtcgttca ctctttgtta aaaggtgaaa atattggcat tacatcacga
      781 cgcaggtctc gtgccagtca aaatatcagc actgttcacg gtcattatac gcgtgctcaa
      841 gcaaatagtc ccagaccagc aatgaactct caagctgctg taccaaaaca gaatacacac
      901 cagcaacagc aacaaagaag tattcgtcca agtaagagga agggctcaga cagcagtgca
      961 cctgatgaag agaggatgaa gggagataaa tacgactatg gatcccgagg agaaaatcct
     1021 aaaggtaaaa acaaacacat ggtgactaaa agacggaaac ctgaggagga tgaaaagagg
     1081 ctgaccatga aaaggctgcg gacggacaat gcttccgacg cttctgagag cagtgactca
     1141 gaaaactcaa gcaagagaat tactgagaat tcctctgaac aaacaccaga gtatgaactg
     1201 aaaaataaaa tcacttcaaa gataaatgga gaggatggtc aaccccaggc agctgagaag
     1261 gcaggagaag agattctcat agatactcgg cctcactggg accagatgca agaagataaa
     1321 aaccatgaag aaggggagaa gctcaagtcc atggatagcc acctacaaga caagataact
     1381 ctccgtgcat ccgagcaagc cacagatgct gaccccaatt ctaatgactc agtccttcaa
     1441 gaatgcaata tggaaaacca acgcacagtg gaattaccat caaaggacag ggtcgtgtcc
     1501 agaacaccga cacccaagtg tgctatggat atcaaaaacg acactcattc agagagggca
     1561 gctcaggaaa agtcaaatac ttttggtctc cagatacctg agaacatgga ttcaaatgtt
     1621 agtgattcca aacattcaaa tgctaaatac ctagaagcag caaagaaaga ttgtgaccag
     1681 agttgggtca gtgatgtagt gaaagtggat ttaacacaat caagtactac aaatactcct
     1741 tcaggaaatg ataaccgaga aatggagaaa gagagaaatc actatgtctc atacatgtct
     1801 tcactaagta cggtttctgt cacagaggat cagctgcata agcgaagtcc acccccagaa
     1861 actataagat ctaaactaac tacttcagta gatactcaga agacaaaatc cagttcttca
     1921 cctgaagttt ttaaacccaa ggtcactcac tctcctgatt ctgtaaagtc tcgggctgct
     1981 tatgggaaca gtcaggccgc tggtgagcga aggcaggcga gtaaagcgga gcacgagtta
     2041 tccagaggta gtttccatgc cgccccgact cgaggcagcg ctctggaaac tacaaagagc
     2101 cctctaatca ttgataaaaa cgagcacttc acggtctata gggaccctgc gcttattgga
     2161 tcagaagcag gagctaatca catttcaccc ttcttgagcc agcatccttt ccctcttcat
     2221 tcctcatccc acagaacctg tttaaaccca ggtagccatc accctgcctt aacgccagga
     2281 ccccacttac tagctgggtc atctagtcaa actccattac ccaccattaa cactcaccct
     2341 ctcactagtg gtccacacca tcctgtccat caccctcatt tacttcccac tgtgttacct
     2401 ggagtgccta ctgcctcttt actgggtggc cacccgcgcc tggagagtgc tcacacaggc
     2461 agcttgagcc atttagcact agctcaccag cagcagcagc tgctacagca ccagtcacct
     2521 catcttctcg gacaagccca tccttccgct tcctataacc agcttggact ttacccaatt
     2581 atttggcaat atccgaatgg aacacatgca tactcaggac ttggtctccc ttcttctaag
     2641 tgggttcacc cagaaaatgc agttaatgct gaagcttcat tgaggaggaa ttctcccagt
     2701 ccttggttac atcaacccac tcctgtgacc tcagcggatg gtattgggtt acttagtcac
     2761 attcctgtca gaccttccag tgcagagcct ccccgacctc acaagatgac agtgcattcc
     2821 agtcctccac tgacaaagac attagcagat caccacaaag aagaattgga gaggaaagct
     2881 tttatggaac ctttgcggtc taacgcatcc acatcagtaa aaggtgacct ggatcttaac
     2941 aggtcacagg caggaaaaga ttgtcacttg cataggcatt ttgtgggccc gaggctgccc
     3001 ccagagactg gcgagagact gaacaaatac aaggaggagc accgccggat tcttcaggag
     3061 agcattgacg tggctccatt tacaaccaag atcaagggcc atgaggttga gagagagaat
     3121 tactccagag tagtgccatc gtcttctagt cctaaaagcc atgctatcaa accagataaa
     3181 gacatggacc gctcggtgtc agagctgtat aagatgaagc actcggtgtc tcagagcctg
     3241 ccccagagca actacttcac cacgctgtct aacagtgtgc tcaatgagcc gccaaggtcc
     3301 tacccatcca aagaagtctc cagtatccac actgagaagc agaacagtaa cctttccgca
     3361 gcagccaatc ctcaaactct gtctttcata tcatctctct cgaagcctcc acctttgatt
     3421 aaacaccagc cagaaagtga aagtttggtt ggcaaggtac cagaccatct tccccaccag
     3481 agtgcatctc actcagtcac gacgttcaga agcgattgca ggagtcctac ccatctgacc
     3541 gtgtgttcta ccaacgcact ccgcagtatg cccgccctgc acagggcacc agtgttccat
     3601 ccaccaatcc atcacagcct ggaaagaaag gagagcagct acagcagcct ttcccctccc
     3661 actctgaccc cagtgatgcc agtcaatgct ggtggcaaag ctcaggagtc tcagaagccc
     3721 ccgacgctaa ttcctgagcc aaaggactct caggcagacc ttaagagttc tgaccagagt
     3781 ctagtggaag tgtggaggtc taacaacctc agcaaggaga aagccgagtg gcctgtggaa
     3841 aagaatagtg gaaagtctca ggctgctgtg gcatccgtca ttgtccgtcc accttctagt
     3901 acaaaagtcg atagtgtgcc atctggacct ttagctgcca aagatcgagt ttgtgaaaga
     3961 gcatcatccg gggcaaacaa aacagattac ctcaaaccgg aagccggaga gactggaaga
     4021 attcttctac ccaatgtgaa tttagaaagt gctcatgtga aatctgagaa gaactttgaa
     4081 gctgcctccc agggcagtgt tcctgtttca gtcatgtctg ctgtaaatgt agtctctgct
     4141 acccagacag atgtgctcac atctgctggc cctaccacca gtgtctccag cttggctggt
     4201 tcagaagcaa cttattcttt atcaaatatc atatcggcct ccacgccctt agaatgtcct
     4261 tcttcaaaaa gtgttagtca gtcagtggcg caagcaaagg gttgcaaagt cagcacccca
     4321 gttccagtta ctctggcctg tagtaagaca gcaaatgctg ttcagcctgg ttctggcttc
     4381 tcaggcacaa ctgattttat tcatttaaaa aagcacaagg cagcattggc tgcagctcag
     4441 tataaaaata gtaatgtcag tgaggctgag ctcaatactg tgagaaatca gactgcagca
     4501 gcctctcttc ccctggatag caccatgacc tgcgctgcaa gtaacaaagc agtctctgta
     4561 gggaatgggc cggcagccca gcccagccag cccaactacc acaccaaact gaagaaggcc
     4621 tggctcacca gacattcaga agaagacaaa aatactaaca aaatggaaaa ttcagggacc
     4681 tgtgtatcag agatgattaa gccatgttct gtcaacctaa tagcctctac atctagtgac
     4741 atacagaata gtgtggatgg cagggtcact gtagacaagt atggaaggga tgagaaagcc
     4801 agcaggagga aagccaaaag aacttacgag tctggctctg aaagcgcaga ctcagatggg
     4861 agtgaaagta aggcggagca gaggactaaa cggcagccca agccgactta caaaaagaag
     4921 cagaacgatc tgcagaagag gaagggcgag atcgaggaag acttgaagcc caatggtgtt
     4981 ctcagcagga gcgccaaaga gaaaagtaaa ttgaagttgc agaacagcag tactggcgtc
     5041 cctcgctcag tgttgaaaga ctggcggaag gtcaagaagc tgaagcaaac cggagagtcg
     5101 tttctgcagg atgactcttg ctgtgagata gggcccaact tacaaaagtg ccgagaatgt
     5161 agacttatcc gtagtaaaaa gggagaagaa tcaactcact caccagtgtt ttgtagattt
     5221 tactacttta ggagattgtc cttcagtaag aatggagtag tcaggataga tggtttctct
     5281 tctcctgatc aatatgatga tgaagccatg agcttatgga cccatgaaaa ttatgaagat
     5341 gatgacatag atgttgaaac ctctaaatat atcttggaca taataggtga caagttctgt
     5401 cagttagtaa catctgaaaa gacagctttg tcctgggtga aaaaggacgc caaaattgcc
     5461 tggaaaagag cagtgcgagg tgtccgggag atgtgtgacg cgtgcgaggc cacactgttc
     5521 aatgtccact gggtgtgccg caagtgtgga tttgtggctt gcttggattg ctacaaggcc
     5581 aaggagagga agagttctag agataaagaa ttgtatgctt ggatgaagtg tgtgaaaggt
     5641 cagcctcatg accataaaca tctgatgcca actcagatta tccctggctc tgtgttgaca
     5701 gaccttctcg atgccatgca cgttcttagg gagaagtatg gaattaaatc ccattgccac
     5761 tgtgcgaaca gacagaattt acagggtgga aatgtcccta caatgaatgg cgtgtctcaa
     5821 gttctacaga atgctcttca tcacagtaat aaaacctctg cgtgcccgcc tgagtctcag
     5881 cagcagagca ccccccagag agctcaggct aatggcagca gcagccctgg aagtgcaagc
     5941 acagacagca ggttgacgcc tcccgagtcc cagtcaccac tgcactggct ggctgatctt
     6001 gctgagcaaa aatccagaga ggaaaaacaa gaaaacaaag aatttacact tgaaaaggaa
     6061 attaaagaag atgaagaaca agatacccct gactctccaa atggcagcac atcccctcca
     6121 gcatcccaga acagtgaaca gggttcaacc ctgcgggatt tgctgaccac aacagctggc
     6181 aagcttcgtg tgggctctac cgatgctggc attgcctttg cgccagtgta ttcaatggga
     6241 gcctcaagtg gcaaaggcgg ccggactatg cctaacattc ttgatgacat cattgcctca
     6301 gtcgttgaaa acaaaatccc accgaataaa acgtccaaga tcaatgtaaa atcagagcct
     6361 aacgaagaac ctaaagaaag cagacaatct gccacgaatg aaagcaataa gttttaccgt
     6421 gacataccac acacttggat ctgtgatcag catgtcttat ggcttaaaga ttacaagaat
     6481 agtaacaact ggaagctttt caaagagtgt tggaaacaag gacagcctgc agtggtttcc
     6541 ggtgtgcata agaaaatgaa cgttagcttg tggaaggcag aatcaattag tctggatttt
     6601 ggagaccacc aagctgatct cctcaactgc aaagacagca ttgtttccaa tgccaacgtt
     6661 aaggagttct gggatggttt tgaagaagtg tcaaaacgtc aaaaaaacaa aggtggagaa
     6721 acagtggtgt taaaattgaa agactgcccg tctggagaag acttcaagac catgatgccg
     6781 gcaagatacg aagacttttt aagaagtctg ccattgccag aatactgcaa cccagaaggg
     6841 aagttcaatt tggcctccca tttgccaggg ttctttgtac gccctgatct agggcccagg
     6901 ctgtgcagtg cctatggcgt tgctgctgct aaggaccatg acataggaac cacaaacctt
     6961 cacatcgaag cttctgacgt tgtcaatgtt cttgtgtatg tcggcatagc caaaggaaat
     7021 ggcgtcctct caaaagcagg aatacttaag aagtttgaag aagaagaatt ggatgacatt
     7081 ttaaggaaaa gattgaagga ttcgagtgaa atccctggtg ctctgtggca tatttatgct
     7141 ggaaaagatg ttgacaagat aagggaattt cttcaaaagg tttcaaaaga gcaaggcctt
     7201 gaagtcctgc cagagcacga cccagtccgg gaccagggct ggtatgtgaa caggaggctc
     7261 cgccagaggc tgcttgagga gtacggggtg agagcctgca ctctggttca gttccttgga
     7321 gatgccattg tcctgccagc aggaacgctt catcaggtac agaatttcca cagctgcatt
     7381 caggtgacgg aagacttcgt ctccccagaa catcttgtac agtccttcca cttaacccag
     7441 gagctgaggc tcttgaagga agagatcaat tatgatgaca aactgcaggt taagaatatc
     7501 ttgtatcatg cagtcaagga aatggtgaga gctttgaaga tgcatgaaga tgaagtagag
     7561 gacatggaag acacttaagt gcttggaact gggatatccc ttgagtgaca ctaggtctga
     7621 cttaagctcc attaaaccat cagtgccaag aaattctctt tgtagtaatt acttgctact
     7681 gacaccacac cagtatagca ttgtgtcgca gccctgcgat tcagtgctag ctgtcaacca
     7741 agctgtgtgt aaaagcagct ctctagctgc tcctgtacca tgtgtatatg atgtttgtga
     7801 agacgccaga tttaaaatga tgtatttatt tttggtaaaa aaaaaaaaaa tctatgctat
     7861 attgttgatc aagtgtaaat gtgctgtgta cagtttaata aaataactga tatttttcac
     7921 tacatgagac agttactgtg agactaggac acaaacacca gctgttgcct gcgtttggaa
     7981 aattgctgga ttgcacagca gtcatgtcat aatcagaaaa ttactgccaa ataactgtaa
     8041 gatgtgtaag atacaaagta tataagtaga tactaaactc agacacttca atattttgtt
     8101 gaagctattg actgtacaat taaacatttt caaaaggtgt aatttattta aaattgtctc
     8161 attttggtaa aatttatgtg aagttttaaa gctaaatatt aaacttaata tgctatgtaa
     8221 atatatacat atatccattt caggatgtat ttttttaaag cgttggctgg cttttgttaa
     8281 agtgtaagtg ttacatatgg ctttgtacat tacagttgaa aggggtttac attttccatt
     8341 aaagacttta tcaagaactt gga
//
