LOCUS       NM_053894               1762 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Jun dimerization protein 2 (Jdp2), mRNA.
ACCESSION   NM_053894
VERSION     NM_053894.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Nakane,T., Matsumoto,S., Iida,S., Ido,A., Fukunaga,K., Murao,K. and
            Sugiyama,Y.
  TITLE     Candidate plasticity gene 16 and jun dimerization protein 2 are
            involved in the suppression of insulin gene expression in rat
            pancreatic INS-1 beta-cells
  JOURNAL   Mol Cell Endocrinol 527, 111240 (2021)
   PUBMED   33676985
  REMARK    GeneRIF: Candidate plasticity gene 16 and jun dimerization protein
            2 are involved in the suppression of insulin gene expression in rat
            pancreatic INS-1 beta-cells.
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Kimura,M.
  TITLE     IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor
            of ATF2-dependent transcription
  JOURNAL   FEBS Lett 582 (19), 2833-2837 (2008)
   PUBMED   18671972
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Nakade,K., Pan,J., Yoshiki,A., Ugai,H., Kimura,M., Liu,B., Li,H.,
            Obata,Y., Iwama,M., Itohara,S., Murata,T. and Yokoyama,K.K.
  TITLE     JDP2 suppresses adipocyte differentiation by regulating histone
            acetylation
  JOURNAL   Cell Death Differ 14 (8), 1398-1405 (2007)
   PUBMED   17464331
REFERENCE   4  (bases 1 to 1762)
  AUTHORS   Wardell,S.E., Kwok,S.C., Sherman,L., Hodges,R.S. and Edwards,D.P.
  TITLE     Regulation of the amino-terminal transcription activation domain of
            progesterone receptor by a cofactor-induced protein folding
            mechanism
  JOURNAL   Mol Cell Biol 25 (20), 8792-8808 (2005)
   PUBMED   16199860
  REMARK    GeneRIF: JDP-2 enhances transcriptional activity of progesterone
            receptor through a protein folding mechanism by an interdomain
            communication.
REFERENCE   5  (bases 1 to 1762)
  AUTHORS   Jin,C., Ugai,H., Song,J., Murata,T., Nili,F., Sun,K., Horikoshi,M.
            and Yokoyama,K.K.
  TITLE     Identification of mouse Jun dimerization protein 2 as a novel
            repressor of ATF-2
  JOURNAL   FEBS Lett 489 (1), 34-41 (2001)
   PUBMED   11231009
REFERENCE   6  (bases 1 to 1762)
  AUTHORS   Aronheim,A., Zandi,E., Hennemann,H., Elledge,S.J. and Karin,M.
  TITLE     Isolation of an AP-1 repressor by a novel method for detecting
            protein-protein interactions
  JOURNAL   Mol Cell Biol 17 (6), 3094-3102 (1997)
   PUBMED   9154808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 7, 2022 this sequence version replaced NM_053894.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.1092419.1,
                                           SRR21887623.2265945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000006.1  110993591-110993806
            217-449             JAXUCZ010000006.1  111002382-111002614
            450-554             JAXUCZ010000006.1  111027043-111027147
            555-1762            JAXUCZ010000006.1  111032185-111033392
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1762
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2"
                     /note="Jun dimerization protein 2"
                     /db_xref="GeneID:116674"
                     /db_xref="RGD:621611"
     exon            1..216
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..449
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..740
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2"
                     /codon_start=1
                     /product="jun dimerization protein 2"
                     /protein_id="NP_446346.1"
                     /db_xref="GeneID:116674"
                     /db_xref="RGD:621611"
                     /translation="MMPGQIPDPSVTAGSLPGLGPLTGLPSSALTTEELKYADIRNIG
                     AMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQR
                     ESERLELMNAELKTQIEELKLERQQLILMLNRHRPTCIVRTDSVRTPESEGNPLLEQL
                     DKK"
     exon            450..554
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1762
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcccgcc acagcctgcg ggagggactc tcggcggccg cgacgggggg cactggcggc
       61 ggcgggcgct gcagcggcgg cggcggggct ggcgccgcgg cggctcccgg gccgggacgg
      121 gcctgggcag cgggcggcag cagcgcggag agggcacggc gcctgcagca gggttctggg
      181 cccggggccg ccgcctccgc cagcggcttc tgcacgcccc tccaggccgg cctgccactc
      241 ctcctgctat gatgcctggg cagatcccag acccttcagt gaccgcaggc tctctgccag
      301 ggctcggccc cctcaccgga cttcccagct ctgctctgac cacagaggag ctgaaatacg
      361 ctgacatccg caacattggg gcgatgattg cgcccttgca cttcctggag gtgaaactgg
      421 gcaagaggcc ccaacccgtg aagagtgagc tagatgagga agaagagcga aggaaaaggc
      481 gccgggagaa gaacaaagtt gctgcagcca gatgccggaa caagaagaag gagcgcacgg
      541 agttcctgca gagggagtca gagaggctgg agctcatgaa cgcagagcta aagacccaga
      601 tagaggagct gaagcttgag aggcagcagc tgatcctgat gctcaaccgc caccggccca
      661 cctgtatcgt gcgtacagac agcgtcagga cgccggagtc ggaaggcaac ccgctgctgg
      721 agcagctgga caagaagtga ctgaaagcct ggaggaggca gcggaggaag aggaggaaga
      781 ggaggagcag caaagaggag gaggagcaaa gtgatggagg gcccctcccg ggcacgtgac
      841 aaactctatg atgaggctta gcataactgg cctccagctg gctctttttg gaaactcagc
      901 ccagccgcac aagagcaaga gcggactgaa gaaaccagag ggaccaggtg ctgagaccaa
      961 ggttgacccg cagatagggg ctgccccact ccagggccca acttgaaggg cacctaagcc
     1021 ggagaggtgc caaaccaggt agccaccttg ggctctctcc gccaagactc ccacccaggg
     1081 gactacggag cagccaagaa aagccatgca ttgcaaacac agtgtggccg aggatggagc
     1141 tcagcggagt ctgtaatcca ccttccccag ccctgcccaa gcccggtgga aagggggtgc
     1201 actgtggggc tgcgatggcc cagctggagt ttgctgaggc actgaggcgc gggcgccctt
     1261 ccaaagcaca cacccaatca atgaatgttt acagactggc tgtcctggcg gggcttccaa
     1321 ctgcacacgg tttttttata ctttctttct ttcttttttt tttttttaat attttttaca
     1381 aaaaaaagat tttatacgag caatatatat atgtggattt ctataatcac tcgatgtgac
     1441 acagtacaaa tatgctatgg tctgctgtta cagccattgt aattcctaag tactgtaggc
     1501 tctgggtgtt gggggggtag ccaggcgggt ggggtacatt tccatccttg taaccccttc
     1561 ctagtactca gtcctgtatc gctcagtaaa cattgctctt aattacccag ctgcctcgag
     1621 tggtgtctgc ccagggagag ggcatgccca gggcagatgt ttgggaagag tttccaaacc
     1681 tgccctacca agtaagcctg aatatgccca tttcacagat gaggagtctg aggcctagag
     1741 atgttaaaga actctgcaca ta
//
