LOCUS       NM_001402445            1987 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus joining chain of multimeric IgA and IgM (Jchain),
            mRNA.
ACCESSION   NM_001402445
VERSION     NM_001402445.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1987)
  AUTHORS   Almogren,A.
  TITLE     Characterization, quantification, and assessment of immune
            protection potential of secretory immunoglobulin A in colostrum
            samples from Saudi women
  JOURNAL   Saudi Med J 34 (10), 1013-1019 (2013)
   PUBMED   24145934
REFERENCE   2  (bases 1 to 1987)
  AUTHORS   Kolka,R., Valdimarsson,H., Bodvarsson,M., Hardarson,S. and
            Jonsson,T.
  TITLE     Defective immunoglobulin A (IgA) glycosylation and IgA deposits in
            patients with IgA nephropathy
  JOURNAL   APMIS 121 (9), 890-897 (2013)
   PUBMED   23398317
REFERENCE   3  (bases 1 to 1987)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 1987)
  AUTHORS   Longet,S., Miled,S., Lotscher,M., Miescher,S.M., Zuercher,A.W. and
            Corthesy,B.
  TITLE     Human plasma-derived polymeric IgA and IgM antibodies associate
            with secretory component to yield biologically active
            secretory-like antibodies
  JOURNAL   J Biol Chem 288 (6), 4085-4094 (2013)
   PUBMED   23250751
REFERENCE   5  (bases 1 to 1987)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (bases 1 to 1987)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   7  (bases 1 to 1987)
  AUTHORS   Petrusic,V., Zivkovic,I., Stojanovic,M., Stojicevic,I.,
            Marinkovic,E., Inic-Kanada,A. and Dimitijevic,L.
  TITLE     Antigenic specificity and expression of a natural idiotope on human
            pentameric and hexameric IgM polymers
  JOURNAL   Immunol Res 51 (1), 97-107 (2011)
   PUBMED   21786026
REFERENCE   8  (bases 1 to 1987)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   9  (bases 1 to 1987)
  AUTHORS   Braathen,R., Hohman,V.S., Brandtzaeg,P. and Johansen,F.E.
  TITLE     Secretory antibody formation: conserved binding interactions
            between J chain and polymeric Ig receptor from humans and
            amphibians
  JOURNAL   J Immunol 178 (3), 1589-1597 (2007)
   PUBMED   17237408
REFERENCE   10 (bases 1 to 1987)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097960.1, CO573224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000014.1  19822976-19823068
            94-214              JAXUCZ010000014.1  19824549-19824669
            215-295             JAXUCZ010000014.1  19828350-19828430
            296-1987            JAXUCZ010000014.1  19829381-19831072
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1987
                     /gene="Jchain"
                     /gene_synonym="Igj"
                     /note="joining chain of multimeric IgA and IgM"
                     /db_xref="GeneID:360922"
                     /db_xref="RGD:1310155"
     exon            1..93
                     /gene="Jchain"
                     /gene_synonym="Igj"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..509
                     /gene="Jchain"
                     /gene_synonym="Igj"
                     /note="immunoglobulin joining chain; immunoglobulin J
                     chain"
                     /codon_start=1
                     /product="immunoglobulin J chain precursor"
                     /protein_id="NP_001389374.1"
                     /db_xref="GeneID:360922"
                     /db_xref="RGD:1310155"
                     /translation="MKTHLLLWGVLAIFVKAVIVTGDNKGTILADNKCMCTRITSRII
                     PSPEDPNEDIVERSIRIVVPLNNRENISDPTSPVRTNFVYHLSDVCKKCDPVEVELED
                     QVVTATQSNICSGDSGVPETCYMYDRNKCYTAMVPLRYHGETKMVQTALTPDSCYPD"
     exon            94..214
                     /gene="Jchain"
                     /gene_synonym="Igj"
                     /inference="alignment:Splign:2.1.0"
     exon            215..295
                     /gene="Jchain"
                     /gene_synonym="Igj"
                     /inference="alignment:Splign:2.1.0"
     exon            296..1987
                     /gene="Jchain"
                     /gene_synonym="Igj"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcagtc tttcaaaagt gaagacaaga tgaagaccca cttgcttctc tggggagtcc
       61 tggccatttt tgttaaggct gtcattgtaa caggtgacaa taaagggacc attcttgccg
      121 acaacaaatg catgtgtacc cgaattactt ccaggatcat cccttccccc gaggatccta
      181 atgaggacat tgtggagagg agtatccgaa ttgttgtccc tttgaacaac agggagaata
      241 tctccgatcc cacctcccca gtgagaacga actttgtgta ccatttgtca gacgtctgta
      301 agaaatgcga tcctgtggaa gtggagctgg aagatcaggt cgttactgcc acccagagca
      361 atatctgcag tggagacagc ggtgttcctg agacctgcta catgtatgac agaaacaagt
      421 gctatacagc tatggtccca cttaggtatc atggtgagac caaaatggtg caaacggccc
      481 tgacccctga ttcttgctac cctgactagt ttgagtcact cgccgtgcag cgctgtcttc
      541 agaggctctc cattgcaccc agaagttata ctcactgcta gtgaatttga aacgagtgct
      601 ttattttctt gtggtacaaa actaatgttc cctttcaaca gttagaatat cagcattgct
      661 gtcattatta ttattagtaa atcctcatgc ctggccaagg aggtgtgttt aagagttcat
      721 tttctggtgt taaaaattgt aagcaagggg agaaagtaaa attccaaggg taaaaatcaa
      781 aaggcataat tcaattcaat ccccttcctt cctccctccc tcccttcctc cctccctccc
      841 tccctccctc cctccctccc tcccttcctt ccttccttcc ttccttcctt ccttccttcc
      901 ttccttcctt cgctgtggag agctggagct tctgcactct atcctagtct ttctcactgt
      961 gcagagaaaa catcacataa acatagggca ggttatatct tcatgagaag ttataagggt
     1021 tgtggtttgg aactatctac taatgtttat gaaagtcata taatttgatg cacaaatgaa
     1081 aaaatgaatg ttgatagaat acatagactt gacattagat tttctttaaa attttttgac
     1141 agtgagatta ttgtctgaaa ttcttagggg actctttggc atctcagctg aatctaatga
     1201 aatctgtatt gcaaaatatg tattctctag tacagtttga acaattaaat agatcgataa
     1261 gcatatacct gtgtgaatga ttctttggaa aaaatttgct tgtgtttaac cttcttgtat
     1321 gtaaattaaa tatattatta ttggcaaacg gtttctaagt atgatgcaat ggtgcacttg
     1381 tcacttagct tatacgagca catatttgag aaatctttgt tatttcacag gtaaaattaa
     1441 gtccaaaggc agagtccatg gcacatagca ccttttggaa gcaggaggtg tactctgtgg
     1501 tagggagctt gcttatcatg cttaagacct tgatgtccac cactgtgaac agaagggagc
     1561 aaaacaaagc atagcaaaac aaaacaaaca accacaaaac ttttacaact tcatcccagt
     1621 agaatctcac tttaatggta ggcttatttc aaaggaataa ctcgtcacat acaaagaaac
     1681 attatggtag gacaccatgg tcaattgatg catttatcta agggcactac agaaagtaac
     1741 tgctgattca gaggctcatg tgaagatact tctgagctgg gaacaggggt tcagtgtcca
     1801 ggtctgagct gtatgccagc agtgcatatg aggtctagga ggcaacgcta atggcccaat
     1861 tgaaatttat attcttacaa ggctgaacta atatcaggca aggtaattaa atttaagatc
     1921 atttcttctt ttaaaatgag attacaaata actatttcct agattttata agaatgacga
     1981 tacatcc
//
