LOCUS       NM_001004269            1912 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus junctional adhesion molecule 3 (Jam3), mRNA.
ACCESSION   NM_001004269 XM_235956
VERSION     NM_001004269.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Aramsangtienchai,P., Spiegelman,N.A., Cao,J. and Lin,H.
  TITLE     S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its
            Tight Junction Localization and Cell Migration
  JOURNAL   J Biol Chem 292 (13), 5325-5334 (2017)
   PUBMED   28196865
REFERENCE   2  (bases 1 to 1912)
  AUTHORS   Arcangeli,M.L., Bardin,F., Frontera,V., Bidaut,G., Obrados,E.,
            Adams,R.H., Chabannon,C. and Aurrand-Lions,M.
  TITLE     Function of Jam-B/Jam-C interaction in homing and mobilization of
            human and mouse hematopoietic stem and progenitor cells
  JOURNAL   Stem Cells 32 (4), 1043-1054 (2014)
   PUBMED   24357068
REFERENCE   3  (bases 1 to 1912)
  AUTHORS   Manetti,M., Guiducci,S., Romano,E., Rosa,I., Ceccarelli,C.,
            Mello,T., Milia,A.F., Conforti,M.L., Ibba-Manneschi,L. and
            Matucci-Cerinic,M.
  TITLE     Differential expression of junctional adhesion molecules in
            different stages of systemic sclerosis
  JOURNAL   Arthritis Rheum 65 (1), 247-257 (2013)
   PUBMED   23001478
REFERENCE   4  (bases 1 to 1912)
  AUTHORS   Avari,P., Huang,W., Averill,S., Colom,B., Imhof,B.A., Nourshargh,S.
            and Priestley,J.V.
  TITLE     The spatiotemporal localization of JAM-C following sciatic nerve
            crush in adult rats
  JOURNAL   Brain Behav 2 (4), 402-414 (2012)
   PUBMED   22950044
REFERENCE   5  (bases 1 to 1912)
  AUTHORS   Hou,X., Hu,D., Wang,Y.S., Tang,Z.S., Zhang,F., Chavakis,T., Li,Y.
            and Li,X.
  TITLE     Targeting of junctional adhesion molecule-C inhibits experimental
            choroidal neovascularization
  JOURNAL   Invest Ophthalmol Vis Sci 53 (3), 1584-1591 (2012)
   PUBMED   22323465
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1912)
  AUTHORS   Gliki,G., Ebnet,K., Aurrand-Lions,M., Imhof,B.A. and Adams,R.H.
  TITLE     Spermatid differentiation requires the assembly of a cell polarity
            complex downstream of junctional adhesion molecule-C
  JOURNAL   Nature 431 (7006), 320-324 (2004)
   PUBMED   15372036
REFERENCE   7  (bases 1 to 1912)
  AUTHORS   Zen,K., Babbin,B.A., Liu,Y., Whelan,J.B., Nusrat,A. and Parkos,C.A.
  TITLE     JAM-C is a component of desmosomes and a ligand for
            CD11b/CD18-mediated neutrophil transepithelial migration
  JOURNAL   Mol Biol Cell 15 (8), 3926-3937 (2004)
   PUBMED   15194813
REFERENCE   8  (bases 1 to 1912)
  AUTHORS   Santoso,S., Sachs,U.J., Kroll,H., Linder,M., Ruf,A., Preissner,K.T.
            and Chavakis,T.
  TITLE     The junctional adhesion molecule 3 (JAM-3) on human platelets is a
            counterreceptor for the leukocyte integrin Mac-1
  JOURNAL   J Exp Med 196 (5), 679-691 (2002)
   PUBMED   12208882
REFERENCE   9  (bases 1 to 1912)
  AUTHORS   Liang,T.W., Chiu,H.H., Gurney,A., Sidle,A., Tumas,D.B., Schow,P.,
            Foster,J., Klassen,T., Dennis,K., DeMarco,R.A., Pham,T., Frantz,G.
            and Fong,S.
  TITLE     Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2
            interacts with T, NK, and dendritic cells through JAM 3
  JOURNAL   J Immunol 168 (4), 1618-1626 (2002)
   PUBMED   11823489
REFERENCE   10 (bases 1 to 1912)
  AUTHORS   Arrate,M.P., Rodriguez,J.M., Tran,T.M., Brock,T.A. and
            Cunningham,S.A.
  TITLE     Cloning of human junctional adhesion molecule 3 (JAM3) and its
            identification as the JAM2 counter-receptor
  JOURNAL   J Biol Chem 276 (49), 45826-45832 (2001)
   PUBMED   11590146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079429.1.
            
            On Sep 10, 2004 this sequence version replaced XM_235956.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079429.1, SRR8487231.69733.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1912
                     /gene="Jam3"
                     /note="junctional adhesion molecule 3"
                     /db_xref="GeneID:315509"
                     /db_xref="RGD:1303248"
     exon            1..93
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..950
                     /gene="Jam3"
                     /note="junctional adhesion molecule C; JAM-3; JAM-C"
                     /codon_start=1
                     /product="junctional adhesion molecule C precursor"
                     /protein_id="NP_001004269.1"
                     /db_xref="GeneID:315509"
                     /db_xref="RGD:1303248"
                     /translation="MALSRRLRLRLCARLPDFFLLLLFRGCVIEAVNLKSSNRNPVVH
                     EFESVELSCIITDSQTNDPRIEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRI
                     WNVTRSDSAIYRCEVVALNDRKEVDELTIELIVQVKPVAPVCRVPKAVPVGKAATLQC
                     QESEGYPRPYYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFSAVHKEDSGQYY
                     CIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSK
                     QDGESYKSPGKHEGVNYIRTSEEGDFRHKSSFVI"
     exon            94..159
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     exon            160..273
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..426
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     exon            427..629
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     exon            630..729
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     exon            730..859
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..914
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1882
                     /gene="Jam3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcacattcc cctcgacatg gcgctgagcc ggcggctgcg acttcgcctg tgcgcgcggc
       61 tacccgactt cttcctgctg ctgctcttca ggggctgcgt gatagaggca gtgaacctca
      121 aatccagcaa ccgcaaccca gtggttcatg aatttgaaag tgtggaattg tcttgtatca
      181 ttacggactc acagacaaat gaccctagga ttgaatggaa gaaaattcaa gatggccaaa
      241 ccacatatgt gtattttgac aacaagattc aaggagacct ggccggtcgc acagatgtgt
      301 ttggaaaaac ttccctgagg atctggaacg tgacacggtc agactcagcc atctatcgct
      361 gtgaggttgt tgctctaaat gaccgaaaag aagttgatga gcttaccatt gagttaattg
      421 tgcaagtgaa gccagtggcc cctgtgtgca gagttccaaa ggctgtgcct gttggcaagg
      481 cagcaacact gcaatgccaa gagagcgagg gctatcctcg gccgtactac agctggtacc
      541 gcaatgatgt gccactgcct acggattcca gagccaatcc caggttccag aattcctcct
      601 tccacgtgaa ctcggagaca ggcactctgg ttttcagtgc tgtgcacaag gaagactctg
      661 ggcaatatta ctgcattgct tccaatgacg caggcgcagc ccggtgtgag gggcaggaca
      721 tggaagtcta tgatttgaac attgctggga ttattggggg agtcctggtt gtccttattg
      781 ttcttgctgt gatcacaatg ggcatctgct gtgcgtacag acgaggctgc ttcatcagca
      841 gtaaacagga tggagaaagt tataaaagcc cagggaagca tgaaggcgtt aactacatcc
      901 ggacaagtga agagggtgac ttcagacaca agtcatcctt tgttatctga gacctgttgg
      961 ctgggagagc acatacaagc acctgtgtgg gaagctggtc acgggctgcg gggacccaga
     1021 gcacccgaca gagctggatg cgcagaagca ttttgttttg gccaaagttg attccttcct
     1081 tcctctttaa caagccgcaa gaataaaaga aatcctcctg aggacggacg tagacagact
     1141 gttgctagcc tgatcttatg ggcattaggg tggtctccaa ggcccttctg gtcagctctc
     1201 cggcaaaggg cagttggggc tgtttagctg ccaggacaac actggccgag agaggctgag
     1261 gcgctgggct gcagcagcag tgtgcctgac gcccgtgaca gtgcccagga aggttttcag
     1321 gcagtgcctt gctccctgga ccctgaccca ccatggtgcc tctgttgatt ggccagtatt
     1381 atcatttcta tcctggagaa tctgtttgga tcagcatttt ataaaaaccc aaatcagaaa
     1441 ggtgaaactg cttgctggga agagggttct tgcctaagga actctccttc caaagagttg
     1501 ccaggagtta ggagaacctc tgtcttaagc taagtctgaa atggtactga attctccttt
     1561 tctattggtc ttgcttattt tataaaaatt taacattcta aatttttgct aaagatgtat
     1621 tttgattatt gaaaatttct atataaactg taaatatatt agcatagagt gttttaaaac
     1681 ttattttttt aagagttcaa cttaaggtag aaggcttggg ctgctagtgt tcaattggaa
     1741 agtaccagta ataaagtctt ttaaggtttt tcttaaggtt gaatattcct ttgttcaaaa
     1801 gaagttttag catttttttc ataagaaaac ttactctgtc tgaccactgt tgcttaggaa
     1861 accattaaag aattccaatt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
