LOCUS       NM_001034004            4225 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus junctional adhesion molecule 2 (Jam2), mRNA.
ACCESSION   NM_001034004
VERSION     NM_001034004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4225)
  AUTHORS   Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen
            YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E and Chan JR.
  TITLE     Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte
            Myelination
  JOURNAL   Neuron 91 (4), 824-836 (2016)
   PUBMED   27499083
REFERENCE   2  (bases 1 to 4225)
  AUTHORS   Arcangeli ML, Bardin F, Frontera V, Bidaut G, Obrados E, Adams RH,
            Chabannon C and Aurrand-Lions M.
  TITLE     Function of Jam-B/Jam-C interaction in homing and mobilization of
            human and mouse hematopoietic stem and progenitor cells
  JOURNAL   Stem Cells 32 (4), 1043-1054 (2014)
   PUBMED   24357068
REFERENCE   3  (bases 1 to 4225)
  AUTHORS   Ludwig RJ, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke HH,
            Podda M, Schon MP, Kaufmann R, Henschler R, Pfeilschifter JM,
            Santoso S and Boehncke WH.
  TITLE     Junctional adhesion molecule (JAM)-B supports lymphocyte rolling
            and adhesion through interaction with alpha4beta1 integrin
  JOURNAL   Immunology 128 (2), 196-205 (2009)
   PUBMED   19740376
REFERENCE   4  (bases 1 to 4225)
  AUTHORS   Ludwig RJ, Zollner TM, Santoso S, Hardt K, Gille J, Baatz H, Johann
            PS, Pfeffer J, Radeke HH, Schon MP, Kaufmann R, Boehncke WH and
            Podda M.
  TITLE     Junctional adhesion molecules (JAM)-B and -C contribute to
            leukocyte extravasation to the skin and mediate cutaneous
            inflammation
  JOURNAL   J Invest Dermatol 125 (5), 969-976 (2005)
   PUBMED   16297198
REFERENCE   5  (bases 1 to 4225)
  AUTHORS   Lamagna C, Meda P, Mandicourt G, Brown J, Gilbert RJ, Jones EY,
            Kiefer F, Ruga P, Imhof BA and Aurrand-Lions M.
  TITLE     Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin:
            function in junctional complexes and leukocyte adhesion
  JOURNAL   Mol Biol Cell 16 (10), 4992-5003 (2005)
   PUBMED   16093349
REFERENCE   6  (bases 1 to 4225)
  AUTHORS   Gliki G, Ebnet K, Aurrand-Lions M, Imhof BA and Adams RH.
  TITLE     Spermatid differentiation requires the assembly of a cell polarity
            complex downstream of junctional adhesion molecule-C
  JOURNAL   Nature 431 (7006), 320-324 (2004)
   PUBMED   15372036
REFERENCE   7  (bases 1 to 4225)
  AUTHORS   Johnson-Leger CA, Aurrand-Lions M, Beltraminelli N, Fasel N and
            Imhof BA.
  TITLE     Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte
            transendothelial migration
  JOURNAL   Blood 100 (7), 2479-2486 (2002)
   PUBMED   12239159
REFERENCE   8  (bases 1 to 4225)
  AUTHORS   Cunningham SA, Rodriguez JM, Arrate MP, Tran TM and Brock TA.
  TITLE     JAM2 interacts with alpha4beta1. Facilitation by JAM3
  JOURNAL   J Biol Chem 277 (31), 27589-27592 (2002)
   PUBMED   12070135
REFERENCE   9  (bases 1 to 4225)
  AUTHORS   Liang TW, Chiu HH, Gurney A, Sidle A, Tumas DB, Schow P, Foster J,
            Klassen T, Dennis K, DeMarco RA, Pham T, Frantz G and Fong S.
  TITLE     Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2
            interacts with T, NK, and dendritic cells through JAM 3
  JOURNAL   J Immunol 168 (4), 1618-1626 (2002)
   PUBMED   11823489
REFERENCE   10 (bases 1 to 4225)
  AUTHORS   Arrate MP, Rodriguez JM, Tran TM, Brock TA and Cunningham SA.
  TITLE     Cloning of human junctional adhesion molecule 3 (JAM3) and its
            identification as the JAM2 counter-receptor
  JOURNAL   J Biol Chem 276 (49), 45826-45832 (2001)
   PUBMED   11590146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105305.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105305.1, FQ213229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..4225
                     /gene="Jam2"
                     /note="junctional adhesion molecule 2"
                     /db_xref="GeneID:619374"
                     /db_xref="RGD:1561692"
     exon            1..221
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1051
                     /gene="Jam2"
                     /note="junctional adhesion molecule B; junction adhesion
                     molecule 2"
                     /codon_start=1
                     /product="junctional adhesion molecule B precursor"
                     /protein_id="NP_001029176.1"
                     /db_xref="GeneID:619374"
                     /db_xref="RGD:1561692"
                     /translation="MARSPQGLLLLLLLHYLMVALDYHKANGFSASKDHRQEVSVIEY
                     QEAILACKTPKKTTSSRLEWKKLGQGVSLVYYQQALQGDFKDRAEMIDFNIRIKNVTR
                     HDAGEYRCEVSAPTEQGQNLQEDTVMLEVLVAPAVPSCEVPTSVMSGSVVELRCQEKE
                     GNPAPEYIWFKDGTSLLGNPKGGAHRNSSYTMNTKSGTLQFNMISKMDSGEYYCEARN
                     SVGHRRCPGKRMQVDVLNISGIIAAVVVVAFVISACGLSICYAQRKGYFSKETSFQKG
                     SPASKATTMSENDFKHTKSFII"
     exon            222..290
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..398
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..551
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..751
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..959
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..975
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1018
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..4199
                     /gene="Jam2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagactga catcgcgaca ggacccgccc ctctgcttcc acctctcagg gacctcctct
       61 gctccgccac cccgcgaagt gctgggggac ccagccgcct gtcgcgctcc tgcgggggga
      121 ccctcggcta ggcagccagc tggcgcccgc gtagatggcg aggagccccc aaggccttct
      181 gctgctgcta ctgctgcact acttgatggt cgccctggac tatcataagg caaatggatt
      241 ttctgcatca aaagaccacc gtcaagaagt ttcagtaata gagtaccaag aggctatttt
      301 agcttgtaaa accccaaaga agaccacttc ctccagacta gagtggaaga agctaggaca
      361 gggtgtctcc ctggtctact atcaacaggc tctccaaggc gactttaaag accgtgcgga
      421 gatgatagat ttcaatatac gaatcaagaa tgtcacaaga catgatgctg gagagtatcg
      481 ctgcgaagtc agcgccccga ctgagcaagg ccagaacctg caggaagata cagtcatgct
      541 ggaagtcctg gtggcccccg ctgtcccttc atgtgaagta cctacttccg ttatgagtgg
      601 gagtgttgtg gagctacggt gtcaagaaaa agaaggaaat ccagcccctg agtacatatg
      661 gtttaaagat ggcacaagtt tgctgggcaa tccaaagggc ggcgcacaca ggaacagctc
      721 gtacacaatg aatacaaaat ctggaactct gcaattcaac atgatctcca agatggacag
      781 tggagagtat tactgtgaag cccgcaactc tgttgggcat cgcaggtgtc ccgggaaacg
      841 gatgcaagta gatgttctca acataagtgg catcatagca gctgtggttg ttgtggcctt
      901 cgtcatttct gcgtgtggcc ttagtatatg ctatgctcag agaaagggct acttttcaaa
      961 agaaacttcc ttccagaagg gcagtcctgc atctaaagcc actacaatga gcgaaaatga
     1021 tttcaagcac acaaaatcct ttataattta aaagaattcc acttctgaga tgcaccaaaa
     1081 ccacagttgt cacacaagtt attaaactat tgtaaacctc tgctttgtct tacatttgca
     1141 aagagacgga cgaagaaacg agagtgggaa ctcatcataa ctgttatgac ctctaactca
     1201 caagaaatat tttaagcaaa gtgttcttgc catcactaaa atacaatttg ggatcttatg
     1261 tctgacctaa agtgaaatgt ctgaggtttt gaaatgcaaa tgaatgttaa ttttggagtt
     1321 gactagatca tactgactgt aaagctaacc caagaggcag gaatatactg tatgtgctct
     1381 ggtgagaatg gcttacatgt tcaggaaata ctctaacgaa tggaaaccct gttcgcaaaa
     1441 ttcctaccag aatcctcttc ttacctctaa ataatccggg ttcctttgcc ctgtgtctct
     1501 gtatcccgta ggggaatccc agggctgggc cttccgtcta agggtttgca ctttatattt
     1561 tctttcactt ctcagaacca aaagcaacat gaagggagct gctgccgcca attcctgaga
     1621 ctcttggagg ggctcagtga cctggacatc agaatgcact actagaacct acacagctcc
     1681 agatcctttc tgtgcttaag tggtgacctt ttatctgtct ctaaaagcaa ttctgaactg
     1741 ggctagctcc tccctggtga agatacaggg ttcccagcct gcttaggatg aacaggagca
     1801 caggggagag aaacatttgc cccatgagta agaggtggat gaacaagctc actttgactc
     1861 ttgatccagt caaggcacag gagaaaccgt ggctgaaatg agacaggggt ctaatgtctt
     1921 ctgaactggt tatccacaga ggccaccaac cagctagtgt cagattagat tcccagggct
     1981 caacagaaaa ccggtcctgc tgggggctgg tttaccccta tttaaaataa aaaaaatgca
     2041 actgaggatg tctagctctg ggtaaatatg cacgaaaggt cacttacttc ctttaccggc
     2101 tttgaacatg gtcacgttgg ctttctaccc aaagggcaaa gcaaagtctc aggattctca
     2161 tcaaaagcaa acggggtgag tggccagtga gtacctggta gtgatctggt caccggggtg
     2221 atgcctactg ccatactgct cccctttaac tttgtggcct tgaatctttc ctaatcagta
     2281 gacaccttcc caaagggctg acttctgtaa agtggctcgg ccctcaaggt cagatccaca
     2341 cttaactgag ccagcaatct acaaagaaca ccacagtaca taattcagcc cacagggttc
     2401 ttgttacaac cactcatctc tgtcacaacg tacagtacaa gtgtgtcagc ggtataggat
     2461 ttgcccacag atccaagctc ctctctcctg gtagcaaatg acaaagaaac actgtggtgt
     2521 acaagaaatc agggtaaatg ttgcctgtgc cgtgactaag agatttgctt tggtaggagg
     2581 aggctgtcct gcagtgccaa gcagacgtac aactctcaag gatgtctctt caggcccaca
     2641 tagcatcaca agaccaactg cgtcaattta aataacacaa atccacattg cgagaggaca
     2701 attacgtagt gccttacctt cactaataga agaaaagctt ccttttaaga cactgaagcc
     2761 taaaggttca ttttaagcag tgtagacacc taacaaagtc tgtgccaaac acctattata
     2821 catccttaac tactgtatac agctaagcac aagtcgctgt gtagagaatg cgctcttctg
     2881 cataaaggac ctgactgtgc acactaatct cctagttatt aagtctatcg ggagtcactg
     2941 ccatgaagac ttgtcccttt gctgttttct gagacttgaa ctctaacatt gtgtcaaaat
     3001 tgaattgtag tttctagaac atgttgattt tatttttcca cagtgaaagt ttgataaggg
     3061 tctagaaatt atgagagcaa gttttagtat cgtcgctgtt gtaactagat tcaacttatt
     3121 tttagtcagg gtaggggtta acagctaagt ctggatgttt atttttcaat acaactttac
     3181 aaagaacttc cttcattcta caactcactt tgtttgatta aagttcatgc tacaaaaata
     3241 gctatgcaca gctcaaggtt ttagtcccct tcaacagagg ggggaagtca ctcacctatt
     3301 gttcagtaaa acccaggaaa ctcctccctc cctcacacct gcacttgtga ggcagctcca
     3361 gcagtttcaa atcaaggtct ctctggtctc tcagcttgga cacctgccaa cttgtgtttt
     3421 gtgtgtgtca gaggttgagg ataagggagt gcaggccact gtgaagagga gcctgtcgtt
     3481 ctacagtggg tgactgctcg gcttgggttt gcagtgcagt tacggaggag ctggggtctt
     3541 tatgaataca gccacctgat ccacagctca cacattttct tcattttaaa ttttccagtt
     3601 ctctacattc tcttcatcct cagtaaccct ggctcaccca cccacctacc ccggccccaa
     3661 acttatcttt gtaaaacttt aacatttaaa aacaaaagga tacaacaact ttatacacaa
     3721 ccaatccaga acctgctctc ttttgttgcc ttattattca ccaaactgaa ctgtttgttt
     3781 ttacaattta gtctgccctt tccgatacat ttgtattaca ttccttagat cgttagtcct
     3841 caccacaagc tatggaaatc ctatttactc ctgacaagtc aaattcagct ctcgtgggac
     3901 agcgttctcc catttcctag cagtgagttt tgtctctcaa gtccaatggt atttggttct
     3961 tttgtgatat ttattgattt ctgtgttaca gtacagggag gtatgtatgt gtgacatctc
     4021 caccaacctg aaaccctgaa aaagacccat gttgtacagg tcttcataaa ccctaaggtg
     4081 tttaatggca tctgacatga aaaaagtttc taaaaacgct gaatacctgt gaagcataaa
     4141 gaatgattaa atgtaagcat ctacttagaa tattaataaa acattgtatt ctgatacaaa
     4201 aaaaaaaaaa aaaaaaaaaa aaaaa
//
