LOCUS       NM_001401059            4378 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus janus kinase and microtubule interacting protein
            1 (Jakmip1), transcript variant 3, mRNA.
ACCESSION   NM_001401059 XM_017599198
VERSION     NM_001401059.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4378)
  AUTHORS   Berg,J.M., Lee,C., Chen,L., Galvan,L., Cepeda,C., Chen,J.Y.,
            Penagarikano,O., Stein,J.L., Li,A., Oguro-Ando,A., Miller,J.A.,
            Vashisht,A.A., Starks,M.E., Kite,E.P., Tam,E., Gdalyahu,A.,
            Al-Sharif,N.B., Burkett,Z.D., White,S.A., Fears,S.C., Levine,M.S.,
            Wohlschlegel,J.A. and Geschwind,D.H.
  TITLE     JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates
            Synaptic Function and Autistic-like Behaviors in Mouse
  JOURNAL   Neuron 88 (6), 1173-1191 (2015)
   PUBMED   26627310
REFERENCE   2  (bases 1 to 4378)
  AUTHORS   Vidal,R.L., Fuentes,P., Valenzuela,J.I., Alvarado-Diaz,C.P.,
            Ramirez,O.A., Kukuljan,M. and Couve,A.
  TITLE     RNA interference of Marlin-1/Jakmip1 results in abnormal
            morphogenesis and migration of cortical pyramidal neurons
  JOURNAL   Mol Cell Neurosci 51 (1-2), 1-11 (2012)
   PUBMED   22828129
  REMARK    GeneRIF: RNA interference of Marlin-1 in vivo results in abnormal
            migration and abnormal morphology of newborn pyramidal neurons
            during the formation of the cortex.
REFERENCE   3  (bases 1 to 4378)
  AUTHORS   Vidal,R.L., Valenzuela,J.I., Lujan,R. and Couve,A.
  TITLE     Cellular and subcellular localization of Marlin-1 in the brain
  JOURNAL   BMC Neurosci 10, 37 (2009)
   PUBMED   19386132
  REMARK    GeneRIF: Marlin-1 is enriched in restricted areas of the brain
            including olfactory bulb, cerebral cortex, hippocampus and
            cerebellum; it is abundant in dendrites and axons of hippocampal
            neurons, associated with microtubules at the ultrastructural level.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4378)
  AUTHORS   Vidal,R.L., Ramirez,A., Castro,M., Concha,I.I. and Couve,A.
  TITLE     Marlin-1 is expressed in testis and associates to the cytoskeleton
            and GABAB receptors
  JOURNAL   J Cell Biochem 103 (3), 886-895 (2008)
   PUBMED   17668444
  REMARK    GeneRIF: Our findings demonstrate that Marlin-1 associates with a
            microtubule fraction and with GABA(B) receptors in testis
            suggesting that the set of protein interactions of Marlin-1 are
            conserved in different tissues.
REFERENCE   5  (bases 1 to 4378)
  AUTHORS   Nishimura,Y., Martin,C.L., Vazquez-Lopez,A., Spence,S.J.,
            Alvarez-Retuerto,A.I., Sigman,M., Steindler,C., Pellegrini,S.,
            Schanen,N.C., Warren,S.T. and Geschwind,D.H.
  TITLE     Genome-wide expression profiling of lymphoblastoid cell lines
            distinguishes different forms of autism and reveals shared pathways
  JOURNAL   Hum Mol Genet 16 (14), 1682-1698 (2007)
   PUBMED   17519220
REFERENCE   6  (bases 1 to 4378)
  AUTHORS   Vidal,R.L., Ramirez,O.A., Sandoval,L., Koenig-Robert,R., Hartel,S.
            and Couve,A.
  TITLE     Marlin-1 and conventional kinesin link GABAB receptors to the
            cytoskeleton and regulate receptor transport
  JOURNAL   Mol Cell Neurosci 35 (3), 501-512 (2007)
   PUBMED   17532644
REFERENCE   7  (bases 1 to 4378)
  AUTHORS   Couve,A., Restituito,S., Brandon,J.M., Charles,K.J., Bawagan,H.,
            Freeman,K.B., Pangalos,M.N., Calver,A.R. and Moss,S.J.
  TITLE     Marlin-1, a novel RNA-binding protein associates with GABA
            receptors
  JOURNAL   J Biol Chem 279 (14), 13934-13943 (2004)
   PUBMED   14718537
  REMARK    GeneRIF: Marlin-1 functions to regulate the cellular levels of
            GABA(B) R2 subunits, which may have significant effects on the
            production of functional GABA(B) receptor heterodimers.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 1, 2022 this sequence version replaced XM_017599198.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000014.1  77991278-77991525   c
            249-511             JAXUCZ010000014.1  77931831-77932093   c
            512-1006            JAXUCZ010000014.1  77925770-77926264   c
            1007-1216           JAXUCZ010000014.1  77916154-77916363   c
            1217-1336           JAXUCZ010000014.1  77915107-77915226   c
            1337-1483           JAXUCZ010000014.1  77912567-77912713   c
            1484-1624           JAXUCZ010000014.1  77911748-77911888   c
            1625-1684           JAXUCZ010000014.1  77910278-77910337   c
            1685-1813           JAXUCZ010000014.1  77900084-77900212   c
            1814-1942           JAXUCZ010000014.1  77898614-77898742   c
            1943-2026           JAXUCZ010000014.1  77896569-77896652   c
            2027-2089           JAXUCZ010000014.1  77895378-77895440   c
            2090-2188           JAXUCZ010000014.1  77893802-77893900   c
            2189-2290           JAXUCZ010000014.1  77891305-77891406   c
            2291-2344           JAXUCZ010000014.1  77890723-77890776   c
            2345-2410           JAXUCZ010000014.1  77890126-77890191   c
            2411-2479           JAXUCZ010000014.1  77884711-77884779   c
            2480-2569           JAXUCZ010000014.1  77883357-77883446   c
            2570-2773           JAXUCZ010000014.1  77879497-77879700   c
            2774-2839           JAXUCZ010000014.1  77878247-77878312   c
            2840-2884           JAXUCZ010000014.1  77873587-77873631   c
            2885-4378           JAXUCZ010000014.1  77871034-77872527   c
FEATURES             Location/Qualifiers
     source          1..4378
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4378
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="janus kinase and microtubule interacting protein 1"
                     /db_xref="GeneID:305434"
                     /db_xref="RGD:1562401"
     exon            1..248
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..511
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..2989
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     multiple alpha helices and RNA-linker protein 1; multiple
                     coiled-coil GABABR1-binding protein"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     1 isoform 3"
                     /protein_id="NP_001387988.1"
                     /db_xref="GeneID:305434"
                     /db_xref="RGD:1562401"
                     /translation="MSKKGRSKGEKPETETDSVQMANEELRAKLTNIQIEFQQEKSKV
                     GKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREALIRQHEQEAART
                     AKIKEGELQRLQATLNVLRDGAADKVKTALLADAREEARRTFDGERQRLQQEILELKA
                     ARKQAEEALSNCMQADKAKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKERV
                     ILALEKELGVQAGQTQRLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMAELMG
                     GQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVE
                     KNKRMNKKNEDLLHSIQRMEEKLKSLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDE
                     QEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVD
                     SETLSETSYNTDRTDRTPATPEEDLDETTTREEADLRFCQLTREYQALQRAYALLQEQ
                     VGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQDL
                     LEKIYRLEMEENQLKSEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENNSS
                     ALQLFCHQEGVKGVNISELMKNLDILGDNGNLRNEEQVAVIQAGTVLALCEKWLKQIE
                     GTEAALTQKMMDLEKEKDQFSRQKGYLEQELDYRKEALDQAYLVGPEKIQDLEATLYN
                     ALQQEPGRRASESLSASQREDLQAAVEKVRRQLLRQSREFDSQILRERMELLQQAQQK
                     IREMEGKLELQRRQLKELEEKHSFCGLEDSHAPRTRARQRISGITRVPVVPHPHSNQN
                     PTVQQSYSKSGA"
     exon            512..1006
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1216
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1336
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1483
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1624
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1684
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1813
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1942
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2026
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2089
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2188
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2290
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2344
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2410
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2479
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2569
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2773
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2839
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2884
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..4378
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgctagc gtgcggcgcc tgtccccgcc gttcccgcat cgtgcacggg ttctccgcgg
       61 gccgagcctc ctcggctacg gtccaggttt tctttatttt cattttttgc atgcattcat
      121 tttctgttct atcttgtccc ttttaaggca gcggtgactg ggacagcagc gtaggcgcgc
      181 gcggggagga ggcggctgga gaatgcggct cccggctgct gcccggtttg ggtcggagcg
      241 tcaagcagac tctccagtga tggtgtgcac agaggacgag cggaggcctg cacgactgct
      301 tagcacagct gagctggtag ctgtgcttgc cggtgggcag gcgtgaacct caggacctca
      361 gcgtctcact ccaagaggaa acatgtctaa aaagggccgc agcaagggtg agaagcccga
      421 gacagagaca gactctgtac agatggccaa tgaagagcta cgggccaagc tgacgaacat
      481 ccagatcgag ttccagcagg agaagagcaa ggtggggaag ctgcgggagc gtctgcagga
      541 ggccaagctg gaacgggagc aggagcagcg tcgccacacg gcctacatct cagaactcaa
      601 ggccaagctg cacgaagaga agacgaagga actgcaggcg ctgcgcgagg cgctcatccg
      661 gcagcacgag caggaggcag cgcggaccgc caagatcaag gaaggcgagc tgcagcgact
      721 gcaggccacg ctgaatgtgc tgcgcgatgg cgccgcggac aaagtcaaga ctgcattgct
      781 ggccgacgcg cgcgaggagg cgcgcaggac ctttgatggc gagcgccaga ggctgcagca
      841 ggagattctg gaactgaagg ctgcgcgcaa acaggcagaa gaggcactca gcaactgcat
      901 gcaggcagac aaggccaaag ccgcggacct gcgcgctgcg taccaggcgc accaggatga
      961 ggtgcaccgc atcaagcggg agtgtgaacg tgacatccgc agactgatgg acgagatcaa
     1021 aggaaaggaa cgcgtgatcc tggccctgga gaaggagctt ggtgtgcagg ccgggcagac
     1081 ccagcggctg ctattacaga aggaggctct ggatgagcag ctggtccagg tcaaggaggc
     1141 cgaacgccac cacagcagcc caaagaggga gcttcctcca ggcattggtg acatggctga
     1201 gcttatgggt ggccaggatc agcatatgga cgagcgagat gtgaggcgat ttcagctgaa
     1261 gattgccgaa ctgaattcag tgattcggaa gctggaggac aggaacaccc tgctggctga
     1321 tgagaggaac gaactgctga agcgctctcg ggagacggag gtgcagctga agccgctggt
     1381 ggagaagaac aaacgcatga ataaaaagaa cgaggatctg ctgcacagca tccaaaggat
     1441 ggaggagaaa ctcaagagcc tcacgaggga aaacgtggag atgaaagaaa agctgtctgc
     1501 ccaggcctca ctaaagcgac acacatccct gaatgacctc agtctgacca gggacgagca
     1561 ggagatagag ttcctgaggc tgcaggtgct ggaacagcag catgtcattg atgacctctc
     1621 tctggaaaga gaacgcctgc tgcgctccaa gaggcatcga gggaagagcc tgaaaccccc
     1681 caagaagcat gttgtggaga cattttttgg atttgatgag gagtctgtgg actctgaaac
     1741 attgtcagag acgtcctaca acacagacag gacagaccgg accccagcca cgcctgaaga
     1801 ggacttagat gagaccacaa ccagagaaga ggctgacctg aggttctgcc agctgaccag
     1861 ggagtaccag gctctgcaga gggcttatgc cctgcttcag gagcaggttg gggggacgct
     1921 ggatgctgag agggaggctc ggactcggga gcaacttcag gctgacctgc tgagatgcca
     1981 ggccaaaatt gaggacttag agaagctgct ggttgagaag ggacaggatg ctgcgtgggt
     2041 agaggagaag caggtactca tgaggacaaa ccaggacctg ctggagaaga tttacaggct
     2101 ggagatggag gagaaccagc taaagagtga aatgcaagac gccaaggacc agaacgagct
     2161 gttagaattc agagtgctag aactcgaaga gagagagcgg aggtcgccag cctttaacct
     2221 ccaaatcacc accttccccg agaacaacag cagcgccctc cagctgttct gtcaccagga
     2281 aggagtaaag ggtgtgaata tctctgaact tatgaagaac ttagatatcc ttggcgataa
     2341 cgggaatttg aggaatgaag agcaggttgc agtaatccaa gcgggaactg tgcttgccct
     2401 gtgtgaaaag tggctgaagc agatagaggg aacggaggca gccctcacgc agaagatgat
     2461 ggacctggag aaggagaagg accagttcag caggcagaaa ggatacctgg agcaggaact
     2521 ggactacagg aaagaagccc tcgaccaggc ctacctggta ggaccggaaa aaatccagga
     2581 cctggaggcc accttgtaca atgcactgca gcaggagccg gggcggaggg ccagcgagtc
     2641 cctgagtgcc agccagcgtg aggacctcca ggccgctgta gagaaggtgc gcagacagct
     2701 cctgcgtcaa agccgggagt tcgacagtca gatcctgcgg gagcggatgg agctgctaca
     2761 gcaggcccag cagaaaatcc gggagatgga aggcaagctg gagctgcaga ggcgtcagct
     2821 gaaggagcta gaggaaaagc attcattctg tggccttgaa gactcccatg cgccgagaac
     2881 tcgggctaga caacgaattt ctggaatcac ccgagtcccc gtggtgcccc atcctcactc
     2941 aaaccaaaat ccaacagtgc aacaaagcta ttcaaaatcc ggagcctgaa cacagaactt
     3001 atgcacaatt gacagtcact tgaaggggag gcctggggac ctggccagcc tctgctgtgg
     3061 aattctgcag gacaatggca agcctcccca gtatccccac tgtgacgtct ccaagagcca
     3121 agggcaaagg tggatctgga tggcagaaat ttaagtgcaa ttagtggaaa cccaggacat
     3181 gggagctgct gccttgggga ataggcacag gccctgtgtc catgctgtgt gtctccctga
     3241 aggcattaca tgtgcctaga tggactcaga cagcccctct gccctgtgta cataaatctc
     3301 catggactga gtgtgttctt ctggattctg tctgtcagag taaccaacga aacctctgag
     3361 gccatgcaca gctggacttg cagctggtga ccagcaaggg agagttagag tcgccaacgt
     3421 ggggaaccct gtgcattgta gacttctgag aaaagctgaa ggttctgaca ctcacatagg
     3481 tgtgacactg cataagtccc agaacatggc tgtgccccag accagggaag agcgaggact
     3541 gagaaaacag acctaagcta tctgttgtaa tgtgtagggg catcctgaaa aggggctcgg
     3601 gctggtagtg cagtacccag aggctctgag ttccgaggtc tgaagccatg ggcacccttt
     3661 accatagaaa gccttcactt cccaggatac ttggtggaga gcagagtctt ctcctcgggt
     3721 gttggagcct cccagagcac agggggtagc gcaggggtgg tgtaccctaa gttcactgag
     3781 aactagatgc tggaagttga cttccagagg aaatttccca agaagtaatt ttgggatgct
     3841 cctgtcaatc tggagcaggt agggcacctc caaaaagtat ctgcctatgt ggctatactc
     3901 tttcaaactc ggggtggaga gaatgttagc cctcaggttg acagtgtgga aaaggatgtg
     3961 gaggagtctg tggtgagtcg agaggggacg tggcagcagc agccacttga agcctcttgc
     4021 tgtgtagtta caggaccaag tgggtagcgc catgacttcc tggaagcaag cagaatgatt
     4081 agagttcaga tcaggcccat taagggaact atggagcagg gacctgacat tggagggaag
     4141 ccaggtccaa agacagagat gcaaagacag agctctgaac agaagagggg ctgtccagac
     4201 aggaggtcgt gccagcagat atgacgtctc cagcttgaag caaacacggc aggatggctc
     4261 agaagtgttg actctctgct gaattctgag ttccccaaca cccatgaccc acaagcccag
     4321 cctctgcgac ttaccaatac ctagtggctt aattaaatcc caaggaacct atccttga
//
