LOCUS       NM_012855               3793 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Janus kinase 3 (Jak3), mRNA.
ACCESSION   NM_012855
VERSION     NM_012855.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3793)
  AUTHORS   Wang,Y.C., Cai,D., Cui,X.B., Chuang,Y.H., Fay,W.P. and Chen,S.Y.
  TITLE     Janus Kinase 3 Deficiency Promotes Vascular
            Reendothelialization-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (6), 2019-2026 (2021)
   PUBMED   33910370
  REMARK    GeneRIF: Janus Kinase 3 Deficiency Promotes Vascular
            Reendothelialization-Brief Report.
REFERENCE   2  (bases 1 to 3793)
  AUTHORS   Hou,Y., Li,H. and Huo,W.
  TITLE     MicroRNA-495 alleviates ulcerative interstitial cystitis via
            inactivating the JAK-STAT signaling pathway by inhibiting JAK3
  JOURNAL   Int Urogynecol J 32 (5), 1253-1263 (2021)
   PUBMED   33416962
  REMARK    GeneRIF: MicroRNA-495 alleviates ulcerative interstitial cystitis
            via inactivating the JAK-STAT signaling pathway by inhibiting JAK3.
REFERENCE   3  (bases 1 to 3793)
  AUTHORS   Tan,S., Xu,J., Lai,A., Cui,R., Bai,R., Li,S., Liang,W., Zhang,G.,
            Jiang,S., Liu,S., Zheng,M. and Wang,W.
  TITLE     Curculigoside exerts significant anti-arthritic effects in vivo and
            in vitro via regulation of the JAK/STAT/NF-kappaB signaling pathway
  JOURNAL   Mol Med Rep 19 (3), 2057-2064 (2019)
   PUBMED   30664158
  REMARK    GeneRIF: treatment downregulated the expression of JAK1, JAK3 and
            STAT3, and upregulated cytosolic nuclear factor (NF)kappaB p65 and
            IkappaB. In conclusion, the results of the present study indicated
            that curculigoside exhibited significant antiarthritic effects in
            vivo and in vitro, and the molecular mechanism may be associated
            with the JAK/STAT/NFkappaB signaling pathway.
REFERENCE   4  (bases 1 to 3793)
  AUTHORS   Wang,Y.C., Cui,X.B., Chuang,Y.H. and Chen,S.Y.
  TITLE     Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation
            and Vascular Remodeling
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (7), 1352-1360 (2017)
   PUBMED   28473442
  REMARK    GeneRIF: JAK3 mediates smooth muscle cell proliferation and
            survival during injury-induced vascular remodeling.
REFERENCE   5  (bases 1 to 3793)
  AUTHORS   Ge,S., Zhang,J., Du,Y., Hu,B., Zhou,Z. and Lou,J.
  TITLE     Dynamic changes in the gene expression profile during rat oral
            carcinogenesis induced by 4-nitroquinoline 1-oxide
  JOURNAL   Mol Med Rep 13 (3), 2561-2569 (2016)
   PUBMED   26860129
REFERENCE   6  (bases 1 to 3793)
  AUTHORS   Tortolani,P.J., Lal,B.K., Riva,A., Johnston,J.A., Chen,Y.Q.,
            Reaman,G.H., Beckwith,M., Longo,D., Ortaldo,J.R., Bhatia,K.,
            McGrath,I., Kehrl,J., Tuscano,J., McVicar,D.W. and O'Shea,J.J.
  TITLE     Regulation of JAK3 expression and activation in human B cells and B
            cell malignancies
  JOURNAL   J Immunol 155 (11), 5220-5226 (1995)
   PUBMED   7594533
REFERENCE   7  (bases 1 to 3793)
  AUTHORS   Macchi,P., Villa,A., Giliani,S., Sacco,M.G., Frattini,A., Porta,F.,
            Ugazio,A.G., Johnston,J.A., Candotti,F., O'Shea,J.J. et al.
  TITLE     Mutations of Jak-3 gene in patients with autosomal severe combined
            immune deficiency (SCID)
  JOURNAL   Nature 377 (6544), 65-68 (1995)
   PUBMED   7659163
REFERENCE   8  (bases 1 to 3793)
  AUTHORS   Rolling,C., Treton,D., Beckmann,P., Galanaud,P. and Richard,Y.
  TITLE     JAK3 associates with the human interleukin 4 receptor and is
            tyrosine phosphorylated following receptor triggering
  JOURNAL   Oncogene 10 (9), 1757-1761 (1995)
   PUBMED   7538655
REFERENCE   9  (bases 1 to 3793)
  AUTHORS   Kirken,R.A., Rui,H., Malabarba,M.G. and Farrar,W.L.
  TITLE     Identification of interleukin-2 receptor-associated tyrosine kinase
            p116 as novel leukocyte-specific Janus kinase
  JOURNAL   J Biol Chem 269 (29), 19136-19141 (1994)
   PUBMED   7518451
REFERENCE   10 (bases 1 to 3793)
  AUTHORS   Witthuhn,B.A., Silvennoinen,O., Miura,O., Lai,K.S., Cwik,C.,
            Liu,E.T. and Ihle,J.N.
  TITLE     Involvement of the Jak-3 Janus kinase in signalling by interleukins
            2 and 4 in lymphoid and myeloid cells
  JOURNAL   Nature 370 (6485), 153-157 (1994)
   PUBMED   8022486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jul 3, 2010 this sequence version replaced NM_012855.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28508.1, SRR26360186.1636.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000016.1  18421197-18421247
            52-244              JAXUCZ010000016.1  18422001-18422193
            245-368             JAXUCZ010000016.1  18422364-18422487
            369-480             JAXUCZ010000016.1  18422866-18422977
            481-626             JAXUCZ010000016.1  18423088-18423233
            627-912             JAXUCZ010000016.1  18423438-18423723
            913-1035            JAXUCZ010000016.1  18424086-18424208
            1036-1193           JAXUCZ010000016.1  18424291-18424448
            1194-1305           JAXUCZ010000016.1  18424534-18424645
            1306-1492           JAXUCZ010000016.1  18425286-18425472
            1493-1617           JAXUCZ010000016.1  18425848-18425972
            1618-1749           JAXUCZ010000016.1  18426062-18426193
            1750-1834           JAXUCZ010000016.1  18426643-18426727
            1835-1962           JAXUCZ010000016.1  18427028-18427155
            1963-2095           JAXUCZ010000016.1  18427635-18427767
            2096-2247           JAXUCZ010000016.1  18427904-18428055
            2248-2398           JAXUCZ010000016.1  18428154-18428304
            2399-2538           JAXUCZ010000016.1  18428778-18428917
            2539-2728           JAXUCZ010000016.1  18429001-18429190
            2729-2853           JAXUCZ010000016.1  18429365-18429489
            2854-3026           JAXUCZ010000016.1  18429569-18429741
            3027-3144           JAXUCZ010000016.1  18430522-18430639
            3145-3255           JAXUCZ010000016.1  18431221-18431331
            3256-3793           JAXUCZ010000016.1  18431978-18432515
FEATURES             Location/Qualifiers
     source          1..3793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3793
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /note="Janus kinase 3"
                     /db_xref="GeneID:25326"
                     /db_xref="RGD:2940"
     exon            1..51
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            52..244
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..3363
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /EC_number="2.7.10.2"
                     /note="Janus kinase 3, protein-tyrosine kinase; JAK-3"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK3"
                     /protein_id="NP_036987.2"
                     /db_xref="GeneID:25326"
                     /db_xref="RGD:2940"
                     /translation="MAPPSEETPLISQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFS
                     FGDYLAEDLCVRAAKACGILPVYHSLFALATEDLSCWFPPSHIFSIEDVDTQVLVYRL
                     RFYFPGWFGLETCHRFGLHKDLTSAILDVHVLEHLFAQHRSDLVSGRLPVGLSLKDQG
                     EFLSLAVLDLAQMARKQAQRPGELLKSVSYKACLPPSLRDLIQGQSFVTRRRIRRTVV
                     QALRRVVACQADRYALMAKYILDLERLHPAATTESFLVGLPGAQEEPGCLRVTGDNGI
                     AWSSKDQELFQTFCDFPEIVDVSIKQAPRVGPAGEHRLVTITRMDGHILEAEFPGLPE
                     ALSFVALVDGYFRLICDSRHFFCKEVAPPRLLEEEAELCHGPITLDFAIHKLKAAGSL
                     PGSYILRRSPQDYDSFLLTACVQTPLGPDYKGCLIRQDPSGAFSLVGLSQLHRSLQEL
                     LTACWHSGLQVDGTALNLTSCCVPRPKEKSNLIVVRRGRNPTPAPGHSPSCCALTKLS
                     FHTIPADSLEWHENLGHGSFTKIFHGHRREVVDGETHDTEVLLKVMDSRHQNCMESFL
                     EAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDTYLRKRGHLVPASWKLQVT
                     KQLAYALNYLEDKGLPHGNVSARKVLLAREGVDGNPPFIKLSDPGVSPTVLSLEMLTD
                     RIPWVAPECLQEAGTLNLEADKWGFGATTWEVFSGAPMHITSLEPAKKLKFYEDRGQL
                     PALKWTELEGLIAQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTPGIPNPRDEL
                     CGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHS
                     GPEQQRDFQREIQILKALHCDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHR
                     ARLHNDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPL
                     GKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYSDKSCSPSTEF
                     LRMMGPEREGSPLCHLLELLAEGRRLPPPSTCPTEVQELMQLCWSPNPQDRPAFDTLS
                     PQLDALWRGSPG"
     exon            245..368
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..480
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            481..626
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..912
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1035
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1193
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1305
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1492
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1617
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1749
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1834
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1962
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2095
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2247
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2398
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2538
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2728
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2853
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3026
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3144
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3255
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3793
                     /gene="Jak3"
                     /gene_synonym="RATJAK3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttgaact tctaatcttc cgcctccatc tctggagttt tctggtaaca agctatactc
       61 atggcacctc caagcgagga gacacctctc atctctcagc gctcttgtag cctctcatcc
      121 tcagaagcag gagccctgca tgtgctcctt cctccccggg gacctgggcc tccccagcga
      181 ctgtcattct cttttgggga ctacttggct gaggacctgt gtgtgcgggc tgccaaggcc
      241 tgtggcatcc tgcccgttta tcattcgctc ttcgctctgg ccaccgagga cttgtcttgc
      301 tggttccccc caagccacat cttctccata gaggacgtgg acactcaagt cttggtctac
      361 aggctacgct tttattttcc tggttggttt ggactggaga cctgtcaccg ctttgggtta
      421 cacaaagatt tgaccagtgc catccttgac gtacatgttt tagaacacct ctttgcccag
      481 caccgcagtg acctggtgag tgggcgtctc ccagtaggcc ttagcctgaa ggaccaggga
      541 gagttcctga gcctagctgt gctggacctg gcccagatgg ctcgtaagca ggcccagcgg
      601 ccaggagagc tgctgaagtc cgtcagttac aaagcctgtc tgccgcccag cctgcgcgac
      661 ctgatccagg gccagagctt cgtgacgcgc aggcgcatcc gcaggaccgt ggtccaggcg
      721 ctgcgccgtg tagtagcctg ccaagccgac cgctacgcac tcatggccaa gtacatccta
      781 gaccttgagc ggctgcatcc agcggccacc actgagtcct tcctcgtggg actcccgggc
      841 gcccaggagg agccgggttg cctgcgtgtg acaggggata atggcatcgc ctggagctcc
      901 aaggaccagg agcttttcca gaccttctgt gactttccag aaatcgtgga tgtcagcatc
      961 aagcaggctc cacgcgtggg tccggcaggg gagcaccggc tagtcaccat caccaggatg
     1021 gacggtcaca tcctggaagc ggagttcccg gggctgcctg aggcgctgtc tttcgtggcg
     1081 ctcgtggatg ggtactttcg cctgatctgc gactccaggc atttcttctg caaggaggtg
     1141 gcaccgccac ggctgctgga ggaagaggcg gagctgtgcc atggacccat cacgttagac
     1201 tttgccatcc acaagctgaa ggctgctggc tccctcccgg gctcctacat tctccgacgc
     1261 agcccgcagg actatgacag ctttcttctt actgcctgtg tccagactcc tcttggcccc
     1321 gactacaagg gctgcctcat ccgccaagac cccagtgggg ctttctccct ggttggtctc
     1381 agccagctgc acagaagcct acaggagctg ctcacagcct gctggcattc tggactgcaa
     1441 gtagacggca ctgccctgaa cctcacatct tgctgcgtcc ccagacccaa ggaaaagtcc
     1501 aatttgatcg tggtgcgtag gggccgcaac cccacgcctg cccccgggca ctccccatcc
     1561 tgctgtgcgc tgactaagtt gagcttccac acaatcccag cagacagcct ggagtggcac
     1621 gagaatcttg gtcacggctc ttttaccaag atcttccatg gccataggcg ggaggttgtg
     1681 gatggtgaga cacatgacac agaagtcctc ctgaaggtta tggactccag acaccagaac
     1741 tgcatggagt cctttctgga agccgcaagc ttgatgagcc aagtatccta cccgcacctg
     1801 gtgttgctgc atggagtctg catggctgga gacagcatca tggtgcagga atttgtgtac
     1861 cttggagcaa ttgacacgta cctgcgcaag cgtggtcacc tggtgccggc cagctggaaa
     1921 ctgcaggtga ccaagcagct ggcctatgcc cttaactact tggaggacaa aggcctccct
     1981 catggcaacg tctcagcgag gaaggtgctg ctagctcgtg agggggttga tgggaatcca
     2041 cctttcatca agctgagtga tcctggtgtc agcccaactg ttttgagcct ggaaatgctc
     2101 actgacagga ttccctgggt ggccccggag tgtctccagg aagctggaac gctcaacttg
     2161 gaggctgaca agtggggctt tggcgccacc acgtgggagg tgttcagcgg ggcacccatg
     2221 cacattacct cgctggagcc cgccaagaag ctgaagttct atgaggaccg gggacagctg
     2281 ccggccctca aatggacaga gctggagggg ctcatcgcac agtgcatggc gtatgatcct
     2341 ggccggcgcc cctccttccg agccatcctc agagacctca acggcctcat tacatcagat
     2401 tacgagctcc tctcagaccc cacacctggc atcccgaatc cccgagatga gctgtgtggt
     2461 ggtgcccagc tctatgcctg ccaggacccc gccatcttcg aggagagaca ccttaagtac
     2521 atctccctgc tgggcaaggg gaacttcggc agcgtggagc tgtgccgcta cgaccctctg
     2581 ggagacaata cgggacccct ggtagcagtg aagcagttac agcacagcgg gccagaacag
     2641 cagagggact tccagcgaga gattcagatc ctcaaggctc tacactgtga cttcatcgtc
     2701 aagtaccggg gagtcagcta tgggcctggt cgccagagcc tgcggttagt gatggagtac
     2761 ctgcccagcg gctgcctgcg ggacttcctg cagcgccacc gcgcgcgcct gcacaacgac
     2821 cgcctactgc tgttcgcctg gcagatctgc aagggcatgg agtacctggg cgcacgccgc
     2881 tgcgtgcatc gtgacctggc tgcgcgcaac atcctggtgg agagtgaggc gcatgtgaag
     2941 attgctgact tcggcctcgc taagctgctg cctctcggaa aagactacta cgtggtccgc
     3001 gagccgggcc aaagtcccat cttctggtac gcccctgagt ccctatctga caacatcttc
     3061 tcccgccaat ctgacgtgtg gagcttcggc gtggtgctgt atgagctctt cacctacagc
     3121 gacaagagct gcagcccatc cactgagttc ctgcgcatga tggggcctga gcgtgaggga
     3181 tccccgctct gccacctctt ggagctgctg gcagagggcc gccgtctccc accaccctcc
     3241 acctgcccta ctgaggttca agagctcatg cagctgtgct ggtcgcccaa cccacaagac
     3301 cggccagcat ttgacaccct gagcccccag ctggatgcgc tgtggcgcgg aagccccgga
     3361 tagcaagcag ccagggatga gcgtgagctt ggttcctatg atctggcggt gtgacttcag
     3421 gcgggaagct gtccctctct gggccccagc acccccaatc ccctctggcc acctcttccc
     3481 atcattcttc cctcccagaa tggggatgtt aaataagtga ccccaggctc tgcacggttg
     3541 tcattacctc tggaaatgct ttactagcaa gtctgccttc tgcagaactc acaaccccag
     3601 gtcccaagag caccctagac ttggccagaa acccacccag actcccagac cctctcttga
     3661 ccctaggtct gtgcccagtc ccttgctctc ctgtccatgg gtttcttggg ggctgtgaaa
     3721 cctcagcatg gtctcctgaa agattgggtt ctgggagtgt ttgttgaatg aataaatgaa
     3781 ttcaatagaa aaa
//
