LOCUS       NM_031514               3731 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Rattus norvegicus Janus kinase 2 (Jak2), mRNA.
ACCESSION   NM_031514
VERSION     NM_031514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3731)
  AUTHORS   Zhang,Z., Shang,G., Lu,Z., Hu,J., Liu,H., Lu,T. and Lu,X.
  TITLE     Daucosterol regulates JAK2-STAT3 signaling pathway to promote
            megakaryocyte differentiation
  JOURNAL   Blood Cells Mol Dis 107, 102858 (2024)
   PUBMED   38796983
  REMARK    GeneRIF: Daucosterol regulates JAK2-STAT3 signaling pathway to
            promote megakaryocyte differentiation.
REFERENCE   2  (bases 1 to 3731)
  AUTHORS   Xiong,C., Li,B., Song,R., Ma,Z., Huber,S.A. and Liu,W.
  TITLE     IFITM3 mediates inflammation induced myocardial injury through
            JAK2/STAT3 signaling pathway
  JOURNAL   Mol Immunol 167, 1-15 (2024)
   PUBMED   38306778
  REMARK    GeneRIF: IFITM3 mediates inflammation induced myocardial injury
            through JAK2/STAT3 signaling pathway.
REFERENCE   3  (bases 1 to 3731)
  AUTHORS   Yang,Z., Liang,Z., Rao,J., Xie,H., Zhou,M., Xu,X., Lin,Y., Lin,F.,
            Wang,C. and Chen,C.
  TITLE     Hypoxic-preconditioned mesenchymal stem cell-derived small
            extracellular vesicles promote the recovery of spinal cord injury
            by affecting the phenotype of astrocytes through the
            miR-21/JAK2/STAT3 pathway
  JOURNAL   CNS Neurosci Ther 30 (3), e14428 (2024)
   PUBMED   37641874
  REMARK    GeneRIF: Hypoxic-preconditioned mesenchymal stem cell-derived small
            extracellular vesicles promote the recovery of spinal cord injury
            by affecting the phenotype of astrocytes through the
            miR-21/JAK2/STAT3 pathway.
REFERENCE   4  (bases 1 to 3731)
  AUTHORS   Bao,H., Wang,X., Zhou,H., Zhou,W., Liao,F., Wei,F., Yang,S., Luo,Z.
            and Li,W.
  TITLE     PCSK9 regulates myofibroblast transformation through the JAK2/STAT3
            pathway to regulate fibrosis after myocardial infarction
  JOURNAL   Biochem Pharmacol 220, 115996 (2024)
   PUBMED   38154546
  REMARK    GeneRIF: PCSK9 regulates myofibroblast transformation through the
            JAK2/STAT3 pathway to regulate fibrosis after myocardial
            infarction.
REFERENCE   5  (bases 1 to 3731)
  AUTHORS   Alnajem,A. and Al-Maghrebi,M.
  TITLE     The Regulatory Effects of JAK2/STAT3 on Spermatogenesis and the
            Redox Keap1/Nrf2 Axis in an Animal Model of Testicular Ischemia
            Reperfusion Injury
  JOURNAL   Cells 12 (18), 2292 (2023)
   PUBMED   37759514
  REMARK    GeneRIF: The Regulatory Effects of JAK2/STAT3 on Spermatogenesis
            and the Redox Keap1/Nrf2 Axis in an Animal Model of Testicular
            Ischemia Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3731)
  AUTHORS   Argetsinger,L.S., Hsu,G.W., Myers,M.G. Jr., Billestrup,N.,
            White,M.F. and Carter-Su,C.
  TITLE     Growth hormone, interferon-gamma, and leukemia inhibitory factor
            promoted tyrosyl phosphorylation of insulin receptor substrate-1
  JOURNAL   J Biol Chem 270 (24), 14685-14692 (1995)
   PUBMED   7782332
REFERENCE   7  (bases 1 to 3731)
  AUTHORS   Duhe,R.J., Rui,H., Greenwood,J.D., Garvey,K. and Farrar,W.L.
  TITLE     Cloning of the gene encoding rat JAK2, a protein tyrosine kinase
  JOURNAL   Gene 158 (2), 281-285 (1995)
   PUBMED   7607555
REFERENCE   8  (bases 1 to 3731)
  AUTHORS   He,T.C., Jiang,N., Zhuang,H. and Wojchowski,D.M.
  TITLE     Erythropoietin-induced recruitment of Shc via a receptor
            phosphotyrosine-independent, Jak2-associated pathway
  JOURNAL   J Biol Chem 270 (19), 11055-11061 (1995)
   PUBMED   7538110
REFERENCE   9  (bases 1 to 3731)
  AUTHORS   Bacon,C.M., McVicar,D.W., Ortaldo,J.R., Rees,R.C., O'Shea,J.J. and
            Johnston,J.A.
  TITLE     Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and
            TYK2: differential use of Janus family tyrosine kinases by IL-2 and
            IL-12
  JOURNAL   J Exp Med 181 (1), 399-404 (1995)
   PUBMED   7528775
REFERENCE   10 (bases 1 to 3731)
  AUTHORS   Miura,O., Miura,Y., Nakamura,N., Quelle,F.W., Witthuhn,B.A.,
            Ihle,J.N. and Aoki,N.
  TITLE     Induction of tyrosine phosphorylation of Vav and expression of
            Pim-1 correlates with Jak2-mediated growth signaling from the
            erythropoietin receptor
  JOURNAL   Blood 84 (12), 4135-4141 (1994)
   PUBMED   7527668
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U13396.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U13396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3731
                     /gene="Jak2"
                     /note="Janus kinase 2"
                     /db_xref="GeneID:24514"
                     /db_xref="RGD:2939"
     exon            1..48
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            49..131
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            132..382
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..3555
                     /gene="Jak2"
                     /EC_number="2.7.10.2"
                     /note="JAK-2; Janus kinase 2 (a protein tyrosine kinase)"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK2"
                     /protein_id="NP_113702.1"
                     /db_xref="GeneID:24514"
                     /db_xref="RGD:2939"
                     /translation="MGMACLTMTEMEGTSTSPAHQNGDIPGNANSVKQTEPVLQVYLY
                     HSLGQAEGDYLKFPNGEYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVF
                     HIDESTRHNILYRIRFYFPHWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHD
                     FVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQTPLAVYNSISYKTFLPKCVRAKI
                     QDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKESA
                     RGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPDIIDVSIKQANQE
                     CSTESRVVTVHKQDGKVLEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAV
                     LENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
                     HCLITKNENGEYNLSGTKRNFSSLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSN
                     LLVFRTNGVSDVQLSPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRRE
                     VGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENIL
                     VQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLI
                     REEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLTLATDKWSFG
                     TTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINTCMDYEPDFRPAF
                     RAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
                     KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK
                     GVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRY
                     IHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK
                     FSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRL
                     PRPEGCPDEIYVIMTECWNNNVNQRPSFRDLSLRVDQIRDSMAA"
     exon            383..506
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..624
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..770
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1092
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1212
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1370
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1482
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1669
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1797
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1932
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2020
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2148
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2287
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2439
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2590
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2727
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2917
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3042
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3215
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3333
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3447
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3731
                     /gene="Jak2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctgcgcg cctccgggcg ctcctgtgtg gcccgacccg tgtcgccggt tcctgaagca
       61 ggcgacggga acaagatgtg aactgttttt cctccacaga agaagaggcc cttctttccc
      121 ctcccgggaa ggccgatgtt ctgaaaaagg ctgtggatgg gaatggcttg ccttacaatg
      181 acagaaatgg agggaacctc cacatctcct gcacatcaga atggtgatat tcctggaaat
      241 gctaactctg tgaagcagac agagccagtc cttcaagtgt acctgtacca ttctcttggg
      301 caagctgaag gagactatct gaagtttcca aatggagagt atgttgccga agaaatttgt
      361 gtggctgctt ctaaagcatg tggtattacg cctgtgtatc ataatatgtt tgctttaatg
      421 agtgaaacag aaaggatctg gtatccaccc aatcatgtct tccacataga tgagtcaacc
      481 aggcataata tactctacag aataaggttt tactttcctc attggtactg cagtggcagc
      541 aacagaacct ataggtacgg agtatctcgt ggggctgaag ctcctctcct tgacgacttt
      601 gtcatgtctt acctttttgc tcagtggcgg catgattttg ttcatgggtg gataaaagta
      661 cctgtgactc acgaaactca ggaagaatgt cttggcatgg cagtgttaga catgatgaga
      721 atagctaagg agaaggacca gactcccctg gctgtctata actccatcag ctacaagacg
      781 ttcttaccga agtgcgtgcg agcgaagatc caggactatc acattttaac tcggaagcgg
      841 ataaggtaca gattccgcag gttcattcag cagttcagtc agtgcaaagc cactgccagg
      901 aacctaaaac ttaagtatct cataaacctg gagaccctgc agtctgcctt ctacacagaa
      961 cagtttgaag taaaagaatc tgcaagaggt ccttcaggtg aggagatttt tgcaaccatt
     1021 ataataactg gaaacggtgg aattcagtgg tcaagaggga aacataagga aagtgagaca
     1081 ctgacagaac aggatttaca gttgtattgt gattttcctg atattattga tgtcagtatt
     1141 aagcaagcaa atcaggaatg ctcaactgaa agtagagttg tgaccgtcca caagcaggac
     1201 gggaaggtct tggaaataga acttagctca ttaaaagaag ccttgtcatt tgtgtcgtta
     1261 attgacgggt attacagact aactgcggat gcacaccatt acctctgtaa agaggtggct
     1321 cctccagccg tgcttgaaaa catacacagc aactgtcacg gcccaatttc aatggatttt
     1381 gccatcagca aactaaagaa ggcaggaaac cagactggac tgtatgtact tcgatgtagc
     1441 cctaaggact tcaacaaata cttcctgacc tttgccgttg agcgagaaaa tgttattgaa
     1501 tataaacact gtttgattac aaagaatgag aatggagagt acaacctcag tgggactaag
     1561 aggaacttca gtagtcttaa ggaccttttg aattgctacc agatggaaac tgtgcgctca
     1621 gacagtatca tcttccagtt caccaaatgc tgtcctccaa agccgaaaga taaatcaaac
     1681 cttcttgtct tcagaacaaa tggtgtttct gatgttcagc tctcaccaac attacagagg
     1741 cataataatg tgaatcaaat ggtgtttcac aaaatcagga atgaagattt gatatttaat
     1801 gaaagccttg gccaaggcac ttttacaaaa atatttaaag gtgtaagaag agaagttgga
     1861 gattatggtc agctgcacga aaccgaagtt cttttgaaag tcctagataa agcacataga
     1921 aactattcag agtctttctt tgaagcagca agcatgatga gtcagctttc tcacaagcat
     1981 ttggttttga attatggagt atgtgtctgt ggagaggaga acattttggt tcaagagttt
     2041 gtaaaatttg gatccctgga tacatacctg aaaaaaaaca aaaattccat aaatatacta
     2101 tggaaacttg gagtggccaa acagttggca tgggccatgc acttcctcga agaaaaatcc
     2161 cttattcatg ggaatgtgtg tgccaaaaat atcctgctta tcagagaaga agacaggaaa
     2221 acagggaatc cacctttcat caaacttagt gatcctggga ttagcatcac agttctacca
     2281 aaggacattc ttcaggagag aataccatgg gtaccacctg agtgcattga aaaccctaaa
     2341 aatctaactt tggcaacaga caagtggagc tttggcacca ctctgtggga gatctgcagt
     2401 ggaggagaca agcctctgag tgctctggac tctcaaagaa agctgcagtt ctatgaagat
     2461 aagcaccagc tcccagcacc caagtggaca gagttggcaa accttataaa tacttgcatg
     2521 gattatgagc cagacttcag gcctgccttc agagctgtca tccgtgatct gaacagcctg
     2581 tttactccag attatgaact gctgacagaa aatgacatgc tacccaacat gagaataggt
     2641 gccctaggat tttctggtgc ttttgaagac agggacccta cacagtttga agagagacac
     2701 ttgaaatttc tacagcaact tggcaagggt aactttggga gtgtggagat gtgccgctat
     2761 gacccgctgc aggacaacac tggagaggtg gtagctgtta agaagctcca gcacagcacg
     2821 gaagagcatc tccgagactt tgaaagggaa attgaaatcc tgaaatcctt gcagcatgac
     2881 aacatcgtga agtacaaggg agtgtgctac agtgctggtc ggcgcaacct aagattaatt
     2941 atggaatatt tgccgtatgg aagtttacga gactatctcc aaaaacataa agaacggata
     3001 gatcacaaaa aacttctgca gtatacatcc cagatatgca agggcatgga gtatcttggt
     3061 acaaaaaggt atatccaccg ggatctggca acaaggaata tattggtaga aaatgagaac
     3121 agagttaaaa taggagattt tggattaacc aaagtcttgc cacaggacaa agaatactac
     3181 aaagtaaagg aaccaggtga aagtcccata ttctggtatg ctcccgaatc cttgacagag
     3241 agcaagtttt ctgtggcctc agatgtgtgg agctttggtg tggttctgta cgaacttttc
     3301 acgtatatcg agaagagcaa aagcccacct gtggaattta tgcgaatgat cggcaatgat
     3361 aaacaagggc agatgatcgt attccatttg atagagctac tgaagaacaa cggaagactg
     3421 ccgagaccag aagggtgccc agacgagatt tatgtgatca tgacagaatg ctggaacaac
     3481 aatgtcaacc aacgtccctc tttcagggac ctttcccttc gggtggatca aatccgggac
     3541 agtatggctg catgaaagag gtgaccttta ctcagagacc aagtagactt ccagaaccag
     3601 agcaaagctc tgtagccaca tggccatgga ctcgtgtcca cgggccctta tcatgatgct
     3661 agccagaagg aaatgtgatg ctgtctgctc aagactttgg aagcgttgtg gatttttatg
     3721 taccatctgt a
//
