LOCUS       XM_006238453            4717 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Janus kinase 1 (Jak1), transcript
            variant X2, mRNA.
ACCESSION   XM_006238453
VERSION     XM_006238453.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051340.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006238453.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006238453.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4717
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4717
                     /gene="Jak1"
                     /note="Janus kinase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 5 mRNAs, 83 ESTs, 4 long
                     SRA reads, 10 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 5 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:84598"
                     /db_xref="RGD:69056"
     CDS             125..3586
                     /gene="Jak1"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK1 isoform X1"
                     /protein_id="XP_006238515.1"
                     /db_xref="GeneID:84598"
                     /db_xref="RGD:69056"
                     /translation="MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLD
                     REPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMS
                     LRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFA
                     QGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYK
                     RYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLET
                     LTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVE
                     KEKNKLKRKKLDYNKHKKEDDRNKLREEWNSFSYFPEITHIVIKESVVSINKQDNKNM
                     ELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAI
                     NKLRQEGSEEGMYVLRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSL
                     HGSVDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPV
                     YSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLD
                     PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS
                     DALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPG
                     IPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL
                     IEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVS
                     EKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG
                     GNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKN
                     KINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD
                     KEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFL
                     KMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIE
                     GFEALLK"
ORIGIN      
        1 gaggtctctt ctggtgagat ggtgccatta ctccagtttc tagagttgat cagctctgaa
       61 tgggctttgg aaggtaaaga agaaaatcca gtctgctttt cagggacact ggacaaccga
      121 ataaatgcag tatctaaata taaaagagga ctgcaatgcc atggctttct gtgctaaaat
      181 gaggagcttc aagaagacgg aggtgaagca ggtggcccct gagccaggag tggaagtgac
      241 tttctatctg ttggacaggg agcccctccg cctgggcagc ggagagtaca ccgcggagga
      301 gctgtgcatc agggccgcac aggaatgcag tatctctcct ctctgccaca acctcttcgc
      361 cttgtatgat gagagcacca agctctggta tgctccaaac cacatcatca ctgtggatga
      421 caaaatgtct ctccggctgc actaccgcat gaggttctac tttaccaact ggcatggaac
      481 caatgacaat gaacagtctg tatggcgaca ttctccaaag aagcagaaaa atggctatga
      541 gaagaaaaag gttccagaag caaccccact ccttgatgcc agttcactgg agtatctgtt
      601 tgcgcaggga cagtatgatt tgatcaaatg cctggctccc attcgggacc ccaagacaga
      661 gcaagatgga catgatattg agaatgagtg cctgggcatg gctgtcctgg ccatctcaca
      721 ctatgccatg atgaagaaga tgcagttgcc agagcttccc aaagacatca gctacaagcg
      781 atatattcca gaaacattga ataaatccat cagacagagg aatcttctta ccaggatgcg
      841 aataaataat gttttcaagg atttcttgaa ggaatttaac aacaagacca tctgtgacag
      901 cagtgtgtct acacacgacc tgaaggtgaa gtacctggct accttggaaa ccttaaccaa
      961 gcattatgga gccgagatat ttgagacttc tatgctcctg atttcatcag aaaatgagct
     1021 gagtcggtgc cattccaacg acagtggcaa tgttctctat gaagtcatgg taacaggaaa
     1081 tctcgggatc cagtggcggc agaaaccaaa tgttcttcct gttgaaaagg aaaaaaataa
     1141 actgaagcgg aaaaaactgg actataataa acacaagaag gaggatgaca gaaacaaact
     1201 ccgggaagag tggaacagtt tttcctattt ccccgagatt acccacattg ttatcaagga
     1261 gtctgtggtc agcattaaca aacaggacaa caagaacatg gaactaaagc tctcttctca
     1321 tgaggaagcc ttgtccttcg tgtccctggt agatggctac ttccggctca ctgcagatgc
     1381 tcaccattac ctctgtactg atgtggctcc cccgctgatt gtccacaaca tacagaatgg
     1441 ctgtcacggt ccaatctgca cagaatatgc catcaataag ctgcggcagg aggggagtga
     1501 ggaggggatg tacgtgctga ggtggagctg caccgacttt gacaacattc ttatgactgt
     1561 cagctgcttc gaaaagtccg aggtattggg taatcagaag cagttcaaga actttcagat
     1621 tgaggtgcag aagggccgct acagcctgca tggctctgtt gaccactttc ccagcctgag
     1681 agacctcatg aaccacctca agaagcagat cctgcgcacg gacaatataa gctttgtgct
     1741 gaaacgctgc tgtcagccta agcctcgaga aatctccaac ctacttgtag ccactaagaa
     1801 agcccaggag tggcagcctg tctactctat gagccagctg agtttcgatc ggatccttaa
     1861 gaaagatatt atccaaggtg agcaccttgg cagaggcaca agaacacata tctattctgg
     1921 gaccctgctg gattacaagg acgatgaagg aattgctgaa gaaaagaaga taaaagtgat
     1981 tctcaaagtc ctagacccta gccaccggga catttcactg gccttctttg aggcagccag
     2041 catgatgaga caggtttccc acaaacacat cgtgtacctc tacggcgtct gtgtccgaga
     2101 tgtggaaaat atcatggtgg aagagtttgt ggaggggggg ccattggatc tcttcatgca
     2161 ccggaaaagt gatgcactta ctaccccttg gaagtttaaa gttgccaaac agctggccag
     2221 cgccctgagt tacttggaag ataaagacct cgttcatgga aatgtgtgca ctaaaaacct
     2281 cctcctggcc cgtgagggca ttgacagtga cattggcccg ttcatcaagc ttagtgaccc
     2341 tggcatccca gtctctgtgc tgaccaggca agagtgcata gagcgaattc cctggatcgc
     2401 tcctgagtgt gttgaagact ccaagaacct gagtgtggct gctgacaagt ggagctttgg
     2461 aaccacactc tgggaaatct gctacaatgg cgagatccca ctcaaggaca agaccctcat
     2521 tgagaaagag aggttttatg aaagccgctg caggccagtg acaccatctt gcaaggagct
     2581 agctgacctc atgactcgct gcatgaacta tgatcccaac cagagacctt tcttccgagc
     2641 catcatgagg gacattaaca agctggagga gcagaatcca gacattgttt cagaaaagca
     2701 gccaataaca gaggtggatc ccactcattt tgaaaagcgt ttcctaaaga ggattcgtga
     2761 cttgggagag ggtcactttg ggaaggttga gctctgcaga tatgatcctg agggagacaa
     2821 cacaggggaa caggtagctg tcaagtccct gaagcctgag agtggaggta accacatagc
     2881 tgatctgaag aaggagatag agatcttacg gaacctctac cacgagaaca ttgtgaagta
     2941 taaaggaatc tgcatggaag acggagggaa tggtatcaag ctcatcatgg agtttctgcc
     3001 ttcgggaagc ctaaaggaat atctgccaaa gaataagaac aaaatcaacc tcaaacagca
     3061 gctaaaatat gccatccaga tttgtaaggg gatggactat ctgggctctc ggcaatatgt
     3121 tcaccgggac ttagcagcaa gaaatgtcct tgttgagagt gaacaccaag tgaagatcgg
     3181 agactttggt ttaaccaaag caattgagac cgataaggag tactacacag tcaaggatga
     3241 ccgggacagc ccagtgtttt ggtacgctcc ggagtgttta atccagtgta aattttatat
     3301 cgcctctgat gtctggtctt ttggagtgac actgcacgag ttgctcacgt actgtgactc
     3361 agattttagt cccatggcct tgttcctgaa aatgataggc ccaactcatg gccagatgac
     3421 agtaacacgg cttgtgaata ctctgaaaga aggaaagcgc ctgtcctgtc cacccaactg
     3481 tcccgatgag gtttatcagc ttatgagaaa atgctgggaa ttccaaccat ctaatcggac
     3541 aacctttcag aaccttattg aaggatttga agcactttta aaataagaag catgaacatt
     3601 taaattccca tttatcaagt ccttctctcc caagccattt aaaaacgttt tttaagtgaa
     3661 aaagtttgta ttttgcctct aaagttgatc aacaaatact cgagttacat atatacatgt
     3721 atatgtcaca tggtcactca gtgtgtgaaa ctttctcttt aaagttgtaa catcttaaat
     3781 ttagtgatga ataacgacca ccaaaatact agaatgtgcc gaagccactc gttttggaac
     3841 agttggaact atcagttgtg tagcaaagga cgtctggcac cgtgctgctg ggatgtgatc
     3901 ttagagaaaa agtgtggact tggctgaaac tctctcttgc cctgaaatct caatgtctat
     3961 acagtgatag tacaagcaga tgccacttag tatactattg tttctagtaa agaaagtcta
     4021 tccctgctcc ctagtaggac cgcagtttta agctgtgcgt gcagtggcac agctgctgtt
     4081 ctcttggcta agcactggtt cccactgtgg gacagacctg tgcggcagga ggagcctggc
     4141 acatacactc tgcatgctac ttcacgagaa ccagaccgcg actgtgttct catgcacagc
     4201 ctgccttcca gcagacagat tcctctggat gctgtcactt ctgccgttga gaatattagt
     4261 gcttactcct tcctaacgat cccctggggg caagctgcca acagttttgc aaacaggaga
     4321 tatcaccacc ctatactgca aaactacaaa aaggaagacc cagctcggcc caccggactg
     4381 aagttcagag tttgctaggt agttctcagt ttacttggag gtagctaggt agtcaacaat
     4441 gttcagttca ggattcaatg cgaaccacaa agttattcat gaccaggagt ctggcaaact
     4501 tattaataat gctgtttaat acttgtttga tatttttttc accttttgag ccccaccccc
     4561 taaagaattc aggatcaagt tagtaccaac agtgctcttg cggtttaaat ttgtttagtt
     4621 gctgtacatt accgtagtcc ctgtttactt caaacctgtg gcccgctcta tatgcacttt
     4681 gtttattctt tatacaataa acgtactaaa gacttca
//
