LOCUS       NM_053466               4291 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Rattus norvegicus Janus kinase 1 (Jak1), transcript variant 1,
            mRNA.
ACCESSION   NM_053466 XM_001061647 XM_342872
VERSION     NM_053466.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4291)
  AUTHORS   Cheng,M., Liang,X., Shi,L., Zhang,Q., Zhang,L., Gong,Z., Luo,S.,
            Wang,X. and Zhang,X.
  TITLE     Folic acid deficiency exacerbates the inflammatory response of
            astrocytes after ischemia-reperfusion by enhancing the interaction
            between IL-6 and JAK-1/pSTAT3
  JOURNAL   CNS Neurosci Ther 29 (6), 1537-1546 (2023)
   PUBMED   36794521
  REMARK    GeneRIF: Folic acid deficiency exacerbates the inflammatory
            response of astrocytes after ischemia-reperfusion by enhancing the
            interaction between IL-6 and JAK-1/pSTAT3.
REFERENCE   2  (bases 1 to 4291)
  AUTHORS   Wang,L., Zhu,K., Yang,B. and Cai,Y.
  TITLE     Knockdown of Linc00052 alleviated spinal nerve ligation-triggered
            neuropathic pain through regulating miR-448 and JAK1
  JOURNAL   J Cell Physiol 235 (10), 6528-6535 (2020)
   PUBMED   32012267
REFERENCE   3  (bases 1 to 4291)
  AUTHORS   Tan,S., Xu,J., Lai,A., Cui,R., Bai,R., Li,S., Liang,W., Zhang,G.,
            Jiang,S., Liu,S., Zheng,M. and Wang,W.
  TITLE     Curculigoside exerts significant anti-arthritic effects in vivo and
            in vitro via regulation of the JAK/STAT/NF-kappaB signaling pathway
  JOURNAL   Mol Med Rep 19 (3), 2057-2064 (2019)
   PUBMED   30664158
  REMARK    GeneRIF: treatment downregulated the expression of JAK1, JAK3 and
            STAT3, and upregulated cytosolic nuclear factor (NF)kappaB p65 and
            IkappaB. In conclusion, the results of the present study indicated
            that curculigoside exhibited significant antiarthritic effects in
            vivo and in vitro, and the molecular mechanism may be associated
            with the JAK/STAT/NFkappaB signaling pathway.
REFERENCE   4  (bases 1 to 4291)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   5  (bases 1 to 4291)
  AUTHORS   Chough,C., Joung,M., Lee,S., Lee,J., Kim,J.H. and Kim,B.M.
  TITLE     Development of selective inhibitors for the treatment of rheumatoid
            arthritis:
            (R)-3-(3-(Methyl(7H-pyrrolo[2,
            3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a
            JAK1-selective inhibitor
  JOURNAL   Bioorg Med Chem 26 (8), 1495-1510 (2018)
   PUBMED   29452839
REFERENCE   6  (bases 1 to 4291)
  AUTHORS   Hellgren,G., Jansson,J.O., Carlsson,L.M. and Carlsson,B.
  TITLE     The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in
            human liver
  JOURNAL   Growth Horm IGF Res 9 (3), 212-218 (1999)
   PUBMED   10502458
REFERENCE   7  (bases 1 to 4291)
  AUTHORS   Witthuhn,B.A., Silvennoinen,O., Miura,O., Lai,K.S., Cwik,C.,
            Liu,E.T. and Ihle,J.N.
  TITLE     Involvement of the Jak-3 Janus kinase in signalling by interleukins
            2 and 4 in lymphoid and myeloid cells
  JOURNAL   Nature 370 (6485), 153-157 (1994)
   PUBMED   8022486
REFERENCE   8  (bases 1 to 4291)
  AUTHORS   Muller,M., Briscoe,J., Laxton,C., Guschin,D., Ziemiecki,A.,
            Silvennoinen,O., Harpur,A.G., Barbieri,G., Witthuhn,B.A.,
            Schindler,C. et al.
  TITLE     The protein tyrosine kinase JAK1 complements defects in
            interferon-alpha/beta and -gamma signal transduction
  JOURNAL   Nature 366 (6451), 129-135 (1993)
   PUBMED   8232552
REFERENCE   9  (bases 1 to 4291)
  AUTHORS   Silvennoinen,O., Witthuhn,B.A., Quelle,F.W., Cleveland,J.L., Yi,T.
            and Ihle,J.N.
  TITLE     Structure of the murine Jak2 protein-tyrosine kinase and its role
            in interleukin 3 signal transduction
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8429-8433 (1993)
   PUBMED   8378315
REFERENCE   10 (bases 1 to 4291)
  AUTHORS   Velazquez,L., Fellous,M., Stark,G.R. and Pellegrini,S.
  TITLE     A protein tyrosine kinase in the interferon alpha/beta signaling
            pathway
  JOURNAL   Cell 70 (2), 313-322 (1992)
   PUBMED   1386289
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473998.1.
            
            On or before Aug 23, 2008 this sequence version replaced
            XM_342872.3, XM_001061647.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4291
                     /gene="Jak1"
                     /note="Janus kinase 1"
                     /db_xref="GeneID:84598"
                     /db_xref="RGD:69056"
     exon            1..62
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..144
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..3600
                     /gene="Jak1"
                     /EC_number="2.7.10.2"
                     /note="Janus protein tyrosine kinase 1"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK1"
                     /protein_id="NP_445918.1"
                     /db_xref="GeneID:84598"
                     /db_xref="RGD:69056"
                     /translation="MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLD
                     REPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMS
                     LRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFA
                     QGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYK
                     RYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLET
                     LTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVE
                     KEKNKLKRKKLDYNKHKKEDDRNKLREEWNSFSYFPEITHIVIKESVVSINKQDNKNM
                     ELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAI
                     NKLRQEGSEEGMYVLRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSL
                     HGSVDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPV
                     YSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLD
                     PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS
                     DALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPG
                     IPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL
                     IEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVS
                     EKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG
                     GNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKN
                     KINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD
                     KEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFL
                     KMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIE
                     GFEALLK"
     exon            145..343
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..467
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..621
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..785
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1125
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1314
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1472
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1596
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1783
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1890
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2034
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2122
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2250
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2386
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2538
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2689
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2784
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2977
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3102
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3275
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3393
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3504
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..4291
                     /gene="Jak1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttggcc aagatataat ttgggaggaa tgtactgggc gtcttggaag accaacataa
       61 agatcagctc tgaatgggct ttggaaggta aagaagaaaa tccagtctgc ttttcaggga
      121 cactggacaa ccgaataaat gcagtatcta aatataaaag aggactgcaa tgccatggct
      181 ttctgtgcta aaatgaggag cttcaagaag acggaggtga agcaggtggc ccctgagcca
      241 ggagtggaag tgactttcta tctgttggac agggagcccc tccgcctggg cagcggagag
      301 tacaccgcgg aggagctgtg catcagggcc gcacaggaat gcagtatctc tcctctctgc
      361 cacaacctct tcgccttgta tgatgagagc accaagctct ggtatgctcc aaaccacatc
      421 atcactgtgg atgacaaaat gtctctccgg ctgcactacc gcatgaggtt ctactttacc
      481 aactggcatg gaaccaatga caatgaacag tctgtatggc gacattctcc aaagaagcag
      541 aaaaatggct atgagaagaa aaaggttcca gaagcaaccc cactccttga tgccagttca
      601 ctggagtatc tgtttgcgca gggacagtat gatttgatca aatgcctggc tcccattcgg
      661 gaccccaaga cagagcaaga tggacatgat attgagaatg agtgcctggg catggctgtc
      721 ctggccatct cacactatgc catgatgaag aagatgcagt tgccagagct tcccaaagac
      781 atcagctaca agcgatatat tccagaaaca ttgaataaat ccatcagaca gaggaatctt
      841 cttaccagga tgcgaataaa taatgttttc aaggatttct tgaaggaatt taacaacaag
      901 accatctgtg acagcagtgt gtctacacac gacctgaagg tgaagtacct ggctaccttg
      961 gaaaccttaa ccaagcatta tggagccgag atatttgaga cttctatgct cctgatttca
     1021 tcagaaaatg agctgagtcg gtgccattcc aacgacagtg gcaatgttct ctatgaagtc
     1081 atggtaacag gaaatctcgg gatccagtgg cggcagaaac caaatgttct tcctgttgaa
     1141 aaggaaaaaa ataaactgaa gcggaaaaaa ctggactata ataaacacaa gaaggaggat
     1201 gacagaaaca aactccggga agagtggaac agtttttcct atttccccga gattacccac
     1261 attgttatca aggagtctgt ggtcagcatt aacaaacagg acaacaagaa catggaacta
     1321 aagctctctt ctcatgagga agccttgtcc ttcgtgtccc tggtagatgg ctacttccgg
     1381 ctcactgcag atgctcacca ttacctctgt actgatgtgg ctcccccgct gattgtccac
     1441 aacatacaga atggctgtca cggtccaatc tgcacagaat atgccatcaa taagctgcgg
     1501 caggagggga gtgaggaggg gatgtacgtg ctgaggtgga gctgcaccga ctttgacaac
     1561 attcttatga ctgtcagctg cttcgaaaag tccgaggtat tgggtaatca gaagcagttc
     1621 aagaactttc agattgaggt gcagaagggc cgctacagcc tgcatggctc tgttgaccac
     1681 tttcccagcc tgagagacct catgaaccac ctcaagaagc agatcctgcg cacggacaat
     1741 ataagctttg tgctgaaacg ctgctgtcag cctaagcctc gagaaatctc caacctactt
     1801 gtagccacta agaaagccca ggagtggcag cctgtctact ctatgagcca gctgagtttc
     1861 gatcggatcc ttaagaaaga tattatccaa ggtgagcacc ttggcagagg cacaagaaca
     1921 catatctatt ctgggaccct gctggattac aaggacgatg aaggaattgc tgaagaaaag
     1981 aagataaaag tgattctcaa agtcctagac cctagccacc gggacatttc actggccttc
     2041 tttgaggcag ccagcatgat gagacaggtt tcccacaaac acatcgtgta cctctacggc
     2101 gtctgtgtcc gagatgtgga aaatatcatg gtggaagagt ttgtggaggg ggggccattg
     2161 gatctcttca tgcaccggaa aagtgatgca cttactaccc cttggaagtt taaagttgcc
     2221 aaacagctgg ccagcgccct gagttacttg gaagataaag acctcgttca tggaaatgtg
     2281 tgcactaaaa acctcctcct ggcccgtgag ggcattgaca gtgacattgg cccgttcatc
     2341 aagcttagtg accctggcat cccagtctct gtgctgacca ggcaagagtg catagagcga
     2401 attccctgga tcgctcctga gtgtgttgaa gactccaaga acctgagtgt ggctgctgac
     2461 aagtggagct ttggaaccac actctgggaa atctgctaca atggcgagat cccactcaag
     2521 gacaagaccc tcattgagaa agagaggttt tatgaaagcc gctgcaggcc agtgacacca
     2581 tcttgcaagg agctagctga cctcatgact cgctgcatga actatgatcc caaccagaga
     2641 cctttcttcc gagccatcat gagggacatt aacaagctgg aggagcagaa tccagacatt
     2701 gtttcagaaa agcagccaat aacagaggtg gatcccactc attttgaaaa gcgtttccta
     2761 aagaggattc gtgacttggg agagggtcac tttgggaagg ttgagctctg cagatatgat
     2821 cctgagggag acaacacagg ggaacaggta gctgtcaagt ccctgaagcc tgagagtgga
     2881 ggtaaccaca tagctgatct gaagaaggag atagagatct tacggaacct ctaccacgag
     2941 aacattgtga agtataaagg aatctgcatg gaagacggag ggaatggtat caagctcatc
     3001 atggagtttc tgccttcggg aagcctaaag gaatatctgc caaagaataa gaacaaaatc
     3061 aacctcaaac agcagctaaa atatgccatc cagatttgta aggggatgga ctatctgggc
     3121 tctcggcaat atgttcaccg ggacttagca gcaagaaatg tccttgttga gagtgaacac
     3181 caagtgaaga tcggagactt tggtttaacc aaagcaattg agaccgataa ggagtactac
     3241 acagtcaagg atgaccggga cagcccagtg ttttggtacg ctccggagtg tttaatccag
     3301 tgtaaatttt atatcgcctc tgatgtctgg tcttttggag tgacactgca cgagttgctc
     3361 acgtactgtg actcagattt tagtcccatg gccttgttcc tgaaaatgat aggcccaact
     3421 catggccaga tgacagtaac acggcttgtg aatactctga aagaaggaaa gcgcctgtcc
     3481 tgtccaccca actgtcccga tgaggtttat cagcttatga gaaaatgctg ggaattccaa
     3541 ccatctaatc ggacaacctt tcagaacctt attgaaggat ttgaagcact tttaaaataa
     3601 gaagcatgaa catttaaatt cccatttatc aagtccttct ctcccaagcc atttaaaaac
     3661 gttttttaag tgaaaaagtt tgtattttgc ctctaaagtt gatcaacaaa tactcgagtt
     3721 acatatatac atgtatatgt cacatggtca ctcagtgtgt gaaactttct ctttaaagtt
     3781 gtaacatctt aaatttagtg atgaataacg accaccaaaa tactagaatg tgccgaagcc
     3841 actcgttttg gaacagttgg aactatcagt tgtgtagcaa aggacgtctg gcaccgtgct
     3901 gctgggatgt gatcttagag aaaaagtgtg gacttggctg aaactctctc ttgccctgaa
     3961 atctcaatgt ctatacagtg atagtacaag cagatgccac ttagtatact attgtttcta
     4021 gtaaagaaag tctatccctg ctccctagta ggaccgcagt tttaagctgt gcgtgcagtg
     4081 gcacagctgc tgttctcttg gctaagcact ggttcccact gtgggacaga cctgtgcggc
     4141 aggaggagcc tggcacatac actctgcatg ctacttcacg agaaccagac cgcgactgtg
     4201 ttctcatgca cagcctgcct tccagcagac agattcctct ggatgctgtc acttctgccg
     4261 ttgagaatat tagtgcttac tccttcctaa c
//
