LOCUS       NM_001044272            1184 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus jagunal homolog 1 (Jagn1), mRNA.
ACCESSION   NM_001044272 XM_001054553 XM_001078768
VERSION     NM_001044272.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Nosak,C., Silva,P.N., Sollazzo,P., Moon,K.M., Odisho,T.,
            Foster,L.J., Rocheleau,J.V. and Volchuk,A.
  TITLE     Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin
            Biosynthesis
  JOURNAL   PLoS One 11 (2), e0149177 (2016)
   PUBMED   26882284
  REMARK    GeneRIF: These results identify a novel role for Jagn1 in
            regulating proinsulin biosynthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1184)
  AUTHORS   Baris,S., Karakoc-Aydiner,E., Ozen,A., Delil,K., Kiykim,A.,
            Ogulur,I., Baris,I. and Barlan,I.B.
  TITLE     JAGN1 Deficient Severe Congenital Neutropenia: Two Cases from the
            Same Family
  JOURNAL   J Clin Immunol 35 (4), 339-343 (2015)
   PUBMED   25851723
REFERENCE   3  (bases 1 to 1184)
  AUTHORS   Wirnsberger,G., Zwolanek,F., Stadlmann,J., Tortola,L., Liu,S.W.,
            Perlot,T., Jarvinen,P., Durnberger,G., Kozieradzki,I., Sarao,R., De
            Martino,A., Boztug,K., Mechtler,K., Kuchler,K., Klein,C., Elling,U.
            and Penninger,J.M.
  TITLE     Jagunal homolog 1 is a critical regulator of neutrophil function in
            fungal host defense
  JOURNAL   Nat Genet 46 (9), 1028-1033 (2014)
   PUBMED   25129145
REFERENCE   4  (bases 1 to 1184)
  AUTHORS   Boztug,K., Jarvinen,P.M., Salzer,E., Racek,T., Monch,S.,
            Garncarz,W., Gertz,E.M., Schaffer,A.A., Antonopoulos,A.,
            Haslam,S.M., Schieck,L., Puchalka,J., Diestelhorst,J.,
            Appaswamy,G., Lescoeur,B., Giambruno,R., Bigenzahn,J.W., Elling,U.,
            Pfeifer,D., Conde,C.D., Albert,M.H., Welte,K., Brandes,G.,
            Sherkat,R., van der Werff Ten Bosch,J., Rezaei,N., Etzioni,A.,
            Bellanne-Chantelot,C., Superti-Furga,G., Penninger,J.M.,
            Bennett,K.L., von Blume,J., Dell,A., Donadieu,J. and Klein,C.
  TITLE     JAGN1 deficiency causes aberrant myeloid cell homeostasis and
            congenital neutropenia
  JOURNAL   Nat Genet 46 (9), 1021-1027 (2014)
   PUBMED   25129144
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098749.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XM_001054553.1, XM_001078768.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098749.1, FQ225993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1184
                     /gene="Jagn1"
                     /note="jagunal homolog 1"
                     /db_xref="GeneID:502872"
                     /db_xref="RGD:1565488"
     exon            1..184
                     /gene="Jagn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..647
                     /gene="Jagn1"
                     /codon_start=1
                     /product="protein jagunal homolog 1"
                     /protein_id="NP_001037737.1"
                     /db_xref="GeneID:502872"
                     /db_xref="RGD:1565488"
                     /translation="MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVH
                     LVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSIVPSVLGLLSFPRNNISYLVL
                     SMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHA
                     WQLYYSKKLLDSWFTSTQEKKRK"
     exon            185..1149
                     /gene="Jagn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggaagcgg agaggaggag gcaggaaagc ggttctctgg gagcctggct aggtgtgagc
       61 cagagggtcg gcgttagggc cttaggttct tcacgatggc gtctcgggca ggcccacgag
      121 cggccggcac cgacggcagc gactttcagc accgggaacg agtcgccatg cactaccaaa
      181 tgagtgtgac cctcaagtac gaaatcaaga agctgatcta cgtgcatctc gtcatatggc
      241 tgctgttggt tgccaagatg agtgtgggac acctgaggct cttgtcacat gaccaggtgg
      301 ccatgcccta tcagtgggaa tatccgtatt tgttgagcat tgtgccctct gtcttgggtc
      361 ttctctcctt ccctcgaaac aacattagct acctggtgct ctctatgatc agcatggggc
      421 tcttctccat cgctcccctc atttatggca gcatggagat gttccctgcg gcacagcagc
      481 tctaccgcca tggcaaggcc tatcgcttcc tgttcggttt ttccgccgtc tctgtcatgt
      541 acctggtgtt ggtactggca gtccaagttc atgcctggca actctactac agcaagaaac
      601 tcctagactc ttggttcacc agcacacagg agaagaaacg taaatgatga agcctgcttg
      661 atgaactgct atgggggtag aacctagggc tcccactgag caggtggagg gggctgttca
      721 gaatctccac agactggcat ctgtgatgtt gacacccagt gcactctagg ctcaaagctt
      781 ggcctagagt tctctctcac catctgctga ggcggcaaag ctgtagtatt taatttattc
      841 ttgactagct acagcggggt aaccagtggc tgtgaaacgc tttaactggt tgaacttgag
      901 gccctctaga gtttgggttt tgcagactga gccttacctt gccttctctt ggtcatactc
      961 cctacttccg tgcatcacct cctcaccacc aattacaaaa agaaatctgg aataatccat
     1021 atgtcaagtg gacttcaacc cgtaggtcac agggcaggca acatttggga agctgctccc
     1081 ctacaggctg ttctgtttac tgcaaaccat tttaaatcaa gaacctcaat aaagttaaga
     1141 ctgtcctgta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
