LOCUS       NM_001414899            5212 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus jagged canonical Notch ligand 2 (Jag2),
            transcript variant 1, mRNA.
ACCESSION   NM_001414899 XM_039111822
VERSION     NM_001414899.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5212)
  AUTHORS   Liu,H., Pan,Z., Wu,X., Gong,C. and Hu,J.
  TITLE     Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage
            and pulmonary hypertension through Sirtuin 1 signaling
  JOURNAL   PLoS One 19 (1), e0297525 (2024)
   PUBMED   38277398
  REMARK    GeneRIF: Jagged 2 inhibition attenuates hypoxia-induced
            mitochondrial damage and pulmonary hypertension through Sirtuin 1
            signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5212)
  AUTHORS   He,W., Hu,J., Xia,Y. and Yan,R.
  TITLE     beta-site amyloid precursor protein cleaving enzyme 1(BACE1)
            regulates Notch signaling by controlling the cleavage of Jagged 1
            (Jag1) and Jagged 2 (Jag2) proteins
  JOURNAL   J Biol Chem 289 (30), 20630-20637 (2014)
   PUBMED   24907271
  REMARK    GeneRIF: Although Jag1 shares a high degree of homology with Jag2
            in the ectodomain region, BACE1 fails to cleave Jag2 effectively,
            indicating a selective cleavage of Jag1.
REFERENCE   3  (bases 1 to 5212)
  AUTHORS   Chen,G., Qiu,Y., Sun,L., Yu,M., Wang,W., Xiao,W., Yang,Y., Liu,Y.,
            Yang,S., Teitelbaum,D.H., Ma,Y., Lu,D. and Yang,H.
  TITLE     The jagged-2/notch-1/hes-1 pathway is involved in intestinal
            epithelium regeneration after intestinal ischemia-reperfusion
            injury
  JOURNAL   PLoS One 8 (10), e76274 (2013)
   PUBMED   24098462
  REMARK    GeneRIF: The Jagged-2/Notch-1/Hes-1 signaling pathway is involved
            in intestinal epithelium regeneration early after I/R injury by
            increasing crypt epithelial cell proliferation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5212)
  AUTHORS   Tando,Y., Fujiwara,K., Yashiro,T. and Kikuchi,M.
  TITLE     Localization of Notch signaling molecules and their effect on
            cellular proliferation in adult rat pituitary
  JOURNAL   Cell Tissue Res 351 (3), 511-519 (2013)
   PUBMED   23232913
  REMARK    GeneRIF: In situ hybridization detected transcripts of Notch1 and 2
            and Jagged1 and 2.
REFERENCE   5  (bases 1 to 5212)
  AUTHORS   Truog,W.E., Xu,D., Ekekezie,I.I., Mabry,S., Rezaiekhaligh,M.,
            Svojanovsky,S. and Soares,M.J.
  TITLE     Chronic hypoxia and rat lung development: analysis by morphometry
            and directed microarray
  JOURNAL   Pediatr Res 64 (1), 56-62 (2008)
   PUBMED   18344904
REFERENCE   6  (bases 1 to 5212)
  AUTHORS   Lanford,P.J., Lan,Y., Jiang,R., Lindsell,C., Weinmaster,G.,
            Gridley,T. and Kelley,M.W.
  TITLE     Notch signalling pathway mediates hair cell development in
            mammalian cochlea
  JOURNAL   Nat Genet 21 (3), 289-292 (1999)
   PUBMED   10080181
REFERENCE   7  (bases 1 to 5212)
  AUTHORS   Gray,G.E., Mann,R.S., Mitsiadis,E., Henrique,D., Carcangiu,M.L.,
            Banks,A., Leiman,J., Ward,D., Ish-Horowitz,D. and
            Artavanis-Tsakonas,S.
  TITLE     Human ligands of the Notch receptor
  JOURNAL   Am J Pathol 154 (3), 785-794 (1999)
   PUBMED   10079256
REFERENCE   8  (bases 1 to 5212)
  AUTHORS   Jiang,R., Lan,Y., Chapman,H.D., Shawber,C., Norton,C.R.,
            Serreze,D.V., Weinmaster,G. and Gridley,T.
  TITLE     Defects in limb, craniofacial, and thymic development in Jagged2
            mutant mice
  JOURNAL   Genes Dev 12 (7), 1046-1057 (1998)
   PUBMED   9531541
REFERENCE   9  (bases 1 to 5212)
  AUTHORS   Luo,B., Aster,J.C., Hasserjian,R.P., Kuo,F. and Sklar,J.
  TITLE     Isolation and functional analysis of a cDNA for human Jagged2, a
            gene encoding a ligand for the Notch1 receptor
  JOURNAL   Mol Cell Biol 17 (10), 6057-6067 (1997)
   PUBMED   9315665
REFERENCE   10 (bases 1 to 5212)
  AUTHORS   Shawber,C., Boulter,J., Lindsell,C.E. and Weinmaster,G.
  TITLE     Jagged2: a serrate-like gene expressed during rat embryogenesis
  JOURNAL   Dev Biol 180 (1), 370-376 (1996)
   PUBMED   8948600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 14, 2022 this sequence version replaced XM_039111822.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.49606.1,
                                           SRR26643429.25248.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000006.1  137826337-137826738 c
            403-753             JAXUCZ010000006.1  137825802-137826152 c
            754-811             JAXUCZ010000006.1  137818788-137818845 c
            812-1063            JAXUCZ010000006.1  137817065-137817316 c
            1064-1124           JAXUCZ010000006.1  137816907-137816967 c
            1125-1255           JAXUCZ010000006.1  137813514-137813644 c
            1256-1375           JAXUCZ010000006.1  137813313-137813432 c
            1376-1489           JAXUCZ010000006.1  137813044-137813157 c
            1490-1603           JAXUCZ010000006.1  137812692-137812805 c
            1604-1717           JAXUCZ010000006.1  137812428-137812541 c
            1718-1764           JAXUCZ010000006.1  137812291-137812337 c
            1765-1938           JAXUCZ010000006.1  137812005-137812178 c
            1939-2089           JAXUCZ010000006.1  137811131-137811281 c
            2090-2242           JAXUCZ010000006.1  137810900-137811052 c
            2243-2356           JAXUCZ010000006.1  137810710-137810823 c
            2357-2470           JAXUCZ010000006.1  137810392-137810505 c
            2471-2584           JAXUCZ010000006.1  137810179-137810292 c
            2585-2701           JAXUCZ010000006.1  137809973-137810089 c
            2702-2729           JAXUCZ010000006.1  137809521-137809548 c
            2730-2815           JAXUCZ010000006.1  137809357-137809442 c
            2816-2929           JAXUCZ010000006.1  137808746-137808859 c
            2930-3045           JAXUCZ010000006.1  137808540-137808655 c
            3046-3294           JAXUCZ010000006.1  137807902-137808150 c
            3295-3426           JAXUCZ010000006.1  137807230-137807361 c
            3427-3583           JAXUCZ010000006.1  137805920-137806076 c
            3584-5212           JAXUCZ010000006.1  137804133-137805761 c
FEATURES             Location/Qualifiers
     source          1..5212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..5212
                     /gene="Jag2"
                     /note="jagged canonical Notch ligand 2"
                     /db_xref="GeneID:29147"
                     /db_xref="RGD:2938"
     exon            1..402
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..4080
                     /gene="Jag2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein jagged-2; jagged 2"
                     /codon_start=1
                     /product="protein jagged-2 isoform 1 precursor"
                     /protein_id="NP_001401828.1"
                     /db_xref="GeneID:29147"
                     /db_xref="RGD:2938"
                     /translation="MRARGWGRLPRRLLLLLVLCVQATRPMGYFELQLSALRNVNGEL
                     LSGACCDGDGRTTRAGGCGRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNS
                     FYLPPAGAAGDRARARSRTGGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPDEE
                     LLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFF
                     GHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGKFCDEC
                     VPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCINAEPDQYLCA
                     CPDGYLGKNCERAEHACASNPCANGGSCHEVLSGFECHCPSGWSGPTCALDIDECASN
                     PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCL
                     PGWKGANCHININDCHGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYYKCASSPCR
                     RGGICEDLVDGFRCHCPRGLSGPLCEVDVDLCEPNPCLNGARCYNLEDDYYCACPEDF
                     GGKNCSVPRETCPGGACRVIDGCGFEAGSRAHGAAPSGVCGPHGHCVSLPGGNFSCIC
                     DSGFTGTYCHENIDDCMGQPCRNGGTCIDEVDSFRCFCPSGWEGELCDINPNDCLPDP
                     CHSRGRCYDLVNDFYCVCDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP
                     GWKGSTCTIAKNSSCVPNPCVNGGTCVGSGDSFSCICRDGWEGRTCTHNTNDCNPLPC
                     YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG
                     RSGPRCQEVVIFTRPCWSRGVSFPHGSSWVEDCNSCRCLDGHRDCSKVWCGWKPCLLS
                     PQPSALSAQCPPGQQCREKAMGQCLQPPCENWGECTAEDPLPPSTPCLPRTTHLDNNC
                     ARLTLHFNRDQVPQGTTVGAICSGIRALPATRAAARDRLLLLLCDRASSGASAVEVAV
                     SFSPARDLPDSSLIQSTAHAIVAAITQRGNSSLLLAVTEVKVETVVMGGSSTGLLVPV
                     LCSVFSVLWLACVVICVWWTRKRRKERERSRLPRDESANNQWAPLNPIRNPIERPGSS
                     GLGTGGHKDVLYQCKNFTPPPRRAGEALPGPASHGAGGEDEEDEELSRGDGDSPEAEK
                     FLSHKFTKDPSCSLGRPACWAPGPKVDNRAVRSTKDVRCAGRE"
     exon            403..753
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..811
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1063
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1124
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1255
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1375
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1489
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1603
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1717
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1764
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1938
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2089
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2242
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2356
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2470
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2584
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2701
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2729
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2815
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2929
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3045
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3294
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3426
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3583
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..5212
                     /gene="Jag2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcgtcc cgaacttgtt ggctgcggtg ccgggagcgc gggcgcgcag agccgaggcc
       61 aggacccgcc gccgccgtcg ccgccgccgc cgccgccgcc gggtgggagc cgggccggcc
      121 gccggagagc ggctgcagta agccggagcc gccgcctccc ctgcacgccc gccgcgcagc
      181 ccgcgcgcac tgctcgaccc cgcccgcgcc gcctgtgcgg ccgccgccgc ctgtgcgccg
      241 ccgggctcgg agggcgggcg ggcgctggag gccggcgcgg cggctatagc gggcgcgggc
      301 ggcggcggcg gggccgcggg cggggtcgag gcggcgatgc gggcacgcgg ctggggacgc
      361 ctgcctcggc ggctgctgct gctgctggtt ctatgcgtgc aggcgacgcg gcccatgggc
      421 tatttcgagc tgcagctgag cgcgctgcgg aacgtgaacg gggagctgct gagcggcgcc
      481 tgctgtgacg gcgacggccg gacgacgcgc gcggggggct gcggccgcga cgagtgcgac
      541 acgtacgtgc gcgtgtgcct taaggagtac caggccaagg tgacgcccac ggggccctgc
      601 agctacggct acggcgccac gcccgtgctg ggtggcaact ccttctacct gccgccggcg
      661 ggcgctgcgg gagaccgagc gcgcgcgcgg tctcggaccg gcggccacca ggacccgggc
      721 ctcgtcgtca ttccctttca gttcgcctgg ccgcgttctt tcaccctcat cgtggaggcc
      781 tgggattggg acaatgacac cacaccagat gaggagctgc tgattgagcg ggtgtcccat
      841 gctggcatga tcaaccctga ggaccgctgg aagagcctgc acttcagcgg ccacgtggca
      901 cacctggagc tgcagatccg agtgcgctgt gacgagaact actacagtgc cacctgcaac
      961 aagttctgcc ggccccggaa cgacttcttc ggccactaca cctgtgacca gtacggcaac
     1021 aaggcctgca tggatggctg gatgggcaag gagtgcaaag aagccgtgtg taaacaagga
     1081 tgtaatttgc tccacggggg atgcactgtg cctggggagt gcaggtgcag ctatggctgg
     1141 cagggcaagt tctgtgatga atgtgtcccc taccctggct gcgtgcatgg cagctgtgtg
     1201 gagccctggc actgtgactg tgagaccaac tggggtggcc tgctctgtga caaagacctg
     1261 aactactgtg gcagccacca cccctgtgtc aatggaggca cctgtatcaa cgccgagcct
     1321 gaccaatacc tctgcgcctg cccagatggc tacttgggca agaactgcga acgggctgag
     1381 cacgcctgcg cctccaaccc gtgtgccaac gggggctctt gccacgaagt gctgtctggc
     1441 tttgaatgcc actgtccgtc gggatggagt ggacccacct gtgcgcttga catcgatgag
     1501 tgtgcctcta atccgtgtgc ggcgggtggc acctgcgtgg atcaggtgga cggcttcgag
     1561 tgcatctgcc cggagcagtg ggtgggggct acctgccagc tggacgccaa tgagtgtgaa
     1621 gggaaaccgt gccttaatgc tttttcttgc aaaaacctga ttggcggcta ttactgtgat
     1681 tgcctcccgg gctggaaggg cgccaactgc cacatcaata tcaacgattg ccatgggcag
     1741 tgtcagcatg ggggcacctg caaggacctg gtaaatgggt accagtgcgt atgcccacgg
     1801 ggcttcggag gtcgtcactg cgaactagag tactacaagt gtgccagcag cccctgccgt
     1861 cggggtggca tctgtgagga cctggtggat ggcttccgct gccactgccc acggggcctc
     1921 tctggtccgc tctgtgaggt ggacgtggat ctctgcgaac caaacccctg cctcaacggt
     1981 gctcgctgct acaaccttga ggatgactac tactgcgcct gcccagaaga ctttggcggc
     2041 aagaactgct ctgtgcccag ggagacatgc cctggtgggg cctgtagagt gatcgatggc
     2101 tgtgggttcg aggcagggtc cagggcgcat ggtgctgcgc cctccggcgt gtgcggtcct
     2161 cacgggcact gtgtcagcct gcctggggga aacttctcct gcatctgtga cagcggcttc
     2221 acgggcacct actgccatga gaacatcgac gactgcatgg gtcagccctg ccgcaacggg
     2281 ggcacgtgca ttgatgaagt ggactccttc cgctgcttct gccccagtgg ctgggaagga
     2341 gagctctgtg acatcaatcc caacgactgc ctccccgacc cctgccacag ccgcggccgc
     2401 tgctatgacc tggtcaatga cttctactgt gtctgcgatg atggctggaa gggcaagacc
     2461 tgccactcac gcgagttcca gtgtgacgcc tacacctgca gcaacggtgg cacatgctat
     2521 gacagcggcg acaccttccg ctgcgcgtgc cccccaggct ggaagggcag cacctgcacg
     2581 atcgccaaga acagcagctg cgtgcccaat ccctgtgtga atggaggcac ctgtgtgggc
     2641 agtggagact ctttctcctg catctgccgg gatggctggg agggccgcac ctgcacacac
     2701 aacaccaatg actgcaaccc tctgccctgc tacaacggag gcatctgtgt ggatggcgtc
     2761 aactggttcc gctgcgagtg tgcacctggc tttgcgggtc ctgactgccg tatcaacatc
     2821 gatgagtgcc agtcctcacc ctgtgcctac ggagccacgt gtgtagatga gatcaatggg
     2881 taccgctgca gctgcccacc aggacgttcc ggccccagat gccaggaagt ggtcatattc
     2941 acgaggccct gctggtcccg gggcgtgtcc ttcccacatg ggagttcctg ggtagaagac
     3001 tgcaacagct gccgctgcct ggatggccac cgggactgca gcaaggtgtg gtgtggttgg
     3061 aagccttgtc tgctgtcccc tcagcccagt gctctgagtg cccagtgccc accagggcag
     3121 cagtgccggg agaaggccat gggtcagtgt ctgcagcccc cctgtgagaa ctggggggag
     3181 tgtacagcag aggatcctct gccccccagc accccctgtc tgccacggac cactcatttg
     3241 gacaacaact gtgctcgcct cacactgcac tttaaccgtg accaagtgcc tcagggcacc
     3301 accgtgggcg ccatctgctc tggaatccga gccctgcccg ccacgagggc ggcggcacga
     3361 gaccgcctcc tcctgctgct ctgtgaccgc gcatcctcag gggccagtgc cgtggaggtg
     3421 gctgtgtctt tcagccctgc aagggacctg cccgacagca gcctgatcca gagcacagcc
     3481 catgccatcg tggctgccat cacccagaga ggaaacagct cactgctgct ggctgtcacc
     3541 gaggtcaagg tggaaacagt tgttatgggt ggctcttcca caggtctgtt ggtacctgtg
     3601 ctgtgtagcg tgttcagtgt gctgtggctt gcctgtgtgg ttatctgcgt gtggtggaca
     3661 cggaagcgca ggaaagaacg tgagaggagc cggctaccac gggacgagag cgccaacaac
     3721 cagtgggctc cgctcaatcc catccgcaac cccattgagc ggccaggcag cagtggtctg
     3781 ggaaccgggg gccacaagga cgtactctac cagtgcaaga acttcacacc gccgccccgc
     3841 agggcaggcg aggcactgcc tgggccggcc agccacgggg ctggtgggga ggacgaggag
     3901 gatgaggagc tgagccgagg agatggggac tctccagaag cagagaagtt cctctcacac
     3961 aaattcacca aagaccccag ctgctccctg ggaaggccag cctgctgggc tccggggccc
     4021 aaagtggaca accgcgccgt cagaagcacc aaggatgtgc gctgtgctgg cagggagtag
     4081 ccagcctcca ggctggtacc cagaaccctt gccagcacca cgctgcctcc cggaccatag
     4141 gaggccaagg ccgtgtgcat agtttcttta ttttgtgtaa aaaacaaaac caaaaacaaa
     4201 aaacaaatgt ttatttttta cgtttcttta accttgtata aattattcag tggctgtcag
     4261 gcggaaaaca acggagtatt ctcggatcac tgctattttt gtaaggtttc cgtgtccgca
     4321 cgcactgtgg caggagagca gggcgggcgt gtttgtgttc tcaccaaatc gtataatgtt
     4381 tgttaccacg ggctgtcgct gtttacagaa tcttcttttt tattcctcat ttgggtttct
     4441 ctctagctca aggcccaaaa gcccatgaga cccgtgggct gggccgtggc tctcagtgag
     4501 atctgtggct ttcagtgtgg cctgtggctc tcagtgggac ctgtggctga cagtatggcc
     4561 tgaggctgtc agtgggactg tggctgttgt cttagctgta gctctcagtg ggacctgtgg
     4621 ctgtcagtgg cacctgtggc aattggcctg gcctgtggat gtccgtggga cctgtggctg
     4681 ttagggacat ctgtggctat tggcttgtgg cttggctgtc agtgacaccc atggccgtca
     4741 gtggcactgg ctgctggact ggcctgtagc tgtcagtggg acccgtggtg gcccgtgtga
     4801 tgctggttac catagctgtt ggtggcacct gtggttgtca atggggttgg aggtcactgg
     4861 tgtggcctaa ggccgcaagc aaacctggcc catgcctcgg ctagcccctc cagcctgctg
     4921 tccttgcttc ctcctgccca gaactctcca gagatctcca actgtgcttt cagaagtgcc
     4981 cttcccaact gctcggtgtc cctccaggga cggcggcagt attgaagctt gtgacaagtg
     5041 ccttcacaca gaccccctcc cagctgtcag cgtttgccgt gggcaccagg ccgctgccca
     5101 cctgccggcc ccggccaccc tccttgtgaa agtgcatttc tgtaaatatg tacacattaa
     5161 atgaatcact ctgtatattt gatttaataa cttaaacgtt ttggcctccc tg
//
