LOCUS       NM_019147               5600 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus jagged canonical Notch ligand 1 (Jag1), mRNA.
ACCESSION   NM_019147
VERSION     NM_019147.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5600)
  AUTHORS   Wang,K., Zhu,H., Yang,L., Xu,Q., Ren,F. and Liu,X.
  TITLE     [Inhibition of the Notch1/Jagged1 pathway promotes homing of bone
            mesenchymal stem cells to improve asthma in rats]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (10), 1464-1472 (2021)
   PUBMED   34755661
  REMARK    GeneRIF: [Inhibition of the Notch1/Jagged1 pathway promotes homing
            of bone mesenchymal stem cells to improve asthma in rats].
REFERENCE   2  (bases 1 to 5600)
  AUTHORS   Cheng,F., Qin,W., Yang,A.X., Yan,F.F., Chen,Y. and Ma,J.X.
  TITLE     Propofol alleviates neuropathic pain in chronic constriction injury
            rat models via the microRNA-140-3p/Jagged-1 peptide/Notch signaling
            pathway
  JOURNAL   Synapse 75 (10), e22219 (2021)
   PUBMED   34269482
  REMARK    GeneRIF: Propofol alleviates neuropathic pain in chronic
            constriction injury rat models via the microRNA-140-3p/Jagged-1
            peptide/Notch signaling pathway.
REFERENCE   3  (bases 1 to 5600)
  AUTHORS   Li,H., Fan,L., Zhang,Y., Cao,Y. and Liu,X.
  TITLE     SNHG16 aggravates chronic constriction injury-induced neuropathic
            pain in rats via binding with miR-124-3p and miR-141-3p to
            upregulate JAG1
  JOURNAL   Brain Res Bull 165, 228-237 (2020)
   PUBMED   33049352
  REMARK    GeneRIF: SNHG16 aggravates chronic constriction injury-induced
            neuropathic pain in rats via binding with miR-124-3p and miR-141-3p
            to upregulate JAG1.
REFERENCE   4  (bases 1 to 5600)
  AUTHORS   Lan,J.Z., Pan,Q., Tao,Q., Shi,X., Wang,W.Z., Xu,B.W. and Luo,J.W.
  TITLE     TMEM45A is involved in renal fibrosis in rats by regulating
            Jagged1/Notch pathway
  JOURNAL   Front Biosci (Landmark Ed) 25 (4), 593-605 (2020)
   PUBMED   31585906
  REMARK    GeneRIF: TMEM45A is involved in renal fibrosis in rats by
            regulating Jagged1/Notch pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5600)
  AUTHORS   Miloudi,K., Oubaha,M., Menard,C., Dejda,A., Guber,V., Cagnone,G.,
            Wilson,A.M., Tetreault,N., Mawambo,G., Binet,F., Chidiac,R.,
            Delisle,C., Buscarlet,M., Cerani,A., Crespo-Garcia,S., Bentley,K.,
            Rezende,F., Joyal,J.S., Mallette,F.A., Gratton,J.P., Larrivee,B.
            and Sapieha,P.
  TITLE     NOTCH1 signaling induces pathological vascular permeability in
            diabetic retinopathy
  JOURNAL   Proc Natl Acad Sci U S A 116 (10), 4538-4547 (2019)
   PUBMED   30787185
REFERENCE   6  (bases 1 to 5600)
  AUTHORS   Li,L., Krantz,I.D., Deng,Y., Genin,A., Banta,A.B., Collins,C.C.,
            Qi,M., Trask,B.J., Kuo,W.L., Cochran,J., Costa,T., Pierpont,M.E.,
            Rand,E.B., Piccoli,D.A., Hood,L. and Spinner,N.B.
  TITLE     Alagille syndrome is caused by mutations in human Jagged1, which
            encodes a ligand for Notch1
  JOURNAL   Nat Genet 16 (3), 243-251 (1997)
   PUBMED   9207788
REFERENCE   7  (bases 1 to 5600)
  AUTHORS   Oda,T., Elkahloun,A.G., Pike,B.L., Okajima,K., Krantz,I.D.,
            Genin,A., Piccoli,D.A., Meltzer,P.S., Spinner,N.B., Collins,F.S.
            and Chandrasekharappa,S.C.
  TITLE     Mutations in the human Jagged1 gene are responsible for Alagille
            syndrome
  JOURNAL   Nat Genet 16 (3), 235-242 (1997)
   PUBMED   9207787
REFERENCE   8  (bases 1 to 5600)
  AUTHORS   Zimrin,A.B., Pepper,M.S., McMahon,G.A., Nguyen,F., Montesano,R. and
            Maciag,T.
  TITLE     An antisense oligonucleotide to the notch ligand jagged enhances
            fibroblast growth factor-induced angiogenesis in vitro
  JOURNAL   J Biol Chem 271 (51), 32499-32502 (1996)
   PUBMED   8955070
REFERENCE   9  (bases 1 to 5600)
  AUTHORS   Lindsell,C.E., Boulter,J., diSibio,G., Gossler,A. and Weinmaster,G.
  TITLE     Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3
            genes identify ligand-receptor pairs that may function in neural
            development
  JOURNAL   Mol Cell Neurosci 8 (1), 14-27 (1996)
   PUBMED   8923452
REFERENCE   10 (bases 1 to 5600)
  AUTHORS   Lindsell,C.E., Shawber,C.J., Boulter,J. and Weinmaster,G.
  TITLE     Jagged: a mammalian ligand that activates Notch1
  JOURNAL   Cell 80 (6), 909-917 (1995)
   PUBMED   7697721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000118.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_019147.3.
            
            On Feb 25, 2021 this sequence version replaced NM_019147.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L38483.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132302,
                                           SAMD00155330 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               JACYVU010000118.1  48308823-48309285   c
            464-769             JACYVU010000118.1  48308042-48308347   c
            770-821             JACYVU010000118.1  48299651-48299702   c
            822-1076            JACYVU010000118.1  48294063-48294317   c
            1077-1137           JACYVU010000118.1  48292575-48292635   c
            1138-1268           JACYVU010000118.1  48288592-48288722   c
            1269-1388           JACYVU010000118.1  48287808-48287927   c
            1389-1502           JACYVU010000118.1  48286759-48286872   c
            1503-1616           JACYVU010000118.1  48285505-48285618   c
            1617-1730           JACYVU010000118.1  48284797-48284910   c
            1731-1777           JACYVU010000118.1  48284251-48284297   c
            1778-1951           JACYVU010000118.1  48283769-48283942   c
            1952-2102           JACYVU010000118.1  48283178-48283328   c
            2103-2267           JACYVU010000118.1  48282093-48282257   c
            2268-2381           JACYVU010000118.1  48281604-48281717   c
            2382-2495           JACYVU010000118.1  48281033-48281146   c
            2496-2609           JACYVU010000118.1  48280830-48280943   c
            2610-2726           JACYVU010000118.1  48280562-48280678   c
            2727-2754           JACYVU010000118.1  48280069-48280096   c
            2755-2840           JACYVU010000118.1  48279562-48279647   c
            2841-2954           JACYVU010000118.1  48278369-48278482   c
            2955-3064           JACYVU010000118.1  48277659-48277768   c
            3065-3298           JACYVU010000118.1  48277332-48277565   c
            3299-3430           JACYVU010000118.1  48277010-48277141   c
            3431-3581           JACYVU010000118.1  48276712-48276862   c
            3582-5600           JACYVU010000118.1  48273848-48275866   c
FEATURES             Location/Qualifiers
     source          1..5600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..5600
                     /gene="Jag1"
                     /note="jagged canonical Notch ligand 1"
                     /db_xref="GeneID:29146"
                     /db_xref="RGD:2937"
     exon            1..463
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..4042
                     /gene="Jag1"
                     /note="protein jagged-1; jagged 1"
                     /codon_start=1
                     /product="protein jagged-1 precursor"
                     /protein_id="NP_062020.2"
                     /db_xref="GeneID:29146"
                     /db_xref="RGD:2937"
                     /translation="MRSPRTRGRPGRPLSLLLALLCALRAKVCGASGQFELEILSMQN
                     VNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVI
                     GGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTIQPDSIIEKASHSGM
                     INPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRPRDDFFGHYACDQNGNK
                     TCMEGWMGPECNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGTC
                     NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPNCE
                     IAEHACLSDPCHNRGSCKETSSGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL
                     VNGFKCVCPPQWTGKTCQLDANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCDIN
                     INDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR
                     FQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDH
                     CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSESGGKFTCDCNKGFTGT
                     YCHENINDCEGNPCTNGGTCIDGVNSYKCICSDGWEGAHCENNINDCSQNPCHYGGTC
                     RDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVDTFKCMCPGGWEGTTC
                     NIARNSSCLPNPCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSGTCV
                     DGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSGAKCH
                     EVSGRSCITMGRVILDGAKWDDDCNTCQCLNGRVACSKVWCGPRPCQLHKGHGECPNG
                     QSCIPVLDDQCFVRPCTGAGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSP
                     GLTTEHICSELRNLNILKNVSAEYSIYIACEPSLSANNEIHVAISAEDIRDDGNPVKE
                     ITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWVCCLVTA
                     FYWCVRKRRRKPSSHTHSAPEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSK
                     MSKIRTHNSEVEEDDMDKHQQKVRFAKQPVYTLVDREEKAPSGTPTKHPNWTNKQDNR
                     DLESAQSLNRMEYIV"
     exon            464..769
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..821
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1076
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1137
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1268
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1388
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1502
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1616
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1730
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1777
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1951
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2102
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2267
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2381
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2495
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2609
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2726
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2754
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2840
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2954
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3064
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3298
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3430
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3581
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..5600
                     /gene="Jag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttt tcctcccctc cctcccccgc gtttcatgca gctgatccga aagggaataa
       61 aaggctgcgc ataatcataa tataaaagaa ggggagcgcg agagaaggaa agaaagccga
      121 gaggtggaag aggggggagc gcctcaaaga agcgatcaga ataataaaag gaggccgggc
      181 tctttgcctt ctggaacgcg cggctcttga aagggctttt gaaaagtagt gttgttttcc
      241 agtcgtgcat gctccaatcc acggagtata ttagagccgg gacgcggcgg tcgcgggggc
      301 agcgacgacg gcagcctcgg agggagcacc agcgctagca gcggcggcgg cgtccggagt
      361 gcccccggcg cgcggcgcag cgatgcggtc cccacggacg cgcggccggc cggggcgccc
      421 cttgagcctt ctgctcgccc tgctctgtgc cctgcgagcc aaggtgtgcg gggcctcggg
      481 tcaatttgag ctggagatcc tgtccatgca gaacgtgaac ggagagttac agaatgggaa
      541 ctgttgcggc ggagcccgga accctggcga ccgcaagtgc acccgcgacg agtgtgacac
      601 gtacttcaaa gtgtgcctca aggagtatca gtcccgcgtc acggccgggg gaccctgcag
      661 cttcggctca gggtctacgc ctgtcatcgg gggcaatacc ttcaatctca aggccagccg
      721 cggcaacgac cgtaatcgca tcgtactgcc tttcagtttc gcctggccga ggtcctacac
      781 tttgctggtg gaggcatggg attccagtaa tgacactatt caacctgata gcataattga
      841 aaaggcttct cactcaggca tgataaaccc cagccggcag tggcagacac tgaaacagaa
      901 cacagggatt gcccactttg agtatcagat ccgagtgacc tgtgatgacc actactatgg
      961 ctttggctgc aacaagttct gtcggcccag agatgacttc tttggacatt atgcctgcga
     1021 ccagaatggc aacaaaacct gcatggaagg ctggatgggt cctgagtgta acaaagcaat
     1081 atgccgacag ggctgcagtc ccaagcatgg ctcctgcaaa ctcccaggtg actgcaggtg
     1141 ccagtatggt tggcagggcc tgtactgtga taagtgcatc ccgcacccag gatgtgtcca
     1201 cggcacctgc aatgaaccct ggcagtgcct ctgtgaaacc aactggggtg gacagctctg
     1261 tgacaaagat ctgaattact gtgggactca tcagccctgt ctcaaccggg gaacatgtag
     1321 caacactggc cctgacaaat accagtgttc ctgccccgag ggctactcag gaccgaactg
     1381 tgaaattgct gagcatgcct gcctctctga tccctgccac aacagaggca gctgcaagga
     1441 gacctcctcg ggctttgagt gtgagtgttc tccaggctgg actggaccca cgtgttccac
     1501 aaacatcgat gactgttctc caaataactg ttcccatgga ggcacctgcc aggatctagt
     1561 gaatggattc aagtgcgtgt gcccacccca gtggactggc aagacttgtc agttagatgc
     1621 aaatgagtgc gaggccaagc cttgtgtaaa tgccagatcc tgtaagaatc tgattgccag
     1681 ctactactgt gattgtcttc ctggctggat gggtcagaat tgtgacataa atatcaatga
     1741 ctgccttggc cagtgtcaga atgatgcctc ctgtcgggat ttggttaatg gttatcgctg
     1801 tatctgtcca cctggctatg cgggcgatca ctgtgaaaga gacatcgatg aatgtgctag
     1861 caacccctgc ttgaatgggg gtcactgtca gaatgaaatt aacagattcc agtgtctgtg
     1921 tcccactggt ttctctggaa acctctgtca gctggacatc gattactgcg agcccaaccc
     1981 ttgccagaat ggcgcccaat gctacaatcg tgccagtgac tatttctgca agtgccctga
     2041 ggactacgag ggcaagaact gctcacacct gaaagaccac tgccgcacca ctccctgtga
     2101 agtgattgac agctgcaccg tggccatggc ctccaacgat acgcctgaag gggtgcggta
     2161 tatctcttcc aacgtctgtg gtccccatgg gaagtgcaag agcgagtcag gaggcaaatt
     2221 cacctgtgac tgtaacaaag gcttcaccgg cacctactgc catgaaaata tcaacgactg
     2281 tgagggcaac ccctgtacga acggtggcac gtgcatcgac ggcgtcaact cctacaagtg
     2341 tatctgtagt gacggctggg agggcgcgca ctgtgagaac aacataaatg actgtagcca
     2401 gaacccttgc cactatgggg gtacatgtcg agacctggtc aatgactttt actgtgactg
     2461 caaaaatggg tggaaaggga aaacctgcca ctcgcgtgac agccagtgtg acgaagccac
     2521 gtgtaataac ggtggtacct gctatgatga agtggatacg tttaagtgca tgtgtcctgg
     2581 tggctgggaa ggaacaacct gtaatatagc tagaaacagt agctgcctgc cgaacccctg
     2641 tcataatgga ggcacctgcg tggtcaatgg agactccttc acctgtgtct gcaaagaagg
     2701 ctgggagggg ccgatttgta ctcaaaatac caacgactgc agtcctcacc cttgttacaa
     2761 cagcggaacc tgtgtggatg gagataactg gtaccggtgc gaatgtgccc ctggttttgc
     2821 tgggccagac tgcaggataa acatcaatga gtgtcagtct tccccttgtg cctttggggc
     2881 cacctgtgtg gatgagatca atggctacca gtgtatctgc cctccaggac atagtggtgc
     2941 caagtgccat gaagtttcag ggagatcttg catcaccatg gggagagtga tacttgatgg
     3001 ggccaagtgg gatgacgact gtaacacctg ccagtgcctg aatggacggg tggcctgctc
     3061 caaggtctgg tgtggcccga gaccttgcca gctccacaaa gggcacggcg agtgtcccaa
     3121 tgggcagagc tgcatcccag tcctggatga ccagtgtttc gtgcgcccct gcactggtgc
     3181 tggcgagtgt cggtcctcca gcctccagcc agtgaagacc aagtgtacat cggactctta
     3241 ttaccaggac aattgtgcga acatcacttt cacctttaac aaggagatga tgtctccagg
     3301 tctcaccact gagcacattt gcagcgaatt gaggaatctg aatattctga agaatgtttc
     3361 tgctgagtat tcaatctaca tagcctgtga gccttcctta tcagcaaaca atgaaataca
     3421 cgtggccatt tctgccgaag acatccggga tgatggaaac cctgtcaagg aaattactga
     3481 taaaataata gatctcgtta gtaaacggga tgggaacagc tcacttatcg ctgctgttgc
     3541 agaagtcaga gttcagaggc gccctctgaa aaacagaaca gatttcctgg ttcctctgct
     3601 gagctctgtc ttaacagtgg cttgggtctg ttgcttggtg acagccttct actggtgtgt
     3661 gcggaagcgg cggcggaagc ccagcagcca cacccactct gcccctgagg acaacaccac
     3721 caacaatgtg cgcgaacagc tgaaccaaat caaaaacccc atcgagaaac acggagccaa
     3781 cacagtcccc atcaaggatt atgagaacaa aaactccaaa atgtcaaaaa tcaggacaca
     3841 caactcggaa gtggaagagg atgatatgga taagcaccag cagaaagtcc ggtttgccaa
     3901 acagcccgtg tacacgctgg tagacagaga ggagaaggcc cccagcggca cgccgacaaa
     3961 acacccgaac tggacaaaca aacaggacaa cagagacttg gaaagtgccc agagcttgaa
     4021 ccggatggag tacatcgtat agcagacagt gggctgccgc cataggtaga gtttgagggc
     4081 accccggggc ttgtagtttc tttaaactgt tgtcgtatcc cagtctgagg ctgttgttga
     4141 cttagagtcc tgtgttaatt taagtttcga caagctggct tccactggca ctggtagttt
     4201 ctgtggttgg ctgggaaatc gagtgcagcg ctcacagcta tgcaaaaacc agtgaatgtg
     4261 cccgggtgta cattcccctg cagccgacac gtcgggctcc caggagctgc ccaggcctag
     4321 gcctcggagc ttccacatct gccagcggtc ctaatggtga tggcagcctt aggatcatag
     4381 ttttatttat atttattgac tcttgagttg tttttgtata ttggttttat gatgacgtac
     4441 aagtagttct gtatttgaaa gtgcctttgc agctcagaac cacagcaact atcacaaatg
     4501 actttattat ttattttttt tattgtattt ttgttgttgg gggagggggg gatttgatgt
     4561 cagcagttgc tggtaaaatg aagaatttaa agaggaaaaa tgtgtcaaag tagaattttt
     4621 gtatagttat gtaaataatt cttttttatt aatcactctg tatatttgat ttattaactt
     4681 aataatcaag agccttaaaa catcattcct ttttatttat atgtatgtgt ttagaattga
     4741 aggtttttga tagtgttgga aacatatggg tttttttttt tttttttttt tttttttttt
     4801 gtgaactttt tctcattacg tgttgcctgt aagccaaaag taaggtgttt ggaaatagtt
     4861 tctcttggaa ggatgggata ggcttcttcc cctgggaata ctgatggatt tttttttttt
     4921 tttttttttt ttgtacgacg tcaggtgttc aaacacttcc ttgatagcat cactttaaga
     4981 cacattctaa ggactgactg aggcagattg agaattcgtc tagaacaggt tttttttttt
     5041 ttttctcttt tcttttttta ttttttcctg ctttagactt gaaaagagac aggcaggcga
     5101 tctgtgacag agcagtttaa gggaacaaac tgagctatgt agtcagaatg tgactggttg
     5161 gatctcatta aaagtatcag attgtgtgaa gttggaagct taccaatctt actttgtaaa
     5221 ttctgatttc ttttcaccat tcgtatgtaa tgctgaacca cttgtagatt tgatttcatt
     5281 gttgttgtct actgcattta gggagtattc taataagcta gatgaatact tgaaccataa
     5341 aatgtccagt tagagcactg tttagattgg ccatagagta cactgcctgc cttaagtgag
     5401 gacatgaaag tgctattacc aagttcaaga tcaaacaagg cttataaaac agtcatcctg
     5461 gctcaccacg gagcccagga agatactttg tattgtccta ttagtgttat atgaacataa
     5521 aatacatctt tgatgtgttg ttcctggcaa taaattttga aaagtgatat ttattaaatt
     5581 ttttgtatga aaacctggaa
//
