LOCUS       NM_001106998            6641 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus jade family PHD finger 2 (Jade2), mRNA.
ACCESSION   NM_001106998 XM_001073159 XM_220398
VERSION     NM_001106998.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6641)
  AUTHORS   Han,X., Gui,B., Xiong,C., Zhao,L., Liang,J., Sun,L., Yang,X.,
            Yu,W., Si,W., Yan,R., Yi,X., Zhang,D., Li,W., Li,L., Yang,J.,
            Wang,Y., Sun,Y.E., Zhang,D., Meng,A. and Shang,Y.
  TITLE     Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking
            system in neural development
  JOURNAL   Mol Cell 55 (3), 482-494 (2014)
   PUBMED   25018020
REFERENCE   2  (bases 1 to 6641)
  AUTHORS   Redshaw,N., Camps,C., Sharma,V., Motallebipour,M., Guzman-Ayala,M.,
            Oikonomopoulos,S., Thymiakou,E., Ragoussis,J. and Episkopou,V.
  TITLE     TGF-beta/Smad2/3 signaling directly regulates several miRNAs in
            mouse ES cells and early embryos
  JOURNAL   PLoS One 8 (1), e55186 (2013)
   PUBMED   23390484
REFERENCE   3  (bases 1 to 6641)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 6641)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 18, 2022 this sequence version replaced NM_001106998.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.42486.1,
                                           SRR26643284.13119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               JAXUCZ010000010.1  36623368-36623709   c
            343-400             JAXUCZ010000010.1  36615114-36615171   c
            401-495             JAXUCZ010000010.1  36612357-36612451   c
            496-653             JAXUCZ010000010.1  36600354-36600511   c
            654-814             JAXUCZ010000010.1  36595819-36595979   c
            815-1026            JAXUCZ010000010.1  36595006-36595217   c
            1027-1194           JAXUCZ010000010.1  36593100-36593267   c
            1195-1311           JAXUCZ010000010.1  36591278-36591394   c
            1312-1776           JAXUCZ010000010.1  36589664-36590128   c
            1777-1894           JAXUCZ010000010.1  36583888-36584005   c
            1895-2026           JAXUCZ010000010.1  36581461-36581592   c
            2027-6641           JAXUCZ010000010.1  36576187-36580801   c
FEATURES             Location/Qualifiers
     source          1..6641
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..6641
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /note="jade family PHD finger 2"
                     /db_xref="GeneID:303113"
                     /db_xref="RGD:1309152"
     exon            1..342
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..2832
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /EC_number="2.3.2.27"
                     /note="protein Jade-2; PHD finger protein 15"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Jade-2"
                     /protein_id="NP_001100468.1"
                     /db_xref="GeneID:303113"
                     /db_xref="RGD:1309152"
                     /translation="MEEKRRKYSISSDNSDTTDGHVTSTSASRCSKLPSSTKSGWPRQ
                     NEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPV
                     VRILPPLKGPPTLMSPESPTLGEGAHPDWPGGSRYDLDEIDAYWLELLNSELKEMEKP
                     ELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVF
                     CDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHV
                     SCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSTPSCLTAFH
                     VTCAFDRGLEMRTILADNDEVKFKSLCQEHSDGGPRSEPSSEPVEPSQAVEDLEKVTL
                     RKQRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDE
                     VDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHTICKLQEQIFHLQM
                     KLIEQDLCREPSGRRSKGKKNDSKRKGREGPKGSSPEKKEKMKAGPESVLGQLGLSTS
                     FPIDGTFFNSWLAQSVQITAEDMAMSEWSLNSGHREDPAPGLLSEELLQDEETLLSFM
                     RDPSLRPGDPARKARGRTRLPAKKKPPPLQDGPSARTTPEKPAKKAWAQDGKGTQGPP
                     ARKPPRRTSSHLPSSPAAGDCPVPATLESPPTLASEILDETVPAASDLNVQVPGPTVS
                     PKPLGRLRPPREMKVSRKSPGARSDAGTGLPSTVAERPKVSLHFDTEADGYFSDEEMS
                     DSDVEAENRGVQRASREAGAEEVVRMGVLAS"
     exon            343..400
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            401..495
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            496..653
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            654..814
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1026
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1194
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1311
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1776
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1894
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2026
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..6641
                     /gene="Jade2"
                     /gene_synonym="Phf15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaacatac acgggggttg gtgaatggtg ccgaccgcgg ccatcgcagt tggaggctat
       61 tttttggggg ggtgagtagc gtccatggag ttactttgcg cccactccta gtggcaccag
      121 ctctggactg gagggctgac catcttccca gcaggggtgc ggggcttggg ggacgctgcg
      181 gcccggtcgc ctccctcgcc acgaccccgg atggatgcgc gccccccgcc ctcccgcgcc
      241 ggccccagga gctcctggct tcaggagcat ccttcccgcg ccggcccccg ccgcggcgcg
      301 tagccgaggg cagcgcccct cgggagggca ccgcggagca agatggaaga gaagagacga
      361 aaatactcca tcagcagcga caactctgat accactgacg gtcacgtgac atccacatca
      421 gcatcaagat gttccaaact gcccagcagt accaagtcgg gctggccccg gcagaacgaa
      481 aagaagccct cagaggtttt ccggacagac ttgatcacag ccatgaagat cccagattcc
      541 taccagctca gcccggatga ctactacatc ctggcggacc catggcgaca agaatgggag
      601 aaaggtgtgc aggtacctgc tggagcggag gccattccag agcccgtggt gaggatcctc
      661 ccaccactaa aaggcccccc tacactgatg tccccagaga gccccacact tggtgagggt
      721 gcccatcctg actggccagg aggcagccgc tatgacctgg atgaaattga tgcatactgg
      781 ttggaacttc tcaactcgga gctcaaggag atggagaaac ccgagctgga cgaactgacg
      841 ttggagcgtg ttctggagga actagagacg ttgtgccacc agaatatggc acaggccatc
      901 gagacacagg aggggctggg catcgagtac gatgaggacg tggtctgtga tgtgtgccgc
      961 tcccctgaag gcgaggatgg gaacgagatg gtcttctgtg acaaatgcaa tgtctgtgtg
     1021 caccaggcat gctacgggat cctcaaggtg cctacgggca gctggctgtg ccggacctgt
     1081 gccctgggag tccagcctaa gtgcctgctc tgccccaagc gaggaggagc cttgaagccc
     1141 accagaagtg ggaccaagtg ggtacacgtc agctgtgccc tgtggattcc tgaggtcagc
     1201 attggctgtc cagagaagat ggagcccatt accaagatct cacatattcc cgccagccgc
     1261 tgggccctgt cctgcagcct ctgcaaggag tgcacgggaa cctgcatcca gtgttccacg
     1321 ccttcctgcc tcacagcatt ccacgttacc tgcgccttcg accgaggcct ggaaatgcgg
     1381 actatattag ccgacaatga cgaggtcaag ttcaagtcac tttgccagga gcacagtgat
     1441 gggggccctc gaagtgagcc tagttctgag cctgtggagc ccagccaggc cgttgaggat
     1501 ctggaaaagg tgaccctacg caagcagcgg ctgcagcagc tggaagaaaa cttctatgag
     1561 ctggtggagc cagctgaggt ggctgaacgg ctagacctgg ctgaggcact ggtggacttc
     1621 atctaccagt actggaagct gaagaggaga gctaatgcca accagccact gctgacgccc
     1681 aagactgacg aggtggacaa cctggcccag caggagcagg atgtccttta tcgacgcctg
     1741 aagcttttca cccacctgcg gcaggacctg gagagggtga ggaacctgtg ctacatggtg
     1801 acaaggcggg agagaacgaa gcacaccatc tgtaagcttc aggagcagat attccatctg
     1861 cagatgaaac tcattgagca agatctttgc agagagcctt ctgggaggag atcaaagggc
     1921 aagaagaatg actcaaaaag gaaaggccga gagggtccca agggcagcag ccctgagaag
     1981 aaagaaaaaa tgaaggctgg gccggagtct gtgctggggc agctgggtct gtccacctcg
     2041 ttccccatcg atggcacttt cttcaacagc tggttggcac agtctgttca gatcacagcc
     2101 gaggacatgg ccatgagcga gtggtctttg aacagtgggc accgggagga tcctgctccg
     2161 ggtctgctgt cagaggaatt gctacaagat gaggaaacac tgctcagctt catgagggac
     2221 ccctcgctac gacccggcga ccctgccagg aaggcccgag gccgcactcg cctgcctgcc
     2281 aagaagaaac cacccccgct gcaggatggg cccagtgcac ggaccactcc agaaaagcca
     2341 gccaagaagg cctgggccca ggacggcaag ggcacgcaag gaccacccgc gaggaagcca
     2401 ccacggagga cgtcttctca tttgccgtcc agccctgcag ctggggactg tcctgtccca
     2461 gcaacactgg aaagtcctcc aacactggcc tccgagatcc tggacgagac agtccccgcg
     2521 gcttccgact tgaatgtcca agtgcctggc cctacagtga gccccaaacc cttgggcagg
     2581 ctccggccac cccgagagat gaaggtcagt cggaaatctc cgggtgctag gtctgatgct
     2641 gggacaggac tgccgtctac ggtggccgag aggccaaagg tcagcctgca tttcgacacc
     2701 gaggctgacg gctacttctc tgatgaggag atgagcgatt ctgatgtaga ggcagagaac
     2761 aggggggtac aacgggcttc cagggaggca ggagcagagg aggtggttcg catgggggtg
     2821 ctggcctcct aactcaccca ggccctactc tggtccccta caaggcctca gcccaaccac
     2881 aactgccatt tccaactgct gagtgtctca gacccaccac tctgtcgtgg ttttattttt
     2941 aatatagaga gagttctgaa ttccactccg ttgtctttcc tctgtgctgg cctaggacat
     3001 tagggttcct cccgtggccc tggctacagg gactagacca ggttctacgt gccacccctg
     3061 tcccagccca tgcaacatcg ccgggcttct ggcttgatgt agacgaggtg agggagagag
     3121 ctcagggctc ctgcccactg ccattgggtg acacagactg tcgtttgggc attattttgt
     3181 ggcagatggg ccatctcggg gcccgccccg cctcgtctcc ccaagattgc attggggtcc
     3241 attttgggtg ggtgggtggg ggtgtcctgc tgcactccac tgatccctaa ggaagtataa
     3301 caaatgatac ccagccagtc tattcactgt cacaagcaca acgagtttct atgagaaagc
     3361 actgaggggg tgcagggggc ccgctggctc ctgaatagct cacaacatct gaggcccgcc
     3421 cacctgcccg aaacccccct cccttgctgc tctgtccctg ccagtgtcca gcgtaagcag
     3481 ctctgggaaa ggttcccaga aacctttctg agctgtgttc tttactcagg ggactcccca
     3541 aacggtcctc cccctgtaca ggtggagggc tccaagggag ggccagtgcc cagcccggga
     3601 cttggggctc agatcagccc actgcagaga atcactctgg ggctttaact tcctttcttc
     3661 ctttggggcc agtcttggcc acagtcttgc tgtctccata tagagccggc cagaccagac
     3721 cgtttgcctt ttgaagtttc ctgatcctgc taagagatga gcttcctcaa tggtttcctt
     3781 ctggaaacat ccttccaaca agtgtagtgg gatcccgggg cccagggcag gccactgttg
     3841 gcctgctggg gctggttgaa ttgttgctgg atcttcctgt attcccttgt cccttaacgc
     3901 cttaaccccc ctttccctcc ctactgtacc cccctcttcc ttctcctctt caaatccccc
     3961 cttcctccaa gcccccaggt agttctgaag agttttgatg gagtggcccc agggtgatag
     4021 atagctcagg gaacaaagga attccgtgaa aacatttttt tttttctttt atgaattact
     4081 cttgggtcac ttccgccact ggtaaagcca gaacttctcc aaacagaacc ttgcaaaagt
     4141 ccagtgaacc agtcgaatca ttctgagaat gccaaagaat cttttgacca ttaatacaca
     4201 gcacagcccg gacctgaaac tgtcgacttg aactcccttc tcaaaggaat tggttagcaa
     4261 cgaagttcag atacttggtt acggcgtaca cacctacaga gaaacacacc tacagagaag
     4321 agcccaaggc ctcggaggag ctgcactgct gttgctgctg ctagcgccgc cgccgccgct
     4381 gctgctgttg ttggtttacg gtccctgggc tgagccgctg tgagtgtggt cctaaacttt
     4441 gaggactccc tcccccttct gagggggtgg gagaatcctg actgtgaatc cagcgtggtt
     4501 cccccatcgc caccacatag atacgcaaag agcaaataca cgggaccttc acccacctcg
     4561 actccaaaat tatcaaggta cgacagtgag ttttgagcaa aatcagaaac caagacaatg
     4621 acttcagttt ggggattgga caaacatgtc ttatccaaat ggactctgag ggcgtggggt
     4681 gggtgggctc caaggatcct gggcatccgg atggcatcag ctaccacata gacttagtct
     4741 gccttcccgt cttggtagta ttgactgctc agtgtcggcg tcggtgtccc cacctgtctc
     4801 ttgtttactg ccttcgaaca gaccttcctt acccttgtgc tttgggtcac ttcgggtctc
     4861 aatctcatct gctggactgc ctggtggtct gacctgcggg acacgaaggg catgggggct
     4921 taaagaacca ccaaatgctg cagggcaagg aaggggatgt cctgaccgct ctgtcccacc
     4981 aggctctgtg ccacagaagc ccagttgtct gtgataatgg ctggttagca gaccccttca
     5041 ctaggccaag ccctaaggca gtcttcatcc ggcagctctc cacctgtgaa atgtccatca
     5101 ggccacgggg aggatgagga tgtcccacag cccctcttta gttcctccca ggcctcactg
     5161 tctacggtgt agatggcttt gccacaaata cgaccaaggc acttttttcc aggccagagg
     5221 caatgcccac tcttgccctc atccactacc cctccttagg gagggagaaa ggactctgtg
     5281 actcgttctg gctaatgtac cccttccacc tcatttcctc atcacaggct aatgtgcaag
     5341 gaaagtattt ttctgtatca taagtgtatt ttgaaacaag taaagaaaag aaagatagaa
     5401 tgctcgttta ctttattaaa tgggctctga ctttgcgaat ggcatgagag tgagtctttg
     5461 caatgtaagg gcctcaggtt tgttggagaa gccagccacc caggttcctg ggcagaggta
     5521 ttggagagag ggagagtgag tgagtgagtg agtgtgtgtg tgtgtgtgtg catatgtgtg
     5581 tgtgtacata atgtgtatgt gtgtgtgcat gtgtgtgtgc atgtgtgtgc gtgcgtgcat
     5641 gaatatgcat gtgcgtgcgt gcatgaatat gcatgtgcgc atgcatatgt gtgtgcgcgc
     5701 gtgcgcgtgt gtgtgcatat gtgtgtgcat gcgcgcgcgc gtgtgtgtgt gtgtgtgtgt
     5761 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtcagagtgc tgtgcagatg tatgtgcagt
     5821 gcatggatac cctatgggac ttgctgggtt ttttggagac tcaactgcct gattctacag
     5881 gaacattggc agcaggttag actttgggtt tcctcaccat tgccacataa ggtcaacctg
     5941 tgcccatgcc tgaagctctg cgtaacaata tgtgatctct gtagtaaggt ccttgaggag
     6001 gctactctcc cgtgcccttg gcccagctgg ccacattggc cgaggagcca gaggtgttgg
     6061 agtcggggga cctttggtcg ttctttaagc cacttcctgc cgccttctct caaggatgca
     6121 cgcttgtgct ccatccaaat cgattggggg tggcggtggg gagggtccta tgaatgtcac
     6181 aggaggagat accttctgtc tttgtttcaa agaaagtgat gtgccatttg ttaatataca
     6241 agagaaatat tgaaaatata ttgaaaagag caattttaaa ttatttttgg cttatgttgc
     6301 aatatttatt ttcttgtatt agagaagatt tctttgtaga gaaaaaaatg tatttttcat
     6361 taccgcaaag acctatttct cctttttgta cattgtcctc gttcgcgacc cttaacgagc
     6421 aatagaatgt tcggtcaccc cgcgtggcca gtgcccactg tgccctgcat gactgtgttg
     6481 ttgctgctgc tgctgctgca tagtttccgg ccctgtcctg tcctgctcac tcacaagggc
     6541 atctggatcg cagcccccac cagggtctgt gtctaaggag cccacagcac tcctcgtgtg
     6601 ttggcaaatt cagttaataa agcaatgttt tctgtgctgg c
//
