LOCUS       NM_001398801            1120 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus IZUMO1 receptor, JUNO (Izumo1r), mRNA.
ACCESSION   NM_001398801 XM_017595964
VERSION     NM_001398801.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1120)
  AUTHORS   Lai,X., Liu,R., Li,M., Fan,Y., Li,H., Han,G., Guo,R., Ma,H., Su,H.
            and Xing,W.
  TITLE     Participation of WD repeat-containing protein 54 (WDR54) in rat
            sperm-oocyte fusion through interaction with both IZUMO1 and JUNO
  JOURNAL   Theriogenology 214, 286-297 (2024)
   PUBMED   37951137
  REMARK    GeneRIF: Participation of WD repeat-containing protein 54 (WDR54)
            in rat sperm-oocyte fusion through interaction with both IZUMO1 and
            JUNO.
REFERENCE   2  (bases 1 to 1120)
  AUTHORS   Kato,K., Satouh,Y., Nishimasu,H., Kurabayashi,A., Morita,J.,
            Fujihara,Y., Oji,A., Ishitani,R., Ikawa,M. and Nureki,O.
  TITLE     Structural and functional insights into IZUMO1 recognition by JUNO
            in mammalian fertilization
  JOURNAL   Nat Commun 7, 12198 (2016)
   PUBMED   27416963
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1120)
  AUTHORS   Bianchi,E., Doe,B., Goulding,D. and Wright,G.J.
  TITLE     Juno is the egg Izumo receptor and is essential for mammalian
            fertilization
  JOURNAL   Nature 508 (7497), 483-487 (2014)
   PUBMED   24739963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 23, 2021 this sequence version replaced XM_017595964.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2275001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418971, SAMN16418986
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000008.1  20029524-20029578   c
            56-196              JAXUCZ010000008.1  20028168-20028308   c
            197-385             JAXUCZ010000008.1  20027424-20027612   c
            386-524             JAXUCZ010000008.1  20026536-20026674   c
            525-1120            JAXUCZ010000008.1  20025831-20026426   c
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..1120
                     /gene="Izumo1r"
                     /gene_synonym="Folr4; JUNO"
                     /note="IZUMO1 receptor, JUNO"
                     /db_xref="GeneID:690037"
                     /db_xref="RGD:1585174"
     exon            1..55
                     /gene="Izumo1r"
                     /gene_synonym="Folr4; JUNO"
                     /inference="alignment:Splign:2.1.0"
     exon            56..196
                     /gene="Izumo1r"
                     /gene_synonym="Folr4; JUNO"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..793
                     /gene="Izumo1r"
                     /gene_synonym="Folr4; JUNO"
                     /note="probable folate receptor delta; folate receptor 4
                     (delta); sperm-egg fusion protein Juno; FR-delta; IZUMO1
                     receptor protein JUNO"
                     /codon_start=1
                     /product="sperm-egg fusion protein Juno precursor"
                     /protein_id="NP_001385730.1"
                     /db_xref="GeneID:690037"
                     /db_xref="RGD:1585174"
                     /translation="MAQWWLILLGLWTVLPSLAGGKLLNVCMNSKHHKQEPGPEDKLY
                     FECMPWKDNACCTRDTSWEAHLDEPLLFNFSMTHCGLLTPLCHKHFIQAICFYECSPN
                     LGPWIQPVVPNRQEEQRLWDVPLCLEDCEEWWKDCRTSHTCKADWLHGWVWDQGKNGC
                     PAHAPCLPFSDYFPTPADLCEKIWNNTFKASPERRNSGRCLQKWFEPTHGNPNVEVAL
                     HFAGSASAPQLSYSITAFSLCLLLHA"
     exon            197..385
                     /gene="Izumo1r"
                     /gene_synonym="Folr4; JUNO"
                     /inference="alignment:Splign:2.1.0"
     exon            386..524
                     /gene="Izumo1r"
                     /gene_synonym="Folr4; JUNO"
                     /inference="alignment:Splign:2.1.0"
     exon            525..1120
                     /gene="Izumo1r"
                     /gene_synonym="Folr4; JUNO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctgctca cctctctggg cccaggaaga gcaaccagag ggccctgcct tgagggtcat
       61 ggcacaatgg tggctgatcc tcctgggctt gtggacagtc ctgcccagct tggccggggg
      121 caagctgctc aatgtctgca tgaattccaa gcaccacaag caagagcctg gcccagaaga
      181 caagctctac tttgagtgca tgccctggaa ggacaatgcc tgctgcacac gcgacacaag
      241 ctgggaagcc caccttgatg agcccttgct ctttaacttc agcatgacgc actgtggact
      301 gctgaccccg ctctgccata agcacttcat ccaggccatc tgcttctatg agtgttcccc
      361 caacctgggg ccttggatcc agccggtggt gccaaacagg caggaagagc agcggctttg
      421 ggacgtgcca ctgtgcctgg aggattgtga ggaatggtgg aaagactgcc gcacatctca
      481 cacttgtaaa gccgactggc tccacggctg ggtctgggat caggggaaga acgggtgccc
      541 agcacacgca ccctgtctcc cgttctcgga ttacttcccc acccccgcgg acctgtgtga
      601 gaagatctgg aacaacacct tcaaggccag tcctgagcgc aggaatagtg ggcggtgtct
      661 gcagaagtgg tttgagccca cccacggcaa ccctaacgtt gaagtggccc tccacttcgc
      721 gggctctgcc tcagccccgc agctctctta ctccatcaca gccttctctc tgtgcctgtt
      781 gctccatgcc tgagccccat tccctcgcct acccacactt cctgatcctc tgggccatgg
      841 ccatctcttc cctcaggcta ttcatgttgg ggacaggctg gtgtctgact ttcccaagct
      901 gcccagcgtc ccctccactg cttggctcca tctccactgg tctggatggc agctggtacc
      961 cagcagacta cggtgcctca tttctcctgc ctttaggaac gggcactact acaggactcc
     1021 ggcacttctg ttcacagcca tctcttttgt gacatattca atgttgacag ccagtggacc
     1081 tgtcctatca tggtaccttc aataaatggc caggaaactc
//
