LOCUS       NM_001025000            1434 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus iodotyrosine deiodinase (Iyd), mRNA.
ACCESSION   NM_001025000 XM_217829
VERSION     NM_001025000.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Sun,X., Zhang,X., Jiang,Y., Bao,S., Shan,Z. and Teng,W.
  TITLE     Expression of Iodotyrosine Deiodinase in Thyroid and Other Organs
            in Iodine-Deficient and Iodine-Excess Rats
  JOURNAL   Biol Trace Elem Res 167 (2), 272-279 (2015)
   PUBMED   25850545
  REMARK    GeneRIF: iodine deficiency results in an increased expression of
            IYD in thyroid, whereas excess iodine decreases the expression of
            thyroidal IYD.
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Hu,J., Chuenchor,W. and Rokita,S.E.
  TITLE     A switch between one- and two-electron chemistry of the human
            flavoprotein iodotyrosine deiodinase is controlled by substrate
  JOURNAL   J Biol Chem 290 (1), 590-600 (2015)
   PUBMED   25395621
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Friedman,J.E., Watson,J.A. Jr., Lam,D.W. and Rokita,S.E.
  TITLE     Iodotyrosine deiodinase is the first mammalian member of the NADH
            oxidase/flavin reductase superfamily
  JOURNAL   J Biol Chem 281 (5), 2812-2819 (2006)
   PUBMED   16316988
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Gnidehou,S., Caillou,B., Talbot,M., Ohayon,R., Kaniewski,J.,
            Noel-Hudson,M.S., Morand,S., Agnangji,D., Sezan,A., Courtin,F.,
            Virion,A. and Dupuy,C.
  TITLE     Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein
            involved in the recycling of iodide close to the thyroglobulin
            iodination site
  JOURNAL   FASEB J 18 (13), 1574-1576 (2004)
   PUBMED   15289438
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091241.1.
            
            On Jun 25, 2005 this sequence version replaced XM_217829.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091241.1, CO561896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..1434
                     /gene="Iyd"
                     /gene_synonym="RGD1309288"
                     /note="iodotyrosine deiodinase"
                     /db_xref="GeneID:308129"
                     /db_xref="RGD:1309288"
     exon            1..175
                     /gene="Iyd"
                     /gene_synonym="RGD1309288"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..867
                     /gene="Iyd"
                     /gene_synonym="RGD1309288"
                     /EC_number="1.21.1.1"
                     /note="iodotyrosine dehalogenase 1; IYD-1"
                     /codon_start=1
                     /product="iodotyrosine deiodinase 1"
                     /protein_id="NP_001020171.1"
                     /db_xref="GeneID:308129"
                     /db_xref="RGD:1309288"
                     /translation="MFLLTPVLVAVVCILVIWVFKNADRSLEEKKEEARAQPWVDEDL
                     KDNTEHLQVEEDTEEWQESEESVEHILFSHTRYPEQEMRMRSQEFYELLSKRRSIRFI
                     SSEPVPMEVIDNVIKAAGTAPSGAHTEPWTFVVVKDPDMKHKIREIIEEEEEINYMKR
                     MGKRWVTDLKKLRTNWIKEYLDTAPVLILIFKQVHGFAVNGKKKVHYYNEISVSIACG
                     ILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPSHEKLLVLLPVGYPSRGATVPDLKRK
                     TLDQIMVTV"
     exon            176..367
                     /gene="Iyd"
                     /gene_synonym="RGD1309288"
                     /inference="alignment:Splign:2.1.0"
     exon            368..527
                     /gene="Iyd"
                     /gene_synonym="RGD1309288"
                     /inference="alignment:Splign:2.1.0"
     exon            528..684
                     /gene="Iyd"
                     /gene_synonym="RGD1309288"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1380
                     /gene="Iyd"
                     /gene_synonym="RGD1309288"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcagacca tgtttctcct cactccagtc ttggtagcag ttgtctgtat cttggtcata
       61 tgggtcttta aaaatgctga caggagtctg gaggaaaaga aggaggaggc tcgagctcag
      121 ccctgggtgg atgaagactt gaaagacaac acggaacacc ttcaagtgga agaagatact
      181 gaggaatggc aagagtcgga ggagagtgtg gaacacatcc tattctccca cacccgatac
      241 ccagagcagg aaatgaggat gagatcccag gaattctatg agctcctcag taagagacgc
      301 tccatcagat ttatcagcag cgagccagtc ccgatggaag tgattgacaa tgtcatcaaa
      361 gcagcaggaa cagctccaag tggagcccat acagagccct ggacgtttgt ggtggtaaag
      421 gacccagaca tgaagcataa gatccgagag attatcgagg aggaggaaga aatcaattac
      481 atgaaaagga tgggaaagcg atgggtcaca gatctgaaga aactgagaac caactggatt
      541 aaggagtact tggacactgc ccctgttctg atcctcattt tcaaacaagt ccatggtttt
      601 gcggtaaatg ggaagaaaaa ggtccactac tacaacgaga tcagtgtgtc cattgcctgt
      661 ggcattctgc tggctgcact gcagaatgca gggctggtga cggtcactac cactcccctc
      721 aactgtggtc ctcgtctgag ggtgctcctg ggccgcccct cacatgagaa gctgctagtg
      781 ctccttcctg tggggtaccc tagcagaggt gccacagtgc ctgacctcaa gcggaaaact
      841 ctggaccaga tcatggtgac agtatagaca gacagcccaa cgagatgctg ggatgctggg
      901 atgacacctg cttccttctt ctcgggtctg ctggctcctc ttgctctctg agtcaggtct
      961 tctgcaaacc agtgtacagg gaagaccaat ttccatgtag caatgttttc acactttcta
     1021 gaactttcag tcaagtaagt agtttttgat ggactgttct agttatgtat ggggcaaggg
     1081 accaaaaaag caggcatact ttaacttctc tagaaaagta taaatgattt ttttcattta
     1141 cttataaaag ttatatagag aaggcacatg agaatatgtg ctctagttcc aagagttacc
     1201 tacgcaataa tttttcattt aaatattaac taatcaagtg ttctttctgc tctctgcttt
     1261 ctggtgtcat tgagactgag aatgtactat tgagacctat tctgtcactg attctcatag
     1321 ggagtctgcc aatcttgaat gaataacctt taaagtaaat aaaatatgac actcacagaa
     1381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
