LOCUS       NM_022195               2712 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus involucrin (Ivl), mRNA.
ACCESSION   NM_022195 XM_017591066
VERSION     NM_022195.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Niderla-Bielinska,J. and Moskalewski,S.
  TITLE     Involucrin, but not filaggrin and Kdap mRNA, expression is
            downregulated in 3-D cultures of intact rat hair bulbs after
            calcium stimulation
  JOURNAL   Folia Histochem Cytobiol 49 (2), 335-343 (2011)
   PUBMED   21744336
  REMARK    GeneRIF: The level of mRNA for differentiation markers: involucrin,
            filaggrin, keratinocyte differentiation associated protein and
            trichohyalin, was studied by RealTime PCR.
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Niderla-Bielinska,J., Jankowska-Steifer,E. and Moskalewski,S.
  TITLE     Keratinization of outer root sheath cells is prevented by contact
            with inner root sheath of rat hair follicles
  JOURNAL   Arch Dermatol Res 301 (5), 337-345 (2009)
   PUBMED   18648826
  REMARK    GeneRIF: expression in outer root sheath cells of hair follicles is
            upregulated by Epidermal Growth Factor
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 2712)
  AUTHORS   Tong,L., Corrales,R.M., Chen,Z., Villarreal,A.L., De Paiva,C.S.,
            Beuerman,R., Li,D.Q. and Pflugfelder,S.C.
  TITLE     Expression and regulation of cornified envelope proteins in human
            corneal epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 47 (5), 1938-1946 (2006)
   PUBMED   16639001
REFERENCE   5  (bases 1 to 2712)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
REFERENCE   6  (bases 1 to 2712)
  AUTHORS   Lee,C.H., Marekov,L.N., Kim,S., Brahim,J.S., Park,M.H. and
            Steinert,P.M.
  TITLE     Small proline-rich protein 1 is the major component of the cell
            envelope of normal human oral keratinocytes
  JOURNAL   FEBS Lett 477 (3), 268-272 (2000)
   PUBMED   10908733
REFERENCE   7  (bases 1 to 2712)
  AUTHORS   Djian,P., Phillips,M., Easley,K., Huang,E., Simon,M., Rice,R.H. and
            Green,H.
  TITLE     The involucrin genes of the mouse and the rat: study of their
            shared repeats
  JOURNAL   Mol Biol Evol 10 (6), 1136-1149 (1993)
   PUBMED   8277848
REFERENCE   8  (bases 1 to 2712)
  AUTHORS   Rice,R.H. and Green,H.
  TITLE     Presence in human epidermal cells of a soluble protein precursor of
            the cross-linked envelope: activation of the cross-linking by
            calcium ions
  JOURNAL   Cell 18 (3), 681-694 (1979)
   PUBMED   42494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Dec 3, 2020 this sequence version replaced
            XM_017591066.1, NM_022195.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.10809.1,
                                           SRR26643295.9922.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JAXUCZ010000002.1  180846297-180846578 c
            283-2712            JAXUCZ010000002.1  180842307-180844736 c
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2712
                     /gene="Ivl"
                     /note="involucrin"
                     /db_xref="GeneID:60583"
                     /db_xref="RGD:620141"
     exon            1..282
                     /gene="Ivl"
                     /inference="alignment:Splign:2.1.0"
     exon            283..2712
                     /gene="Ivl"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..2345
                     /gene="Ivl"
                     /codon_start=1
                     /product="involucrin"
                     /protein_id="NP_071531.2"
                     /db_xref="GeneID:60583"
                     /db_xref="RGD:620141"
                     /translation="MSHQHTVPVTVPAVVQESLKTVCSPAQTQQEQTKQPTPYPAQCQ
                     VFTDTQEKGFPKHEEKEANPVKDLPEQESEHHQQPGPQKQQLQVKKPEQELQEQELHS
                     EKQQTPQEPQGLLCLGQQQQREPQEQEQHLRQHQQPQQESQGQGLCLGQQQDVLAPQE
                     LHMGQHQKEKLQEPELPLGQQQKTPEEQELILGEKQQKLHLVERHQEPQEQELHLGQK
                     QKQQQPQEQELQLVQHQKQKQHEPELCLRKQQQQESHERELHLGKQQHQESHEPELHL
                     GKQQHQESHEPELHLGKQQHQESCEPELHLGEQQHQEQQQHQESCEPELHLGKQQHQE
                     TQESELQLGKQQKPHEPDMVLDPKEKHKLHDPELHLGKQQHQESHERELHLGKQQHQE
                     SHEPELHLGKQQHQESCEPELHLGEQQHQEQQQHQESCEPELHLGKQQHQETQESELQ
                     LGKQQKPHEPDMVLDPKEKQKLHDPELHLGKQQHQESQESELQVEKKQHEKSPEPELH
                     LGKQQELHEPDMTEDQKEKQSLHEPELHLGKQQESHEPDMTEDQKEKQSLYESELHLG
                     KQQEQQIEYEGYQRSKSLNQLLKQEKASRGQELDDSHLEQEKELLDQRLDQELVNKDE
                     QLERKKHKLENLTQKEKQIKQLVPSTDRVQETQPIQPVKEDSLTTKKQQHSHEVQ"
ORIGIN      
        1 tgcccaggtc agatgatctc agctaggaga gttgagccct cacactccca catggtccaa
       61 tagaagctag aaaagggagc cctgcgggtg taggggtttg ctgcgtaagt tatccaatga
      121 ctcagaaagg agctggagga agttgaccaa ctggagtggt gaaaccagtc caccaccccc
      181 aacctgagaa ggacagtagg caggaacaat ataaagggcc ctagttgctg ctcagatcaa
      241 gattctgctg gaagcgtttg ccttctccct tccgtgagtt tgtttggtct aaggaagctt
      301 ccaagatgtc ccatcaacac acagtgccag tgactgttcc agctgtggtt caggaatctc
      361 tcaagactgt atgttctcca gctcaaactc agcaggaaca aacaaagcaa ccaactccat
      421 atcctgcaca atgccaggtc ttcactgaca ctcaagagaa gggctttccc aaacatgagg
      481 agaaggaggc aaaccccgtg aaagatctgc ctgagcaaga gagtgagcac caccagcagc
      541 caggaccaca gaagcagcag ctgcaggtga aaaagccaga gcaggagctg caggaacagg
      601 aactgcattc ggagaagcag cagacaccac aggagccaca ggggctcctg tgcctgggac
      661 agcaacagca gcgagagcca caagagcaag aacagcacct tagacagcac cagcagccac
      721 agcaagagtc acaggggcag gggctgtgct tggggcagca gcaagatgtg ctggcaccac
      781 aggagctgca tatgggacag caccagaagg agaagctgca ggagccagaa ctgcctctgg
      841 gtcagcagca gaaaactcca gaggaacagg aactgattct aggagaaaag cagcagaagc
      901 tgcacctggt agagaggcac caagagccac aggagcagga gctgcacctc ggacagaaac
      961 agaagcaaca gcaaccacaa gaacaggagt tgcagttggt acagcaccag aagcagaagc
     1021 agcatgaacc agaattgtgc ctgaggaagc agcagcagca ggagtcacat gagcgagaac
     1081 tgcacctggg aaagcagcag catcaggagt cacatgagcc agaactgcac ctgggaaagc
     1141 agcagcatca ggagtcacat gagccagaac tgcacctggg aaagcagcag catcaggagt
     1201 catgtgagcc agaactgcac ctaggggaac agcagcatca ggagcagcag cagcatcagg
     1261 agtcatgtga gccagaactg cacctaggga aacagcagca tcaagagact caggagtcag
     1321 aactgcaact gggaaagcag cagaaaccac atgagccaga tatggtactg gatccgaaag
     1381 agaagcacaa acttcatgac ccagaactgc acctgggaaa gcagcagcat caggagtcac
     1441 atgagcgaga actgcacctg ggaaagcagc agcatcagga gtcacatgag ccagaactgc
     1501 acctgggaaa gcagcagcat caggagtcat gtgagccaga actgcaccta ggggaacagc
     1561 agcatcagga gcagcagcag catcaggagt catgtgagcc agaactgcac ctagggaaac
     1621 agcagcatca agagactcag gagtcagaac tgcaactggg aaagcagcag aaaccacatg
     1681 agccagatat ggtactggat ccgaaagaga agcagaaact tcatgaccca gaactgcacc
     1741 tgggaaagca gcagcaccag gagtctcagg agtcagaact gcaagtggaa aagaaacagc
     1801 atgagaagtc cccagagcca gaactgcacc tgggaaagca gcaggagtta catgagcctg
     1861 atatgacaga ggatcagaaa gagaagcaga gtcttcatga accagaactg cacctgggaa
     1921 agcagcagga gtcacatgag cctgatatga cagaggatca gaaagagaag cagagtcttt
     1981 atgaatcaga actgcacctg ggaaagcagc aggaacaaca gatagagtat gaaggctacc
     2041 aaagatcaaa aagtctgaat cagttactta agcaagagaa agcttccagg ggacaggagc
     2101 tggatgactc acatctagaa caggagaagg agctcttgga ccagcgattg gatcaagaac
     2161 tagtaaataa ggatgagcaa ctggaaagaa agaagcacaa attggagaac ctgacacaga
     2221 aggagaagca gataaagcaa ttagtaccaa gcactgacag agtccaagag actcagccaa
     2281 tccaaccagt gaaagaagac tctctcacta caaagaagca gcagcacagc catgaagtgc
     2341 agtgaagtaa aactaaagta accaccccag tgtcccagag actctccaac catcccacat
     2401 atgggaagag aatcacccac acttccttaa ggaccctggc tggcctactc atccatgaat
     2461 ctgtctgacc ctgaatatct tcttatctgt gacaggctgg gcacaggatc caggcccagg
     2521 atacaggatt atggcccagt atccactcca agaagctcaa tcccaacctt aggtatcaga
     2581 gcctcttcct gaggtagggg ctgggggaaa gggggaggcc tgtcattagt tagcaactct
     2641 gatgtcattc ctagtgttgc cacagaatct gtgaataagc acaatgtcta ataaatcata
     2701 aaagtcctgt ga
//
