LOCUS       NM_031046              10704 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus inositol 1,4,5-trisphosphate receptor, type 2
            (Itpr2), mRNA.
ACCESSION   NM_031046
VERSION     NM_031046.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10704)
  AUTHORS   Xiao,Q., Tang,Y., Luo,H., Chen,S., Tang,Q., Chen,R., Xiong,L.,
            Xiao,J., Hong,D., Wang,L., Li,G. and Li,Y.
  TITLE     Inositol 1,4,5-trisphosphate receptor type 2 is associated with the
            bone-vessel axis in chronic kidney disease-mineral bone disorder
  JOURNAL   Ren Fail 45 (1), 2162419 (2023)
   PUBMED   36645057
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate receptor type 2 is associated
            with the bone-vessel axis in chronic kidney disease-mineral bone
            disorder.
REFERENCE   2  (bases 1 to 10704)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   3  (bases 1 to 10704)
  AUTHORS   Kruglov,E., Ananthanarayanan,M., Sousa,P., Weerachayaphorn,J.,
            Guerra,M.T. and Nathanson,M.H.
  TITLE     Type 2 inositol trisphosphate receptor gene expression in
            hepatocytes is regulated by cyclic AMP
  JOURNAL   Biochem Biophys Res Commun 486 (3), 659-664 (2017)
   PUBMED   28327356
  REMARK    GeneRIF: The findings provide evidence that IP3R2 expression is
            transcriptionally regulated by cyclic AMP via CREB binding to CRE
            elements in its promoter.
REFERENCE   4  (bases 1 to 10704)
  AUTHORS   Sankar,N., deTombe,P.P. and Mignery,G.A.
  TITLE     Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate
            receptor (InsP3R2) expression during cardiac remodeling
  JOURNAL   J Biol Chem 289 (9), 6188-6198 (2014)
   PUBMED   24415751
  REMARK    GeneRIF: ITPR2 and hypertrophy specific gene expression is
            regulated, in part, by a positive feedback regulation between
            InsP3R2 and calcineurin-NFATc signaling pathways.
REFERENCE   5  (bases 1 to 10704)
  AUTHORS   Schulman,J.J., Wright,F.A., Kaufmann,T. and Wojcikiewicz,R.J.H.
  TITLE     The Bcl-2 protein family member Bok binds to the coupling domain of
            inositol 1,4,5-trisphosphate receptors and protects them from
            proteolytic cleavage
  JOURNAL   J Biol Chem 288 (35), 25340-25349 (2013)
   PUBMED   23884412
REFERENCE   6  (bases 1 to 10704)
  AUTHORS   Adkins,C.E., Morris,S.A., De Smedt,H., Sienaert,I., Torok,K. and
            Taylor,C.W.
  TITLE     Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3
            inositol trisphosphate receptors
  JOURNAL   Biochem J 345 Pt 2 (Pt 2), 357-363 (2000)
   PUBMED   10620513
REFERENCE   7  (bases 1 to 10704)
  AUTHORS   Fissore,R.A., Longo,F.J., Anderson,E., Parys,J.B. and Ducibella,T.
  TITLE     Differential distribution of inositol trisphosphate receptor
            isoforms in mouse oocytes
  JOURNAL   Biol Reprod 60 (1), 49-57 (1999)
   PUBMED   9858485
REFERENCE   8  (bases 1 to 10704)
  AUTHORS   Lee,B., Bradford,P.G. and Laychock,S.G.
  TITLE     Characterization of inositol 1,4,5-trisphosphate receptor isoform
            mRNA expression and regulation in rat pancreatic islets, RINm5F
            cells and betaHC9 cells
  JOURNAL   J Mol Endocrinol 21 (1), 31-39 (1998)
   PUBMED   9723861
REFERENCE   9  (bases 1 to 10704)
  AUTHORS   De Smedt,H., Missiaen,L., Parys,J.B., Bootman,M.D., Mertens,L., Van
            Den Bosch,L. and Casteels,R.
  TITLE     Determination of relative amounts of inositol trisphosphate
            receptor mRNA isoforms by ratio polymerase chain reaction
  JOURNAL   J Biol Chem 269 (34), 21691-21698 (1994)
   PUBMED   8063813
REFERENCE   10 (bases 1 to 10704)
  AUTHORS   Sudhof,T.C., Newton,C.L., Archer,B.T. 3rd, Ushkaryov,Y.A. and
            Mignery,G.A.
  TITLE     Structure of a novel InsP3 receptor
  JOURNAL   EMBO J 10 (11), 3199-3206 (1991)
   PUBMED   1655411
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031046.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X61677.1, AF329470.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000004.1  181134530-181134867 c
            339-409             JAXUCZ010000004.1  181105956-181106026 c
            410-525             JAXUCZ010000004.1  181057883-181057998 c
            526-612             JAXUCZ010000004.1  181056954-181057040 c
            613-771             JAXUCZ010000004.1  181054106-181054264 c
            772-870             JAXUCZ010000004.1  181049746-181049844 c
            871-954             JAXUCZ010000004.1  181049276-181049359 c
            955-1101            JAXUCZ010000004.1  181048935-181049081 c
            1102-1197           JAXUCZ010000004.1  181046786-181046881 c
            1198-1242           JAXUCZ010000004.1  181036589-181036633 c
            1243-1394           JAXUCZ010000004.1  181031147-181031298 c
            1395-1494           JAXUCZ010000004.1  181025384-181025483 c
            1495-1655           JAXUCZ010000004.1  181024867-181025027 c
            1656-1797           JAXUCZ010000004.1  181019776-181019917 c
            1798-1959           JAXUCZ010000004.1  181016432-181016593 c
            1960-2132           JAXUCZ010000004.1  181009661-181009833 c
            2133-2252           JAXUCZ010000004.1  181008599-181008718 c
            2253-2438           JAXUCZ010000004.1  181008324-181008509 c
            2439-2690           JAXUCZ010000004.1  181006891-181007142 c
            2691-2835           JAXUCZ010000004.1  181005547-181005691 c
            2836-2986           JAXUCZ010000004.1  181003564-181003714 c
            2987-3180           JAXUCZ010000004.1  180998552-180998745 c
            3181-3310           JAXUCZ010000004.1  180993368-180993497 c
            3311-3368           JAXUCZ010000004.1  180989286-180989343 c
            3369-3534           JAXUCZ010000004.1  180986290-180986455 c
            3535-3708           JAXUCZ010000004.1  180984458-180984631 c
            3709-3798           JAXUCZ010000004.1  180967951-180968040 c
            3799-3924           JAXUCZ010000004.1  180967713-180967838 c
            3925-4047           JAXUCZ010000004.1  180966705-180966827 c
            4048-4248           JAXUCZ010000004.1  180965886-180966086 c
            4249-4500           JAXUCZ010000004.1  180962819-180963070 c
            4501-4626           JAXUCZ010000004.1  180961005-180961130 c
            4627-4755           JAXUCZ010000004.1  180948787-180948915 c
            4756-4876           JAXUCZ010000004.1  180946678-180946798 c
            4877-5067           JAXUCZ010000004.1  180930354-180930544 c
            5068-5210           JAXUCZ010000004.1  180927695-180927837 c
            5211-5319           JAXUCZ010000004.1  180924964-180925072 c
            5320-5428           JAXUCZ010000004.1  180891080-180891188 c
            5429-5616           JAXUCZ010000004.1  180890473-180890660 c
            5617-5800           JAXUCZ010000004.1  180886137-180886320 c
            5801-6057           JAXUCZ010000004.1  180884526-180884782 c
            6058-6258           JAXUCZ010000004.1  180881763-180881963 c
            6259-6369           JAXUCZ010000004.1  180879318-180879428 c
            6370-6465           JAXUCZ010000004.1  180876437-180876532 c
            6466-6588           JAXUCZ010000004.1  180873866-180873988 c
            6589-6696           JAXUCZ010000004.1  180845727-180845834 c
            6697-6889           JAXUCZ010000004.1  180841364-180841556 c
            6890-7015           JAXUCZ010000004.1  180838038-180838163 c
            7016-7191           JAXUCZ010000004.1  180830208-180830383 c
            7192-7356           JAXUCZ010000004.1  180823357-180823521 c
            7357-7552           JAXUCZ010000004.1  180822430-180822625 c
            7553-7645           JAXUCZ010000004.1  180819089-180819181 c
            7646-7776           JAXUCZ010000004.1  180811466-180811596 c
            7777-7942           JAXUCZ010000004.1  180809601-180809766 c
            7943-8103           JAXUCZ010000004.1  180795849-180796009 c
            8104-8265           JAXUCZ010000004.1  180763453-180763614 c
            8266-10704          JAXUCZ010000004.1  180760442-180762880 c
FEATURES             Location/Qualifiers
     source          1..10704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..10704
                     /gene="Itpr2"
                     /note="inositol 1,4,5-trisphosphate receptor, type 2"
                     /db_xref="GeneID:81678"
                     /db_xref="RGD:69649"
     exon            1..338
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..8352
                     /gene="Itpr2"
                     /note="inositol 1,4,5-triphosphate receptor, type 2;
                     insP3R2; type 2 InsP3 receptor; IP3 receptor; type 2
                     inositol 1,4,5-trisphosphate receptor; IP3R 2; inositol
                     1,4,5-triphosphate receptor 2; inositol triphosphate
                     receptor type 2"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR2"
                     /protein_id="NP_112308.2"
                     /db_xref="GeneID:81678"
                     /db_xref="RGD:69649"
                     /translation="MSDKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAG
                     DLTNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQ
                     NESENRKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSW
                     FYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNVELLDNPGCKEVNAVNCNTSW
                     KITLFMKFSSYREDVLKGGDVVRLFHAEQEKFLTCDDYEKKQHIFLRTTLRQSATSAT
                     SSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKTVRD
                     GELPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHL
                     CTNTWVTSTSIPIDTEEERPVMLKIGTCQTKEDKEAFAIVCVPLSEVRDLDFANDANK
                     VLATTVKKLENGSITQNERRFVTKLLEDLIFFVADVTNNGQDVLDVVITKPNRERQKL
                     MREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYVLRLCYRVLRHSQQD
                     YRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRR
                     NREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPGNADILIQTKLVSMQVENPMESS
                     ILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGTKADLEVLTYYRYQLNLFARM
                     CLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPV
                     RYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKE
                     KNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGS
                     NNVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPSVHPSKQASPGEQEDVTVMDTKLK
                     VIEILQFILSVRLDYRISYMLSIYKKEFGENDGNGDPSASGTPETLLPSALVPDIDEI
                     AAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLLFKHFSQRA
                     EVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSSYENGDMGEGQA
                     KGGEEANEESNLLSPVQDGAKTPQIDSNKGNNYRIVKEILIRLSKLCVQNKKCRNQHQ
                     RLLKNMGAHSVVLDLLQIPYEKTDEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHLNL
                     FLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD
                     GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMCSERARGDESGPLAYHITL
                     VELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEV
                     EMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSP
                     FSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRALAEVAKNRGIAIP
                     VDLDSQVNTLFMKNHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVV
                     ASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEE
                     KLCIKILQTLREMLEKKDSFMEEGSTLRKILLNRYFKGDHSVGVNGPLSGAYAKTAQV
                     GGGFTGQDADKTGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEG
                     GNTQTQNSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSD
                     LMALGPRMRVRDSSLHLKEGMKGQLTEASSATSKAYCVYRREMDPDIDTMCPGQEAGS
                     AEEKSAEEVTMSPAITIMRPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQF
                     LDCICGSTTGGLGLLGLYINEKNVALVNQTLESLTEYCQGPCHENQTCIATHESNGID
                     IIIALILSDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPKELV
                     DVMKNAYNQGLECNHGDEEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDP
                     EEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEFLTRESKYRVFNTTERDEQG
                     SKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFY
                     PFGDDGDEGTLSPLFSALLWVAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGP
                     TLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHE
                     FFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFT
                     MEVDRLKNRTPVTGNDGVPTMTLTSMLGTCPKENCSPTIPSSNAAGEGGEDGIERTCD
                     TLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFFFIVIIIVLNLIFG
                     VIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFI
                     VLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGDSEQNEIRNLQEKLE
                     STMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH"
     exon            339..409
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..525
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..612
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..771
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..870
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..954
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1101
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1197
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1242
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1394
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1494
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1655
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1797
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1959
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2132
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2252
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2438
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2690
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2835
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2986
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3180
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3310
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3368
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3534
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3708
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3798
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3924
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4047
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4248
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4500
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4626
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4627..4755
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4756..4876
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4877..5067
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5068..5210
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5211..5319
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5320..5428
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..5616
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5617..5800
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5801..6057
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6058..6258
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6259..6369
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6370..6465
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6466..6588
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6589..6696
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6697..6889
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6890..7015
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7016..7191
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7192..7356
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7357..7552
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7553..7645
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7646..7776
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7777..7942
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7943..8103
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            8104..8265
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            8266..10704
                     /gene="Itpr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacgcaga gggagcgcgg gccagggagg aggagcgaag gtgtaggaca gaacttcgcc
       61 aggaacagga aacccacggc cgggcagggg cggcgacggc ggcgcggggc catcgcagtg
      121 tccccagcgg tggcctcgct gccgcgtccc gagctgagcc gcttggaccc ctcggactca
      181 gaggacccaa gctcaccctt gcgagcagcg gagacagcgg ggacggcctc acgagcgtga
      241 agcagcatgt ctgacaaaat gtccagcttc ctctacattg gggacatcgt gtccctgtac
      301 gcggagggct cggtcaatgg cttcatcagc accctggggt tggtggatga ccgttgtgtg
      361 gtgcatccgg aggcggggga tcttaccaac ccacccaaga agttcagaga ctgcctcttc
      421 aaggtgtgcc ccatgaatcg atactctgcc cagaagcagt actggaaagc caagcaggcg
      481 aagcagggaa accacacgga ggctgccctg ctgaagaagc tccagcacgc cgcagagctg
      541 gaacaaaaac agaatgagtc agagaacagg aaacttttgg gagaaattgt gaaatacagc
      601 aacgttatac aactactgca cataaaaagc aacaagtacc tcaccgtgaa caagaggtta
      661 cctgccttac tggagaagaa tgccatgcgt gtgtccctgg atgctgcagg gaacgaaggg
      721 tcctggttct acatccatcc cttctggaag ctgagaagcg agggtgataa tatcgtcgtg
      781 ggagataaag tcgttctgat gcctgtaaat gctgggcagc ccctgcatgc cagcaacgtg
      841 gagctcctgg acaaccccgg ctgcaaagag gtgaatgctg ttaattgcaa cactagctgg
      901 aaaatcactt tattcatgaa gttcagctcc taccgagagg atgtattaaa agggggtgac
      961 gttgtgagac tgtttcatgc ggaacaagag aagtttctga cctgtgatga ctatgagaaa
     1021 aaacagcaca ttttcctgcg gacgaccttg cgtcaatcag caacgtcggc cactagctct
     1081 aaagcactct gggagataga ggtggttcac catgatccat gccgcggagg tgcaggacag
     1141 tggaacagcc tgttcaggtt taagcatctt gcaactggga actacttagc tgcagagctt
     1201 aaccctgact atcgagatgc tcaaaatgaa ggaaaaactg tgagagacgg ggagcttcca
     1261 acctcaaaga aaaaacgcca ggcaggggag aagatcatgt acacgctggt ctcggtcccg
     1321 cacggaaatg acatcgcgtc cctttttgaa cttgacgcca caactctgca gagagctgac
     1381 tgcctggttc cgaggaactc ctacgtgcgg ttgaggcacc tgtgtaccaa cacgtgggta
     1441 acaagcacca gcatccccat agacacagag gaagagaggc ctgtcatgct gaaaattggg
     1501 acctgccaga ccaaggaaga caaagaagcc tttgccatcg tgtgcgtccc gctgtctgag
     1561 gtccgagacc tggactttgc caacgatgcc aacaaagtat tggccaccac ggtgaagaag
     1621 ctggagaatg gcagcatcac ccagaatgag aggaggtttg tgactaagtt gttggaagac
     1681 ctcattttct ttgtggctga tgtgaccaac aacggacagg atgttctgga tgtggtcatc
     1741 accaagccca accgggaacg gcaaaaacta atgagggaac agaatattct ggcacaggtg
     1801 tttgggatcc ttaaagcccc tttcaaggag aaggctgggg aaggctcgat gctgaggctg
     1861 gaggacctgg gcgaccagcg ctatgccccg tacaagtacg tgctgcgtct ctgctaccgc
     1921 gtgctgcggc attcgcagca ggactacagg aagaaccagg agtacatcgc taagaacttc
     1981 tgcgtcatgc agtctcagat cggctatgat attttggcag aagatacgat cacagccttg
     2041 ctacacaaca accgcaaact cctggagaaa cacatcacgg ccaaagaaat cgagaccttc
     2101 gtcagcctgc tcaggaggaa ccgggagccg aggtttctgg actatctgtc tgacctctgc
     2161 gtgtccaata gcaccgccat ccctgtgact caggagctca tctgcaaatt catgctgagc
     2221 cccggcaatg cggacatcct cattcagacg aagctggtgt ccatgcaagt ggaaaacccc
     2281 atggagagtt ccatccttcc cgatgacatc gacgacgagg aggtttggct ttactggatt
     2341 gacagcaaca aggagcctca cggcaaggcc atcaggcacc tggcccagga ggccagggaa
     2401 ggcaccaagg ctgacctaga agtcctgacc tattacaggt accagctaaa cctctttgca
     2461 aggatgtgct tggaccgcca gtacctggcc atcaaccaga tttcaacaca gctgtctgta
     2521 gacctgatcc tgcggtgcgt gtctgacgag agcctgccct ttgacctccg agcctctttc
     2581 tgccgactca tgctccacat gcacgtggac cgggaccccc aggagtctgt ggtgcctgtc
     2641 cgctacgccc ggctctggac tgagatcccc accaagatca cgatccatga gtatgactcc
     2701 atcacagact cttccagaaa tgacatgaag aggaagtttg ccctgacaat ggaatttgtc
     2761 gaagaatatt tgaaagaagt tgtgaatcaa ccgtttcctt ttggagacaa agagaaaaat
     2821 aaactgacat ttgaggtggt ccacctggcc cggaacctca tctacttcgg attctacagc
     2881 ttcagcgagt tgctgcggct gacgagaact ctgctggcga tcctggacat cgtccaggcc
     2941 cccatgtcgt cgtattttga aagattaagc aagtttcaag atggaagcaa caatgtcatg
     3001 aggaccatcc acggggtggg agagatgatg acacagatgg tgctcagcag aggctccatt
     3061 ttcccagtga gcgtgcccga cgcacagccc agcgtccacc ccagcaagca ggcgagcccc
     3121 ggcgagcagg aggatgtgac ggttatggat accaagctaa aggttatcga gattttacag
     3181 ttcatcctga gtgtcaggct ggactaccgt atctcttaca tgctgtccat atacaagaag
     3241 gaatttgggg agaatgatgg caacggtgac ccctctgcca gcggcacccc ggaaacattg
     3301 ctaccatcag ctcttgtccc tgacattgat gagattgcgg ctcaggcaga aacgatgttt
     3361 gctggaagaa aagaaaaaac tccagttcag cttgatgatg agggaggcag aaccttctta
     3421 agagtcctca tccacctgat catgcatgac tatgctccac tgctgtccgg ggccctgcag
     3481 ctgctgttca aacacttcag ccagagagca gaagtgcttc aggccttcaa acaggtgcag
     3541 ttactagtgt cgaaccaaga tgtcgataac tacaagcaaa tcaaggcaga cctggaccaa
     3601 cttcggctga cggtggagaa gtccgagcta tgggtggaaa agagcagcag ctatgagaat
     3661 ggagacatgg gcgagggcca ggccaaagga ggcgaagagg caaatgagga gtccaacctc
     3721 ttgagcccgg tgcaggacgg cgcgaagaca cctcagatcg acagcaacaa gggcaacaac
     3781 taccggatcg tcaaggagat cttgattagg ctgagtaagc tctgtgtgca gaacaagaaa
     3841 tgtcgtaatc aacaccaacg gttgctgaaa aatatggggg ctcactccgt ggtactggac
     3901 cttctgcaga tcccctatga gaagaccgac gagaagatga acgaggtgat ggacttagcc
     3961 cacaccttcc tgcagaactt ctgccgcggg aatccacaga accaagttct ccttcacaag
     4021 catctcaacc tgttcctaac ccctggactc ctggaggcgg aaaccatgcg gcacatcttc
     4081 atgaacaatt accatctgtg caatgagatc agcgagaggg tggtccagca ctttgtgcac
     4141 tgcattgaga cacacggccg ccacgtggag tacctgaggt tcctgcagac catcgtgaaa
     4201 gcagacggca aatacgtgaa gaaatgccag gacatggtga tgaccgagct gatcaatggg
     4261 ggtgaagacg tactgatatt ctacaacgac cgagcctcat ttcccatcct tctcaacatg
     4321 atgtgctccg agagagcccg tggggatgag agcggccccc tggcctacca tatcaccctt
     4381 gtggagttgc tggcagcgtg cactgagggg aagaacgtct acacggagat caagtgcaat
     4441 tctctcttgc ctctggacga catagtgagg gtggtgaccc acgacgactg cattcctgag
     4501 gtaaaaattg catacgtgaa ctttgtcaac cattgttacg ttgacacaga agtggagatg
     4561 aaggaaatct atacaagtaa ccacatttgg aagttatttg agaacttctt ggtggatatg
     4621 gcaagggtct gcaacaccac cacggaccgg aaacacgcag acacctttct ggagaggtgt
     4681 gtgacagagt cagtcatgaa catcgtgagc ggcttcttca actcgccgtt ttcggataac
     4741 agtaccagcc tccagaccca tcagccggtc tttatccagc tgctgcagtc cgccttcaga
     4801 atttacaact gcacctggcc caacccagcc cagaaagcct ccgtggaatc ctgcatcaga
     4861 gccctggctg aagtggccaa aaaccgtggg attgcgattc cggtggattt ggacagccag
     4921 gtcaacacac tcttcatgaa gaatcactca agtacagtgc agagggcggc catgggctgg
     4981 aggctctctg ctcgctccgg acctcgcttc aaggaagctc ttggagggcc agcatgggac
     5041 tacaggaata ttattgaaaa gttacaggat gtcgtggcct ctctggaaca gcagttcagc
     5101 cccatgatgc aggctgagtt ctctgtgctt gtggatgtgc tgtacagccc ggagctactg
     5161 ttcccagaag gaagcgatgc caggatacga tgtggtgcct tcatgtccaa gctgattaat
     5221 cacacaaaga aactgatgga aaaagaagaa aaactgtgca ttaaaatcct ccagacgtta
     5281 cgggagatgc tggagaagaa agacagcttc atggaagagg gtagcacatt acggaaaatc
     5341 ctcctgaatc ggtacttcaa gggtgaccac agcgttggtg tgaacggacc tctgtcagga
     5401 gcctacgcca agacagcaca agtgggaggg ggcttcactg gacaggatgc cgataagacg
     5461 gggatttcca tgtccgatat ccagtgtttg ctggacaagg aaggggcctc cgaacttgtc
     5521 atcgatgtca ttgtgaacac caaaaacgac aggatctttt ccgagggcat cttgcttggc
     5581 attgccctgc tggaaggagg aaacacacaa acccagaatt ctttctacca gcagttgcat
     5641 gaacaaaaaa agtcagagaa attcttcaaa gtcctttacg atcggatgaa ggctgctcag
     5701 aaagagatca gatccacggt gactgtcaac accatagact tagggagcaa gaagagagag
     5761 gaggacagtg acctcatggc cttgggccct cggatgagag tgagagactc atcgctgcat
     5821 ttgaaagagg gaatgaaagg gcagttgact gaggcgtctt cagccacgtc caaagcatac
     5881 tgtgtgtaca gaagggaaat ggacccagac attgacacaa tgtgcccggg acaggaagca
     5941 ggaagtgcgg aggaaaagtc tgcagaggaa gttaccatga gcccagccat cactatcatg
     6001 cggcccatcc tcaggttcct gcagttactg tgtgagaatc acaaccggga gcttcagaac
     6061 ttcttgagga accagaacaa caaaacaaac tacaaccttg tctgtgaaac acttcagttt
     6121 ctggactgca tctgtggaag caccacaggg ggcctaggcc tgctggggct ctacatcaat
     6181 gagaagaacg tagctctggt caaccagacc ctggagagct tgaccgagta ctgccagggc
     6241 ccgtgtcatg agaaccagac ctgtatcgcc actcacgaat ccaatgggat tgacatcatc
     6301 atcgccttga ttctgagtga catcaaccct ctgggcaagt acagaatgga cctggtgcta
     6361 cagctgaaga acaacgcctc caagcttctg ctggccatta tggagagcag acacgacagt
     6421 gagaatgcag agagaattct cttcaacatg agacccaagg aactggtgga tgtcatgaag
     6481 aatgcctata accaaggcct ggaatgtaac catggggacg aggagggagg agatgatggt
     6541 gtttctccaa aagacgttgg acacaacatc tacatcctgg cccatcagtt ggcccgccac
     6601 aataaactcc tacagcagat gctcaagcct ggatccgatc cagaggaagg ggatgaagcc
     6661 ttgaagtact atgccaacca caccgcacag atcgagattg tgcggcacga ccggactatg
     6721 gagcagattg ttttccccgt ccccaatatc tgcgaattcc tcactcggga atccaaatac
     6781 cgggtgttca acacaacgga gagggatgag caaggaagca aggtgaacga cttcttccag
     6841 caaacggaag atctctacaa cgagatgaaa tggcaaaaga agatcaggaa caaccccgcc
     6901 ctgttctggt tctccaggca catctccctg tgggggagca tctccttcaa cctggctgtg
     6961 ttcatcaacc tggccgtggc tctcttctac ccattcgggg atgacggcga tgaaggtacg
     7021 ctctccccgc tgttctcagc cctcctttgg gtagcagtgg cgatctgcac gtctatgctg
     7081 ttcttcttct ccaagcctgt gggcatccgg ccattccttg tgtctatcat gctcagatca
     7141 atatacacca tcggtctggg gccaacgcta atacttcttg gtgctgccaa tctatgcaat
     7201 aaaatcgtgt tcctggtgag ttttgtggga aaccgaggca cattcacccg agggtaccga
     7261 gcagtcattc tggacatggc ctttctttac cacgtggcct atgtcttggt ttgcatgctt
     7321 ggcctcttcg tccacgagtt cttctacagc ttcctgcttt ttgacttggt gtacagagaa
     7381 gagaccctgc tgaacgtcat caaaagcgtc acacggaatg gccgctccat catcctgact
     7441 gcggtcttgg ctcttatcct ggtctacctg ttctccatca tcggcttcct tttcttaaag
     7501 gatgacttca ccatggaggt ggacagattg aaaaacagaa ctccagtcac aggtaacgac
     7561 ggggttccca ctatgacctt aacttccatg ctgggaacct gccctaagga aaactgctca
     7621 cccacgatcc cctcttcgaa tgcagccggt gagggaggtg aggacggcat cgagaggacc
     7681 tgtgacaccc tgctcatgtg cattgtcacc gtgctgaacc agggcctcag gaatggtggc
     7741 ggagttggtg acgtgctgag acgaccctcg aaggatgagc ctttgtttgc tgcccgggtg
     7801 gtctacgacc tccttttctt cttcatcgtc atcatcatcg tccttaacct gatttttggt
     7861 gtaatcattg acactttcgc tgacctcagg agtgagaagc agaagaaaga agaaattctc
     7921 aagacaacct gcttcatctg tggcttggag agggacaagt ttgataacaa gacggtgtcc
     7981 tttgaggagc acatcaagtc agagcacaac atgtggcatt acttgtactt catcgtcctg
     8041 gtgaaggtga aggacccaac agaatacaca gggcctgaga gctacgtggc tcagatgatc
     8101 acagagaaga atttagactg gtttcctcgg atgcgagcca tgtcacttgt cagcaatgaa
     8161 ggtgacagtg agcaaaatga gatccggaac ctgcaggaga agctggagtc cactatgagt
     8221 ctggtgaaac agttgtcggg gcagctggca gagctgaagg agcagatgac agaacaaagg
     8281 aaaaacaagc aaaggctggg cttccttgga tcaaacacac cccatgtgaa ccatcacatg
     8341 ccaccgcact gacaccatgg gggcacgccg tgaccagcct ttcatcagat gcctgcctca
     8401 tcgctgaggg atggagatgg aggggagcga acagtggcta ttgttgaaaa gctgaaaaca
     8461 accaagtgcc aaggtgctga gccattcagc tcccagaaca atctgtaact gtgtttgcac
     8521 gcttgagaag gttcaagctt ggaaaaaaac aaaacaaaac agtatagggc acagcctctc
     8581 catgtggcag gaagcggcca gcctgagggg ctggaggggg tgggagagtc tgatcgggga
     8641 gcggcagacc tccccctgct cgatcgatag gccttggact tgtctcacac actgactgca
     8701 gtgtccatcg tggctggttg aaattttttc ttcaaactgt ggcactgggg tcagcgagac
     8761 aggaagccac actctgctgg ctaagtctaa gaaatttaaa agattaaaaa ggagaattga
     8821 aaagggtgtc gttaaacttc cgaaccttac gtgttaactg gacattttct tcttggcatg
     8881 agacgggctc agagcactac ccctcagtgc tttggagttc acaccccacc cactgcaaaa
     8941 cataactgga tcagggtggc tgtgtccaga gctctgtaca gggctgtgca acagaaagct
     9001 ttcatagaat tggctaagac tgctcaaagc ctggtgccta tgtgctgaga tgttaaagac
     9061 ttggggaaga gaagcttgtc tgtaacactc aggaaacaac gtttccagtg tatatgctac
     9121 taaagtatgt gggcattgaa agaaaaactc gagggtaaca gccaacactg agaagcgtta
     9181 ctcgggtggc cttgccttta aaagcaggtt gatttatatt tgaggtgctt gacccaagtg
     9241 cttgcgatcc ccgaagctga gggggttggg gggaatctaa gaattgcatt gactacgtaa
     9301 gaatatgcaa catttcaaca gcacatttaa ggctgttaga gtaacagctt ttcaaaatgt
     9361 aggcagatca taattccttc ccccaaactg ttttcatgtt gactcatgca accagatttt
     9421 gtcaagggaa aaaataactt ggaaggagag attccttttg gagactgtct gaggtgtcag
     9481 agacagacag atcatgtaag tgtgagacca tctggtggtg aggggccacc agccaagaca
     9541 ctacattctg aaacagagac cctctctggc ctccagattc tttaaactct cagccaccaa
     9601 gggccacatg gggtttgtta cagcaagttt taaagctttc tggcatttca atacagtttt
     9661 agcagttggc tcctaaaaat aaacaaacaa acaaacaagt caaatcctgg gtgtgtatag
     9721 acccactgta caggcagaaa ctcaaatggc ttaccttctc ttgggtgtag ccttggaacc
     9781 accgagatgt actttctaac taaatgctgc acacactagg accacccaga gttacaaagt
     9841 gctcttggac agggccctgc tccccttagc ctaaagtgga aagatgctgg tgccttgacc
     9901 tcaggtgttc taggctaaaa cactgcacca ctgaccctcg actcttgtaa gagacctgtc
     9961 ttcagttacc cttaattctt tgctaaagct tcaaactata atcacaaaca tttttttgaa
    10021 gggtatcacc aaaattaggc cacggcagcc atttttaaag ctcaggacca tggatacttc
    10081 gacggtattt ggtaaaagta aaataggctg ggcgatcaga aggataggag ctgcttcagt
    10141 ctgctgtaac ctaaccctcc atccgttgtg ccagcagccc acagttcgac accgtggctt
    10201 cctcctgtgg gaactatcca aaagatttca cctaacgaga ctctcactat gtcaaaatta
    10261 atttttttca gttgtacttt ttctttcccc tctacaagat gaaagattat aaagtgaaat
    10321 tttataaaca tcaaccaaag caaaggcact ttctaggaca ctgacttcat aaagatgtta
    10381 gaaatgagga aatttgatgt caggtgagag tttatacttg ttatgtatgg ttactaatgc
    10441 agcgggtgta gctgactgaa gtttgatata gttgtattct cacatttata gtgatattaa
    10501 aaatacagtc acctctgact tctatgccag ggaaggcttt tttaaatttt aggttattaa
    10561 aatccatatt ggttaaaagt cacagttccc actgaataat atttttaatt cacagaaggg
    10621 tttgttccca ggtgtgctcc attctgcatc acaagagttt agtcgaagac attttctaaa
    10681 ttaaaataat tgtttgtaat taga
//
