LOCUS       NM_001007235            9784 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus inositol 1,4,5-trisphosphate receptor, type 1
            (Itpr1), transcript variant 1, mRNA.
ACCESSION   NM_001007235 XM_342732
VERSION     NM_001007235.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9784)
  AUTHORS   Pan,D., Jiang,M., Tao,G., Shi,J., Song,Z., Chen,R. and Wang,D.
  TITLE     The role of Ca2+ signalling and InsP3R in the pathogenesis of
            intrahepatic cholestasis of pregnancy
  JOURNAL   J Obstet Gynaecol 44 (1), 2345276 (2024)
   PUBMED   38685831
  REMARK    GeneRIF: The role of Ca[2+] signalling and InsP3R in the
            pathogenesis of intrahepatic cholestasis of pregnancy.
REFERENCE   2  (bases 1 to 9784)
  AUTHORS   Shi,R., Liu,Z., Yue,H., Li,M., Liu,S., De,D., Li,R., Chen,Y.,
            Cheng,S., Gu,X., Jia,M., Li,J., Li,J., Zhang,S., Feng,N., Fan,R.,
            Fu,F., Liu,Y., Ding,M. and Pei,J.
  TITLE     IP3R1-mediated MAMs formation contributes to mechanical
            trauma-induced hepatic injury and the protective effect of
            melatonin
  JOURNAL   Cell Mol Biol Lett 29 (1), 22 (2024)
   PUBMED   38308199
  REMARK    GeneRIF: IP3R1-mediated MAMs formation contributes to mechanical
            trauma-induced hepatic injury and the protective effect of
            melatonin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9784)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   4  (bases 1 to 9784)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   5  (bases 1 to 9784)
  AUTHORS   Fan,G., Baker,M.R., Terry,L.E., Arige,V., Chen,M., Seryshev,A.B.,
            Baker,M.L., Ludtke,S.J., Yule,D.I. and Serysheva,I.I.
  TITLE     Conformational motions and ligand-binding underlying gating and
            regulation in IP3R channel
  JOURNAL   Nat Commun 13 (1), 6942 (2022)
   PUBMED   36376291
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9784)
  AUTHORS   Zhang,S.X., Zhang,J.P., Fletcher,D.L., Zoeller,R.T. and Sun,G.Y.
  TITLE     In situ hybridization of mRNA expression for IP3 receptor and
            IP3-3-kinase in rat brain after transient focal cerebral ischemia
  JOURNAL   Brain Res Mol Brain Res 32 (2), 252-260 (1995)
   PUBMED   7500836
REFERENCE   7  (bases 1 to 9784)
  AUTHORS   Takei,K., Stukenbrok,H., Metcalf,A., Mignery,G.A., Sudhof,T.C.,
            Volpe,P. and De Camilli,P.
  TITLE     Ca2+ stores in Purkinje neurons: endoplasmic reticulum
            subcompartments demonstrated by the heterogeneous distribution of
            the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin
  JOURNAL   J Neurosci 12 (2), 489-505 (1992)
   PUBMED   1311032
REFERENCE   8  (bases 1 to 9784)
  AUTHORS   Suzuki,T., Abe-Dohmae,S. and Tanaka,R.
  TITLE     P400 protein is one of the major substrates for
            Ca2+/calmodulin-dependent protein kinase II in the postsynaptic
            density-enriched fraction isolated from rat cerebral cortex,
            hippocampus and cerebellum
  JOURNAL   Neurochem Int 20 (1), 61-67 (1992)
   PUBMED   1338970
REFERENCE   9  (bases 1 to 9784)
  AUTHORS   Danoff,S.K., Ferris,C.D., Donath,C., Fischer,G.A., Munemitsu,S.,
            Ullrich,A., Snyder,S.H. and Ross,C.A.
  TITLE     Inositol 1,4,5-trisphosphate receptors: distinct neuronal and
            nonneuronal forms derived by alternative splicing differ in
            phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 88 (7), 2951-2955 (1991)
   PUBMED   1849282
REFERENCE   10 (bases 1 to 9784)
  AUTHORS   Mignery,G.A., Newton,C.L., Archer,B.T. 3rd and Sudhof,T.C.
  TITLE     Structure and expression of the rat inositol 1,4,5-trisphosphate
            receptor
  JOURNAL   J Biol Chem 265 (21), 12679-12685 (1990)
   PUBMED   2165071
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from J05510.1, BF402715.1,
            GQ233032.1 and BC091346.1.
            
            On Jul 20, 2012 this sequence version replaced NM_001007235.1.
            
            Summary: This gene belongs to the Insp3 receptor family. It encodes
            an intracellular receptor for inositol 1,4,5-trisphosphate. Upon
            stimulation by inositol 1,4,5-trisphosphate, this receptor mediates
            calcium release from the endoplasmic reticulum. Alternatively
            spliced transcript variants encoding distinct isoforms have been
            found for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               J05510.1           92-751
            661-1042            BF402715.1         6-387               c
            1043-4351           J05510.1           1134-4442
            4352-8485           GQ233032.1         4114-8247
            8486-8779           J05510.1           8580-8873
            8780-9784           BC091346.1         669-1673
FEATURES             Location/Qualifiers
     source          1..9784
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..9784
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /note="inositol 1,4,5-trisphosphate receptor, type 1"
                     /db_xref="GeneID:25262"
                     /db_xref="RGD:2933"
     exon            1..152
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            153..222
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            223..330
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..8485
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /note="isoform 1 is encoded by transcript variant 1;
                     IP-3-R; type 1 InsP3 receptor; IP3 receptor; type 1
                     inositol 1,4,5-trisphosphate receptor; IP3R 1; inositol
                     1,4,5-triphosphate receptor, type 1; inositol
                     1,4,5-triphosphate receptor 1; inositol
                     1,4,5-trisphosphate-gated calcium channel ITPR1"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR1 isoform 1"
                     /protein_id="NP_001007236.2"
                     /db_xref="GeneID:25262"
                     /db_xref="RGD:2933"
                     /translation="MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAG
                     DLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQ
                     NETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSW
                     FYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSW
                     KIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSAT
                     SSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVD
                     PDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRH
                     LCTNTWVHSTNIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLDFANDAS
                     KVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQK
                     LMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQD
                     YRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRK
                     NREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVST
                     GENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLF
                     ARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQV
                     TPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSD
                     KEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMTKGEE
                     NKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKL
                     KIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEGPSNVPGALDF
                     EHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFS
                     QRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDEPMDGA
                     SGENEHKKTEEGTSKPLKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRL
                     LRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLF
                     LNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG
                     KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLV
                     ELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVE
                     MKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPF
                     SDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPV
                     DLDSQVNNLFLKSHNIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSAL
                     EDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEE
                     KLCIKVLQTLREMMTKDRGYGEKQISIDELENAELPQPPEAENSTEELEPSPPLRQLE
                     DHKRGEALRQILVNRYYGNIRPSGRRESLTSFGNGPLSPGGPSKPGGGGGGPGSGSTS
                     RGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFF
                     CRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAK
                     EPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQSGEGTQATTDKAKDDLEMS
                     AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGL
                     GLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINP
                     LGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEV
                     EFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGDEALEFYAKH
                     TAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDL
                     FNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPH
                     WSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKI
                     IFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYRE
                     ETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPE
                     TGESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLS
                     HGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRS
                     EKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEY
                     TGPESYVAEMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSG
                     QLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA"
     exon            331..401
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            402..517
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            518..604
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            605..763
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            764..862
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            863..946
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1093
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1189
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1234
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1389
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1489
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1650
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1792
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1951
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2124
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2244
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2439
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2691
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2833
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2987
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3175
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3314
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3369
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3535
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3706
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3772
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3910
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4036
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4237
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            4238..4489
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4615
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4744
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4865
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            4866..5050
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5051..5199
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5200..5311
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5312..5344
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5345..5380
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5381..5428
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..5561
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5752
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5753..5933
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            5934..6187
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            6188..6388
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            6389..6499
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            6500..6595
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            6596..6718
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            6719..6823
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            6824..7016
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            7017..7139
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            7140..7315
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            7316..7480
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            7481..7676
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            7677..7769
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            7770..7909
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            7910..8075
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            8076..8236
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            8237..8398
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     exon            8399..9757
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9737..9742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
     polyA_site      9757
                     /gene="Itpr1"
                     /gene_synonym="I145TR; InsP3R; InsP3R1; IP3R1; P400"
ORIGIN      
        1 gagagaaagc gcacgccgag aggaggtgtg ggtgttccgc tcccatccta acggaacgag
       61 ctccctcttc gcggacatgg gattgcccag cggctgctaa cccctgtcct ggtcctgatc
      121 cctcaaaccg gcgtggctcc ccggtcacca aggagctgac tacaaaggat ttgcatcctt
      181 ggctgggagt ccattggcta cagagtgcct gacctgggtc aggcttttca acaaggacat
      241 gtctgacaaa atgtctagtt tcctacatat cggagacatt tgttctctgt atgcagaggg
      301 atctacgaat ggatttatca gcaccttggg cttggttgat gaccgttgcg ttgtacagcc
      361 agaagctggg gaccttaaca atccacccaa gaaattcaga gactgcctct ttaagctatg
      421 tcctatgaat cgatattctg cacagaagca gttctggaaa gctgctaagc ccggggccaa
      481 cagtacaaca gatgcggtgc tgctcaacaa attgcatcat gctgcagact tggaaaagaa
      541 gcagaatgag acagaaaaca ggaaattgct ggggacggtc atccagtatg gcaacgtgat
      601 ccagctccta catttgaaaa gcaataaata cttaactgtg aataagaggc ttcctgccct
      661 gctggagaag aacgccatga gagtgacgtt ggatgaggct ggaaatgaag ggtcttggtt
      721 ttacattcag ccgttctaca agctccgctc catcggagac agtgtggtca taggtgacaa
      781 ggtagttttg aaccctgtca atgctgggca gccgctacat gccagcagcc atcagctggt
      841 ggataacccg ggctgcaatg aggtcaactc cgtcaactgt aacacaagct ggaaaatagt
      901 gcttttcatg aaatggagtg ataacaaaga tgacattcta aaaggaggtg atgtggtaag
      961 actcttccat gctgagcaag agaagtttct cacgtgcgat gagcacagga agaagcagca
     1021 cgtcttcctg aggacaaccg gcagacagtc agccacgtcg gccaccagct ccaaagccct
     1081 gtgggaagtg gaggtagtcc agcatgaccc atgtcggggt ggagctgggt actggaatag
     1141 cctcttccgg ttcaagcacc tggctacagg gcattacttg gcagcagagg tagaccctga
     1201 ctttgaggaa gaatgcctgg agtttcagcc ctcagtggac cctgatcagg acgcatctcg
     1261 gagcaggttg agaaatgccc aagaaaaaat ggtgtactct ctggtctctg tgcctgaggg
     1321 caacgacatc tcctccatct ttgagctaga ccccacaact ctacgtggag gtgacagcct
     1381 tgtcccaagg aactcctatg tccggctcag acacctgtgt acaaacacct gggttcacag
     1441 cacaaacatc cccattgaca aggaagagga aaaacctgtc atgctgaaga ttggtacctc
     1501 tcccctgaag gaggacaagg aagcttttgc catagtcccc gtttctcctg ctgaggttcg
     1561 ggacctggac tttgccaatg atgccagcaa ggtgctgggc tccatcgctg ggaagttgga
     1621 aaagggcacc atcacccaga atgagagaag gtctgtcacc aagctgctgg aagacttggt
     1681 ttactttgtc acgggtggaa cgaactctgg ccaagacgtg cttgaagtag tcttctctaa
     1741 gcccaaccga gagcggcaga agctgatgag ggaacagaat attctcaagc agatcttcaa
     1801 gcttttgcag gcccccttca cggactgcgg ggatggccca atgcttcggc tggaggagct
     1861 gggggaccag cggcacgctc ctttcagaca catttgccga ctctgctaca gggtcctgag
     1921 acactcacag caagactaca ggaagaacca ggagtacata gccaagcagt ttggcttcat
     1981 gcagaagcag attggctatg atgtgctggc cgaagacacc atcactgccc tgctccacaa
     2041 caaccgaaag ctcctggaaa agcacatcac cgcagcagag attgacacgt ttgtcagcct
     2101 ggtgcgaaag aacagggagc ccaggttctt ggattacctc tctgacctct gtgtatccat
     2161 gaataagtca atccctgtga cccaggagct catttgtaaa gctgtgctga atcccaccaa
     2221 tgctgacatc ctgattgaga ccaagttggt tctttctcgt tttgagtttg aaggcgtttc
     2281 caccggagag aatgctctgg aagctgggga agatgaggaa gaggtgtggc tgttctggag
     2341 ggacagcaac aaagagatcc gtagcaagag tgttagggaa ttggcacaag atgctaaaga
     2401 gggacagaag gaagacaggg atgtcctcag ctactacagg tatcagctga acctctttgc
     2461 aaggatgtgt ctggaccgcc agtacctggc catcaatgaa atatccgggc agctggatgt
     2521 tgacctcatc ctccgctgca tgtccgatga gaacctcccc tatgacctca gagcatcctt
     2581 ttgccgcctc atgcttcaca tgcatgtgga ccgagatccc caggagcagg tgacccctgt
     2641 gaaatacgcc cgtctgtggt cagaaattcc ctccgagatc gccattgacg actatgacag
     2701 cagtggagca tcgaaggatg aaatcaagga gaggtttgct cagacgatgg agtttgtgga
     2761 ggagtacctg agagatgtgg tttgtcaaag attccccttt tctgataagg agaaaaataa
     2821 gctcacattt gaggttgtga acttagccag gaacctcata tactttggct tctacaactt
     2881 ttctgacctt ctccgattaa ccaagatcct cttggcaatc ttagactgtg ttcatgtgac
     2941 aaccatcttc cccattagca agatgacgaa aggcgaagag aataaaggca gcaacgtgat
     3001 gagatctatc catggagttg gggagctcat gacccaggtg gtgcttcggg gaggaggctt
     3061 tttgcccatg actcctatgg ctgctgcccc tgaaggaaat gtgaagcagg cagagccaga
     3121 gaaagaggat atcatggtca tggacaccaa gttaaagatc attgaaatac tccagtttat
     3181 tttgaatgtg agattggatt ataggatctc ctgcctcctg tgtatattta agcgggagtt
     3241 tgatgaaagc aattcccagt catcagaaac atcctccgga aacagcagcc aagaagggcc
     3301 aagtaatgta ccaggtgctc ttgactttga acacattgaa gagcaagcag aaggcatctt
     3361 tgggggaagt gaggagaaca cacctctgga cttggatgat catggtggca gaaccttcct
     3421 cagggtcctg ctccacttga caatgcatga ttacccaccc ctggtgtctg gggccctgca
     3481 gctcctcttc cggcatttca gccagaggca ggaggtcctt caggccttca aacaggttca
     3541 actgctggtt actagccaag atgtggacaa ctacaaacag atcaagcaag acttggacca
     3601 gctaagatcc atcgtggaga agtctgagct ctgggtatac aaaggccagg gtcccgatga
     3661 gcctatggac ggagcctctg gtgaaaacga acataagaaa actgaggagg ggaccagtaa
     3721 gccactgaag cacgaaagca ccagcagcta caactaccga gtggtgaaag agattctgat
     3781 tcgacttagc aagctctgtg ttcaagagag cgcgtcggtg aggaagagca ggaagcagca
     3841 gcagcgactg ctgaggaaca tgggtgccca tgctgtggtg ctggagctgc tgcagatccc
     3901 ctatgagaag gccgaagata ccaagatgca ggagatcatg aggctggctc acgaatttct
     3961 gcagaatttc tgcgcaggca accagcagaa ccaagctttg ctacataaac acataaacct
     4021 gtttctcaac ccagggatcc tggaagcagt gaccatgcag cacatcttca tgaacaactt
     4081 ccagctgtgc agtgagatca acgagagagt ggtccagcat ttcgttcact gcatagagac
     4141 ccacggtcga aatgtccagt atatcaagtt tctccagact attgtcaagg ccgaagggaa
     4201 attcattaaa aagtgccaag acatggtcat ggctgagctt gtcaattctg gagaggacgt
     4261 cctcgtgttc tacaatgaca gagcctcttt ccagactctg atccagatga tgcggtccga
     4321 gcgtgaccgg atggatgaga acagccctct catgtaccac atccatctgg tggagctctt
     4381 ggctgtgtgc acagagggca agaatgtgta cacagagatc aagtgcaact ccctgctccc
     4441 gctcgatgac atcgttcgtg tggtcactca tgaagactgt atccccgagg ttaagattgc
     4501 ttacatcaac ttcctgaatc actgctatgt ggacactgag gtggagatga aggagattta
     4561 cacaagtaat cacatgtgga agttgtttga gaatttcctc gtggacatct gcagggcctg
     4621 taacaacaca agtgacagga agcatgcaga ctcggttctg gagaagtacg tcactgaaat
     4681 cgtgatgagc attgtcacca ccttcttcag ctctcccttc tcagaccaga gtaccactct
     4741 gcagactcgc cagcctgtct ttgtgcagct cctgcaaggc gtgttccgag tttaccactg
     4801 caactggttg atgccgagcc agaaagcctc ggtggagagc tgtatccgcg tgctctctga
     4861 cgtagccaag agccgggcca tagccattcc tgttgaccta gacagccaag tcaacaacct
     4921 cttcctgaag tcccacaaca ttgtgcagaa aacagccatg aactggcggt tatcagcccg
     4981 caacgctgct cgtagagact ctgtcctggc agcttccaga gactaccgaa atattattga
     5041 gaggttacag gacatcgtgt ctgccctgga ggaccgactc aggcccctgg tccaggccga
     5101 gctgtctgtg ctcgtggatg ttctacacag accggaactg cttttccctg agaacacgga
     5161 tgccaggagg aaatgcgaaa gtggaggttt catctgcaag ctcataaaac acaccaagca
     5221 gctgctagag gagaatgaag agaaactgtg cattaaagtc ttacagaccc tcagggaaat
     5281 gatgaccaaa gatagaggct atggagaaaa gcaaatttcc attgatgaat tggaaaatgc
     5341 cgagctgcca cagccaccgg aagctgagaa ctccacagag gagcttgaac caagtccacc
     5401 cctgaggcaa ctggaagacc ataaaagggg tgaggcactc cggcaaattt tggtcaaccg
     5461 ttactatgga aacatcagac cttcaggaag aagagagagc cttaccagct ttggcaatgg
     5521 tccactatca ccaggaggac ccagcaagcc tgggggagga gggggaggtc ctgggtccgg
     5581 ctccacaagc cggggtgaga tgagcctggc tgaggttcaa tgtcatctcg acaaggaagg
     5641 cgcctccaat ctggtcatcg acctcataat gaatgcatcc agcgaccgag tattccacga
     5701 aagcattctc ctggccatcg cacttctgga aggaggcaac accactatcc agcactcatt
     5761 tttctgccgg ctgacggaag ataagaaatc agagaagttc ttcaaggtct tttacgatcg
     5821 aatgaaggtg gcccagcagg aaatcaaggc gacagtgacc gtgaacacca gcgatttggg
     5881 aaacaaaaag aaagatgatg aagtggaccg ggatgcccca tcccggaaga aagccaaaga
     5941 gcccacaaca cagataacag aagaggtccg ggatcagctc ttggaagcat ctgctgccac
     6001 cagaaaagcc tttaccacct tccggaggga ggccgaccct gatgaccatt accaatctgg
     6061 ggagggcacc caggctacaa cggacaaagc caaggatgac ctagagatga gtgcagtcat
     6121 caccatcatg cagcctatcc tgcgcttcct gcagctcctg tgtgaaaacc acaaccgcga
     6181 tctgcagaat ttccttcgtt gccaaaataa taagaccaac tacaacttgg tgtgtgagac
     6241 actgcagttt ctggactgta tctgtgggag cacaactgga ggccttggtc ttctcggact
     6301 gtacataaat gaaaagaatg tagctcttat caaccaaacc ctggagagtc tgactgagta
     6361 ctgtcaaggg ccttgccatg aaaaccagaa ctgcatcgcc acccacgagt ccaatggcat
     6421 cgatatcatc acagccctca tccttaacga tatcaaccct ctggggaaga aacggatgga
     6481 cctggtgtta gaactgaaga acaatgcttc aaagctactc ctggccatca tggaaagcag
     6541 acacgatagt gaaaatgcag agaggatcct gtacaacatg aggcccaagg agctggtgga
     6601 agtgatcaag aaggcctaca tgcaaggcga agtggagttt gaggatgggg agaacggtga
     6661 ggatggagca gcctccccca ggaacgtggg ccataacatc tacatcctcg ctcaccagtt
     6721 ggctcggcat aacaaagaac ttcaaaccat gctgaaacct ggaggccagg tggatggcga
     6781 tgaagctctg gagttctatg cgaagcacac agcacaaatt gagattgtca gactggaccg
     6841 aactatggaa cagattgtct tccctgtgcc cagcatctgt gaatttctga ctaaggaatc
     6901 gaaacttcga atatattaca ccacagagag ggatgagcaa ggcagcaaga tcaatgactt
     6961 cttcctgcgc tccgaggacc tctttaatga gatgaactgg cagaagaaac ttcgagccca
     7021 gcctgtcttg tactggtgcg cccgaaacat gtctttctgg agcagcatct ccttcaacct
     7081 ggccgtcctg atgaacctgc tggtggcgtt tttctaccca tttaaaggag tgagaggagg
     7141 aacactagag ccgcactggt ccggcctcct gtggacagcc atgctcatct ctctggcaat
     7201 tgtcattgcg ctgcccaagc cccatggcat ccgggcctta attgcttcta caatcctacg
     7261 actgatattt tcagttggat tacagcccac actgtttctg ctgggagctt tcaatgtctg
     7321 caataaaatc atcttcctga tgagctttgt gggcaactgt gggaccttca ccagaggcta
     7381 ccgagccatg gttctggacg ttgagttcct ctatcatttg ctgtatctac tgatctgtgc
     7441 catgggcctc ttcgtacatg agtttttcta tagtttgctg ctttttgatt tagtgtacag
     7501 agaggagact ttgcttaatg tcattaaaag tgtcacccgc aatggacggt ccatcatctt
     7561 gacagcggtc ctggctctga ttctggttta cctgttctca attgtgggct acctgttctt
     7621 caaggatgac tttatcttgg aagtagacag gttgcccaat gagacagctg gtccagaaac
     7681 tggtgagagt ttggccaacg atttcctgta ctctgatgtg tgccgggtag agacggggga
     7741 gaactgcacc tctccggcac ccaaagaaga gctgctccct gtggaagaaa cggaacagga
     7801 taaggagcac acgtgtgaga cactgctcat gtgcatcgtc accgttctga gtcacgggct
     7861 gcggagtggg ggcggagtag gagatgtgct caggaagcca tccaaagagg agcctctgtt
     7921 tgctgcaagg gtgatctatg acctcctctt cttcttcatg gtcatcatca ttgtcctgaa
     7981 cctcattttt ggggtcatca tcgacacctt tgctgacctg aggagtgaga agcagaagaa
     8041 ggaagagatc ttaaaaacca cgtgcttcat ttgtggcttg gaaagggaca agtttgacaa
     8101 taagaccgtc acctttgaag agcacattaa ggaagaacac aacatgtggc actatctgtg
     8161 cttcatcgtg ctggtgaaag tgaaggactc caccgagtac accgggcccg agagctacgt
     8221 ggcagagatg atcagggaaa gaaaccttga ttggttcccc aggatgagag ccatgtccct
     8281 ggtcagcagt gactctgaag gggaacagaa cgagctgagg aacctgcagg agaagctgga
     8341 gtccaccatg aagctggtca ccaatctttc tggccagctg tcagaactaa aggaccagat
     8401 gacagaacaa aggaagcaga aacaaagaat tggccttcta ggacatcctc ctcacatgaa
     8461 tgtcaaccca cagcagccag cctaagcaaa tgagacggag ggactgtact caaccctttt
     8521 taaattattg tcagcgtggg tctggctctt ggttctgatc tgccctctaa ggttacatgt
     8581 gcgcttagta catttgtaaa tactcggttt tgtattgtat gtatatgatt gcaattctca
     8641 gaggtttgga ctttcgtatt gtaattagct ctgttggcat ggtgacttgt cactcctgcc
     8701 aaaaatatta aaaatgcctt ttttggaagg actacagaaa gtacctgatt tgcacttgaa
     8761 ccagattata gatttaaaag tatatgacat gtattttgta tttaaaacta gaatagccag
     8821 tatttatgtt ttttataaaa ctgtgcaata caaattatgc aatcaccata actctgtaac
     8881 tcctgagtgt cttaagggag tgcgcatctt tgaagctgat ctgttaatac ttatgtaata
     8941 aatggttaaa tatcaaatga tgatgctgct gccaaaatta tattaatagc aagtttctgg
     9001 cccctgggca attttgtacc ttgtaattat cctatggtga tgctgtttct cgttgctaat
     9061 ggcattagtg cctcgtatcc tagtgataac tccaggtctg tgaaccattc aaacaacatt
     9121 catttttgag acaaagcaac tttagtttca agggtaattt taagcttcaa aattaatcat
     9181 ttaaagtatt tctttaagag agccatgtta gaggctcaca cgttagcttg aaaggagtcg
     9241 atgaaataat ttttttaaag ggaacttttt acacgacgtt tggaataaca gcatattgct
     9301 gaccagtcag tgtcatctcc caggtgaatt ttgatgtcac gttatagtca aatgagctag
     9361 ctgatggttt ctagattctc ttcatctgaa ccaacatgat gcagtaggtg agaagttatt
     9421 atgcatatat acacatatac atccatataa ggcaaagtag gagctgtccc cttaggatgc
     9481 atagctgccc ccttagggtg cagagctcaa cactgacagt gctgttctga gagagccacg
     9541 tttgggtttt atttctttgt cacatgattt cttttctgga tgtgtgcaag tataacagga
     9601 agtgttttct acctgttgct tgttttgtac ctgggtctcg ttttactaga ccatctctgc
     9661 acaaaagttt aaaaaatgaa ccgtaagcag agttctgaag caagtcaagt ttgtaagtgc
     9721 atacctgaaa ttatttaata aatgacgcag aatactaaaa aaaaaaaaaa aaaaaaaaaa
     9781 aaaa
//
