LOCUS       NM_178094               3309 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus inositol-trisphosphate 3-kinase C (Itpkc), mRNA.
ACCESSION   NM_178094
VERSION     NM_178094.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3309)
  AUTHORS   Zhu,L., Zheng,Y., Wu,T., He,J., Fang,X., Zhou,S., Wang,K. and
            Wang,N.
  TITLE     Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are
            associated with risk of colorectal cancer
  JOURNAL   Eur J Cancer Prev 30 (5), 357-363 (2021)
   PUBMED   33470690
REFERENCE   2  (bases 1 to 3309)
  AUTHORS   Pouillon,V., Hascakova-Bartova,R., Pajak,B., Adam,E., Bex,F.,
            Dewaste,V., Van Lint,C., Leo,O., Erneux,C. and Schurmans,S.
  TITLE     Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte
            development
  JOURNAL   Nat Immunol 4 (11), 1136-1143 (2003)
   PUBMED   14517551
REFERENCE   3  (bases 1 to 3309)
  AUTHORS   Nalaskowski,M.M., Bertsch,U., Fanick,W., Stockebrand,M.C.,
            Schmale,H. and Mayr,G.W.
  TITLE     Rat inositol 1,4,5-trisphosphate 3-kinase C is enzymatically
            specialized for basal cellular inositol trisphosphate
            phosphorylation and shuttles actively between nucleus and cytoplasm
  JOURNAL   J Biol Chem 278 (22), 19765-19776 (2003)
   PUBMED   12649294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ440782.1.
            
            On Jun 10, 2007 this sequence version replaced NM_178094.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ440782.1, AY160770.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3309
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /note="inositol-trisphosphate 3-kinase C"
                     /db_xref="GeneID:308451"
                     /db_xref="RGD:631336"
     exon            1..1245
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2145
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /EC_number="2.7.1.127"
                     /function="involved in inositol phosphate metabolism"
                     /note="IP3K C; IP3 3-kinase C; insP 3-kinase C; inositol
                     1,4,5-trisphosphate 3-kinase C"
                     /codon_start=1
                     /product="inositol-trisphosphate 3-kinase C"
                     /protein_id="NP_835195.1"
                     /db_xref="GeneID:308451"
                     /db_xref="RGD:631336"
                     /translation="MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGP
                     GAGGPTGRPEGGGPRAWIEGFSLHSEAERTDFGPAPCPDGPQAEPCGDEHEECEAAGL
                     GVASEKPSQNKELDGSNLQTHPKLSSPLAEMEMAGSWTDGFRTDLHRPDLQARPKRAS
                     LCTQPGFDESWTELDRSELWQTLPERDKPWVDHLRTHQDMSRLQNHPACPSPEPSAGT
                     SCKELSADGSRTPHDTDGFWIESQTDGSLIGPSTQTACRQPANDGFSAQDTDGTLIQP
                     GTDDGPWVDSVLEKSNGDDPLMEPEPRDLVTNLCSHLECSSLCPVPRLIITSESPEPG
                     AQPLGPQARIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRSGSKPWKKLKTVLKY
                     SPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPT
                     YYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEK
                     MVAVDPGAPTPEEHAQGAVTKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKT
                     QALEQVTKVLEDFVNGDVGILRKYVARLEDLRDTLENSPFFKTHEVVGSSLLFVHDHT
                     GLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDGYLWGLDNLICLLQGLAQS"
     exon            1246..1348
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1562
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1767
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1869
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1941
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..3293
                     /gene="Itpkc"
                     /gene_synonym="IP3K-C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggcgggc cggaacccac gagttggggc tccccagcca caccccttgt aggatttaaa
       61 ggggaaggag gggccggacg ggccggagcc cgagccgagg gagcgggtat gaggcgctgc
      121 ccgtgccggg ggagcctgag cgaggcggag gccggcgcat tgccagccga ggcccgcatg
      181 gggctggagg cgctgcgagg tgggcggcgg cgacagccgg gattgcagcg ccctgggccg
      241 ggagcaggtg gcccgacggg acggccagag gggggcggtc cccgggcctg gatcgagggg
      301 ttcagcctgc actcagaggc ggagaggacc gacttcgggc ctgcgccgtg tccggacggt
      361 ccacaggcag aaccctgtgg agacgaacac gaggagtgcg aagcagctgg cctaggagtt
      421 gcctcggaga agcccagcca aaataaggag ctagacgggt ccaacctcca gacacatcca
      481 aaactgagca gccccctggc tgagatggag atggccggtt cctggacaga tggttttcga
      541 actgatcttc acagacctga cctccaggct cggccaaaga gagccagcct ctgtacccaa
      601 ccagggtttg atgaatcctg gaccgaactg gacagatccg agctgtggca gactctacca
      661 gagagggaca agccctgggt tgatcacctc cggacccacc aagacatgtc cagactccaa
      721 aatcacccag cctgcccctc accagagcca agtgctggta cctcctgcaa agaattgagc
      781 gcagatggtt ccaggacacc acatgacacc gatggcttct ggatagagtc ccaaactgat
      841 ggctccctca taggacctag tactcagaca gcctgcagac agcctgcaaa cgatggtttt
      901 tcagcacagg acactgacgg tactttgatt caacctggca ctgatgatgg tccctgggtt
      961 gatagcgttt tggagaagtc caatggagat gatccattaa tggaaccaga gcccagagac
     1021 ttggtgacta acctgtgctc ccacctggag tgcagctccc tgtgtcctgt gccccgcctt
     1081 atcatcacct cagagtctcc tgagcctggg gcccagccgc tgggacccca agcccggatt
     1141 gaggggggga ctggcggctt ctcttctgcc tcctcttttg acgaatctga ggatgacttg
     1201 gtggctgggg gcggaggtac cagcgatcct gaggacagat ctggaagcaa gccctggaag
     1261 aagctgaaga cagttctgaa gtactcgcct ttcgtggtct ccttccataa gcactactac
     1321 ccctgggtac agctttccgg acatgctggg aacttccagg ctggtgagga tggccggatt
     1381 ctgaaacgtt tctgccaatg tgagcagcgc agcctggagc tgctgatggg agaccccctg
     1441 cggcctttcg tgcccactta ttatggcatg gtgcagcggg atggccaggc cttcaaccag
     1501 atggaagacc tcctggccga ctttgagggc ccctctatca tggactgcaa gatgggcagc
     1561 aggacatacc tggaagagga gctggtgaag gcccgggaac gacccaaacc ccggaaagat
     1621 atgtatgaga agatggtggc agtggaccca ggggctccca ccccagagga gcacgctcag
     1681 ggtgcggtca ctaagccccg atacatgcag tggagggaga ccctgagttc aacttccacc
     1741 ctgggcttcc ggattgaagg catcaagaag gccgatggga cctgcaacac caacttcaag
     1801 aagacacagg ctctggagca ggtgacaaag gtgttggaag actttgtgaa tggggacgtt
     1861 ggaatcctaa gaaagtacgt ggcgcgactg gaggaccttc gagacactct ggagaattct
     1921 cccttcttca agacccacga ggtagtgggc agttccctgc tctttgtgca tgaccacacc
     1981 ggcctggcca aggtttggat gattgacttc ggcaagacag tggccctgcc tgaccaccag
     2041 atgctcagtc acaggctgcc ttgggctgag ggcaaccgtg aagatggcta cctctggggt
     2101 ttggacaatt tgatctgcct ccttcagggc ctggcccaga gctgacgtca gctgccactg
     2161 ctaggctcac ttgggaggat agcgagtgtc tggctggaag atgttgtctg gcctgaggct
     2221 gctgatggaa gataaggtgc ctcaaggtgt caccagacca gtatggtctg aggagctcga
     2281 ggatctctgg cagcactggg ctcccctagg ttatgggaaa caagacaggt ggaggcatag
     2341 agttagcaga atgtgaatgg ggaatcctga tcagctagga aagcatctaa gggagtacca
     2401 gaggccacag ctggaagaat gaacatttcc ctgagtcggc tctgagccta gagccgacag
     2461 gttggctttg ttccccagag gaccaggcat catttgtgaa gactacagga actacttgtc
     2521 cacctgggcc agtgacagcc ccatcctagt gctgagagga gggtgtggcc tcctgggata
     2581 cttgctgagg ctgcccaagg cctaatgctc ctgtggggcc agcttgccct ccttgccagg
     2641 acagaagatt cctctctgtt cctttgtgga ctttgagcta ctgcagaccc agaacgcagc
     2701 catatgcact gggccagcac tgtgatcatc ttccttcctt ggtgcaccag ctccagcctc
     2761 agcacctcct cctcctgtcc ctgacacctg ggctcttgtc ttagcaaagt ccagtgacag
     2821 gaaggcattt ctgaggcaag ggaggaggct tctccttggg aaacagccag ccttgcctca
     2881 ctgtgtaagt gccctgactc acacacagaa tgacgtgcca ggttgcccag aagcacaagt
     2941 gggtggggct gttggcccta accgtggact acctggttct aaccaaagac tctagacctc
     3001 tagggtgggg tagatagaaa gcaccctgtc cctgtgcccc agcactgctc cagaaccttg
     3061 gcttcctggc ccacaccgat gggctggcaa ggacaggaac ctacctcttc tctaagctga
     3121 agccctaagg tcgtcaaggc tggctgacac gtcttccttt tttactgact gacttataga
     3181 tatatattta tacgaggtag ttagctgggg tggtggtgtc agggaatcga ggcaaaatga
     3241 ctttactgta cctcctgcct acaacagcac cccaataaac aggacaaagt caaaaaaaaa
     3301 aaaaaaaaa
//
