LOCUS       NM_019312               3951 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus inositol-trisphosphate 3-kinase B (Itpkb), mRNA.
ACCESSION   NM_019312
VERSION     NM_019312.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3951)
  AUTHORS   Jia,Y., Loison,F., Hattori,H., Li,Y., Erneux,C., Park,S.Y., Gao,C.,
            Chai,L., Silberstein,L.E., Schurmans,S. and Luo,H.R.
  TITLE     Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological
            modulator of myelopoiesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (12), 4739-4744 (2008)
   PUBMED   18339802
REFERENCE   2  (bases 1 to 3951)
  AUTHORS   Yu,J.C., Lloyd-Burton,S.M., Irvine,R.F. and Schell,M.J.
  TITLE     Regulation of the localization and activity of inositol
            1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis
  JOURNAL   Biochem J 392 (Pt 3), 435-441 (2005)
   PUBMED   16173920
  REMARK    GeneRIF: The localization and activity of inositol
            1,4,5-trisphosphate 3-kinase B(IP3KB) and its modulation by
            proteolysis are reported.
REFERENCE   3  (bases 1 to 3951)
  AUTHORS   Hascakova-Bartova,R., Pouillon,V., Dewaste,V., Moreau,C.,
            Jacques,C., Banting,G., Schurmans,S. and Erneux,C.
  TITLE     Identification and subcellular distribution of endogenous
            Ins(1,4,5)P(3) 3-kinase B in mouse tissues
  JOURNAL   Biochem Biophys Res Commun 323 (3), 920-925 (2004)
   PUBMED   15381088
REFERENCE   4  (bases 1 to 3951)
  AUTHORS   Wen,B.G., Pletcher,M.T., Warashina,M., Choe,S.H., Ziaee,N.,
            Wiltshire,T., Sauer,K. and Cooke,M.P.
  TITLE     Inositol (1,4,5) trisphosphate 3 kinase B controls positive
            selection of T cells and modulates Erk activity
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5604-5609 (2004)
   PUBMED   15064401
REFERENCE   5  (bases 1 to 3951)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   6  (bases 1 to 3951)
  AUTHORS   Pouillon,V., Hascakova-Bartova,R., Pajak,B., Adam,E., Bex,F.,
            Dewaste,V., Van Lint,C., Leo,O., Erneux,C. and Schurmans,S.
  TITLE     Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte
            development
  JOURNAL   Nat Immunol 4 (11), 1136-1143 (2003)
   PUBMED   14517551
REFERENCE   7  (bases 1 to 3951)
  AUTHORS   Zou,Y., Millette,C.F. and Sperry,A.O.
  TITLE     KRP3A and KRP3B: candidate motors in spermatid maturation in the
            seminiferous epithelium
  JOURNAL   Biol Reprod 66 (3), 843-855 (2002)
   PUBMED   11870094
REFERENCE   8  (bases 1 to 3951)
  AUTHORS   Thomas,S., Brake,B., Luzio,J.P., Stanley,K. and Banting,G.
  TITLE     Isolation and sequence of a full length cDNA encoding a novel rat
            inositol 1,4,5-trisphosphate 3-kinase
  JOURNAL   Biochim Biophys Acta 1220 (2), 219-222 (1994)
   PUBMED   8312366
REFERENCE   9  (bases 1 to 3951)
  AUTHORS   Takazawa,K., Perret,J., Dumont,J.E. and Erneux,C.
  TITLE     Molecular cloning and expression of a new putative inositol
            1,4,5-trisphosphate 3-kinase isoenzyme
  JOURNAL   Biochem J 278 (Pt 3) (Pt 3), 883-886 (1991)
   PUBMED   1654894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA859368.1, BF418570.1, AJ242781.1 and BE113255.1.
            
            On Jan 10, 2008 this sequence version replaced NM_019312.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ242781.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5756307, SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AA859368.1         353-401             c
            50-393              AA859368.1         8-351               c
            394-470             BF418570.1         1-77
            471-3627            AJ242781.1         20-3176
            3628-3951           BE113255.1         1-324               c
FEATURES             Location/Qualifiers
     source          1..3951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..3951
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /note="inositol-trisphosphate 3-kinase B"
                     /db_xref="GeneID:54260"
                     /db_xref="RGD:2932"
     exon            1..295
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
     exon            296..2390
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
     CDS             495..3299
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /EC_number="2.7.1.127"
                     /note="IP3K-B; IP3 3-kinase B; insP 3-kinase B; inositol
                     1,4,5-trisphosphate 3-kinase B"
                     /codon_start=1
                     /product="inositol-trisphosphate 3-kinase B"
                     /protein_id="NP_062185.2"
                     /db_xref="GeneID:54260"
                     /db_xref="RGD:2932"
                     /translation="MAVYCYALNSLVIMNSTNELKSGSPLPSGSETPQPSGRAALSPG
                     SVFSPGRGASFLFPPAESLSLEEPGSAGGWRSGRRRLNSSSGSGGGSSSSNSSSSSGV
                     GSPSWAGRLRGDAQQVVATRILSPPGPEEAQRKLRILQRELQNVQVNQKVGMFEAQIQ
                     AQTSAIQAPRSPRLGRARSPSPCPFRSSSQPPERVLAPCSPSEERRTKSWGEQCTETP
                     DANSRRRSRLSTHPSKDKEGVAPLLGPASPTRLGTQSPSTSVRMERGSPASPRCGSPT
                     PMEIDKRTAPSLEHFGTSLTLATKVAASAASAGPHPGHDSVLMEADCELGAMRPWEAH
                     LERRGQFLGRETGSAPEPIRTHIREPPGRVERVHSVGGQGSWTPEVIKRPEEGTVDAQ
                     SSELSENPRWSRLPGDPGSVGPEKGGSRIPGIRGPQQTLDSMREGSSALGLLGGSQAA
                     QPGSMDVETGISCGRMLEPLPPGEVTTNLKEPQCLPGDRMGMQPESSIVWPSAVEEAP
                     LIWTCDTGIQLKGTWRSQDGDAHPSCQEKSPDQKDKACSPSNIPAIPAVIITDMGAQE
                     DGGLEEIQGSPRGPLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHT
                     LDQQKPRVSKSWRKIKNMVQWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCE
                     SEQRCLDRLMADVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYL
                     EEELTKARKKPSLRKDMYQKMVEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLG
                     FRIEGIKKEDGSVNRDFKKTKTREQVTEAFREFTKGNQNILIAYRDRLKAIRETLEVS
                     PFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYL
                     SGLNNLIDILTEMSQGSPLT"
     exon            2391..2490
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2704
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2909
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3011
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3083
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3935
                     /gene="Itpkb"
                     /gene_synonym="IP3K B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttaaatct tacattgaac aaacactgaa gtagccggga gcagacgctg acagcagtag
       61 tgtctccaac caagcacgga gcagcgcacg acctggcggt gtcccctacg ggatcgccta
      121 gtccctgcgc cggtacattc agcctcgttg caccccacta ttttcgtctt ccaaaagttg
      181 ttgcggaaac cctttggggg cttttttttt taactttaag ccacctggtc tgtacgagcc
      241 cggagtcccc ggggcatgtc gcctgcacag gacctgggag tctgagcaat tgcagccgcg
      301 aaatcgttta tggagcttgg cgcgggggcc aagcctgaga tcttgccccg tgcccgccgc
      361 ctaggccatg ctgctccatc ggcgcgcgga gctgcggccg ccgggcctcc aggactaagc
      421 cgggagccgc gggaggagga ggcgccggcg gtggagcggg accgagagcc gcggcggcgg
      481 gcggacccag tactatggct gtgtactgct atgccctcaa tagcctggtg atcatgaaca
      541 gcaccaacga gctgaagagt ggcagccccc tgcccagcgg cagcgaaacg cctcagccct
      601 ccgggagggc cgcgctgagc cccggcagcg tcttcagccc tgggagaggc gcctcctttc
      661 tcttcccccc agcagagtcg ctgtcgctgg aggagcctgg gagtgctggg ggttggcgca
      721 gcggccgacg gaggctgaat agtagcagcg gtagcggagg tggcagcagc agcagcaaca
      781 gcagcagcag cagtggcgtg ggcagtccca gttgggctgg ccgcctgcga ggggacgcgc
      841 agcaggtggt ggcgacccgc atcctctccc cacctgggcc ggaggaggcc cagaggaagc
      901 tgaggattct gcagcgcgaa ttgcaaaatg tgcaggtgaa ccagaaagtg ggcatgttcg
      961 aggcgcaaat ccaggcacag acctctgcta ttcaagcgcc ccgaagcccg cgtttgggta
     1021 gggctcgttc gccctccccg tgtcccttcc gaagcagcag ccagcctcct gaaagggtct
     1081 tggctccatg ttccccaagt gaggaacgga gaacaaagtc ctggggagaa caatgtacag
     1141 agaccccaga tgccaactcc aggaggagaa gcagactcag cacacacccc tcgaaggaca
     1201 aggagggagt ggcccctctt ttaggcccag ccagcccgac caggttaggg actcagagtc
     1261 catctacttc agtgagaatg gaaagaggtt ccccggccag tccccgctgt ggctcaccca
     1321 cacccatgga aattgacaag aggactgctc cctcactgga gcactttggg actagcttaa
     1381 cgttggccac taaagtggca gcttcggccg catccgctgg accacaccct ggacatgatt
     1441 ctgttctcat ggaggcagac tgtgagctag gggccatgcg cccctgggag gcccacctgg
     1501 agagacgggg gcagtttctg ggcagggaga ccggctcagc cccagagcct atccggaccc
     1561 acattagaga accccctgga agggtggaaa gagttcattc tgttggtggc cagggctcct
     1621 ggacacctga agtcatcaaa agaccagaag agggaactgt ggatgcccaa agctcagagc
     1681 tctcagagaa cccgagatgg tctagactgc ctggagaccc gggttccgta gggcctgaga
     1741 agggaggtag taggatccca ggaatccgag gaccccagca gaccctggac agcatgagag
     1801 aagggtcttc agcactgggc ttgcttgggg gcagccaggc agcacagcca gggagcatgg
     1861 atgtggagac aggcattagt tgtggcagaa tgctggaacc cttaccacct ggggaagtaa
     1921 caacaaattt gaaagaaccc cagtgcctcc ctggggacag gatggggatg cagcctgaga
     1981 gttccatagt ttggcccagt gctgtggagg aagctcccct gatctggacg tgtgacacag
     2041 ggatacagtt aaaggggact tggagaagcc aagatggaga tgctcatcct agctgccaag
     2101 agaagtcccc agaccagaag gacaaggcct gcagccccag caacatcccg gccatccctg
     2161 cagtcatcat tacagatatg ggtgctcagg aggatggagg gttagaggag atccaaggaa
     2221 gccctcgggg tcccctgcct ctgaggaagc tgtcgtcctc ctcagcctcc tccactggct
     2281 tctcctcttc ctatgaggac tcggaggagg acatctccag tgaccctgag cgcactctgg
     2341 accccaactc agcctttttg cataccttgg accagcagaa gcccagagtg agcaagtcat
     2401 ggaggaagat aaagaacatg gtgcagtggt ccccctttgt catgtccttc aagaagaagt
     2461 acccctggat ccagctggca ggacatgcag ggagcttcaa ggcagctgcg aatggccgta
     2521 tccttaagaa gcattgtgag tctgaacagc gatgcctgga ccggttaatg gcggatgtgc
     2581 tgaggccctt cgtgccagcc taccatggcg acgtggtgaa ggacggggaa cgctacaacc
     2641 agatggacga cctgctggct gacttcgatt caccctgcgt gatggactgc aagatgggca
     2701 tcaggacata cctggaggaa gaactcacca aggcccggaa gaagcctagc ttgcggaagg
     2761 acatgtacca gaagatggtg gaggtggacc ctgaggcccc cactgaagag gagaaagccc
     2821 agagagctgt gaccaagcca cgttatatgc agtggcggga aaccatcagt tccacagcta
     2881 ccttaggctt caggatcgag ggcatcaaga aggaagatgg ctctgtgaac cgtgacttca
     2941 agaagaccaa aacaagggag caggtcactg aggccttcag agaattcact aaaggaaacc
     3001 agaacatcct gattgcctac cgggaccggt tgaaggccat tcgagaaacc ctggaagtct
     3061 ctcccttctt caagtgccat gaggtcattg gcagctctct cctcttcatc cacgacaaga
     3121 aggagcaagc caaggtgtgg atgattgact ttgggaaaac cacgcccctt ccggaaggcc
     3181 agaccctaca acacgatgtc ccctggcagg aggggaaccg ggaggatggc tacctctcag
     3241 ggctgaacaa cctcatcgac atcctgacag aaatgtccca gggcagccca ctcacctgag
     3301 gccaccagca ccttgcatag ccatgccacc ttgcccgcca cctctgcctg tcgcagcatc
     3361 tctcttcccc tgattcttct tccttttcct gtctgagcgc ctacctagaa cagagcctcc
     3421 catctgcact acaggacact ttggagaaga gaagagagat ttttttttct aggtctttat
     3481 ctcccgcctt cctacacagg ggcctggagg tggcgtttct aattctctct aaatagaact
     3541 accttctaga agagaattgc acagagctag gcccccgcat cccgttacac ttagagcctg
     3601 cacgggtcta gaaggctgtg ggatccctgg ctgcctaggg tcttaagaga ttgagcctcc
     3661 ctcccagaga ccctcccgcc ccgcacccct caccccccac tcccgagaaa gttctggccc
     3721 acattggcta ccagtggagg ccttctgccc cctggtggct ggtgccataa gtaaacacag
     3781 tcccattcgt gcctcctacc atggaccctg aagctagggt cctgctttct ggaagttggg
     3841 aagccaatct ctgggggatc tgcgtgtggc ttatgagaaa agtctcctgc agttagaagc
     3901 cccagctccc aaatacaccg tgtggcttct ctcgaaaaaa aaaaaaaaaa a
//
