LOCUS       NM_031045               1831 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus inositol-trisphosphate 3-kinase A (Itpka), mRNA.
ACCESSION   NM_031045
VERSION     NM_031045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Lee,D., Lee,H.W., Hong,S., Choi,B.I., Kim,H.W., Han,S.B., Kim,I.H.,
            Bae,J.Y., Bae,Y.C., Rhyu,I.J., Sun,W. and Kim,H.
  TITLE     Inositol 1,4,5-trisphosphate 3-kinase A is a novel
            microtubule-associated protein: PKA-dependent phosphoregulation of
            microtubule binding affinity
  JOURNAL   J Biol Chem 287 (19), 15981-15995 (2012)
   PUBMED   22389500
  REMARK    GeneRIF: Data show that protein kinse A (PKA) phosphorylated
            Ser-119 within inositol 1,4,5-trisphosphate 3-kinase A (IP(3)K-A),
            leading to a significant reduction of microtubule binding affinity.
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Eva,R., Bouyoucef-Cherchalli,D., Patel,K., Cullen,P.J. and
            Banting,G.
  TITLE     IP3 3-kinase opposes NGF driven neurite outgrowth
  JOURNAL   PLoS One 7 (2), e32386 (2012)
   PUBMED   22384237
  REMARK    GeneRIF: IP3 3-kinase opposes NGF driven neurite outgrowth
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Johnson,H.W. and Schell,M.J.
  TITLE     Neuronal IP3 3-kinase is an F-actin-bundling protein: role in
            dendritic targeting and regulation of spine morphology
  JOURNAL   Mol Biol Cell 20 (24), 5166-5180 (2009)
   PUBMED   19846664
  REMARK    GeneRIF: These results suggest that, in addition to its ability to
            regulate intracellular Ca(2+) via Ins(1,4,5)P(3) metabolism, ITPKA
            regulates structural plasticity.
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Kim,I.H., Park,S.K., Hong,S.T., Jo,Y.S., Kim,E.J., Park,E.H.,
            Han,S.B., Shin,H.S., Sun,W., Kim,H.T., Soderling,S.H. and Kim,H.
  TITLE     Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for
            synaptic Rac signaling
  JOURNAL   J Neurosci 29 (44), 14039-14049 (2009)
   PUBMED   19890013
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Ferreri-Jacobia,M., Mak,D.O. and Foskett,J.K.
  TITLE     Translational mobility of the type 3 inositol 1,4,5-trisphosphate
            receptor Ca2+ release channel in endoplasmic reticulum membrane
  JOURNAL   J Biol Chem 280 (5), 3824-3831 (2005)
   PUBMED   15537642
  REMARK    GeneRIF: the large majority of InsP3R3 channels free to diffuse
            throughout the endoplasmic reticulum, at rates that are comparable
            with those measured for other polytopic ER integral membrane
            proteins
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Dupont,G., Koukoui,O., Clair,C., Erneux,C., Swillens,S. and
            Combettes,L.
  TITLE     Ca2+ oscillations in hepatocytes do not require the modulation of
            InsP3 3-kinase activity by Ca2+
  JOURNAL   FEBS Lett 534 (1-3), 101-105 (2003)
   PUBMED   12527368
  REMARK    GeneRIF: these results suggest that oscillations in InsP(3)
            concentration due to Ca(2+)-stimulated InsP(3) catabolism do not
            play a major role for the oscillations in Ca(2+) concentration.
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Jun,K., Choi,G., Yang,S.G., Choi,K.Y., Kim,H., Chan,G.C.,
            Storm,D.R., Albert,C., Mayr,G.W., Lee,C.J. and Shin,H.S.
  TITLE     Enhanced hippocampal CA1 LTP but normal spatial learning in
            inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice
  JOURNAL   Learn Mem 5 (4-5), 317-330 (1998)
   PUBMED   10454357
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Communi,D., Lecocq,R., Vanweyenberg,V. and Erneux,C.
  TITLE     Active site labelling of inositol 1,4,5-trisphosphate 3-kinase A by
            phenylglyoxal
  JOURNAL   Biochem J 310 (Pt 1) (Pt 1), 109-115 (1995)
   PUBMED   7646431
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Takazawa,K., Vandekerckhove,J., Dumont,J.E. and Erneux,C.
  TITLE     Cloning and expression in Escherichia coli of a rat brain cDNA
            encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate
            3-kinase
  JOURNAL   Biochem J 272 (1), 107-112 (1990)
   PUBMED   2176078
REFERENCE   10 (bases 1 to 1831)
  AUTHORS   Choi,K.Y., Kim,H.K., Lee,S.Y., Moon,K.H., Sim,S.S., Kim,J.W.,
            Chung,H.K. and Rhee,S.G.
  TITLE     Molecular cloning and expression of a complementary DNA for
            inositol 1,4,5-trisphosphate 3-kinase
  JOURNAL   Science 248 (4951), 64-66 (1990)
   PUBMED   2157285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M29787.1, JAXUCZ010000003.1 and BQ204027.1.
            
            On Aug 4, 2012 this sequence version replaced NM_031045.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29787.1, X56917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1434              M29787.1           1-1434
            1435-1735           JAXUCZ010000003.1  127188026-127188326
            1736-1831           BQ204027.1         1-96                c
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1831
                     /gene="Itpka"
                     /note="inositol-trisphosphate 3-kinase A"
                     /db_xref="GeneID:81677"
                     /db_xref="RGD:619950"
     exon            1..528
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1425
                     /gene="Itpka"
                     /EC_number="2.7.1.127"
                     /note="IP3K A; IP3 3-kinase A; insP 3-kinase A; inositol
                     145-triphosphate 3-kinase; inositol 1,4,5-triphosphate
                     3-kinase; inositol 1,4,5-trisphosphate 3-kinase A"
                     /codon_start=1
                     /product="inositol-trisphosphate 3-kinase A"
                     /protein_id="NP_112307.2"
                     /db_xref="GeneID:81677"
                     /db_xref="RGD:619950"
                     /translation="MTLPGHPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAA
                     VAAAAAAGEPRARGAKRRGGQVPNGLPRAAPAPVIPQLTVTSEEDVAPASPGPPDREG
                     NWLPAAGSHLQQPRRLSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETSEDVG
                     QKSHWQKIRTMVNLPVMSPFKKRYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYCLV
                     RLMADVLRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKA
                     RERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIK
                     KADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLKRYLNRLQQIRDTLEISDFFRRHE
                     VIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLI
                     GILANLAER"
     exon            529..625
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            626..842
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1047
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1149
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1221
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1814
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgccgcgg gctggtgggc tcggctgccg ctccggtgtc gggagatgac cctgcccgga
       61 cacccgacgg gcatggcgcg accacggggc gcggggccct gcagccccgg gttggagcgg
      121 gctccgcgcc ggagcgtcgg ggagctgcgc ctgctcttcg aagcgcgctg cgccgcagtc
      181 gccgccgcag cggccgcagg ggagccccgg gcccgcgggg ccaagcggcg tgggggacaa
      241 gtgcctaacg ggctcccgcg tgctgcccct gctccggtga tcccgcagct cactgtgaca
      301 agcgaggagg atgtggcccc ggccagcccc gggccgccgg accgggaggg gaactggctc
      361 ccagctgcgg ggtcgcacct gcagcagcca cgccgcctct ccacctcgtc cctctcctcc
      421 accggctcct cgtcgctgct cgaggactcg gaggacgacc tgctgagcga cagcgagagc
      481 cggagccgcg gcaacgtgca gctggaaacc agcgaagacg tggggcagaa aagccattgg
      541 cagaagatcc gtaccatggt caacctgcct gtcatgagtc ctttcaaaaa gcgctactcc
      601 tgggtgcagt tagcagggca cacagggagt ttcaaagctg cgggcaccag cggcctgatc
      661 ctgaagcgca gctcggagcc tgaacactac tgcctggtgc ggttgatggc tgatgtgctg
      721 cgtgggtgtg tgccggcctt ccacggtgtg gtcgagcggg atggtgaaag ctacttacag
      781 ttacaggacc tgcttgatgg cttcgatgga ccttgcgtgc ttgactgcaa gatgggtgtc
      841 agaacttacc tggaagaaga gctgaccaaa gcccgagaac ggcccaagct gcgaaaggac
      901 atgtataaga aaatgctggc cgtggacccc gaggcaccta ctgaggagga gcatgcgcag
      961 cgtgccgtca caaaacctcg atacatgcaa tggcgcgaag gcatcagctc cagcactaca
     1021 ctcggcttcc gcatcgaggg catcaagaaa gccgatggat cttgcagtac tgatttcaaa
     1081 actacacgaa gcagagagca agtgactcga gtctttgagg agttcatgca aggagatgct
     1141 gaagtgctga agaggtatct gaaccgccta cagcagatcc gggataccct ggagatctct
     1201 gatttcttta gacggcacga ggtgattggc agctcactcc tcttcgtgca tgaccattgc
     1261 catcgcgctg gtgtgtggct catcgatttt ggcaagacca cgcctctccc cgatggccag
     1321 atcctggatc atcggaggcc ctgggaggag ggcaatcgtg aggacggcta tttgctgggg
     1381 ctggacaatc tcattggcat cttggccaac ctggctgaga gatgaggctg ggcccttttc
     1441 cctcagcttg ggccagctgg tcagagatgt ggacctgtgg ctgcatcccc accatgcatg
     1501 ccggcaagag actggaaccc cgctgggcgg gcagttcaca tggtcctgga ggaccaggtg
     1561 ccatccacta agggggtgta gtacattagg agctggcttc tacacaagcc tgtctcccag
     1621 agctgaatga cactaattta taggagagga aggaaacagt gggcttctcc cccagccttg
     1681 tcaagtgact ttgcacctct ccagagggtc ccgatccaga attgtacttc acagttatat
     1741 agacttactg gtctaacttc ctacactacc atggacaccc ttcctaataa aactcaaaga
     1801 ttcagcttct gtgaaaaaaa aaaaaaaaaa a
//
