LOCUS       NM_001191985            1635 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus inositol-tetrakisphosphate 1-kinase (Itpk1),
            mRNA.
ACCESSION   NM_001191985 XM_576090
VERSION     NM_001191985.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Dovey,C.M., Diep,J., Clarke,B.P., Hale,A.T., McNamara,D.E., Guo,H.,
            Brown,N.W. Jr., Cao,J.Y., Grace,C.R., Gough,P.J., Bertin,J.,
            Dixon,S.J., Fiedler,D., Mocarski,E.S., Kaiser,W.J., Moldoveanu,T.,
            York,J.D. and Carette,J.E.
  TITLE     MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
  JOURNAL   Mol Cell 70 (5), 936-948 (2018)
   PUBMED   29883610
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Wilson,M.P., Hugge,C., Bielinska,M., Nicholas,P., Majerus,P.W. and
            Wilson,D.B.
  TITLE     Neural tube defects in mice with reduced levels of inositol
            1,3,4-trisphosphate 5/6-kinase
  JOURNAL   Proc Natl Acad Sci U S A 106 (24), 9831-9835 (2009)
   PUBMED   19482943
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Yang,L., Reece,J., Gabriel,S.E. and Shears,S.B.
  TITLE     Apical localization of ITPK1 enhances its ability to be a modifier
            gene product in a murine tracheal cell model of cystic fibrosis
  JOURNAL   J Cell Sci 119 (Pt 7), 1320-1328 (2006)
   PUBMED   16537650
REFERENCE   4  (bases 1 to 1635)
  AUTHORS   Yang,X. and Shears,S.B.
  TITLE     Multitasking in signal transduction by a promiscuous human
            Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 551-555 (2000)
   PUBMED   11042108
REFERENCE   5  (bases 1 to 1635)
  AUTHORS   Wilson,M.P. and Majerus,P.W.
  TITLE     Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning
            and expression of the recombinant enzyme
  JOURNAL   J Biol Chem 271 (20), 11904-11910 (1996)
   PUBMED   8662638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jul 17, 2010 this sequence version replaced XM_576090.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.36880.1,
                                           SRR26643429.24959.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000006.1  127608769-127608863 c
            96-120              JAXUCZ010000006.1  127580269-127580293 c
            121-246             JAXUCZ010000006.1  127530478-127530603 c
            247-364             JAXUCZ010000006.1  127513652-127513769 c
            365-463             JAXUCZ010000006.1  127496974-127497072 c
            464-504             JAXUCZ010000006.1  127496485-127496525 c
            505-670             JAXUCZ010000006.1  127492958-127493123 c
            671-738             JAXUCZ010000006.1  127487227-127487294 c
            739-901             JAXUCZ010000006.1  127481844-127482006 c
            902-1635            JAXUCZ010000006.1  127476808-127477541 c
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1635
                     /gene="Itpk1"
                     /note="inositol-tetrakisphosphate 1-kinase"
                     /db_xref="GeneID:500709"
                     /db_xref="RGD:1595691"
     CDS             1..1266
                     /gene="Itpk1"
                     /EC_number="2.7.1.-"
                     /note="inositol 1,3,4-triphosphate 5/6 kinase"
                     /codon_start=1
                     /product="inositol-tetrakisphosphate 1-kinase"
                     /protein_id="NP_001178914.1"
                     /db_xref="GeneID:500709"
                     /db_xref="RGD:1595691"
                     /translation="MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLS
                     RPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRT
                     LLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRV
                     AHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNF
                     SAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVS
                     LFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVA
                     PLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLP
                     HQRLGCTTGVSPSFQQHCVASLATKASSQ"
     exon            1..95
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            96..120
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            121..246
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..364
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..463
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..504
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..670
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..738
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..901
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1635
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcagacct tcctgaaagg gaagagagtt ggctactggc tgagcgagaa gaaagtcaag
       61 aagctcaatt tccaggcctt cgcggagctg tgcaggaagc gagggatcga ggtcgtgcag
      121 ctgaacctga gccggccaat tgaggagcag ggccccctgg atgtcatcat ccacaagctg
      181 accgatgtca tcctcgaggc tgaccagaat gacagccagt ccctggaatt ggtgcacagg
      241 ttccaagagt acatcgatgc tcaccctgag accatcgtcc tggaccccct tcccgccatc
      301 aggaccctgt tagaccgctc caagtcctac gagctcatcc gcaagatcga ggcctatatg
      361 aaagatgaca ggatctgctc gccacccttc atggagctca cgagcctgtg tggggatgac
      421 accatgaggc tgctggagca gaacggcctg gccttcccct tcatttgcaa aaccagagtg
      481 gctcatggca ccaactctca tgagatggcc attgtgttta accaagaggg cctgagtgcc
      541 atccaacctc cctgtgtggt ccagaacttc atcaaccaca atgctgtgct gtacaaggtg
      601 tttgtggtgg gcgagtccta cacagtggtc cagagaccct cactcaagaa cttctccgcg
      661 ggcacctcag atcgtgaatc catcttcttc aacagccaca atgtgtcaaa gccggagtct
      721 tcctcagtcc tcactgagct ggacaagatt gagggcgtat tcgaacggcc aagtgacgag
      781 gttatccggg agctgtcccg ggctctgcgg caggcgctgg gagtgtcact gtttggaatc
      841 gacatcatca ttaacaacca gacgggtcag cacgcagtca tagatgtcaa tgccttccca
      901 ggctatgagg gagtgagtga gttctttacc gacctcctga accacattgc cacagtactg
      961 caaggccaga gcacaggagg agctgccaca gaggaagtgg ccccactaag gcacaacagg
     1021 ctcctggcag aaccggcagg cagcctggct ggtgagcgga cgtgcagtgc cagccctggc
     1081 tgctgcagca gcatgaaggg ccaggacaca ccctggaaga ctgaggccga agcgggcaac
     1141 atgggcgctg gtggtggtgg ttccgccaag ctgccgcacc agagacttgg ctgcaccacc
     1201 ggcgtgtcac ccagcttcca gcagcactgt gtggcctctc tggccaccaa ggcctcctca
     1261 cagtagccac agagcccagg acccagaggg gcggagcaga gcgtggagca cacccactgg
     1321 gccagcagct ccaaatggga acactactaa gaatccctgg tgatctgacg cttctctgtt
     1381 ttaatttttt acctgatttt ctgatgttag gatcggaatg aggggggaga cagagcagaa
     1441 acaccaagtg gtccagcctg gaggatgccg cctaaactcc tgctgtgcag atctcctcac
     1501 tgagtttaca cacgcttgtg ttctcaacac taggtctgaa tgcgaggtgg ggtgtgcacg
     1561 tgcgtgtgtg cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1621 tgtgtgtggt cgtca
//
