LOCUS       NM_001107774            1184 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus inosine triphosphatase (Itpa), mRNA.
ACCESSION   NM_001107774 XM_001081181 XM_230604
VERSION     NM_001107774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Tsuchiya,A., Aomori,T., Sakamoto,M., Takeuchi,A., Suzuki,S.,
            Jibiki,A., Otsuka,N., Ishioka,E., Kaneko,Y., Takeuchi,T. and
            Nakamura,T.
  TITLE     Effect of genetic polymorphisms of azathioprine-metabolizing
            enzymes on response to rheumatoid arthritis treatment
  JOURNAL   Pharmazie 72 (1), 22-28 (2017)
   PUBMED   29441893
REFERENCE   2  (bases 1 to 1184)
  AUTHORS   Delvaux,N., Costa,V.D., Costa,M.M., Villar,L.M., Coelho,H.S.,
            Esberard,E.B., Flores,P.P., Brandao-Mello,C.E.,
            Villela-Nogueira,C.A., Almeida,A.J. and Lampe,E.
  TITLE     Inosine triphosphatase allele frequency and association with
            ribavirin-induced anaemia in Brazilian patients receiving antiviral
            therapy for chronic hepatitis C
  JOURNAL   Mem Inst Oswaldo Cruz 110 (5), 636-643 (2015)
   PUBMED   26154744
REFERENCE   3  (bases 1 to 1184)
  AUTHORS   Rembeck,K., Waldenstrom,J., Hellstrand,K., Nilsson,S., Nystrom,K.,
            Martner,A., Lindh,M., Norkrans,G., Westin,J., Pedersen,C.,
            Farkkila,M., Langeland,N., Buhl,M.R., Morch,K., Christensen,P.B.
            and Lagging,M.
  TITLE     Variants of the inosine triphosphate pyrophosphatase gene are
            associated with reduced relapse risk following treatment for HCV
            genotype 2/3
  JOURNAL   Hepatology 59 (6), 2131-2139 (2014)
   PUBMED   24519039
REFERENCE   4  (bases 1 to 1184)
  AUTHORS   D'Avolio,A., De Nicolo,A., Cusato,J., Ciancio,A., Boglione,L.,
            Strona,S., Cariti,G., Troshina,G., Caviglia,G.P., Smedile,A.,
            Rizzetto,M. and Di Perri,G.
  TITLE     Association of ITPA polymorphisms rs6051702/rs1127354 instead of
            rs7270101/rs1127354 as predictor of ribavirin-associated anemia in
            chronic hepatitis C treated patients
  JOURNAL   Antiviral Res 100 (1), 114-119 (2013)
   PUBMED   23933495
REFERENCE   5  (bases 1 to 1184)
  AUTHORS   Birerdinc,A., Estep,M., Afendy,A., Stepanova,M., Younossi,I.,
            Baranova,A. and Younossi,Z.M.
  TITLE     Gene expression profiles associated with anaemia and ITPA genotypes
            in patients with chronic hepatitis C (CH-C)
  JOURNAL   J Viral Hepat 19 (6), 414-422 (2012)
   PUBMED   22571903
REFERENCE   6  (bases 1 to 1184)
  AUTHORS   Abolhassani,N., Iyama,T., Tsuchimoto,D., Sakumi,K., Ohno,M.,
            Behmanesh,M. and Nakabeppu,Y.
  TITLE     NUDT16 and ITPA play a dual protective role in maintaining
            chromosome stability and cell growth by eliminating dIDP/IDP and
            dITP/ITP from nucleotide pools in mammals
  JOURNAL   Nucleic Acids Res 38 (9), 2891-2903 (2010)
   PUBMED   20081199
REFERENCE   7  (bases 1 to 1184)
  AUTHORS   Stocco,G., Cheok,M.H., Crews,K.R., Dervieux,T., French,D., Pei,D.,
            Yang,W., Cheng,C., Pui,C.H., Relling,M.V. and Evans,W.E.
  TITLE     Genetic polymorphism of inosine triphosphate pyrophosphatase is a
            determinant of mercaptopurine metabolism and toxicity during
            treatment for acute lymphoblastic leukemia
  JOURNAL   Clin Pharmacol Ther 85 (2), 164-172 (2009)
   PUBMED   18685564
REFERENCE   8  (bases 1 to 1184)
  AUTHORS   Lin,S., McLennan,A.G., Ying,K., Wang,Z., Gu,S., Jin,H., Wu,C.,
            Liu,W., Yuan,Y., Tang,R., Xie,Y. and Mao,Y.
  TITLE     Cloning, expression, and characterization of a human inosine
            triphosphate pyrophosphatase encoded by the itpa gene
  JOURNAL   J Biol Chem 276 (22), 18695-18701 (2001)
   PUBMED   11278832
REFERENCE   9  (bases 1 to 1184)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   10 (bases 1 to 1184)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081181.1, XM_230604.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216056.1, FQ230286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1184
                     /gene="Itpa"
                     /note="inosine triphosphatase"
                     /db_xref="GeneID:311422"
                     /db_xref="RGD:1589751"
     exon            1..129
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..660
                     /gene="Itpa"
                     /EC_number="3.6.1.9"
                     /note="inosine triphosphatase (nucleoside triphosphate
                     pyrophosphatase); ITPase; NTPase; nucleoside-triphosphate
                     diphosphatase; non-standard purine NTP pyrophosphatase;
                     nucleoside-triphosphate pyrophosphatase; non-canonical
                     purine NTP pyrophosphatase"
                     /codon_start=1
                     /product="inosine triphosphate pyrophosphatase"
                     /protein_id="NP_001101244.1"
                     /db_xref="GeneID:311422"
                     /db_xref="RGD:1589751"
                     /translation="MAASLVGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPE
                     YQGEPDEISIQKCQEAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLYQ
                     LLAGFEDKSAYALCTFALSTGDPSQPVLLFRGKTPGQIVMPRGSRDFGWDPCFQPDGY
                     EQTYAEMPKAEKNTISHRFRALFKLQEYFGVTDGAGDH"
     exon            130..187
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
     exon            188..252
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
     exon            253..326
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
     exon            327..358
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
     exon            359..474
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
     exon            475..551
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
     exon            552..1184
                     /gene="Itpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccggaag tgccttcccg gcaaagcgtt tctgggcatt ctggaccgta acccgcgctt
       61 gcaatggccg cgtctttggt tgggaagaag atagtgtttg tgacgggaaa cgcaaagaag
      121 ctggaggagg tcattcagat tctaggagat aagtttccat gcactttggt ggcgcagaaa
      181 attgacctgc ctgagtatca gggagaaccg gatgaaattt ccatacagaa gtgtcaggag
      241 gcagctcgac aggtgcaggg ccctgttctg gtggaggata cctgtttgtg ctttaatgca
      301 cttgggggac tgcctggccc ctacataaaa tggtttctgc agaagctgaa gcctgaaggt
      361 ctctaccagc tcctggccgg ctttgaagac aaatcagcct atgcactctg cacattcgct
      421 ctcagcactg gggaccccag ccagccagtg ctcctgttca gaggcaagac cccgggacag
      481 attgtgatgc ctcgaggtag ccgggacttc ggctgggatc cctgctttca gcctgatgga
      541 tatgagcaaa cgtatgcaga gatgccgaag gctgagaaga acaccatttc ccatcgcttc
      601 cgggctctgt tcaagctcca agagtacttt ggtgtgactg atggggctgg ggaccactag
      661 ggccatgggt gtggggggcc tagtgcagga caccctggga ggcaggcact cctctgggtt
      721 ccccctgccg gggatccggg cagcttcagc agccagttct tggaggagcg gctggctcta
      781 caccagagaa ctcagggcca ggtgacacta aactcctgcc ctttgagatt caagagttcc
      841 ctttgaccag gcatggtggt gcacactttt aatcccagaa ttcgggagga agaggcgaac
      901 agatctttgt gagttcaaag ccagcctggt ttacatattg aatttctgga cagccaaagc
      961 tatatagtga gacactgtct caaaaacaaa atagaaaaac caaaacaaca aacagttgtt
     1021 gttgcagcct ctgactctgg gattctgaga aaattttggg tgttcacatg tcttacctgg
     1081 ttgagggttt ggcaaagcaa cacacaactt ttgattttag agtgtaacaa atgtaaattc
     1141 tggaagacat ttttgtttcc taaataaatg gtgtgtctgt tttg
//
