LOCUS       NM_001009674            2083 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus integral membrane protein 2C (Itm2c), mRNA.
ACCESSION   NM_001009674 XM_217467
VERSION     NM_001009674.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Matsuda,S., Matsuda,Y. and D'Adamio,L.
  TITLE     CD74 interacts with APP and suppresses the production of Abeta
  JOURNAL   Mol Neurodegener 4, 41 (2009)
   PUBMED   19849849
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 2083)
  AUTHORS   Martin,L., Fluhrer,R. and Haass,C.
  TITLE     Substrate requirements for SPPL2b-dependent regulated intramembrane
            proteolysis
  JOURNAL   J Biol Chem 284 (9), 5662-5670 (2009)
   PUBMED   19114711
REFERENCE   4  (bases 1 to 2083)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2083)
  AUTHORS   Gong,Y., Wu,J., Qiang,H., Liu,B., Chi,Z., Chen,T., Yin,B., Peng,X.
            and Yuan,J.
  TITLE     BRI3 associates with SCG10 and attenuates NGF-induced neurite
            outgrowth in PC12 cells
  JOURNAL   BMB Rep 41 (4), 287-293 (2008)
   PUBMED   18452648
REFERENCE   6  (bases 1 to 2083)
  AUTHORS   Wu,H., Liu,G., Li,C. and Zhao,S.
  TITLE     bri3, a novel gene, participates in tumor necrosis
            factor-alpha-induced cell death
  JOURNAL   Biochem Biophys Res Commun 311 (2), 518-524 (2003)
   PUBMED   14592447
REFERENCE   7  (bases 1 to 2083)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087127.1.
            
            On Jan 13, 2005 this sequence version replaced XM_217467.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087127.1, EV776872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2083
                     /gene="Itm2c"
                     /note="integral membrane protein 2C"
                     /db_xref="GeneID:301575"
                     /db_xref="RGD:1309503"
     exon            1..198
                     /gene="Itm2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..882
                     /gene="Itm2c"
                     /note="integral membrane protein 3"
                     /codon_start=1
                     /product="integral membrane protein 2C"
                     /protein_id="NP_001009674.1"
                     /db_xref="GeneID:301575"
                     /db_xref="RGD:1309503"
                     /translation="MVKISFQPAVAGVKAEKADKAAASGPASASAPAAEILLTPAREE
                     RPPRHRSRKGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLY
                     EDSLSSQIRTRLELEEDVKIYLEENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDI
                     SLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVRDKEALGS
                     FIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV"
     exon            199..339
                     /gene="Itm2c"
                     /inference="alignment:Splign:2.1.0"
     exon            340..528
                     /gene="Itm2c"
                     /inference="alignment:Splign:2.1.0"
     exon            529..639
                     /gene="Itm2c"
                     /inference="alignment:Splign:2.1.0"
     exon            640..790
                     /gene="Itm2c"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1948
                     /gene="Itm2c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaagaagta ggcactgcga tcgaggttgc acgggcaagg gctgcaggga gcaggcgcgg
       61 gtcagcgcag ccatggtgaa gatcagcttc cagcccgcgg tagcgggcgt caaggccgaa
      121 aaagcagaca aagcagcggc gtctggtccg gcctcggcat ctgccccggc cgcggagatt
      181 ctgctgacgc cggcgaggga ggaacgcccc cctcgccacc gctccaggaa agggggctcc
      241 gtgggcggtg tgtgctacct gtccatgggc atggttgtac tgcttatggg ccttgtgttt
      301 gcctcggtct acatctacag atacttcttc cttgctcagc tggcccgcga taacttcttc
      361 cactgcggtg tgctctacga agactcccta tcctcccaga tccggactcg gctggaactg
      421 gaggaggatg tgaagatcta tcttgaggag aactatgaac gtattaatgt ccctgtgccc
      481 cagtttggtg gtggggaccc tgcagacatc atccatgact ttcagcgggg tctcactgcc
      541 taccacgaca tctccctgga caagtgctac gtcattgagc tcaacaccac catcgtgctg
      601 cccccacgaa acttctggga gctcctcatg aacgtgaaga gagggaccta cctcccacag
      661 acgtacatca tccaggagga gatggtggtg acagagcatg tccgagacaa ggaggctctg
      721 ggttccttta tctaccacct gtgcaacggg aaggacacct atcggctgcg gcgccgggcc
      781 acccggaggc ggatcaacaa gcgtggggcc aagaactgca atgccatccg ccacttcgag
      841 aatacatttg tggtggagac gctcatctgt ggggtggtgt gaagccttct ctccaggctc
      901 acccctgccc tcctcttctc cttctggcca ctctctggcc ctcctcctcc ctttgcttag
      961 cttgtacctt gggcactttt ccatagatgt gacgtgtctc acccatcctt cccggccccg
     1021 ccctcctccc tgtaccaggg ctgtgatctc tcgggacctc tgcctctgcc gatatttcag
     1081 gcgggagatg ggaggggaca gttgcccaag atggtttctc taattcatta ttttaagtca
     1141 gcttcccagt ggctgggccc aggggaagga ctaaagggag gggctggaca tgtagaagcc
     1201 tggggcaggg gcaggggcag gggcaggggc atggatgggg tttggcatga ggttcacaaa
     1261 tggcccccac atatggggaa gtctgaaaga cttttatttt cttgcaccgc gcactccctc
     1321 tgtcctcctg gttcttagac ctaagtgtgg actaaggatg gggaagtgtg tcctgggtta
     1381 gacccatcag agcacaagat aaggtggcta acctgggttc ttcccaggac tcctgtcagt
     1441 gccttcagcc caccagtagg agcctggagt tggcgggtgg gatgaatctg ccaagcacaa
     1501 ttgttctctg agtggaacca aagaagtgag gagctaggcc gccctggcct ggcacctagg
     1561 aacacaggag caggtgggta tagaagtcat cggctgtgag ctgcaggccc tgggcagtgg
     1621 acggagccca tgccgtgctt tgcgccaggg ctactgtgaa tggtggaagc aggagggaga
     1681 gccacctggt actttcgtcc ctgcctcctc ctccgttccg gatctctccc ctctgtccag
     1741 gggtgtgtga cgtttctcct gcatgttttt actgatgttc gtgctggccg ccctcagccc
     1801 ggagcctggg agaggctttg gtgcctcgca tcagacttcg gtgctccgtg gcggtgaagc
     1861 ccttaaatgc tttgtatatt ttctctatta gatctctttt cagaagtgtc tgtagaaaat
     1921 taaaaaaaac aaaaacaaaa aaaaagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1981 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
