LOCUS       NM_001006963            1781 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus integral membrane protein 2B (Itm2b), mRNA.
ACCESSION   NM_001006963 XM_214228
VERSION     NM_001006963.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Yin,T., Yao,W., Norris,K.A. and D'Adamio,L.
  TITLE     A familial Danish dementia rat shows impaired presynaptic and
            postsynaptic glutamatergic transmission
  JOURNAL   J Biol Chem 297 (3), 101089 (2021)
   PUBMED   34416235
  REMARK    GeneRIF: A familial Danish dementia rat shows impaired presynaptic
            and postsynaptic glutamatergic transmission.
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Martins,F., Marafona,A.M., Pereira,C.D., Muller,T., Loosse,C.,
            Kolbe,K., da Cruz E Silva,O.A.B. and Rebelo,S.
  TITLE     Identification and characterization of the BRI2 interactome in the
            brain
  JOURNAL   Sci Rep 8 (1), 3548 (2018)
   PUBMED   29476059
  REMARK    GeneRIF: the resulting BRI2 brain interactome, associates this
            protein with neurite outgrowth and neuronal differentiation, as
            well as synaptic signalling and plasticity. It follows that further
            studies should address BRI2 particularly given its relevance to
            neuropathological conditions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Martins,F., Serrano,J.B., Muller,T., da Cruz E Silva,O.A.B. and
            Rebelo,S.
  TITLE     BRI2 Processing and Its Neuritogenic Role Are Modulated by Protein
            Phosphatase 1 Complexing
  JOURNAL   J Cell Biochem 118 (9), 2752-2763 (2017)
   PUBMED   28176357
  REMARK    GeneRIF: by modulating BRI2 processing using an ADAM10 inhibitor, a
            dual role for BRI2 in neurite outgrowth is suggested:
            phosphorylated full-length BRI2 appears to be important for the
            formation of neuritic processes, and BRI2 NTF promotes neurite
            elongation.
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Martins,F., Rebelo,S., Santos,M., Cotrim,C.Z., da Cruz e Silva,E.F.
            and da Cruz e Silva,O.A.
  TITLE     BRI2 and BRI3 are functionally distinct phosphoproteins
  JOURNAL   Cell Signal 28 (1), 130-144 (2016)
   PUBMED   26515131
  REMARK    GeneRIF: when BRI2 is phosphorylated a significant increase in
            neuronal outgrowth and differentiation is evident
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Fluhrer,R., Martin,L., Klier,B., Haug-Kroper,M., Grammer,G.,
            Nuscher,B. and Haass,C.
  TITLE     The alpha-helical content of the transmembrane domain of the
            British dementia protein-2 (Bri2) determines its processing by
            signal peptide peptidase-like 2b (SPPL2b)
  JOURNAL   J Biol Chem 287 (7), 5156-5163 (2012)
   PUBMED   22194595
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Fotinopoulou,A., Tsachaki,M., Vlavaki,M., Poulopoulos,A.,
            Rostagno,A., Frangione,B., Ghiso,J. and Efthimiopoulos,S.
  TITLE     BRI2 interacts with amyloid precursor protein (APP) and regulates
            amyloid beta (Abeta) production
  JOURNAL   J Biol Chem 280 (35), 30768-30772 (2005)
   PUBMED   16027166
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Fleischer,A., Ayllon,V., Dumoutier,L., Renauld,J.C. and Rebollo,A.
  TITLE     Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon
            IL-2-deprivation which interacts with Bcl-2
  JOURNAL   Oncogene 21 (20), 3181-3189 (2002)
   PUBMED   12082633
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Holton,J.L., Ghiso,J., Lashley,T., Rostagno,A., Guerin,C.J.,
            Gibb,G., Houlden,H., Ayling,H., Martinian,L., Anderton,B.H.,
            Wood,N.W., Vidal,R., Plant,G., Frangione,B. and Revesz,T.
  TITLE     Regional distribution of amyloid-Bri deposition and its association
            with neurofibrillary degeneration in familial British dementia
  JOURNAL   Am J Pathol 158 (2), 515-526 (2001)
   PUBMED   11159188
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Kim,S.H., Wang,R., Gordon,D.J., Bass,J., Steiner,D.F., Lynn,D.G.,
            Thinakaran,G., Meredith,S.C. and Sisodia,S.S.
  TITLE     Furin mediates enhanced production of fibrillogenic ABri peptides
            in familial British dementia
  JOURNAL   Nat Neurosci 2 (11), 984-988 (1999)
   PUBMED   10526337
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083735.1.
            
            On Nov 22, 2004 this sequence version replaced XM_214228.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083735.1, CF111200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..1781
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /note="integral membrane protein 2B"
                     /db_xref="GeneID:290364"
                     /db_xref="RGD:620727"
     exon            1..279
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..963
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /note="immature BRI2; transmembrane protein BRI"
                     /codon_start=1
                     /product="integral membrane protein 2B"
                     /protein_id="NP_001006964.1"
                     /db_xref="GeneID:290364"
                     /db_xref="RGD:620727"
                     /translation="MVKVTFNSALAQKEAKKDEPKSSEEALIAPPDAVAVDCKDPDDV
                     VPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGLKYIKDDVILSE
                     PSADAPAARYQTIEENIKIFEEDAVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLN
                     LDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENVDHLGFF
                     IYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAVETLICS"
     exon            280..408
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..615
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..726
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..877
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1757
                     /gene="Itm2b"
                     /gene_synonym="Bri; imBRI2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactgagccg ctgctgctgt cgcgcagttc gctcctccgc tgcagagtcg tgccctgagc
       61 tcggccgacg aggctgcacc cgcagccggg atcctgccac ccgcgacccc agccttcgcc
      121 gccgccgccg ccgccgccgc ctagggcgcc ccaggccgca ccatggtgaa ggtgacgttc
      181 aactcggcgc tggcccaaaa ggaggccaag aaggacgagc ccaagagcag cgaggaggcg
      241 ctcatcgccc ctccggatgc cgtggcggtg gattgcaagg acccggatga cgtggtccca
      301 gttggccaga ggagagcgtg gtgttggtgc atgtgctttg gactggcctt catgctcgct
      361 ggcgtcatcc tgggaggagc atacctctac aagtattttg cacttcagcc agatgatgtg
      421 tactactgtg gactaaagta catcaaagat gacgtcatct tgagtgagcc ttctgcagat
      481 gccccagctg ctcgatacca gacaattgaa gagaatatta agatctttga ggaagacgca
      541 gttgaattca tcagtgtgcc tgtaccagag tttgcggaca gcgatcctgc caacattgtg
      601 catgacttta acaagaaact cactgcttat ttggacctta atctggacaa gtgctacgtg
      661 attcctctga acacctccat tgttatgcca cccagaaacc tgttggagct tcttattaac
      721 atcaaggccg ggacctactt gcctcagtca tacctcatcc atgagcacat ggtgatcacc
      781 gaccgcatcg aaaacgtgga ccacctgggc ttcttcattt accgactgtg tcacgacaag
      841 gaaacctaca aactgcagcg cagggaaacc attagaggta ttcagaagcg tgaagccagt
      901 aactgtttca ccattcggca ttttgagaac aaatttgctg tggaaacttt aatttgttct
      961 tgagacgtca agaaaaaaag tgaggagaaa ttcaatgcca cagcataccc tgcccctttg
     1021 tattttgtgc agtgattgtt tttaaaatct tttcatgtaa gtagcaaaca gggcttcact
     1081 gtctcttcat ctcaataatt caattaaaaa ccattatctt aaaaaaaaga aaacaaaacc
     1141 ttcctttttt ctaagtgtgg tgtctttggc atttgagtta gcagatgtat gggttcctag
     1201 ataagatttg cttttccata gagtttacat actaggaaga atataactgt cttgacatca
     1261 ctaatctgga tttttgtgtt acttctgcac ttccatgagg gaagggtacc taaagaatag
     1321 acctttgcat cgctaagagg accgcggtga cttgcctgta gatgccgata gccctgctgc
     1381 ctagcctgtt agcatttgcg gtcaccttct cattgttgtg ttaactactt tagaggattt
     1441 cagccttgat gttttaatat cctaggcctc tgctgtaata agattttaga caactgtttg
     1501 gaatttaaga aacaactcat gttactaatt tgtacagccc atatctgtgc aatggaatat
     1561 aaatatcaca aagccatgtg atgagactgt gcgtcgtttt tcccatgaga taaaaaccaa
     1621 agaaatgatt tggttctcca tattttaagg taatccacgt gcataaagaa tgaaactatt
     1681 ttataaagtc tagttctcta catgcagtta taaaaatcag ctttttaaaa aaataaaaca
     1741 agccattaat tactaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
