LOCUS       NM_001108825            4181 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus IL2-inducible T-cell kinase (Itk), mRNA.
ACCESSION   NM_001108825 XM_001068881 XM_001068937 XM_017597420 XM_343880
VERSION     NM_001108825.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4181)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   2  (bases 1 to 4181)
  AUTHORS   Malhotra,N., Narayan,K., Cho,O.H., Sylvia,K.E., Yin,C.,
            Melichar,H., Rashighi,M., Lefebvre,V., Harris,J.E., Berg,L.J. and
            Kang,J.
  CONSRTM   Immunological Genome Project Consortium
  TITLE     A network of high-mobility group box transcription factors programs
            innate interleukin-17 production
  JOURNAL   Immunity 38 (4), 681-693 (2013)
   PUBMED   23562159
REFERENCE   3  (bases 1 to 4181)
  AUTHORS   Felices,M. and Berg,L.J.
  TITLE     The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine
            production, and survival
  JOURNAL   J Immunol 180 (5), 3007-3018 (2008)
   PUBMED   18292523
REFERENCE   4  (bases 1 to 4181)
  AUTHORS   Hwang,E.S., Szabo,S.J., Schwartzberg,P.L. and Glimcher,L.H.
  TITLE     T helper cell fate specified by kinase-mediated interaction of
            T-bet with GATA-3
  JOURNAL   Science 307 (5708), 430-433 (2005)
   PUBMED   15662016
REFERENCE   5  (bases 1 to 4181)
  AUTHORS   Perez-Villar,J.J., Whitney,G.S., Sitnick,M.T., Dunn,R.J.,
            Venkatesan,S., O'Day,K., Schieven,G.L., Lin,T.A. and Kanner,S.B.
  TITLE     Phosphorylation of the linker for activation of T-cells by Itk
            promotes recruitment of Vav
  JOURNAL   Biochemistry 41 (34), 10732-10740 (2002)
   PUBMED   12186560
REFERENCE   6  (bases 1 to 4181)
  AUTHORS   Schaeffer,E.M., Debnath,J., Yap,G., McVicar,D., Liao,X.C.,
            Littman,D.R., Sher,A., Varmus,H.E., Lenardo,M.J. and
            Schwartzberg,P.L.
  TITLE     Requirement for Tec kinases Rlk and Itk in T cell receptor
            signaling and immunity
  JOURNAL   Science 284 (5414), 638-641 (1999)
   PUBMED   10213685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Jun 4, 2021 this sequence version replaced
            XM_017597420.2, NM_001108825.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.39961.1,
                                           SRR26643284.13057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000010.1  31315777-31316004   c
            229-333             JAXUCZ010000010.1  31294589-31294693   c
            334-415             JAXUCZ010000010.1  31292715-31292796   c
            416-544             JAXUCZ010000010.1  31290845-31290973   c
            545-585             JAXUCZ010000010.1  31287438-31287478   c
            586-737             JAXUCZ010000010.1  31282905-31283056   c
            738-803             JAXUCZ010000010.1  31281076-31281141   c
            804-858             JAXUCZ010000010.1  31275190-31275244   c
            859-941             JAXUCZ010000010.1  31270715-31270797   c
            942-1075            JAXUCZ010000010.1  31269801-31269934   c
            1076-1150           JAXUCZ010000010.1  31269347-31269421   c
            1151-1322           JAXUCZ010000010.1  31267209-31267380   c
            1323-1539           JAXUCZ010000010.1  31265528-31265744   c
            1540-1604           JAXUCZ010000010.1  31264096-31264160   c
            1605-1723           JAXUCZ010000010.1  31263893-31264011   c
            1724-1881           JAXUCZ010000010.1  31260902-31261059   c
            1882-4181           JAXUCZ010000010.1  31254667-31256966   c
FEATURES             Location/Qualifiers
     source          1..4181
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..4181
                     /gene="Itk"
                     /note="IL2-inducible T-cell kinase"
                     /db_xref="GeneID:363577"
                     /db_xref="RGD:1311618"
     exon            1..228
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1953
                     /gene="Itk"
                     /EC_number="2.7.10.1"
                     /codon_start=1
                     /product="tyrosine-protein kinase ITK/TSK"
                     /protein_id="NP_001102295.2"
                     /db_xref="GeneID:363577"
                     /db_xref="RGD:1311618"
                     /translation="MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDR
                     HGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVMHDNYLLYVFAPDCESRQRW
                     VLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKLAVGCAPYDPTKNASKKPLPPT
                     PEDNRRSFQEPEETLVIALYDYQTNDPQELALRRDEEYYLLDSSEIHWWRVQDKNGHE
                     GYAPSSYLVEKSPNSLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVS
                     VFTKAIISENNPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRL
                     RYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKT
                     IQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQ
                     RGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL
                     DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE
                     VVEDISTGFRLYKPRLASPHVYQVMNHCWKEKPEDRPPFSRLLSQLAEIAECGL"
     exon            229..333
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            334..415
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            416..544
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            545..585
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            586..737
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            738..803
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            804..858
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            859..941
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1075
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1150
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1322
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1539
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1604
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1723
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1881
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..4181
                     /gene="Itk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgcatcc tgtcgcgttc ccagccgttc ctctccttca gtcgaactca ggggtgatgc
       61 ccgaggcgcc tcacctttca gaactggacc atgaacaact tcatcctcct ggaagaacag
      121 ctgatcaaga agtcccaaca gaagagaagg acttctccct cgaattttaa agtccgtttc
      181 ttcgtcttaa cgaaagccag cctggcatac ttcgaggacc gccacgggaa gaagcgcacg
      241 ttgaagggct ccatcgaact ctccagaatc aagtgcgtgg agattgtcaa gagtgacatt
      301 agcatcccgt gccactataa ataccctttt caggtcatgc acgacaacta cctcctgtac
      361 gtgtttgctc cagactgcga gagccgtcag cgctgggtgc tcacccttaa agaagaaacg
      421 aggaataaca acagcctagt atccaagtat caccctaatt tctggatgga tgggcggtgg
      481 aggtgctgtt cccagctaga gaagcttgcc gtaggctgtg ctccctacga cccaacgaag
      541 aatgcttcaa agaagcctct tcctcctact cctgaagaca acaggcggtc atttcaggaa
      601 cctgaagaaa ccctggtcat tgccttgtac gactaccaaa ccaacgatcc tcaggagctc
      661 gcgctgcggc gtgatgaaga gtactacctg ctggacagct ccgagatcca ctggtggcgg
      721 gttcaagaca agaatgggca tgaaggatat gcacccagca gttacctggt ggaaaagtct
      781 ccaaatagcc ttgaaaccta cgagtggtac aataaaagca tcagccgaga caaagctgaa
      841 aaacttcttt tggacacagg taaagaagga gcattcatgg tccgagattc caggacaccc
      901 gggacataca cagtctctgt cttcaccaag gccatcataa gtgagaacaa cccctgtata
      961 aaacattatc acatcaaaga aacaaatgac agccccaagc ggtactatgt ggctgagaag
     1021 tatgtgtttg actccatccc tctcctcatc cagtatcacc aatacaatgg aggaggtttg
     1081 gtcactcgac tccggtatcc agtttgctcc tggaggcaga aagcccctgt cacagcaggg
     1141 ctaagatatg ggaagtgggt gatccagccc tcggagctaa ctttcgtgca ggagattggc
     1201 agcgggcagt ttggactggt gcatctcggc tactggctca acaaggacaa ggtggccatc
     1261 aagaccattc aggaaggggc gatgtcagaa gaagacttta tcgaggaggc agaagtcatg
     1321 atgaaactct ctcaccccaa gctggtgcag ctctatgggg tgtgcttgga gcaagccccc
     1381 atctgcctgg tgtttgagtt catggagcac ggctgcctat cggattacct tcgaagtcag
     1441 cggggtctct ttgctgcaga gaccctgctg ggcatgtgcc tggacgtgtg tgagggcatg
     1501 gcctacctag aaaaagcgtg tgtcatccac agagacctgg ccgccaggaa ctgtttggtg
     1561 ggagaaaacc aggtcatcaa ggtgtccgac ttcggcatga caaggtttgt ccttgatgat
     1621 caatatacca gctccacggg caccaaattc ccagtgaagt gggcatcccc agaagtgttc
     1681 tccttcagcc gctacagcag caagtcagat gtgtggtcat ttggtgtact gatgtgggaa
     1741 gtcttcagcg aaggcaaaat cccatatgaa aaccgaagca attcagaggt cgtggaagac
     1801 atcagcactg gctttcggtt atacaagccc cgcctggcct cccctcatgt ctaccaggtc
     1861 atgaatcact gctggaaaga gaaaccggaa gaccggccac ccttctcccg gctgttaagc
     1921 caactggctg aaatcgcaga atgtggactt tagccgggac tcattgacca gccaccgcca
     1981 tgaatcctga gcgaaggaac aatgtccctt ttccaaagca ttaaaagctg ccaccagccc
     2041 aggaccccca caggtgcctg gaccatggcg gcagcacctg tgcagccaca actgcagcat
     2101 cctagaagac gctggagggc cagccgccga gccaacagct gggccgcagc tggagcagtg
     2161 tctctgtgtc tgccccatcc cagcctcttg tcatatgctg tactcgaggc tccattgccc
     2221 gctctcagga acagcccttc cccttctcag caatcaggag aggcagatgt aggccacgct
     2281 cttcttttta ttattatttt aagaatagtt caagtaatct ttaatttgac ccaacgagac
     2341 tatatgccta ttttatggat gggagagtag gaaagcaccg ttctttttct aagaaaccca
     2401 cggggtggtt aaagcagggt gttctactgc tgcaaggctg gcagccatag cttcctgcca
     2461 cacacgaggc agagtggatg cttgtgccag aggccggatg tcatacaact tcagagcaca
     2521 ctgccacctc tctttgatgg ggcacagcga gctccactgg gtggatagag tggggtgaca
     2581 cattcagagc ccatggctgg accacagggt gtctgagtct agtcaggaat gagagggcct
     2641 ccgatggtgg gaataaacgg gtgcagaaga agtctttggg ttgttactga tcctatgacc
     2701 ctgtgtaatg gcgagccacg tgcgtgactg gatctcctgt tctgcgtaga atgctgtggc
     2761 gatgactaca gaatgttcgc cactccagcc tctcaggagc ggcgtccaca cggcactgcc
     2821 cacatgaacc gagatagggc agcactgtga tgatcatgtt actttgagac attgggttct
     2881 ctcaggccct aggggtttgt ttagcagtct gaaggttgag tcaagcactg ggcggtgctt
     2941 ccaaaatgca cagaatgttg attggcactt gcacaggtga caggcatata gcccgcatgc
     3001 tggttattcc tgaggaaccg cagttcatcc caagccagac aactgtcctg gtgacagaac
     3061 tgggaaggac agagattgag acgccaccca aatataatcc agggcagcct cttagctctt
     3121 ctcaacactg cctcctgctg agaccggact gctaaggacg gtaacatagg aaagtcagac
     3181 cttaatcagc cacaccccca cccaaccatg ttgttcctac atagagcact ggggggcaca
     3241 gtgggaccct ccaatttgaa acggactgtt ctctttcttc atcttcatcc tcaccttcat
     3301 ctgagttcac aaccctcgag ccactcaaaa ttaacccttt cattctccca gcctaccaga
     3361 gtcacatcgc ctgaggccat ttatacaaga gcttcaaagg tgctctcaac tagcctcctg
     3421 cagactgttt gctgtaatta tcccttcaac ctagagctgg atctcttgtg aggaggagga
     3481 ttccctgatg ccaggcacac ttgatttccc tgcagtgttc aaacaaagct cctagaaaaa
     3541 tgatcagagt cacagatttc ctcttcctaa gtcacacagc attttgtctg gcttgcactt
     3601 cagatgcatc acttccggct gtaatcacca tgtccagcta aaactctgtc actcagaaaa
     3661 caatcttcct caactggccc acactcgtct ctgtttatgt ctcagcctac tgtacattct
     3721 cttttgggaa cccttaatta agagacggtt tctgggacat ccaacctaga cgctaaacac
     3781 tggaactgag agatgtctgt ggtgtggtct aggagactgc cctcccccac cataccgtgg
     3841 tcttggccct ctaacctcaa atgtgtggag gctttgatgg gcgtgtgtgc accgcttact
     3901 ccagtgtccc gcttaggaag atgggattct cttctgctgg tttctgtctt acatttttgt
     3961 aaatggtgcc cagtgttcac agaaaggttt tggttcgaaa tgtattttgt aggttttgca
     4021 attcgtaatg tttgggacta cgtatttatg cctggatcgg gagagtattt attgcttgtg
     4081 ttccagataa aagtacttca gatatgtctt accctctgta ggaggcacaa gtcaacagtt
     4141 gcttatggaa aaaaaaataa taataaagtt acatgtttta c
//
