LOCUS       NM_019369               2992 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain 4
            (Itih4), mRNA.
ACCESSION   NM_019369
VERSION     NM_019369.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2992)
  AUTHORS   Ma Y, Li R, Wang J, Jiang W, Yuan X, Cui J and Wang C.
  TITLE     ITIH4, as an inflammation biomarker, mainly increases in bacterial
            bloodstream infection
  JOURNAL   Cytokine 138, 155377 (2021)
   PUBMED   33348064
REFERENCE   2  (bases 1 to 2992)
  AUTHORS   Wang J, Zhu X, Xiong X, Ge P, Liu H, Ren N, Khan FA, Zhou X, Zhang
            L, Yuan X, Chen X, Chen Y, Hu C, Robertson ID, Chen H and Guo A.
  TITLE     Identification of potential urine proteins and microRNA biomarkers
            for the diagnosis of pulmonary tuberculosis patients
  JOURNAL   Emerg Microbes Infect 7 (1), 63 (2018)
   PUBMED   29636444
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2992)
  AUTHORS   Ivancic MM, Irving AA, Jonakin KG, Dove WF and Sussman MR.
  TITLE     The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate
            with the number of colonic adenomas in ApcPirc/+ rats
  JOURNAL   Cancer Prev Res (Phila) 7 (11), 1160-1169 (2014)
   PUBMED   25200834
REFERENCE   4  (bases 1 to 2992)
  AUTHORS   Noh CK, Kim SS, Kim DK, Lee HY, Cho HJ, Yoon SY, Lee GH, Hyun SA,
            Kim YJ, Kim HJ, Hwang JA, Ahn SJ, Shin SJ, Lee KM, Yoo BM, Cho SW
            and Cheong JY.
  TITLE     Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and
            prognostic indicator in patients with hepatitis B virus-associated
            hepatocellular carcinoma
  JOURNAL   Clin Biochem 47 (13-14), 1257-1261 (2014)
   PUBMED   24836184
REFERENCE   5  (bases 1 to 2992)
  AUTHORS   Desoubeaux G, Jourdan ML, Valera L, Jardin B, Hem S, Caille A,
            Cormier B, Marchand-Adam S, Bailly E, Diot P and Chandenier J.
  TITLE     Proteomic demonstration of the recurrent presence of
            inter-alpha-inhibitor H4 heavy-chain during aspergillosis induced
            in an animal model
  JOURNAL   Int J Med Microbiol 304 (3-4), 327-338 (2014)
   PUBMED   24360996
REFERENCE   6  (bases 1 to 2992)
  AUTHORS   Fujita Y, Ezura Y, Emi M, Sato K, Takada D, Iino Y, Katayama Y,
            Takahashi K, Kamimura K, Bujo H and Saito Y.
  TITLE     Hypercholesterolemia associated with splice-junction variation of
            inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene
  JOURNAL   J Hum Genet 49 (1), 24-28 (2004)
   PUBMED   14661079
REFERENCE   7  (bases 1 to 2992)
  AUTHORS   Bhanumathy CD, Tang Y, Monga SP, Katuri V, Cox JA, Mishra B and
            Mishra L.
  TITLE     Itih-4, a serine protease inhibitor regulated in
            interleukin-6-dependent liver formation: role in liver development
            and regeneration
  JOURNAL   Dev Dyn 223 (1), 59-69 (2002)
   PUBMED   11803570
REFERENCE   8  (bases 1 to 2992)
  AUTHORS   Gonzalez-Ramon N, Hoebe K, Alava MA, Van Leengoed L, Pineiro M,
            Carmona S, Iturralde M, Lampreave F and Pineiro A.
  TITLE     Pig MAP/ITIH4 and haptoglobin are interleukin-6-dependent
            acute-phase plasma proteins in porcine primary cultured hepatocytes
  JOURNAL   Eur J Biochem 267 (6), 1878-1885 (2000)
   PUBMED   10712621
REFERENCE   9  (bases 1 to 2992)
  AUTHORS   Pineiro M, Alava MA, Gonzalez-Ramon N, Osada J, Lasierra P, Larrad
            L, Pineiro A and Lampreave F.
  TITLE     ITIH4 serum concentration increases during acute-phase processes in
            human patients and is up-regulated by interleukin-6 in
            hepatocarcinoma HepG2 cells
  JOURNAL   Biochem Biophys Res Commun 263 (1), 224-229 (1999)
   PUBMED   10486281
REFERENCE   10 (bases 1 to 2992)
  AUTHORS   Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL and
            Salier JP.
  TITLE     The H4P heavy chain of inter-alpha-inhibitor family largely differs
            in the structure and synthesis of its prolin-rich region from rat
            to human
  JOURNAL   Biochem Biophys Res Commun 243 (2), 522-530 (1998)
   PUBMED   9480842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089806.1.
            
            On Mar 8, 2007 this sequence version replaced NM_019369.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089806.1, Y11283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2992              BC089806.1         1-2992
FEATURES             Location/Qualifiers
     source          1..2992
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2992
                     /gene="Itih4"
                     /note="inter-alpha-trypsin inhibitor heavy chain 4"
                     /db_xref="GeneID:54404"
                     /db_xref="RGD:70881"
     exon            1..105
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2817
                     /gene="Itih4"
                     /note="inter-alpha-inhibitor H4 heavy chain;
                     inter-alpha-trypsin inhibitor heavy chain H4;
                     inter-alpha-trypsin inhibitor heavy chain family, member
                     4"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H4
                     precursor"
                     /protein_id="NP_062242.2"
                     /db_xref="GeneID:54404"
                     /db_xref="RGD:70881"
                     /translation="MKSPAPAHMWNIVLVLLSLLAVLPITTTEKNGIDIYSLTVDSRV
                     SSRFAHTVVTSRVVNRADTVQEATFQVELPRKAFITNFSMIIDGVTYPGVVKEKAEAQ
                     KQYTAAVGRGESAGLVKTTGRKTEQFEVSVNVAPGSKTTFELIYQELLQRRLGMYELL
                     LKVRPEQLVKHLQMDIYIFEPQGISTLETESTFMTQELANALTTSQNKTKAHIQFKPT
                     LSQQRKSQNEQDTVLDGDFTVRYDVDRSSTGGTIQIENGYFVHHFAPEDLPTMAKNVL
                     FVIDKSGSMAGKKIQQTREALIKILKDLSTQDQFNIIVFSGEANQWEQLLVQATEENL
                     NRAVDYASKIPAQGGTNINKAVLSAVELLDKSNQAELLPSKSVSLIILLTDGEPTVGE
                     TNPKIIQKNTQEAINGRYSLFCLGFGFDVNYPFLEKLALDNGGLARRIYEDSDSALQL
                     QDFYQEVANPLLSSVTFEYPSNAVEDVTRYNFQHHFKGSEMVVAGKLRDQGPDVLLAK
                     VSGQMHLQNITFQTEASIAQQEKEFQGPKYIFHNFMERLWALLTIQQQLEQRISASGA
                     ELEALEAQVLNLSLKYNFVTPLTHMVVTKPEDQEQFQVAEKPTEVDGGVWSILSAVQR
                     HFKTPTTGSKLLTSRLRGNRFQTLSRLGDGLVGSRQYMPPPGLPGPPGLPGPPGPPGH
                     PHFASSIDYGRQPSLGRVLDLPSLSSQDPAGPSLAMLPKVVEQEGTTPEESPNPDHPR
                     APTIILPLPGSGVDQLCVDILHSEKPMKLFVDINQGLEVVGKYEKNIGFSWIEVTILK
                     PHLQVHATPERLVVTRGRKNSEYKWKKTLFSVLPGLKMTMDKTGLLQLSGPDKVTISL
                     LSLDDPQRGLMLLLNDTHHFSNDITGELGQFYQDIIWDDTKQTVRVLGIDYPATRELK
                     LSYQDGFPGTEISCWTVKI"
     exon            106..266
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            267..371
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            372..534
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..645
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            646..774
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            775..891
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1060
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1186
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1368
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1554
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1694
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1849
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1879
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1939
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2134
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2191
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2224
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2341
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2513
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2668
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2747
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2964
                     /gene="Itih4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaactgga gacaaatgaa gagccctgcc cctgcccaca tgtggaacat tgtactggtc
       61 ttgctctcgc tgttggctgt gcttccgatc actactactg agaagaatgg catcgatatc
      121 tacagtctca cagtggactc ccgggtctct tcccgatttg ctcatactgt tgttaccagc
      181 cgggtggtca acagagccga tactgttcaa gaagcgacct tccaagtaga gctacccagg
      241 aaagccttca tcaccaactt ctccatgatc attgatggtg tgacctaccc aggggttgtc
      301 aaagagaagg ctgaagccca gaagcaatac actgctgctg tgggccgggg agagagcgct
      361 ggccttgtca agaccactgg gagaaagaca gagcagtttg aagtgtcagt caacgtggcc
      421 cctggttcca agactacctt cgaactcata taccaagagc tgctccaaag acggctggga
      481 atgtatgagc tactcctcaa agtgaggcct gagcagctgg tcaagcacct tcagatggac
      541 atctacatct ttgagcctca gggtatcagc accctggaga cagagagtac tttcatgacc
      601 caggagttgg caaatgccct taccacttca cagaacaaga ccaaggcaca tatccagttc
      661 aagccgacac tctcccagca acggaagtct cagaatgagc aggacacggt gctagatggg
      721 gatttcaccg ttcgctatga tgtggaccgg tcttccactg gcggtaccat tcagattgag
      781 aacggctact ttgtgcacca ctttgcccca gaggaccttc ctacaatggc caagaatgtg
      841 ctctttgtca ttgataaaag cggatctatg gcaggcaaga aaatccaaca gacccgagaa
      901 gccctaatca agatcttgaa agacctcagc acccaagacc agttcaatat cattgtgttc
      961 agtggggaag caaaccagtg ggagcagttg ctggtgcaag caacagaaga gaacttgaac
     1021 agggcggttg actatgcttc caagatcccg gctcagggag ggaccaacat caataaagca
     1081 gtgctatcgg ctgtggaact gctggataaa agcaaccagg ctgagctact gccctccaag
     1141 agcgtttccc tcatcatcct gctcacggat ggcgagccca ctgtggggga gaccaatccc
     1201 aagattatcc agaagaacac acaggaagcc atcaatgggc ggtatagcct cttctgcctg
     1261 gggtttggct ttgatgtgaa ctatcctttc ctggagaagc tggccctgga caacggaggc
     1321 ctggcccggc gcatctacga ggactcagac tctgctctgc agcttcagga cttctaccag
     1381 gaagtggcca atccgctgct gtcatcagtg acctttgaat atcccagcaa tgctgtggag
     1441 gacgtcacgc ggtacaactt ccaacaccac tttaagggct cagagatggt ggtggctggg
     1501 aagctccggg accagggccc tgatgtcctc ttagccaaag tcagtgggca gatgcacctg
     1561 cagaacatca ctttccaaac ggaggccagc atagcccaac aagagaaaga gttccagggt
     1621 cctaagtaca tctttcataa ctttatggag agactctggg cgttgctgac catacagcaa
     1681 cagctggagc agaggatttc agcctcagga gctgagttag aggccctcga ggcccaagtt
     1741 ctgaacttgt cactcaagta caattttgtc actcctctca cgcacatggt ggtcaccaaa
     1801 cctgaagatc aagaacaatt ccaagttgct gagaagccta cggaagtcga tggtggagtg
     1861 tggagtatcc tctcagcagt tcaacggcat ttcaagactc ctaccacagg atctaaactg
     1921 ctgacatcca ggctgagagg aaataggttc cagacattgt ccagactcgg ggatggtctc
     1981 gttggatcta gacaatacat gcctcctcct ggacttcctg gacctcctgg acttcctgga
     2041 cctcctgggc ctcccggaca tcctcatttt gcttctagca ttgactacgg caggcagcct
     2101 tccttgggaa gggtgctaga cctgccatcc ttatcctcac aagatccagc cggcccaagt
     2161 ctagccatgt taccgaaagt ggtggaacaa gaaggcacca caccagagga atccccaaac
     2221 ccagaccacc cccgggctcc taccatcatc ctgccgcttc cgggatctgg tgtggaccag
     2281 ctctgtgtgg atatcttaca ttctgagaag cccatgaagc tgtttgtaga catcaatcag
     2341 gggctggagg tggttggcaa gtatgagaag aatatcgggt tctcatggat cgaagtgacc
     2401 atcctgaagc ctcacctgca ggtccatgca acgcctgaac gactggtggt gacaaggggc
     2461 cgaaaaaact ctgaatacaa gtggaagaag acactgttct ctgtgttacc tggcttaaag
     2521 atgaccatgg ataagacggg actgctacag ctcagtggcc cagacaaagt caccatcagc
     2581 ctcttgtctc tggatgaccc tcagagagga ctcatgctgc ttttgaatga cactcatcac
     2641 ttctccaacg acattacagg ggagcttggt cagttttacc aggatatcat ctgggatgat
     2701 acaaaacaga cagtcagagt tctaggaatc gactacccgg ctaccagaga gctcaagttg
     2761 agttatcaag acgggttccc gggaacagag atttcctgct ggacggtgaa gatatagaac
     2821 tgacaggagc attgtttgct acctgccatg ttgtcctcgt atgcaggcgg atgacactgt
     2881 gtgccaacag ggccgcctgt gaggcctaga ccttgatggg gaagaggatg ctctcttgtt
     2941 acaaataaag aagggtgatg tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
