LOCUS       NM_017351               2783 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus inter-alpha trypsin inhibitor, heavy chain 3
            (Itih3), mRNA.
ACCESSION   NM_017351
VERSION     NM_017351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Kaczmarczyk,A., Thuveson,M. and Fries,E.
  TITLE     Intracellular coupling of the heavy chain of pre-alpha-inhibitor to
            chondroitin sulfate
  JOURNAL   J Biol Chem 277 (16), 13578-13582 (2002)
   PUBMED   11827976
  REMARK    GeneRIF: Intracellular coupling of the heavy chain of
            pre-alpha-inhibitor to chondroitin sulfate
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Lahoz Zamarro,M.T., Abenia Ingalaturre,J.M., Valles Varela,H. and
            Herrero Blasco,T.
  TITLE     [Interaction between hypertriglyceridemia and noise in human
            hearing]
  JOURNAL   Acta Otorrinolaringol Esp 43 (6), 422-426 (1992)
   PUBMED   1299283
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X83231.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X83231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2783
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /note="inter-alpha trypsin inhibitor, heavy chain 3"
                     /db_xref="GeneID:50693"
                     /db_xref="RGD:620633"
     exon            1..100
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..2671
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /note="inter-alpha-trypsin inhibitor heavy chain H3;
                     ITI-HC3; ITI heavy chain H3; inter-alpha-inhibitor heavy
                     chain 3; pre-alpha-inhibitor, heavy chain 3"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H3
                     precursor"
                     /protein_id="NP_059047.1"
                     /db_xref="GeneID:50693"
                     /db_xref="RGD:620633"
                     /translation="MVTLWWPCLVLALLSGLETSGFPRSPLRLLGKRSLPEGVVDGIE
                     IYSTKISCKVTSRFAHNVVTTRAVNRADKAKEVSFDVELPKTAFITNFTLTIDGVTYP
                     GSVKEKEVAQKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVIFELTYEELL
                     KRNKGKYEMYLKVQPKQLVRHFEIDAHIFEPQGISMLDADASFITNDLLGSALTKSFS
                     GKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTIVYDVNRESPGNVQIVNGYFVHFFAPQ
                     GLPVVPKNIAFVIDVSGSMSGRKIQQTREALLKILDDMKEEDYLNFILFSTGVTTWKD
                     HLVKATPANLEEARAFVKNIRDRSMTNINDGLLRGIEMLNKAREDHLVPERSTSILVM
                     LTDGDANTGESRPEKIQENVRNAIRGKFPLYNLGFGNNLNYNFLESLALENHGFARRI
                     YEDSDASLQLQGFYEEVANPLLTNVELEYPENAILDLTRNSYPHFYDGSEIVVAGRLV
                     DRNVDNFKADVKGHGALNDLTFTEEVDMKEMDAALKEQGYIFGDYIERLWAYLTIEQL
                     LEKRKNARGDEKENITAEALELSLKYHFVTPLTSMVVTKPEDNEDQTAIADKPGEEAI
                     SASTAYLTSQQSSHSPYYYVDGDPHFIIQVPGKNDTICFNIDEKPGTVLSLIQDPVTG
                     IAVTGQIIGEKGNNASSRTGKTYFGKLGIANAWMDFRIEVTTEKIILGNGDALSTFSW
                     LDTVTVTQTGLSVTINRKKNMVVSFEDGISFVIVLHQVWKKHPVHQDFLGFYVVDSHR
                     MSAQTHGLLGQFFQPFDFKVFDVRPGSDPMKPDATMVVKSHRLTVTRGSQKDYRKDAS
                     VGTKVVCWFVHNNGEGFIDGVHTDYIVPSLF"
     exon            101..121
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            122..288
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            289..393
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            394..556
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..670
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..796
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..913
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1082
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1208
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1390
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1576
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1716
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1871
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1874
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1901
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1937
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2051
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2256
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2429
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2541
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2768
                     /gene="Itih3"
                     /gene_synonym="PAIHC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagcaatg gtgactctgt ggtggccctg ccttgtcttg gctctgctct ctggcttgga
       61 gacctctggc tttccaagga gtcccctccg gctgcttggg aaacggagcc ttccagaagg
      121 ggtggtggat ggcattgaga tctacagcac caagatcagc tgcaaggtga cctcccgctt
      181 tgctcacaat gttgtcacca caagggctgt caaccgtgca gacaaggcca aggaagtttc
      241 ctttgatgtg gaactgccca agacagcctt catcaccaac ttcaccttga ctattgatgg
      301 tgtcacctac cctgggagtg tcaaggagaa ggaagttgcg cagaaacaat atgaaaaggc
      361 tgtgtcccag ggcaagacag ccggtttggt caaggcctcc gggaggaagc tggagaagtt
      421 cacagtgtct gtcaatgtgg ccgcaggcag caaggtcatc tttgagctga cctatgaaga
      481 gctgctcaag agaaacaagg gaaagtacga gatgtacctt aaggtccagc ccaagcagct
      541 cgtcagacac tttgagatcg acgcacacat ttttgagcca cagggcatca gcatgttgga
      601 cgccgatgcc tcatttatca ctaatgacct cctgggaagt gccctcacca agtccttctc
      661 agggaaaaag gggcatgtgt ctttcaagcc cagcttagac cagcagcgct catgcccaac
      721 ctgtacggac tcccttctca acggggactt caccatcgtc tatgatgtga acagagagtc
      781 tccaggaaat gtgcagatag tcaatggcta cttcgtgcac ttctttgcac cccaaggcct
      841 cccagtggtg cctaagaaca tagcctttgt gattgacgtc agtggctcca tgtctggtcg
      901 gaaaatccag cagaccaggg aagcccttct caaaatcctg gatgatatga aggaagagga
      961 ctatctgaat ttcatcctct tcagcactgg tgtgaccacc tggaaagatc acctagtcaa
     1021 ggccacacct gcaaacctcg aggaggccag ggcgtttgtg aagaacatcc gtgatcgaag
     1081 catgaccaac atcaatgacg ggctgctgag gggtattgaa atgctgaaca aggcccgaga
     1141 agaccacctt gtcccggaga ggagcacctc catcctcgtc atgttgacag atggggatgc
     1201 taatactggc gagagcagac ctgaaaagat ccaggaaaac gtccggaacg ccatcagggg
     1261 caagttccct ttgtataacc tgggttttgg caacaatctg aattataatt tcctggagtc
     1321 tctggccctg gagaaccacg ggtttgcccg gcgtatttat gaagattctg atgccagctt
     1381 acagctgcag ggcttctacg aggaagtagc taatcccttg ttgactaatg tggagttaga
     1441 ataccctgag aatgccatcc tggacctcac cagaaacagt tacccccact tctatgatgg
     1501 ctctgagatt gttgtagcag ggcgtctggt ggacaggaac gtggacaact tcaaagcaga
     1561 tgtgaagggt catggggccc tgaatgacct gaccttcaca gaggaggtag acatgaagga
     1621 aatggacgcg gccctgaagg agcaaggcta catctttggg gactacattg agcggctctg
     1681 ggcctacctc actattgagc agttactgga gaaacgcaag aatgcccgtg gggatgagaa
     1741 ggagaacatc acagcagagg ccctggagct gtccctcaag taccactttg taactccact
     1801 gacctccatg gtggtgacca agcctgagga caacgaggac caaacagcca ttgctgacaa
     1861 gcctggggaa gaagccatct ctgcgtccac ggcctacctg accagtcagc agtccagcca
     1921 tagcccctac tattatgtgg atggggaccc ccacttcatc atccaagtcc cgggaaaaaa
     1981 tgacaccatc tgcttcaaca tcgatgagaa gcctggcacg gtgctgagcc ttattcaaga
     2041 cccagtcaca ggcatcgcag tgaccgggca gatcattgga gagaagggaa ataatgcttc
     2101 ttccaggaca gggaaaactt actttggcaa actgggcatt gccaatgctt ggatggactt
     2161 tcggattgag gtgaccacgg agaagatcat cctggggaac ggggatgcac tgagcacgtt
     2221 cagttggcta gacaccgtca cggtcacaca gacagggctg tctgtgacaa tcaacaggaa
     2281 aaagaatatg gtggtgtcct tcgaagatgg gattagcttt gtgatcgtcc tacaccaggt
     2341 ttggaagaaa catccggttc accaggactt cctagggttc tacgtggtgg acagtcaccg
     2401 gatgtcagca cagacacatg ggctgctggg ccagttcttc caaccctttg actttaaagt
     2461 gtttgacgtc cgcccaggct ctgaccccat gaagccagac gccacaatgg tggtgaagag
     2521 tcatcggttg acagtcacaa ggggctccca aaaagattac aggaaggatg ccagtgtcgg
     2581 caccaaggtc gtctgctggt ttgtccataa caatggggaa gggttcatcg acggtgtcca
     2641 caccgactat attgtcccca gcttgttctg agtacacatg ccagctgctg ctgcagtaga
     2701 aggcctggaa caggacacag aatggggctc gtgggaagga ctgggacaat aaagtgggta
     2761 aaccaaaaaa aaaaaaaaaa aaa
//
