LOCUS       NM_001419801            3106 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain 2
            (Itih2), mRNA.
ACCESSION   NM_001419801 XR_005495483
VERSION     NM_001419801.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 19, 2023 this sequence version replaced XR_005495483.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.43441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000017.1  73285281-73285472
            193-267             JAXUCZ010000017.1  73286765-73286839
            268-300             JAXUCZ010000017.1  73288259-73288291
            301-470             JAXUCZ010000017.1  73289801-73289970
            471-575             JAXUCZ010000017.1  73292571-73292675
            576-738             JAXUCZ010000017.1  73296198-73296360
            739-846             JAXUCZ010000017.1  73298489-73298596
            847-975             JAXUCZ010000017.1  73299209-73299337
            976-1092            JAXUCZ010000017.1  73300589-73300705
            1093-1261           JAXUCZ010000017.1  73303349-73303517
            1262-1387           JAXUCZ010000017.1  73304341-73304466
            1388-1569           JAXUCZ010000017.1  73308040-73308221
            1570-1755           JAXUCZ010000017.1  73309508-73309693
            1756-1895           JAXUCZ010000017.1  73310018-73310157
            1896-2065           JAXUCZ010000017.1  73312372-73312541
            2066-2203           JAXUCZ010000017.1  73314165-73314302
            2204-2317           JAXUCZ010000017.1  73317767-73317880
            2318-2516           JAXUCZ010000017.1  73318249-73318447
            2517-2689           JAXUCZ010000017.1  73319142-73319314
            2690-2801           JAXUCZ010000017.1  73319804-73319915
            2802-3106           JAXUCZ010000017.1  73321251-73321555
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..3106
                     /gene="Itih2"
                     /note="inter-alpha-trypsin inhibitor heavy chain 2"
                     /db_xref="GeneID:498793"
                     /db_xref="RGD:1565426"
     exon            1..192
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2949
                     /gene="Itih2"
                     /note="inter-alpha-trypsin inhibitor heavy chain H2"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H2
                     precursor"
                     /protein_id="NP_001406730.1"
                     /db_xref="GeneID:498793"
                     /db_xref="RGD:1565426"
                     /translation="MQQLVHLLVWLFLLEARAFEIPINGYSEFAEYDDLVELAPDKLP
                     FVQENRRHQRSLSEDSGEEMDSVDPVTLYSYKVQSTITSRMATTTIQSKLVNHSPLPQ
                     NVVFDVQIPKGAFISNFTMTVNGMTFTSSIKEKTVGRALYSQARAKGKTAGWVRSRTL
                     DMENFNTEVNIPPGAKVQFELHYQEVKWRKLGSYEHKIHLQPGKLAKHLEVNVWIIEP
                     QGMRFLHVPDTFEGHFQGVPVISKGQQKAHVSFKPTVAQQRKCPNCTETAVDGELVVV
                     YDVNREEKAGELEVFNGYFVHFFAPENLDPIPKNILFVIDVSGSMWGIKMKQTVEAMK
                     TILDDLRTEDQFSVVDFNHNVRSWRNDLVSATKTQIADAKRYIEKIQPSGGTNINEAL
                     LRAIFILNEASNMGLLNPDSVSLIILVSDGDPTVGELKLSKIQKNVKQNIQDNISLFS
                     LGIGFDVDYDFLKRLSNENRGIAQRIYGNRDTSSQLKKFYNQVSTPLLRNVQFNYPQA
                     SVTDVTQNSFHNYFGGSEIVVAGKFDPSKLSEVQSVITATSANTELVLETLSQMDDLE
                     EFLSKDKHADPEFTKKLWAYLTVNQLLTERSLAPTAASKRKITKAILQMSLDHHIVTP
                     LTAMVIENDAGDERMLADSPPQDHSCCSGALYYGTKVASGPIPSWANPSPTPATAMLA
                     VGAKPLESTPPPHVIRVENDPHFIIYLPKSKKNICFNIDSEPGKILSLVSDPESGLSV
                     NGQLIGAKKTENGKLSTYFGKLGFYFQKEDMKIEISTEAITLSSGSSTSRLSWSDTAR
                     LGNERILISVKKEKSVTLTVNKELVFSVLLHRVWKKHPVNVDFLGIYAPPTDKFSPSV
                     HGLLGQFMHEPDIHIFNERPGKEPGKPEASMEVKGHKLTVTRGMQKDYRTNIVFGTDV
                     PCWFVHNSGKGFIDGHYKDYFVPQLYGFLKRP"
     exon            193..267
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..300
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..470
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..575
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..738
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..846
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..975
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1092
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1261
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1387
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1569
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1755
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1895
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2065
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2203
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2317
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2516
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2689
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2801
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3106
                     /gene="Itih2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacgatctg ctctcaccaa cagacaagtt cctgtgaacc tggttcagca gtggggaatc
       61 gtccccagac catctgctct ggagagcttg gcacagatgt ctggcaaaat gcagcagctc
      121 gtgcacctcc tcgtctggct atttcttctg gaagcacgag ccttcgaaat ccccataaac
      181 ggatactctg agtttgcaga atatgatgat cttgtggaac tggctccaga taaacttcct
      241 tttgttcaag agaacagaag acatcagaga agcctttctg aagactcggg agaggagatg
      301 gactccgttg atccagtaac tctttatagt tacaaagtcc agtccactat tacgtctcgg
      361 atggctacaa ctaccattca gagcaaactg gtgaaccatt ccccattgcc ccaaaatgtc
      421 gtgttcgatg ttcagatccc caaaggggcc tttatctcca acttcaccat gactgtgaac
      481 ggtatgactt ttacaagctc cattaaagag aaaactgtgg gccgagctct ttattcacag
      541 gcaagagcga aaggcaagac ggccggatgg gtgaggagca gaactctcga tatggagaac
      601 ttcaacacgg aggtgaacat ccctcctgga gcaaaggtgc agtttgaact tcattaccag
      661 gaagtgaaat ggaggaaact gggatcctat gagcacaaga ttcatctgca gcctgggaag
      721 ctggccaagc acttggaggt gaatgtctgg attattgaac ctcaaggaat gagatttctt
      781 catgttcctg acacatttga aggtcatttc caaggtgtcc cagtcatatc caaaggacaa
      841 cagaaggcac atgtgtcctt caagcccaca gtagcacagc aaagaaaatg ccccaactgc
      901 acagagactg cagtggatgg agagctggta gtcgtgtatg acgtcaacag agaagaaaag
      961 gctggggaac ttgaggtatt taatggatat tttgtgcact tctttgctcc tgagaacctg
     1021 gacccaattc ccaaaaacat cctctttgtt attgatgtta gtggctccat gtggggaatt
     1081 aaaatgaaac agactgtgga agcgatgaag accatattgg atgacctaag aaccgaggac
     1141 caattctctg tggttgattt caaccataat gttagaagct ggagaaatga tttagtttca
     1201 gctactaaaa cacaaattgc agatgccaag agatacattg agaaaatcca gcctagtgga
     1261 ggcacaaata tcaatgaggc tctgctgaga gcaattttca ttctgaacga agccagtaac
     1321 atgggattgc tgaaccccga ctcagtctct ctgatcattt tggtttctga tggagatcca
     1381 acagtgggtg aactaaaact gtccaaaatt cagaaaaacg tgaagcagaa catccaagat
     1441 aacatctccc tcttcagtct ggggatcgga tttgatgtcg actatgactt tttgaagagg
     1501 ctgtccaatg aaaatcgcgg gattgctcaa cgaatctacg ggaaccggga cacatcctcc
     1561 cagctcaaga aattttacaa ccaggtctct actccgctgc ttagaaacgt tcagttcaac
     1621 taccctcagg catcagtaac agacgtcacc caaaacagtt tccataacta ctttggaggt
     1681 tctgagatcg tggtggcggg gaaatttgat cccagcaaac tgtcggaagt tcagagcgtc
     1741 atcaccgcga cttcggctaa cacagaattg gtcttggaaa ctctcagtca gatggatgac
     1801 ttggaggagt ttctatcaaa ggacaagcat gcagaccctg aattcaccaa gaagctctgg
     1861 gcctacctca cagtcaacca actgctaaca gagagaagtc tggctcctac cgccgctagc
     1921 aagaggaaaa tcacaaaagc catcctgcag atgtctctag accatcacat cgtgactccg
     1981 cttactgcca tggtgataga gaacgatgct ggcgatgagc gcatgctggc cgactcccca
     2041 ccacaggacc actcctgctg ctcaggcgca ctgtattatg gcaccaaggt tgcctcaggt
     2101 cccatcccat cgtgggccaa cccatcccca acaccagcga cggccatgct tgcagtcgga
     2161 gcgaagccac tcgagtctac accacctcct catgtgattc gagtggaaaa tgacccccac
     2221 ttcatcattt acctgccaaa aagcaaaaag aatatttgtt tcaatattga ctcagaacct
     2281 ggaaaaatcc tcagcctggt gtcagatcca gagtcagggc tttcagtcaa cggtcagctt
     2341 attggtgcca aaaagactga gaacgggaaa ctgagcacct actttgggaa actgggattc
     2401 tatttccaaa aggaagacat gaagatagaa atcagcacgg aggccatcac cctgagctcg
     2461 ggctcgtcca catctcgctt gtcttggtcc gacacagctc gtcttgggaa cgagaggatt
     2521 cttatttctg tgaagaaaga aaaatctgtg actctcactg tgaacaaaga gctggtcttt
     2581 tccgttctgc tgcaccgtgt gtggaagaag catccggtta atgtggactt cctggggatc
     2641 tacgctcccc cgacagacaa gttctcacct agtgtgcatg gactgttagg acagttcatg
     2701 catgaaccag acatccatat cttcaatgag aggccaggaa aagagccggg aaaaccagaa
     2761 gcgagcatgg aagtgaaagg acataagttg actgtcacca gaggcatgca gaaagactac
     2821 aggaccaata tagtgtttgg aacagacgtt ccctgctggt tcgtacacaa cagtgggaag
     2881 ggtttcatcg acggacatta caaggattat ttcgtgcctc agctctacgg ctttctcaaa
     2941 cggccttaat ggctttggtt ttggaaactg tacatgtacg tttttctctc ttgacacttt
     3001 ctgcagttag tcctcagttt cagtaacttg aaataaaccc agatattagg gtggcctaaa
     3061 tgcccgctaa cccggctgag aaaaaaataa atatttgcaa aaaaga
//
