LOCUS       NM_001107291            2906 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus inter-alpha trypsin inhibitor, heavy chain 1
            (Itih1), mRNA.
ACCESSION   NM_001107291 XM_001060219 XM_224609
VERSION     NM_001107291.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2906)
  AUTHORS   Disdier C, Zhang J, Fukunaga Y, Lim YP, Qiu J, Santoso A and
            Stonestreet BS.
  TITLE     Alterations in inter-alpha inhibitor protein expression after
            hypoxic-ischemic brain injury in neonatal rats
  JOURNAL   Int J Dev Neurosci 65, 54-60 (2018)
   PUBMED   29079121
  REMARK    GeneRIF: This study demonstrated that Alterations in Itih1
            expression after hypoxic-ischemic brain injury in neonatal rats
REFERENCE   2  (bases 1 to 2906)
  AUTHORS   Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez
            L, Borras FE and Falcon-Perez JM.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 2906)
  AUTHORS   Scarchilli L, Camaioni A, Bottazzi B, Negri V, Doni A, Deban L,
            Bastone A, Salvatori G, Mantovani A, Siracusa G and Salustri A.
  TITLE     PTX3 interacts with inter-alpha-trypsin inhibitor: implications for
            hyaluronan organization and cumulus oophorus expansion
  JOURNAL   J Biol Chem 282 (41), 30161-30170 (2007)
   PUBMED   17675295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166831.1.
            
            On Dec 2, 2010 this sequence version replaced NM_001107291.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2906              BC166831.1         1-2906
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2906
                     /gene="Itih1"
                     /note="inter-alpha trypsin inhibitor, heavy chain 1"
                     /db_xref="GeneID:306251"
                     /db_xref="RGD:1306099"
     exon            1..110
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..2726
                     /gene="Itih1"
                     /note="inter-alpha-trypsin inhibitor heavy chain H1"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H1
                     precursor"
                     /protein_id="NP_001100761.2"
                     /db_xref="GeneID:306251"
                     /db_xref="RGD:1306099"
                     /translation="MDGVTGLRVLLCLLTLQTMPALGLATGRPRGNEKRQAVDTTVNG
                     VSIRSLKVNCKVTSRFAHYVITSQVVNSANKAREVAFDVEIPKTAFISDFAITADGNA
                     FIGDIKDKVTAWKQYRKAAISGENAGLVRASGRNMEQFTIHITVGAQSKATFQLTYEE
                     VLKRRLTQYDIVIKVRPKQLVHHFEIDVDIFEPQGISRLDAQASFLSKELAAQTIKKS
                     FSGKKGHVLFRPTVSQQQSCPTCSTSLLNGDFKVTYDVNRDKLCDLLVANNYFTHFFA
                     PQNLTNMSKNLVFVIDISGSMEGQKVKQTKEALLKILGDMKPVDNFDLVLFGSQVQSW
                     KGSLVPASHANLQAAQDFVRRFSLAGATNLNGGLLRGIEILNRAQGSHPELSSPASIL
                     IMLTDGEPTEGETDRSQILKNVRNAIRGRFPLYNLGFGHDLDFSFLEVMSIENNGWAQ
                     RIYEDHDATQQLQGFYNQVAHPLLTDVELQYPQDAVLALTQHRHKQYYDGSEIVVAGR
                     IADHKLSTFKADVRAHGEKQEFKATCLVDEEEMKKLLRERGHMLENHVERLWAYLTIQ
                     ELLAKRMKTEGEERANLSSQILKMSLDYHFVTPLTSMTIRGLTDEDGLEPIIDKPPED
                     SQPLEMVGPRRTFVLSAAQPSPTAHPIGSKLPTRVTGVDTDPHFIIYVPTKEDSLCFN
                     INEEPGVILNLVQDPDTGFSVNGQLIGIKAGSPGQHESTYFGRLGVSSPTSDFQLEVT
                     PQNITLNPSSGGPVFSWRDQAVLQKDGVVVTINKKRNLVVSVDDGATFEIVLHRTWRG
                     SSIHQDFLGFYVLDSFRMSARTQGLLGQFFSPLDFEVFDLRPGSDPTKTDATMVVKNR
                     QLTVTRGLQKDYSKDPRHGTEVSCWFVHDNGAGLIDGVHTDYIVSDIF"
     exon            111..131
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..298
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..403
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..566
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..680
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..806
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..923
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1092
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1218
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1400
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1586
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1726
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1881
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1896
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1917
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1995
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2109
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2311
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2484
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2596
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2875
                     /gene="Itih1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctggagac catggatggt gtcacaggac tacgggtgct gctgtgtctc ctcactctgc
       61 agaccatgcc tgctctgggc ttggcaacag gcagacccag gggcaatgag aagcgacagg
      121 ctgtggacac aacagtcaat ggtgtgtcca tcaggagctt gaaagtcaat tgcaaagtca
      181 cctctcgctt tgcccactac gtcatcacca gtcaggtggt caacagtgct aacaaagcca
      241 gggaagtggc ttttgatgtg gaaatcccca agacagcctt catcagtgac tttgccataa
      301 cagcagatgg gaatgcattc attggggaca taaaggacaa agtgactgca tggaagcaat
      361 accggaaggc agccatttca ggagagaatg ctggccttgt cagggcctcg ggaagaaata
      421 tggagcagtt taccatccac atcactgttg gagcccagag caaggccacg ttccagctca
      481 cctatgagga ggtactaaag aggagactta cgcagtatga catcgtcatc aaagtgagac
      541 cgaagcagct ggtacaccat tttgagattg atgtggacat ctttgagccg caggggatca
      601 gcaggctgga tgctcaagcc tccttcctca gcaaggaact ggctgctcaa accatcaaga
      661 agtctttctc ggggaagaag ggtcatgtgc tcttccgccc cactgtgagc cagcagcagt
      721 cctgccccac gtgctctacc tccttgctga atggagactt caaggtgacc tacgatgtga
      781 accgagacaa gctctgtgac ctcctggtgg ccaacaatta ctttacacat ttctttgccc
      841 cccaaaacct gaccaacatg agcaagaacc tggtttttgt gattgatatc agtgggtcca
      901 tggaaggcca gaaagtgaag cagacaaagg aggcgctcct taagatattg ggggacatga
      961 agccagtaga caactttgac ctggtcctct ttgggtctca agtgcagtca tggaagggct
     1021 cactggtacc cgcgtctcac gccaatttgc aagcagccca agactttgtg aggcgctttt
     1081 ctttggctgg agccacaaac ctgaatggag gcttgctccg aggaatcgag atcttaaaca
     1141 gagctcaagg aagccaccca gaactcagca gccctgcctc aattcttatc atgttgaccg
     1201 acggagagcc cactgaaggg gagacggacc gttcccagat cctcaagaat gtccgcaacg
     1261 ctatccgggg cagattcccg ctctacaacc ttggctttgg tcacgacctg gactttagct
     1321 tcctggaggt catgtccatt gagaacaacg gatgggccca gagaatttac gaggaccacg
     1381 atgccaccca acagctacag ggtttctaca atcaagtagc ccaccccctg ctgacagatg
     1441 tggagctgca gtacccccag gacgctgtct tggctctaac acagcaccga cacaaacagt
     1501 actatgatgg ctctgagatc gtggtggctg gacgcattgc tgaccacaaa ctgagcacct
     1561 ttaaggcgga tgttcgggct catggggaaa agcaagaatt caaggcaacc tgcctggtgg
     1621 acgaggaaga gatgaagaag ctgctccgag agcgtggcca catgctagag aatcatgtgg
     1681 agaggctctg ggcctacctc actatccagg agctcctggc taagaggatg aagacagaag
     1741 gggaagagag ggccaacctg tcgtcccaga tcttgaagat gtcactggac tatcatttcg
     1801 taacgccgct gacctctatg actatcagag gcctgacaga cgaggatggg ctggagccca
     1861 tcattgacaa gcccccagag gattctcagc ccttagagat ggtgggaccc agaagaacgt
     1921 ttgtgctgtc agccgcacag ccttctccta cagcccaccc cataggctca aagttgccaa
     1981 cccgtgtgac aggtgtggat accgatcccc acttcatcat ctatgtaccc acaaaagagg
     2041 atagcctgtg cttcaacatc aatgaggaac ccggtgtgat cctgaaccta gtgcaggacc
     2101 ctgacacagg attctcggtg aatgggcagc tcattgggat aaaggccggc agccctgggc
     2161 agcatgagag cacatacttt gggagactgg gggtctcaag ccccacatca gactttcagc
     2221 tggaagtgac tcctcagaac attacactga accccagctc tggcgggccg gtgttctcct
     2281 ggagggatca ggctgtgctg cagaaggacg gggtagtggt gaccatcaac aagaagagga
     2341 acctggtggt gtctgtggac gacggggcta cctttgagat tgtcctccac agaacatgga
     2401 gggggagttc aatccaccag gacttcctgg gtttctatgt gctggatagc ttccggatgt
     2461 cagcccggac acagggacta ttggggcaat tcttctcccc actggatttt gaagtatttg
     2521 acctccgccc aggctctgac cctacaaaga cagatgccac aatggtggtt aagaatcggc
     2581 agctgacagt cacccgaggg ttacaaaagg actacagcaa ggaccccaga catggaacag
     2641 aagtgtcttg ctggtttgtc cacgacaatg gagctggact gattgatggc gtccacactg
     2701 actatatcgt ctctgacatc ttctgagccc tccagctagc acagcagccc ttgcctggaa
     2761 ctgcatgtga agtgggaggg acgagcttag caccagatta gctccacctt cctgagcaaa
     2821 ctggcccttt gtttcaagat atcctgtgat ttcattaaag agaagctgtg tccaaaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
