LOCUS       NM_001401817            8337 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus integrin subunit beta 8 (Itgb8), mRNA.
ACCESSION   NM_001401817 XM_006240697
VERSION     NM_001401817.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8337)
  AUTHORS   Cao,Y., Su,H., Zeng,J., Xie,Y., Liu,Z., Liu,F., Qiu,Y., Yi,F.,
            Lin,J., Hammes,H.P. and Zhang,C.
  TITLE     Integrin beta8 prevents pericyte-myofibroblast transition and renal
            fibrosis through inhibiting the TGF-beta1/TGFBR1/Smad3 pathway in
            diabetic kidney disease
  JOURNAL   Transl Res 265, 36-50 (2024)
   PUBMED   37931653
  REMARK    GeneRIF: Integrin beta8 prevents pericyte-myofibroblast transition
            and renal fibrosis through inhibiting the TGF-beta1/TGFBR1/Smad3
            pathway in diabetic kidney disease.
REFERENCE   2  (bases 1 to 8337)
  AUTHORS   Bai,Y.Y. and Niu,J.Z.
  TITLE     miR-222 regulates brain injury and inflammation following
            intracerebral hemorrhage by targeting ITGB8
  JOURNAL   Mol Med Rep 21 (3), 1145-1153 (2020)
   PUBMED   31894320
  REMARK    GeneRIF: miR222 regulates brain injury and inflammation following
            intracerebral hemorrhage by targeting ITGB8.
REFERENCE   3  (bases 1 to 8337)
  AUTHORS   Climent,M., Quintavalle,M., Miragoli,M., Chen,J., Condorelli,G. and
            Elia,L.
  TITLE     TGFbeta Triggers miR-143/145 Transfer From Smooth Muscle Cells to
            Endothelial Cells, Thereby Modulating Vessel Stabilization
  JOURNAL   Circ Res 116 (11), 1753-1764 (2015)
   PUBMED   25801897
REFERENCE   4  (bases 1 to 8337)
  AUTHORS   Li,J.H., Li,D.Y., Chen,D.P., Mu,D.Z. and Qu,Y.
  TITLE     [Effect of integrin beta8 on TGF-beta1 activation in astrocytes
            with oxygen glucose deprivation]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 16 (1), 73-76 (2014)
   PUBMED   24461183
  REMARK    GeneRIF: The highly expressed beta8 plays important roles in the
            regulation of TGF-beta1 activation in neonatal rats with
            hypoxic-ischemic brain damage.
REFERENCE   5  (bases 1 to 8337)
  AUTHORS   LaPointe,V.L., Verpoorte,A. and Stevens,M.M.
  TITLE     The changing integrin expression and a role for integrin beta8 in
            the chondrogenic differentiation of mesenchymal stem cells
  JOURNAL   PLoS One 8 (11), e82035 (2013)
   PUBMED   24312400
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8337)
  AUTHORS   Proctor,J.M., Zang,K., Wang,D., Wang,R. and Reichardt,L.F.
  TITLE     Vascular development of the brain requires beta8 integrin
            expression in the neuroepithelium
  JOURNAL   J Neurosci 25 (43), 9940-9948 (2005)
   PUBMED   16251442
REFERENCE   7  (bases 1 to 8337)
  AUTHORS   Hynes,R.O.
  TITLE     Integrins: bidirectional, allosteric signaling machines
  JOURNAL   Cell 110 (6), 673-687 (2002)
   PUBMED   12297042
  REMARK    Review article
REFERENCE   8  (bases 1 to 8337)
  AUTHORS   Zhu,J., Motejlek,K., Wang,D., Zang,K., Schmidt,A. and
            Reichardt,L.F.
  TITLE     beta8 integrins are required for vascular morphogenesis in mouse
            embryos
  JOURNAL   Development 129 (12), 2891-2903 (2002)
   PUBMED   12050137
REFERENCE   9  (bases 1 to 8337)
  AUTHORS   Nishimura,S.L., Sheppard,D. and Pytela,R.
  TITLE     Integrin alpha v beta 8. Interaction with vitronectin and
            functional divergence of the beta 8 cytoplasmic domain
  JOURNAL   J Biol Chem 269 (46), 28708-28715 (1994)
   PUBMED   7525578
REFERENCE   10 (bases 1 to 8337)
  AUTHORS   Moyle,M., Napier,M.A. and McLean,J.W.
  TITLE     Cloning and expression of a divergent integrin subunit beta 8
  JOURNAL   J Biol Chem 266 (29), 19650-19658 (1991)
   PUBMED   1918072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 25, 2022 this sequence version replaced XM_006240697.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.17075.1,
                                           SRR26360172.2369572.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1145              JAXUCZ010000006.1  146350101-146351245 c
            1146-1231           JAXUCZ010000006.1  146317550-146317635 c
            1232-1406           JAXUCZ010000006.1  146311388-146311562 c
            1407-1653           JAXUCZ010000006.1  146301851-146302097 c
            1654-1819           JAXUCZ010000006.1  146300294-146300459 c
            1820-1978           JAXUCZ010000006.1  146299615-146299773 c
            1979-2074           JAXUCZ010000006.1  146292899-146292994 c
            2075-2164           JAXUCZ010000006.1  146289061-146289150 c
            2165-2299           JAXUCZ010000006.1  146282985-146283119 c
            2300-2702           JAXUCZ010000006.1  146280397-146280799 c
            2703-2928           JAXUCZ010000006.1  146277797-146278022 c
            2929-3035           JAXUCZ010000006.1  146276498-146276604 c
            3036-3199           JAXUCZ010000006.1  146273215-146273378 c
            3200-8337           JAXUCZ010000006.1  146267989-146273126 c
FEATURES             Location/Qualifiers
     source          1..8337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..8337
                     /gene="Itgb8"
                     /note="integrin subunit beta 8"
                     /db_xref="GeneID:362800"
                     /db_xref="RGD:1311374"
     exon            1..1145
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     CDS             1019..3322
                     /gene="Itgb8"
                     /note="integrin, beta 8"
                     /codon_start=1
                     /product="integrin beta-8"
                     /protein_id="NP_001388746.1"
                     /db_xref="GeneID:362800"
                     /db_xref="RGD:1311374"
                     /translation="MCGSALAFLTAALLCLHNCQRGPALVLGAAWVFSLVLGLGQSEH
                     NRCDSANVVSCARCLQLGPECGWCVQEDFVSGGSRSERCDTVSNLISKGCPVDSIEYL
                     SVHVVTSSENEINTQVTPGDVSIQLHPGAEANFMLKIRPLKKYPVDLYYLVDVSASMH
                     NNIEKLNSVGNDLSKKMALFSHDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDC
                     MPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEA
                     KRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLID
                     NNINVIFAVQGKQFHWYKDLLPLLPGAIAGEIESKAANLNNLVVEAYKKLISEVKVQL
                     ESQVHGVHFNITAICPDGARKPGTSGCGNVTSNDEVLFNVTVVMKTCDIIGGKNYAII
                     KPIGFNETTKVHIHRSCSCQCEDHRGLKGQCAEAAPDPKCPQCDDGKCHFDEDQFPSE
                     ACKPQEDQPVCSGRGVCICGKCLCHKTKLGRVYGQYCEKDDFSCPYLHGDVCSGHGEC
                     EGGRCQCFNGWEGDRCQCPSASAQHCVNSKGQVCSGRGTCVCGRCECTDPRSIGRLCE
                     HCPTCHLSCSENWNCLQCLHPHNLSQAVLDQCKASCAVMEQHPVAQTSECLSGPSYLR
                     IFFIIFIVTFLIGLLKVLIIRQVILQWNSNKIKSSSDYRVSASKKDKLILQSVCTRAV
                     TYRREKPEEIKMDISKLNAQEAFRCNF"
     exon            1146..1231
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1406
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1653
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1819
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1978
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2074
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2164
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2299
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2702
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2928
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3035
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3199
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..8337
                     /gene="Itgb8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcgcttg ctggcgaccc aagcaaggag cactgtagcg tggggaggtt tcctagcaac
       61 tctcagctcg gagcgcgccc agacacccga aagctgggag ccctcacggg gggccacaga
      121 actagagcac cccatccctg cccatcgctg cctcgcttcc ctctcatcct ctccgggtac
      181 agcccagaac gcatcagctg ccagggttct gggtggccag acgcctgagc cgacagagtc
      241 cgagaaagaa caagggtacg caactccctc ccagcgaggt gcgtggaacg tccccttcca
      301 gctcagtagg caactgggat gccctgttct ttgcctgcgg gtgcagacgg gagcttctag
      361 ggggttcgcg gagccgctcc cccaagctgc tggcacccgt gtctcctctc ccgccaatcg
      421 ggacgttgcc gcctcgacct cggctagctg agactaagtg gagttggcct ccctgcccac
      481 ctgtggaaga agctagcacc gactgactcg ccagcaactc ccccaccccc ttggccttct
      541 agcgatcccc tcccactaat gcagcatcac cctgtgaatt acattagggt ggttttcccc
      601 ccagcctcag gctttgtttg ggtttgattg tgtttggctc ttcgctaagc tgatttatgc
      661 agcagagccc catcggctgg ggagaaacaa aagctttttt ctttgtctgg gagcggactg
      721 tgcagcccgt acttgcttcg cccccgcggg ccatcggctg tcttaggagg tgcttttggt
      781 tgagactgca agccccggct gtgcaaagct gggagggcct caggggccct gagatgcaga
      841 gagctgccct ggcccgcata cctgtatcgc ctactcagag cgactgggtc gatcaacccg
      901 gcctgttgaa aagttcctag ggattctcgg cccacgagcc tcaaggtgcg ctcccaaggc
      961 gcgagagcgc atcaggaaag caactaggca gcgtgcacgg ggcaggctgc tttgcagtat
     1021 gtgtgggtcg gccctggctt ttctgactgc tgcactgctc tgcctgcaca actgccagcg
     1081 aggtccagcg ttggttcttg gggcggcctg ggtattttca cttgttctcg gattgggcca
     1141 aagtgaacat aatagatgtg actctgcaaa tgtggtctcc tgcgccaggt gcctccagct
     1201 gggtccggaa tgtggatggt gtgttcaaga ggattttgtt tcaggtggat caagaagtga
     1261 acgttgtgat actgtttcca atttgataag caaaggctgt ccagttgact caatagaata
     1321 cctgtctgtg catgtagtaa catcaagtga gaatgaaatc aatacacaag tgactccggg
     1381 agatgtctca atccaactgc atccaggagc tgaagctaat tttatgctaa aaatccgtcc
     1441 cctgaagaag taccctgtgg atctttatta tctggttgat gtgtcagcat caatgcacaa
     1501 taatatagaa aaattgaatt ccgttggaaa cgatttatct aaaaaaatgg cccttttttc
     1561 ccatgacttc cgtcttggtt ttggctcata tgtggataaa actgtctcac catacattag
     1621 tatccacccg gaaaggatcc acaatcagtg cagtgactac aatttagact gtatgcctcc
     1681 ccatggatac attcatgtgc tgtctctgac agaaaacatc actgagtttg aaaaagcagt
     1741 ccacagacaa aagatctctg gaaacataga cactcctgaa ggaggttttg atgccatgct
     1801 tcaggctgcc gtctgtgaga gtcatattgg atggcgaaaa gaagctaaaa gattgctgct
     1861 ggtgatgaca gaccagacat cacatctcgc tcttgacagc aaattggcag gcatagtggt
     1921 gccaaatgac ggaaactgcc atctgaaaaa caatgtctac gtcaaatcaa caaccatgga
     1981 acatccatca ttaggtcaac tttccgaaaa gttaatagac aacaacataa atgtcatttt
     2041 tgcagttcaa ggaaagcagt ttcattggta caaggacctt ctgccccttt tgcctggtgc
     2101 cattgctggt gaaatagaat ccaaagctgc aaatctcaac aatttagtag tagaagccta
     2161 caagaaactc atctcagaag taaaagtgca gctggaaagc caggtacacg gtgtccattt
     2221 caacatcact gccatctgtc cggatggggc cagaaagcca ggcacaagtg ggtgtggaaa
     2281 cgtgacaagc aatgacgaag ttcttttcaa tgtgacagtt gtgatgaaaa catgtgatat
     2341 cataggagga aaaaactatg caataatcaa acctattggt ttcaatgaaa ccactaaagt
     2401 ccacatacac agaagctgca gttgccagtg tgaggaccac agaggactca aaggacagtg
     2461 tgcggaagct gctccagatc ccaagtgtcc acagtgtgat gacggcaaat gtcattttga
     2521 tgaagaccag tttccttccg aagcttgcaa gccacaggag gaccaacctg tctgcagtgg
     2581 ccgaggtgtt tgtatctgtg ggaaatgttt atgtcacaaa accaagcttg gaagagtgta
     2641 tggccaatac tgtgagaagg atgacttctc ttgtccctat ctccatggag atgtgtgttc
     2701 tggacatggg gagtgcgaag gtggcagatg ccagtgcttt aacggctggg aaggggatcg
     2761 gtgtcagtgt ccatcagcct cagcacagca ctgtgtcaac tccaagggcc aagtttgcag
     2821 cgggagaggc acctgcgttt gtggcaggtg tgagtgcacg gatcctagaa gcatcggccg
     2881 cctctgtgag cactgcccaa cctgccatct ctcctgcagt gaaaactgga attgtctaca
     2941 gtgccttcac cctcacaatc tgtctcaagc tgttcttgat cagtgtaaag cctcctgtgc
     3001 tgtcatggaa caacatcctg tggcccaaac atcagagtgt ttatctggcc caagctatct
     3061 gcgaatattt ttcatcatat tcatagtgac attcttgatt gggttgctta aagttcttat
     3121 cattagacaa gtgatactac agtggaatag taataaaata aagtcctcat cagattacag
     3181 agtgtctgct tccaaaaagg ataaactgat tctgcaaagt gtttgcacga gagctgtaac
     3241 ctaccgacga gaaaagcctg aggaaataaa aatggatatc agcaaactaa acgcccagga
     3301 ggctttcagg tgcaacttct aaagaacgat tagcaaacga gcaaaaactg ttggaagctg
     3361 gatgttttta tacaatgtat tctagcaaat atgatataaa aagtcacagg aggagacaaa
     3421 ttattgaaga gtgtgccatg gagactggca ggtgtcttca caactatgtg actcactcag
     3481 ctgctgacat tttcagtgaa ctatgtgtct tactactgtt ggagactagc gttgtagcac
     3541 tttactgtaa tatataactt atttagatca gcgtagaatg tagattgtct ggaaagcact
     3601 gattacactt tacaggtacc tgtcagccct gcgctgctca gacagacaca aggctatgga
     3661 gcgggttgca cggtgtcacc accgcagagc agtgatcctt gtgtgcaacc agctgatgaa
     3721 aagcatccag gagtagtgga aacagtcaac cacacccaac aattggtatt gtctagatgt
     3781 gcacacgcag ctgagcaagg gttagggttt catttcagtt ggaggtgaac agataaactt
     3841 taaatggtgt tgcttttgaa gctgtgcagt tttgtgcatg taggagtctg ctttcttctc
     3901 ttttaaaaaa tggattttga ctcaaacatc ttttcccttt tttgcattta aattctgttt
     3961 tttcctttgg aataagttta taatgtcaca aatgactgga ttaaataagt gctaagttac
     4021 tactgccgta gaaacctata tgacaatgtc actttattag aatactgttt ggtttttaaa
     4081 gctgaatgtt aataagggtc actgtaaggt gtcatctaag tccatagctt ctttgtctga
     4141 aaatagttta tattttctta cctgtcaaac tggatggatt gtttcactct gtcattgatc
     4201 tggcctgtag cctgaagtcc acaggtgtct acaaagctgc ttcaagctga gtaccctctt
     4261 ttctgagtat gttttcttga tttttactcc aagttgatgt caacagtttt caaatgaaaa
     4321 agttgtatta ttcttgccct cctgtgcacc ctaagggcac tccttgaatc atcccaaccc
     4381 tgctcatgag aattcagaaa ggtatagaat tggagacgtg agggtaatgt cttggaaaca
     4441 agctaatcct ccctttttga tagccaggga atggaggctc agaaaattaa aatgctttta
     4501 caaaaacaca gaagcagaga aatgacagta ttcgagaaga gctgccttct aattacaggc
     4561 cagcattgca caataatact ctacctcttg aatctgcaaa atatccatgg caaaaattaa
     4621 aatacgattt actgaatttt tcacgagaat atttcagagc aaagtagaaa agggtactgt
     4681 gcgtaagcag cttctagttt ttcacattac ccaccctctg ataaggcttt gatacagtcc
     4741 ttccctccac agtggctaca agaacaagcc tcctagagct gggcatggct cagcttaaag
     4801 ccttgatcca gaggctcggt acttgaattc taaattccaa ctgtcctttg tgtagcaagt
     4861 gtctcacctg tgacaacaga ggaatctaaa gagtgtctct cctcagttta ctgctctcca
     4921 gcacttgaaa gttctagata ttagcatgtt gaagacaagc ctccattagg tatcactctg
     4981 gggcctggaa agcctgtcca ttattctcta tccagaaaac atgatgtgtc ccttagcaga
     5041 gcagtagtga tgctcttaac tgagtgtttc ttcttcctca atgagaaccg ggcatagtca
     5101 aaatactgtg actgtgtcta aagaaaccac gctcactaca gctgatgtga aaattctact
     5161 ttgctgctca gaacaggatc cttttataaa tatataaatt aatggattct tggtggtctc
     5221 cccaccaagg aagatatcca ttaattaaat gctaacaact caaaagtgag cagtgtttat
     5281 gaataataga ttaatatcca catgaaatga gcataattaa agagaattct tgaaaagcaa
     5341 ggatttgtac atttttaggc cctcactagt ttgcactaat tttaagattg accaaggctg
     5401 ttgccacagg aaagacaaat ttccttgcca ggaattcagt gatgggtgat aatatgtact
     5461 tgcatgtgga atgtcttgta gcctttcttt ctcttctttt tttcaaccta aaaagctaat
     5521 tcttaaagat tgtagggctt atatattact tgaataattg ttctttttaa tagtttgtga
     5581 gaagagaatt aatatttgac taggtagaat taattaatag gtatggggaa acagggtatt
     5641 cttagattaa taatttatgt acttttagac tattttcaaa tgctatgagt tgttgatagt
     5701 aaatgcaatt aattgaattt taaattgtta gcaaaatgaa taacttgagt gattttattt
     5761 ttttttggcc tgtcagcatt ttgtgccctg gtgtgtaatt attcaaaact gtcccatatt
     5821 tccactacat aagcaactgt atacaagtta tttcttctga gacattttta tactgcagta
     5881 cacatgtatt tataaacatt tgttccaatt tttaggcatt ttctactatt tattaaacca
     5941 tatattctct gagacttaaa agtttgttaa aaaaaatcta attatgttcc acatgttcaa
     6001 tttaacttag tttataaaaa taacaaaaaa atctctgggg gcaaattttt caaaatcaca
     6061 aattaatact gtatatactt caaatgcaaa accaccaaag aataaaattc aaatatcttt
     6121 taatatttac taaatcccca ttaaggatat acttttacat atcagcagat acctatgata
     6181 cactgaaatc attgattctt gatagattat gaatgttttt ctcagtagaa ttatatttct
     6241 tctggtactt ggtagactag cttataccca atggctcatc cttccttcct ggctcccatt
     6301 tatcccatcc acatttcttt agaaattgtc cataagcgtc aagccaataa gcctaatttt
     6361 gaaaaataac agcttaacaa tgtaactaag ttcttcattt ccaaagatct cttcttactg
     6421 tcagcactca tttggacaaa tacagcccct ctgaaaacaa agaattttaa atttttacaa
     6481 tgttgtgatt tatgttttcg taaagatagc aactcacttg gcagttcaat ggtatgcatt
     6541 ctgtgctctc tttgtttgct cttgatactt agtttacagc tatccttatg actgtaaaaa
     6601 catcattttg tgtaatgcaa acattttcaa aggaatagga ctaatatttc ttcaaatcct
     6661 ttccttttca tcttccataa tccctgcatg gtaaattagt tgtgcataat tgattagaca
     6721 tacctactgt gtgtcttgct gattctagaa gatatctttt ttttcaattt agcatcccca
     6781 aaattgtgac atctcctgac attgtcatct acagtgtagc gcttaaagtt gtgttgagat
     6841 aaacactaaa ctaattaata ttcatggatg cagtcctttt catataaacg tttataaatt
     6901 cgtttgtgat ggcttgtgaa gccagttttt aacacagctg aaccatgtac tataactcag
     6961 tgcagaccta actggctatt ggctcagatc ctttgaatct ttcagttaca aaagctcttt
     7021 taggcttcca tttatacctt ctgttaagag cagtgattta ggcaaactaa gtttactgag
     7081 gaagtgtgca gtttcttgag ccttcgctta acgatcttta gcattcccat cccttttgaa
     7141 gggattgttt gaaactatca tctcacttct aagtaagtta actggaaaaa agattacatg
     7201 aaaacaccat agttagtttt cacagcactt cctaaggttg gtgtcagtag ccatcttgaa
     7261 aatatttccc ctgagatctc gcaactttct catttctcct tatcctttat gtgcgtttga
     7321 tgctttcttt ggctcaagta acttttcctc tccagcacat gtgatgactg tcaaaaaaaa
     7381 aaaaccctgc agttaaaata tagcatttta tgtgaaacaa ttgttcaact ctctgggcag
     7441 ctttggatgg actatgtgag agtaataaca ctactctgtc tacctgaaat accttcctgc
     7501 ataaaatgta tctttgtaag ctaccttttt caaccgggtg tctattcttc acaaccaatt
     7561 tcagtacaac tgtgtaactc attggcataa aagaagaaaa aaaaacactg caattatcaa
     7621 ggatagaaat caagtgattt ctgactttac tgactttaca catacaaatg tgattctgaa
     7681 aacatgtctg cacaatgaca agtatggtac gtagattttt attgaaatat tgagtaaaat
     7741 tattttcatt ctaaattata agaaactaca aatttgcaca tattaatata gaaattcatt
     7801 ttgtgtatag ttaacatatg tttaaagcta ttttacatgt actagcttct ttatgaaggt
     7861 ctgtaaattt tacaaaagca attagacatg ttttaaaatc aataacagtc tttgacttaa
     7921 caaatactgc ctttgtaaaa acatttaata tagaatgtat ttttaaatca agatatttga
     7981 atataaaata gctcaaagag aaacaaattc ttcatgaaca cattttgtgt tgtttctggc
     8041 tttgattata tgaaaggtga aattgcctta aataaggaag attggtaaat atgacaattt
     8101 cacgtactat actatgaatc tctttgcgta actggttgac tactaacgtt tatgtattta
     8161 ttaaaagctg acactgtaga ttgttgtgag atgtttattt ttctaacaga acttatcaca
     8221 gttgtgacaa ggcatttaat tgatatacca gtctgtttaa atgtaggcgt taattgatat
     8281 aaaattctat gttttaaaac aaaactttaa agatctaata aaaacataaa gaatata
//
