LOCUS       NM_013171               2654 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus integrin subunit beta 7 (Itgb7), mRNA.
ACCESSION   NM_013171 XM_001067562 XM_343336
VERSION     NM_013171.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Sun,J.K., Zhang,Q., Shen,X., Zhou,J., Wang,X., Zhou,S.M. and
            Mu,X.W.
  TITLE     Integrin alphaEbeta7 is involved in the intestinal barrier injury
            of sepsis
  JOURNAL   Aging (Albany NY) 14 (2), 780-788 (2022)
   PUBMED   35042191
  REMARK    GeneRIF: Integrin alphaEbeta7 is involved in the intestinal barrier
            injury of sepsis.
REFERENCE   2  (bases 1 to 2654)
  AUTHORS   Zhang,K., Pan,Y., Qi,J., Yue,J., Zhang,M., Xu,C., Li,G. and Chen,J.
  TITLE     Disruption of disulfide restriction at integrin knees induces
            activation and ligand-independent signaling of alphabeta
  JOURNAL   J Cell Sci 126 (Pt 21), 5030-5041 (2013)
   PUBMED   23986478
REFERENCE   3  (bases 1 to 2654)
  AUTHORS   Kim,S.V., Xiang,W.V., Kwak,C., Yang,Y., Lin,X.W., Ota,M.,
            Sarpel,U., Rifkin,D.B., Xu,R. and Littman,D.R.
  TITLE     GPR15-mediated homing controls immune homeostasis in the large
            intestine mucosa
  JOURNAL   Science 340 (6139), 1456-1459 (2013)
   PUBMED   23661644
REFERENCE   4  (bases 1 to 2654)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 2654)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 2654)
  AUTHORS   Miles,A., Liaskou,E., Eksteen,B., Lalor,P.F. and Adams,D.H.
  TITLE     CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of
            lymphocytes to MAdCAM-1 under shear flow
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 294 (5), G1257-G1267 (2008)
   PUBMED   18308860
REFERENCE   7  (bases 1 to 2654)
  AUTHORS   Takada,Y., Ye,X. and Simon,S.
  TITLE     The integrins
  JOURNAL   Genome Biol 8 (5), 215 (2007)
   PUBMED   17543136
  REMARK    Review article
REFERENCE   8  (bases 1 to 2654)
  AUTHORS   Fernekorn,U., Butcher,E.C., Behrends,J., Hartz,S. and Kruse,A.
  TITLE     Functional involvement of P-selectin and MAdCAM-1 in the
            recruitment of alpha4beta7-integrin-expressing monocyte-like cells
            to the pregnant mouse uterus
  JOURNAL   Eur J Immunol 34 (12), 3423-3433 (2004)
   PUBMED   15484189
REFERENCE   9  (bases 1 to 2654)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   10 (bases 1 to 2654)
  AUTHORS   Tidswell,M., Pachynski,R., Wu,S.W., Qiu,S.Q., Dunham,E.,
            Cochran,N., Briskin,M.J., Kilshaw,P.J., Lazarovits,A.I.,
            Andrew,D.P., Butcher,E.C., Yednock,T.A. and Erle,D.J.
  TITLE     Structure-function analysis of the integrin beta 7 subunit:
            identification of domains involved in adhesion to MAdCAM-1
  JOURNAL   J Immunol 159 (3), 1497-1505 (1997)
   PUBMED   9233649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_343336.3, XM_001067562.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32115.1,
                                           SRR26643284.10826.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000007.1  135238871-135239071 c
            202-403             JAXUCZ010000007.1  135236418-135236619 c
            404-574             JAXUCZ010000007.1  135236162-135236332 c
            575-816             JAXUCZ010000007.1  135233898-135234139 c
            817-975             JAXUCZ010000007.1  135233448-135233606 c
            976-1071            JAXUCZ010000007.1  135233127-135233222 c
            1072-1161           JAXUCZ010000007.1  135232789-135232878 c
            1162-1311           JAXUCZ010000007.1  135230066-135230215 c
            1312-1505           JAXUCZ010000007.1  135229508-135229701 c
            1506-1729           JAXUCZ010000007.1  135228451-135228674 c
            1730-1949           JAXUCZ010000007.1  135227758-135227977 c
            1950-2155           JAXUCZ010000007.1  135227406-135227611 c
            2156-2316           JAXUCZ010000007.1  135226986-135227146 c
            2317-2654           JAXUCZ010000007.1  135226524-135226861 c
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2654
                     /gene="Itgb7"
                     /note="integrin subunit beta 7"
                     /db_xref="GeneID:25713"
                     /db_xref="RGD:2929"
     CDS             1..2424
                     /gene="Itgb7"
                     /note="integrin, beta 7"
                     /codon_start=1
                     /product="integrin beta-7 precursor"
                     /protein_id="NP_037303.1"
                     /db_xref="GeneID:25713"
                     /db_xref="RGD:2929"
                     /translation="MVDSSTVLIFLLVLGGGQSELDTKITSSGETTEWEDPDLSPQGS
                     CQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPEQELEEPRGH
                     QEVLQDRPLSQGDRGEGATQLAPQRIRVTLRPGEPQKFRVRFLRAAGYPVDLYYLMDL
                     SYSMKDDLERVRQLGQALLLRLREVTHSVRIGFGSFVDKTVLPFVSTVPSKLNHPCPS
                     RLERCQAPFSYHHVLPLTRDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIG
                     WRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVA
                     QALTAANIQPIFAVTGATLPVYQELSQLIPKSAVGELSEDSSNVVQLIMDAYDNLSST
                     VTLEHSSLPPGVSISFESHCRSPEKSEGEAGDRRGQCNHVRVNQMVDFWVTLQASHCL
                     PEAHVLRLWALGFSEELTVELHTLCDCNCSDAQPRAPYCSDGQGDLQCGICSCAPGRL
                     GQLCECSEADLSSPDLESGCRAPNGTGPLCSGKGRCQCGRCSCSGQSSGRLCECDDAS
                     CERHEGILCGGFGHCQCGVCHCHANRTGRACECSESVDSCVSPEGGLCSGHGDCKCNR
                     CQCLDGYYGALCDQCLGCKSPCEQYRDCAECGAFGTGPLAANCSAACADVNVTLALAP
                     NLDDGWCKERTLDNQLFFFLVENSARGVILRVRPQEKGADHTRAIILGCVGGIVAVGL
                     GLVLAYRLSVEVYDRLEYSRFEKERQQLNWKQDSNPLYKSAVTTTVNPRFQGGNKQSL
                     SLPLTQEAD"
     exon            1..201
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            202..403
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            404..574
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            575..816
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            817..975
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1071
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1161
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1311
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1505
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1729
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1949
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2155
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2316
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2654
                     /gene="Itgb7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtggatt catcaactgt tctcattttt ctgctcgttc tgggcggagg tcagagtgag
       61 ttagatacca agattacgtc ctcaggggag accacagaat gggaggatcc tgacctgtct
      121 ccacagggat cctgccagcc agctccttcc tgccagaagt gtatactctc acaccccagc
      181 tgtgcatggt gcaagcaact gaacttcact gcctcggggg aggcagaggc gaggcgctgc
      241 gcgcggcgtg aggagctact ggcccgcggg tgccccgagc aggagctgga ggagccgaga
      301 ggccaccagg aggtgctgca ggacaggcca ctcagccagg gagaccgcgg cgagggggcc
      361 acccagctgg ccccgcagcg gatccgcgtc acgttgcgac caggggagcc ccagaaattc
      421 cgggtccgct tcctccgagc tgcgggatat cccgtggacc tgtactacct tatggacctg
      481 agctattcaa tgaaggacga cttggaacgt gtgcgacagc tcgggcaagc cctgctgctc
      541 cggctgcggg aggtcaccca ttctgtgcgc ataggttttg gctcctttgt ggacaaaacg
      601 gtgctaccct ttgtaagcac agtgccctcc aagcttaacc acccatgccc cagccggttg
      661 gagcgctgtc aggcaccctt cagctatcac cacgtgttgc ccctcaccag ggatgctcaa
      721 gccttcgaga gagaggtggg acgccagaac gtctctggca acctggactc acccgaagga
      781 ggctttgatg ccattttgca ggctgctctt tgccaggagc agattggctg gagaaatgtg
      841 tcccggcttc tggtgttcac ttcagacgat acgttccaca cagctgggga tgggaaactg
      901 ggtggcattt tcatgcccag cgatgggcgg tgccacctgg acagcaacgg tgtctacact
      961 aacagcgcag agtttgacta tccctctgtg ggccaagtag cccaggctct cacagcagcg
     1021 aatatccaac ctatctttgc tgtcaccggc gcaacactgc ccgtgtatca ggagctgagc
     1081 cagttgattc ccaagtctgc tgtcggggag ctcagcgaag actccagcaa tgtggtgcag
     1141 ctcatcatgg atgcttacga caacctgtca tccaccgtga ctcttgaaca ctcttcgctc
     1201 ccacctggag tcagcatctc tttcgagtct cactgtagga gtcctgagaa gagtgagggt
     1261 gaggctgggg accgtcgggg acagtgcaat catgtccgag tcaaccagat ggtggatttc
     1321 tgggtcactc ttcaagcctc tcactgcctc ccagaagccc atgtcctacg gctctgggcc
     1381 cttggcttct cagaggagtt aactgtggag ctgcacacac tgtgtgactg caattgtagt
     1441 gatgcccagc ctcgcgctcc ttactgcagc gatggacagg gggaccttca atgcgggata
     1501 tgcagctgtg cccctggccg ccttggtcag ctgtgtgaat gctctgaggc tgacctgtcc
     1561 tccccagatt tggaatctgg ttgccgggcc cccaatggga cagggcccct gtgcagcggg
     1621 aagggtcgat gccaatgtgg acgctgcagt tgcagtggac agagctctgg gcgtctgtgc
     1681 gagtgtgatg atgccagctg tgagcgacac gagggcatcc tctgtggagg ctttggccac
     1741 tgccagtgtg gagtgtgtca ctgccatgcc aaccgcactg gcagagcatg tgagtgcagt
     1801 gagagtgtgg acagctgcgt tagtcccgaa ggagggctct gcagtgggca tggtgactgc
     1861 aaatgcaacc gttgccagtg cctggatggc tactacgggg ctctgtgtga ccagtgccta
     1921 ggctgcaagt caccatgtga gcaatacagg gactgcgcgg agtgtggggc gtttggtacg
     1981 ggtcccctgg cagccaactg cagcgcggct tgtgctgacg tgaatgtgac cttggccttg
     2041 gcccccaatt tggatgatgg ttggtgcaaa gagaggacgc tagacaacca gctgttcttc
     2101 ttcctggtgg agaattcggc cagaggggtc atactgagag tgagacccca agagaaggga
     2161 gcagaccaca cccgtgccat catactgggc tgcgtagggg gcattgtggc agtgggatta
     2221 gggctggtcc tggcttaccg gctctcagtg gaagtctatg accgccttga gtacagccgc
     2281 tttgagaagg agaggcagca actcaactgg aagcaggaca gcaatcctct ctacaaaagt
     2341 gcggtcacaa ctaccgtcaa ccctcgcttc caagggggca acaaacagtc gctgtccctc
     2401 cctctgaccc aggaggctga ctgacttagg attcttgtct tggaggacag agggggcagt
     2461 agggcagggg cagtgtctgt tgcaaagttt tttttcagac tggccttcag agggcagcgt
     2521 aaccacggca acagccaccc cacgtgaagg gctggtcctt ccaccataaa gttctgcctc
     2581 agactttcgg cctgtggcct gtacttcacc ccgggacaaa accagaaaca aataaacaaa
     2641 caaacaaaaa acca
//
