LOCUS       NM_001004263            2818 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus integrin subunit beta 6 (Itgb6), mRNA.
ACCESSION   NM_001004263 XM_229949
VERSION     NM_001004263.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2818)
  AUTHORS   Takizawa,C., Minematsu,T., Nakagami,G., Kitamura,A., Koudounas,S.,
            Kunimitsu,M. and Sanada,H.
  TITLE     Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh
            exudates swabbed from critically colonised and infected
            full-thickness wounds in rats
  JOURNAL   Int Wound J 20 (4), 1088-1097 (2023)
   PUBMED   36307995
  REMARK    GeneRIF: Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1
            in fresh exudates swabbed from critically colonised and infected
            full-thickness wounds in rats.
REFERENCE   2  (bases 1 to 2818)
  AUTHORS   Wang,J., Bao,L., Yu,B., Liu,Z., Han,W., Deng,C. and Guo,C.
  TITLE     Interleukin-1beta Promotes Epithelial-Derived Alveolar
            Elastogenesis via alphavbeta6 Integrin-Dependent TGF-beta
            Activation
  JOURNAL   Cell Physiol Biochem 36 (6), 2198-2216 (2015)
   PUBMED   26279426
  REMARK    GeneRIF: These data support the hypothesis that IL-1beta was
            initially induced by hyperoxia; alphavbeta6 subsequently interacted
            with and activated TGF-beta1.
REFERENCE   3  (bases 1 to 2818)
  AUTHORS   Rognoni,E., Widmaier,M., Jakobson,M., Ruppert,R., Ussar,S.,
            Katsougkri,D., Bottcher,R.T., Lai-Cheong,J.E., Rifkin,D.B.,
            McGrath,J.A. and Fassler,R.
  TITLE     Kindlin-1 controls Wnt and TGF-beta availability to regulate
            cutaneous stem cell proliferation
  JOURNAL   Nat Med 20 (4), 350-359 (2014)
   PUBMED   24681597
REFERENCE   4  (bases 1 to 2818)
  AUTHORS   Chen,G., Zhang,L., Chen,L., Wang,H., Zhang,Y. and Bie,P.
  TITLE     Role of integrin alphavbeta6 in the pathogenesis of
            ischemia-related biliary fibrosis after liver transplantation
  JOURNAL   Transplantation 95 (9), 1092-1099 (2013)
   PUBMED   23422496
  REMARK    GeneRIF: Integrin alphavbeta6 is strongly induced de novo in newly
            formed bile ducts because of cholangiocyte proliferation during
            ischemia-related biliary fibrogenesis after liver transplantation.
REFERENCE   5  (bases 1 to 2818)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   6  (bases 1 to 2818)
  AUTHORS   Ludlow,A., Yee,K.O., Lipman,R., Bronson,R., Weinreb,P., Huang,X.,
            Sheppard,D. and Lawler,J.
  TITLE     Characterization of integrin beta6 and thrombospondin-1 double-null
            mice
  JOURNAL   J Cell Mol Med 9 (2), 421-437 (2005)
   PUBMED   15963261
REFERENCE   7  (bases 1 to 2818)
  AUTHORS   Morris,D.G., Huang,X., Kaminski,N., Wang,Y., Shapiro,S.D.,
            Dolganov,G., Glick,A. and Sheppard,D.
  TITLE     Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes
            Mmp12-dependent emphysema
  JOURNAL   Nature 422 (6928), 169-173 (2003)
   PUBMED   12634787
REFERENCE   8  (bases 1 to 2818)
  AUTHORS   Hynes,R.O.
  TITLE     Integrins: bidirectional, allosteric signaling machines
  JOURNAL   Cell 110 (6), 673-687 (2002)
   PUBMED   12297042
  REMARK    Review article
REFERENCE   9  (bases 1 to 2818)
  AUTHORS   Baudoin,C., Goumans,M.J., Mummery,C. and Sonnenberg,A.
  TITLE     Knockout and knockin of the beta1 exon D define distinct roles for
            integrin splice variants in heart function and embryonic
            development
  JOURNAL   Genes Dev 12 (8), 1202-1216 (1998)
   PUBMED   9553049
REFERENCE   10 (bases 1 to 2818)
  AUTHORS   Wada,J., Kumar,A., Liu,Z., Ruoslahti,E., Reichardt,L., Marvaldi,J.
            and Kanwar,Y.S.
  TITLE     Cloning of mouse integrin alphaV cDNA and role of the
            alphaV-related matrix receptors in metanephric development
  JOURNAL   J Cell Biol 132 (6), 1161-1176 (1996)
   PUBMED   8601592
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079069.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_001004263.2.
            
            On Sep 10, 2004 this sequence version replaced XM_229949.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079069.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2818
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..2818
                     /gene="Itgb6"
                     /note="integrin subunit beta 6"
                     /db_xref="GeneID:311061"
                     /db_xref="RGD:1303119"
     exon            1..51
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            52..127
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2430
                     /gene="Itgb6"
                     /note="integrin beta 6"
                     /codon_start=1
                     /product="integrin beta-6 precursor"
                     /protein_id="NP_001004263.1"
                     /db_xref="GeneID:311061"
                     /db_xref="RGD:1303119"
                     /translation="MGIELVCLFLLLLGRNDHVQGGCAWSGAETCSDCLLTGPHCAWC
                     SQENFTHLSGAGERCDTPENLLAKGCQLPFIENPVSQVEILQNKPLSVGRQKNSSDIV
                     QIAPQSLVLKLRPGGEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLA
                     KEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTD
                     DAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHF
                     GMDSKLAGIVIPNDGLCHLDNRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQ
                     VHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTA
                     LCSNGILFPHQKKCSHMKVGDTASFNVSVSITNCEKRSRKLIIKPVGLGDTLEILVSA
                     ECDCDCQREVEANSSKCHHGNGSFQCGVCACNPGHMGPRCECGEDMVSTDSCKESPGH
                     PSCSGRGDCYCGQCVCHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCR
                     DGWTGEYCNCTTSRDACASEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPC
                     NSRRSCIECYLSADGQAQEECEDKCKATGATISEEEFSKDTSVPCSLQGENECLITFL
                     ITADNEGKTIIHNISEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKE
                     VAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKVGLSSDG"
     exon            128..207
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            208..412
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            413..659
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            660..825
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            826..987
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1083
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1173
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1308
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1726
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1949
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2044
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2164
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2331
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2815
                     /gene="Itgb6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttaatga aagctttcga atttacagct caagttactt ttcaaagcag ttgaaaactg
       61 aaccgaatgg ggattgagct ggtctgcctg ttcctgctac ttctaggaag gaatgatcac
      121 gtccaaggtg gctgtgcctg gagtggtgca gaaacctgct cagactgcct gctcacagga
      181 cctcactgcg cctggtgctc ccaggagaat ttcacccacc tgtccggagc tggcgaaagg
      241 tgcgacaccc ccgagaatct tttagccaaa ggatgtcagt tacccttcat cgaaaaccct
      301 gtctcccaag tagaaatact tcaaaataag cctctcagcg taggtcgaca gaaaaacagt
      361 tctgacattg ttcagattgc tcctcaaagc ttggttctta agttgagacc agggggtgag
      421 cagactctgc aagtgcaggt ccgccagacg gaagattacc cagtagatct gtattacctc
      481 atggacctct cggcctccat ggatgatgac ctcaacacaa tcaaagagct tggctcccgg
      541 ctggccaaag agatgtctaa attaaccagc aactttagac tgggctttgg ctcttttgtg
      601 gaaaagcccg tttctccttt tatgaaaaca acaccagagg aaatcaccaa cccttgcagt
      661 agtatcccct atttctgctt acctacattt ggattcaagc acattttgcc attgactgat
      721 gatgctgaga gattcaatga aattgtgagg aaacagaaga tttccgctaa tattgacacg
      781 cctgaaggcg gattcgatgc catcatgcaa gctgctgtgt gtaaggaaaa gattggctgg
      841 cgcaacgact cgctccacct cctggttttt gtgagtgatg ctgattctca ttttggaatg
      901 gacagcaagc tggcaggcat tgtgattccc aacgatgggc tctgtcactt ggacaacagg
      961 aatgaatact ccatgtcaac tgtcttggaa tatccaacga tcggccaact cattgataaa
     1021 ctggtacaaa acaacgtgct actgatcttt gcggtcaccc aagaacaagt ccatctctat
     1081 gagaattatg cgaaactcat ccctggagcg actgtgggac tgcttcagaa ggattctggg
     1141 aacattcttc agctgatcat ctccgcttac gaagaactgc ggtctgaggt ggaactagaa
     1201 gtattaggag acacagaagg actcaacctg tctttcacag ctctctgtag caatggcatc
     1261 ctcttcccac accaaaagaa gtgttcccac atgaaagtcg gagatacagc atccttcaac
     1321 gtgtctgtga gcataacaaa ctgtgagaaa agaagcagga aacttatcat caagcctgtg
     1381 ggacttgggg acaccctgga aatactcgtc agcgcagaat gtgactgcga ctgccagaga
     1441 gaagtagaag ccaacagttc taagtgccac cacgggaatg gctccttcca gtgtggggtg
     1501 tgtgcctgca accctggcca catgggtcct cgctgcgagt gcggcgagga catggtgagc
     1561 acggattcct gcaaggagtc cccaggtcac ccctcctgca gcggaagggg tgactgctat
     1621 tgtgggcagt gtgtctgcca cttgtctccc tatggaagca tctatggacc ttactgccag
     1681 tgtgacaact tctcctgtct gagacacaaa ggcctgctct gtggagataa tggtgactgt
     1741 gactgtggtg aatgcgtgtg ccgggatggc tggacgggcg agtactgcaa ctgtacaacc
     1801 agcagggatg cgtgtgcatc ggaagatggc gtgctgtgca gcgggcgtgg ggactgtgtc
     1861 tgcggcaagt gtgtctgcag aaaccctgga gcctcgggac ccacctgtga acgctgccct
     1921 acctgtggag acccctgtaa ctcgagacgg agctgcatcg agtgctacct gtctgcagat
     1981 ggccaggccc aagaagagtg cgaggacaag tgcaaagcca ccggtgccac catcagtgag
     2041 gaagagtttt caaaggatac ttctgtcccc tgctcgctac aaggagaaaa tgaatgtctt
     2101 attacattcc taataactgc ggataatgaa gggaaaacca tcattcacaa catcagtgaa
     2161 aaagactgcc ccaaacctcc aaacattccc atgatcatgt tgggggtgtc actggctatc
     2221 ctgctcatcg gtgtcgtgct actgtgcatt tggaagctgc tggtatcctt tcacgaccgg
     2281 aaagaagttg ctaaatttga agcagaacga tcaaaggcca agtggcaaac gggaaccaat
     2341 ccgctgtacc gaggctccac cagcactttt aagaacgtga cctacaaaca cagggagaag
     2401 cacaaagtgg gcctttcttc agatgggtag acagacctcc ttcggccaga gaaagtcagc
     2461 tctgcttacg ttaaaggtta atgcactgta tgatttgtct tcctttgttt cgtcaaaagg
     2521 aggttgactt aagatactaa caggtcattc agagatcagt cattcagggc gtgaaggtga
     2581 gacattgttt gcaagttgga aataatcaag aaaagaatat cccaagcaaa gaggtgaatt
     2641 caagatcact tgaagaatat gaactctgac gcattaatgc ctcaaaaaaa atcatcaaaa
     2701 tgattcatgg ggatttgatt tgcatttgaa aaatgttcag aattagaatc tcatttgctt
     2761 cctgaatcca gctacctaaa gtctttgtct ctaaaaaaaa aaaaaaaaaa aaaaaaaa
//
