LOCUS       NM_147139               3696 bp    mRNA    linear   ROD 27-JUN-2023
DEFINITION  Rattus norvegicus integrin subunit beta 5 (Itgb5), mRNA.
ACCESSION   NM_147139 XM_001064622
VERSION     NM_147139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3696)
  AUTHORS   Su H, Zhu H, Wang S, Li Y, Yan C, Wang J and Ying K.
  TITLE     CircItgb5 promotes synthetic phenotype of pulmonary artery smooth
            muscle cells via interacting with miR-96-5p and Uba1 in
            monocrotaline-induced pulmonary arterial hypertension
  JOURNAL   Respir Res 24 (1), 165 (2023)
   PUBMED   37344798
  REMARK    GeneRIF: CircItgb5 promotes synthetic phenotype of pulmonary artery
            smooth muscle cells via interacting with miR-96-5p and Uba1 in
            monocrotaline-induced pulmonary arterial hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3696)
  AUTHORS   Zhang Q, Yu J, Guo T, Tian L, Quan J, Lin W, Niu XE and Liu J.
  TITLE     High glucose/ox-LDL induced hepatic sinusoidal capillarization via
            alphavbeta5/FAK/ERK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 513 (4), 1055-1062 (2019)
   PUBMED   31010681
  REMARK    GeneRIF: Integrin alphavbeta5 which induces LSECs dysfunction,
            promoting hepatic sinusoidal capillarization regulates VN
            expression via ERK/FAK pathway under high glucose/ox-LDL
REFERENCE   3  (bases 1 to 3696)
  AUTHORS   Perrucci GL, Barbagallo VA, Corliano M, Tosi D, Santoro R, Nigro P,
            Poggio P, Bulfamante G, Lombardi F and Pompilio G.
  TITLE     Integrin alphanubeta5 in vitro inhibition limits pro-fibrotic
            response in cardiac fibroblasts of spontaneously hypertensive rats
  JOURNAL   J Transl Med 16 (1), 352 (2018)
   PUBMED   30541573
  REMARK    GeneRIF: the effects on cardiac fibroblasts , isolated by
            spontaneously hypertensive rats (SHR), of integrin alphanubeta5
            inhibition in myofibroblast differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3696)
  AUTHORS   Garrigues HJ, DeMaster LK, Rubinchikova YE and Rose TM.
  TITLE     KSHV attachment and entry are dependent on alphaVbeta3 integrin
            localized to specific cell surface microdomains and do not
            correlate with the presence of heparan sulfate
  JOURNAL   Virology 464-465, 118-133 (2014)
   PUBMED   25063885
  REMARK    Erratum:[Virology. 2018 Feb;515:264-265. PMID: 29407075]
REFERENCE   5  (bases 1 to 3696)
  AUTHORS   Uehara K and Uehara A.
  TITLE     Integrin alphavbeta5 in endothelial cells of rat splenic sinus: an
            immunohistochemical and ultrastructural study
  JOURNAL   Cell Tissue Res 356 (1), 183-193 (2014)
   PUBMED   24556923
  REMARK    GeneRIF: The possible functional roles of integrin alphavbeta5 in
            endothelial cells of the splenic sinus are discussed.
REFERENCE   6  (bases 1 to 3696)
  AUTHORS   Herrera VL and Ruiz-Opazo N.
  TITLE     Identification of a novel V1-type AVP receptor based on the
            molecular recognition theory
  JOURNAL   Mol Med 7 (7), 499-506 (2001)
   PUBMED   11683375
REFERENCE   7  (bases 1 to 3696)
  AUTHORS   Zhang H, Tan SM and Lu J.
  TITLE     cDNA cloning reveals two mouse beta5 integrin transcripts distinct
            in cytoplasmic domains as a result of alternative splicing
  JOURNAL   Biochem J 331 (Pt 2) (Pt 2), 631-637 (1998)
   PUBMED   9531507
REFERENCE   8  (bases 1 to 3696)
  AUTHORS   Filardo EJ, Deming SL and Cheresh DA.
  TITLE     Regulation of cell migration by the integrin beta subunit
            ectodomain
  JOURNAL   J Cell Sci 109 (Pt 6), 1615-1622 (1996)
   PUBMED   8799848
REFERENCE   9  (bases 1 to 3696)
  AUTHORS   Wada J, Kumar A, Liu Z, Ruoslahti E, Reichardt L, Marvaldi J and
            Kanwar YS.
  TITLE     Cloning of mouse integrin alphaV cDNA and role of the
            alphaV-related matrix receptors in metanephric development
  JOURNAL   J Cell Biol 132 (6), 1161-1176 (1996)
   PUBMED   8601592
REFERENCE   10 (bases 1 to 3696)
  AUTHORS   Nishimura SL, Sheppard D and Pytela R.
  TITLE     Integrin alpha v beta 8. Interaction with vitronectin and
            functional divergence of the beta 8 cytoplasmic domain
  JOURNAL   J Biol Chem 269 (46), 28708-28715 (1994)
   PUBMED   7525578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV216421.1, CB731093.1, EV772196.1, CO405730.1, EV769502.1,
            DY316865.1, EX490541.1, AA859274.1, CO567685.1 and CA506053.1.
            
            On or before Oct 24, 2007 this sequence version replaced
            XM_001064622.1, NM_147139.1.
            
            Sequence Note: This RefSeq record was created from mixed strain
            transcripts because no single transcript from the same strain was
            available for the full length of the gene. The extent of this
            transcript is supported by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                DV216421.1         183-275
            94-165              CB731093.1         64-135
            166-624             EV772196.1         19-477
            625-1253            CO405730.1         29-657
            1254-1409           EV769502.1         585-740
            1410-1995           DY316865.1         154-739
            1996-2415           EX490541.1         368-787
            2416-2830           AA859274.1         17-431              c
            2831-3168           CO567685.1         289-626
            3169-3696           CA506053.1         1-528               c
FEATURES             Location/Qualifiers
     source          1..3696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..3696
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /note="integrin subunit beta 5"
                     /db_xref="GeneID:257645"
                     /db_xref="RGD:628869"
     exon            1..117
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2447
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /note="integrin, beta 5"
                     /codon_start=1
                     /product="integrin beta-5 precursor"
                     /protein_id="NP_671480.2"
                     /db_xref="GeneID:257645"
                     /db_xref="RGD:628869"
                     /translation="MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHP
                     KCAWCSKEYFGNPRSIISRCDLKANLIRNGCGGEIESPASSTHVLRNLPLSSKGSSAM
                     GSDVIQMTPQEIAVSLRPGDQATFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSL
                     GTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFR
                     HLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFT
                     TDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASDQMDYPSLALLGEKLAENNINLI
                     FAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPED
                     LNLFFTATCQDGLSYPGQRKCEGLKIGDTASFEVSVEARSCPGRHTTQSFTLRPVGFR
                     DSLQVEVAYNCTCGCSAGLEPNSARCSGNGTYVCGLCECDPSYLGTRCECQEGENQSG
                     YQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGH
                     GECHCGECKCHVGYIGDNCNCSTDISTCRAKDGQICSDRGRCVCGQCQCTEPGAFGET
                     CEKCPTCPDACSSKRDCVECSLLHQGKPDNQTCHHQCKDEVITWVDSIVKDDQEAVLC
                     FYKTAKDCVMMFSYTELPNGKSNLTVLREPECGSAPNAMTILLAVVGSILLVGMALLA
                     IWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSV
                     D"
     exon            118..203
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            204..408
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            409..658
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            659..827
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            828..989
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1085
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1175
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1310
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1740
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1963
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2064
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2184
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2351
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..3680
                     /gene="Itgb5"
                     /gene_synonym="RGD1563276"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccccgctc cgtccccgcc gcgcgccccc gccgagcggc gcgcaccatg ccgcgggtgc
       61 ccgcgaccct ctacgcctgt ctgctcgggc tctgcgcgct cgtgccgcgc ctcgcagggc
      121 tcaacatatg caccagtgga agtgccacct catgtgaaga atgcctgtta atccacccaa
      181 aatgtgcctg gtgctccaaa gagtactttg gcaacccacg gtccatcatc tctcggtgtg
      241 acctgaaggc aaacctcatc cgaaatggct gtggaggtga gattgagagt ccggccagca
      301 gcacccacgt ccttcggaac ctgcctctca gcagcaaggg ttccagtgcc atgggctctg
      361 acgtcatcca gatgacgcca caggagattg cagtgagcct ccgtccaggt gaccaggcta
      421 ccttccagct gcaggtacgc caggtggagg actatcccgt agacctgtac tacctgatgg
      481 acctctccct ctccatgaag gatgacttgg acaacatccg gagcctgggc accaagcttg
      541 cggaggagat gaggaagctc actagtaact tccggttagg tttcgggtct tttgttgaca
      601 aggacatctc tccgttctcc tacacagcac cgagatacca gaccaatcca tgtattggtt
      661 acaagttatt ccccaactgt gtcccttcct tcgggttccg ccatctgctg cctctcacag
      721 acagagtgga cagtttcaat gaggaagtga ggaagcagag ggtgtcccgg aaccgagatg
      781 cccccgaggg gggctttgat gctgtcctcc aggctgctgt ctgcaaggag aagatcggat
      841 ggcgaaagga tgccctgcac ttgctggtgt tcacgacgga cgacgtgccc cacatcgcgt
      901 tggatggaaa actgggtggc ctggtccagc cacacgatgg ccagtgtcac ctgaatgaag
      961 ccaatgagta cactgcgtcc gaccagatgg actatccatc gcttgccttg cttggggaga
     1021 agctggcaga gaacaatatc aacctcatct ttgcagtgac gaagaaccac tatatgctct
     1081 acaagaattt tacagccctg atacctggaa ccactgtgga gattttgcat ggagattcca
     1141 aaaatattat tcaactgatt atcaatgcgt acagtagcat ccgggctaaa gtggagctgt
     1201 cggtctggga tcagccggaa gaccttaatc tcttcttcac tgctacgtgc caagatggcc
     1261 tatcctaccc tggtcagagg aagtgtgagg gtctgaagat cggggacacg gcgtcctttg
     1321 aagtgtctgt ggaggctcgg agctgccctg gcagacatac aacacagtct tttaccttga
     1381 ggcctgtggg cttccgggac agtctgcagg tagaagtcgc ctacaactgc acgtgcggct
     1441 gtagcgccgg gctggagccc aacagtgcca gatgcagtgg gaatggaaca tacgtctgtg
     1501 ggctgtgcga gtgtgacccc agttacctgg gcactaggtg cgagtgccag gagggcgaga
     1561 accagagcgg gtaccagaac ctgtgccggg aggcggaagg caaacccctg tgcagcggac
     1621 gtggggaatg cagctgcaac cagtgctcct gctttgagag tgagttcggg aggatctacg
     1681 ggcccttctg cgagtgcgac agcttttcct gtgccaggaa caagggcgtc ctatgctcag
     1741 gccatggcga gtgtcactgc ggagaatgca agtgccacgt cggttacatt ggggacaatt
     1801 gtaactgctc aacagacatc agcacgtgca gggccaagga tgggcagatc tgcagcgacc
     1861 gaggccgttg cgtctgtggg cagtgccagt gcacagagcc tggagccttt ggggagacgt
     1921 gtgagaagtg cccaacctgc cctgatgctt gcagctccaa gagagactgt gtggaatgct
     1981 cgctgcttca ccaggggaaa cctgacaacc agacctgcca ccaccagtgc aaagatgagg
     2041 tgatcacgtg ggtagacagc attgtcaaag acgaccagga agctgtgctt tgcttctaca
     2101 aaactgctaa ggactgcgtt atgatgttca gctacacaga actgcccaat ggaaagtcta
     2161 acttgaccgt cctcagggag ccagagtgcg gaagtgcccc caatgccatg accatcctgc
     2221 tggctgtggt tggcagcatc ctcctggttg gaatggcact cctggccatc tggaaactac
     2281 tcgtcaccat ccacgaccgt cgagagtttg ccaagttcca aagcgagcgc tccagggccc
     2341 gttatgaaat ggcctcaaac cccctgtaca gaaagcccat ctccacacat actgtagatt
     2401 ttgccttcaa caagttcaac aaatcctaca atggctcagt ggactgagct cctggatggc
     2461 tggaggggga ctgaggacaa agactggtgt gtctcggact ccttggacca tttgctcacg
     2521 ctagctaggc acgcaccaag atgcctccaa tgagctgtaa gggatccgct ccccgcacag
     2581 caggccacag gcacgtgggg ccacttccct ccaagccagg gagagcaagg agactggcgt
     2641 tcccagcttc cccatggccg acagcttgct gtctccttga actgctgaag gctgcgtggc
     2701 ccctcccttc cctgccgggc cggacgagaa gctatctgga agagtctgcg tgtacaaagc
     2761 cagtgcacca cctggctttt tggggttgat cagtttcttt ttttctatga aataaaatgt
     2821 cacgcatgta tggtgtagat ctgattactg gtcccctgag ggctgtctgc ctggcatctg
     2881 tgggtgttgg tggtggaatc tgggagttgc tttgccttgc aaatgttagg ttttgccctc
     2941 cggtccatgt ttgtttagtt gcttttgtaa tggaaaggaa agactgggat tgaaagtaaa
     3001 aatggaaacc aagcaacttt gtgttggctt tgtacattct ggcatgtgcc tccctttctg
     3061 agaggtcttc agtagcccca gtagagactg gtgtgtctct acacgttgtc agggacagga
     3121 attgaactag accaatactc ctgagcctgg ctctctgaag tgctggggta attacggtgc
     3181 ttcaagagtg ctgagcaagt accgttgggc tttgcttgga gttctagata gaaactgtgt
     3241 ccacctatgt gtttcccacc tatgttctgc gttactaaag ctagaaacag atggtgcaga
     3301 tgctagtggg tggaggtttt gtgtgtcgac ttgacacaag ctggagttat cacagagaaa
     3361 ggagcctccc ttgaggaaat gccgtcatga gatccagctg gaaggcattt tctcaattag
     3421 tgatcaagtg gagagggccc agtccattgt gtgtggtgcc atccctggga tggtggtcct
     3481 gggttctata agaaggcagg ctgagcaagc cagtaagcag cacccctcca cggcctctgc
     3541 atcagctcct gcctccaggt tcctgacctg tgagttcctg tcctgtgtga gttcctgtcc
     3601 tgtgtgagtt cctgtcctga cttcctttgg tgatgaacag caatgtggaa gtgtaagctg
     3661 aataaactct ttctctccaa aaaaaaaaaa aaaaaa
//
