LOCUS       NM_013180               6042 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus integrin subunit beta 4 (Itgb4), mRNA.
ACCESSION   NM_013180
VERSION     NM_013180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6042)
  AUTHORS   Zhang,W., Zhang,X., Zhang,L., Xu,D., Cheng,N., Tang,Y. and Peng,Y.
  TITLE     Astrocytes increase exosomal secretion of oligodendrocyte precursor
            cells to promote their proliferation via integrin beta4-mediated
            cell adhesion
  JOURNAL   Biochem Biophys Res Commun 526 (2), 341-348 (2020)
   PUBMED   32220495
  REMARK    GeneRIF: Astrocytes increase exosomal secretion of oligodendrocyte
            precursor cells to promote their proliferation via integrin
            beta4-mediated cell adhesion.
REFERENCE   2  (bases 1 to 6042)
  AUTHORS   Poitelon,Y., Matafora,V., Silvestri,N., Zambroni,D., McGarry,C.,
            Serghany,N., Rush,T., Vizzuso,D., Court,F.A., Bachi,A., Wrabetz,L.
            and Feltri,M.L.
  TITLE     A dual role for Integrin alpha6beta4 in modulating hereditary
            neuropathy with liability to pressure palsies
  JOURNAL   J Neurochem 145 (3), 245-257 (2018)
   PUBMED   29315582
REFERENCE   3  (bases 1 to 6042)
  AUTHORS   Lu,Y., Han,B., Yu,H., Cui,Z., Li,Z. and Wang,J.
  TITLE     Berberine regulates the microRNA-21-ITGBeta4-PDCD4 axis and
            inhibits colon cancer viability
  JOURNAL   Oncol Lett 15 (4), 5971-5976 (2018)
   PUBMED   29564000
REFERENCE   4  (bases 1 to 6042)
  AUTHORS   Heintz,T.G., Eva,R. and Fawcett,J.W.
  TITLE     Regional Regulation of Purkinje Cell Dendritic Spines by Integrins
            and Eph/Ephrins
  JOURNAL   PLoS One 11 (8), e0158558 (2016)
   PUBMED   27518800
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6042)
  AUTHORS   Ni,X., Epshtein,Y., Chen,W., Zhou,T., Xie,L., Garcia,J.G. and
            Jacobson,J.R.
  TITLE     Interaction of integrin beta4 with S1P receptors in S1P- and
            HGF-induced endothelial barrier enhancement
  JOURNAL   J Cell Biochem 115 (6), 1187-1195 (2014)
   PUBMED   24851274
REFERENCE   6  (bases 1 to 6042)
  AUTHORS   Koster,J., Geerts,D., Favre,B., Borradori,L. and Sonnenberg,A.
  TITLE     Analysis of the interactions between BP180, BP230, plectin and the
            integrin alpha6beta4 important for hemidesmosome assembly
  JOURNAL   J Cell Sci 116 (Pt 2), 387-399 (2003)
   PUBMED   12482924
REFERENCE   7  (bases 1 to 6042)
  AUTHORS   Davies,D. and Holley,M.C.
  TITLE     Differential expression of alpha 3 and alpha 6 integrins in the
            developing mouse inner ear
  JOURNAL   J Comp Neurol 445 (2), 122-132 (2002)
   PUBMED   11891657
REFERENCE   8  (bases 1 to 6042)
  AUTHORS   Feltri,M.L., Arona,M., Scherer,S.S. and Wrabetz,L.
  TITLE     Cloning and sequence of the cDNA encoding the beta 4 integrin
            subunit in rat peripheral nerve
  JOURNAL   Gene 186 (2), 299-304 (1997)
   PUBMED   9074510
REFERENCE   9  (bases 1 to 6042)
  AUTHORS   Dowling,J., Yu,Q.C. and Fuchs,E.
  TITLE     Beta4 integrin is required for hemidesmosome formation, cell
            adhesion and cell survival
  JOURNAL   J Cell Biol 134 (2), 559-572 (1996)
   PUBMED   8707838
REFERENCE   10 (bases 1 to 6042)
  AUTHORS   Feltri,M.L., Scherer,S.S., Nemni,R., Kamholz,J., Vogelbacker,H.,
            Scott,M.O., Canal,N., Quaranta,V. and Wrabetz,L.
  TITLE     Beta 4 integrin expression in myelinating Schwann cells is
            polarized, developmentally regulated and axonally dependent
  JOURNAL   Development 120 (5), 1287-1301 (1994)
   PUBMED   8026337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 20, 2020 this sequence version replaced NM_013180.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U60096.1, SRR26360176.593952.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               JAXUCZ010000010.1  101705592-101705920
            330-424             JAXUCZ010000010.1  101708529-101708623
            425-507             JAXUCZ010000010.1  101709850-101709932
            508-609             JAXUCZ010000010.1  101710165-101710266
            610-814             JAXUCZ010000010.1  101710385-101710589
            815-911             JAXUCZ010000010.1  101711436-101711532
            912-1083            JAXUCZ010000010.1  101711696-101711867
            1084-1347           JAXUCZ010000010.1  101714966-101715229
            1348-1437           JAXUCZ010000010.1  101715515-101715604
            1438-1560           JAXUCZ010000010.1  101715899-101716021
            1561-1725           JAXUCZ010000010.1  101716279-101716443
            1726-1802           JAXUCZ010000010.1  101716969-101717045
            1803-2005           JAXUCZ010000010.1  101718745-101718947
            2006-2109           JAXUCZ010000010.1  101720414-101720517
            2110-2211           JAXUCZ010000010.1  101720611-101720712
            2212-2341           JAXUCZ010000010.1  101720843-101720972
            2342-2464           JAXUCZ010000010.1  101721660-101721782
            2465-2571           JAXUCZ010000010.1  101721867-101721973
            2572-2605           JAXUCZ010000010.1  101723752-101723785
            2606-2797           JAXUCZ010000010.1  101724091-101724282
            2798-2901           JAXUCZ010000010.1  101724538-101724641
            2902-2960           JAXUCZ010000010.1  101724898-101724956
            2961-2984           JAXUCZ010000010.1  101725129-101725152
            2985-3133           JAXUCZ010000010.1  101725862-101726010
            3134-3313           JAXUCZ010000010.1  101726097-101726276
            3314-3462           JAXUCZ010000010.1  101726764-101726912
            3463-3667           JAXUCZ010000010.1  101731637-101731841
            3668-3825           JAXUCZ010000010.1  101733367-101733524
            3826-4006           JAXUCZ010000010.1  101733813-101733993
            4007-4144           JAXUCZ010000010.1  101734128-101734265
            4145-4327           JAXUCZ010000010.1  101736634-101736816
            4328-4459           JAXUCZ010000010.1  101736895-101737026
            4460-4696           JAXUCZ010000010.1  101738973-101739209
            4697-4855           JAXUCZ010000010.1  101739359-101739517
            4856-5005           JAXUCZ010000010.1  101739929-101740078
            5006-5194           JAXUCZ010000010.1  101740522-101740710
            5195-5350           JAXUCZ010000010.1  101740829-101740984
            5351-5515           JAXUCZ010000010.1  101741065-101741229
            5516-5629           JAXUCZ010000010.1  101741310-101741423
            5630-6042           JAXUCZ010000010.1  101741521-101741933
FEATURES             Location/Qualifiers
     source          1..6042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..6042
                     /gene="Itgb4"
                     /note="integrin subunit beta 4"
                     /db_xref="GeneID:25724"
                     /db_xref="RGD:2928"
     exon            1..329
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            330..424
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..5769
                     /gene="Itgb4"
                     /note="integrin beta-4; GP150"
                     /codon_start=1
                     /product="integrin beta-4 precursor"
                     /protein_id="NP_037312.2"
                     /db_xref="GeneID:25724"
                     /db_xref="RGD:2928"
                     /translation="MAGLCSSPWVKLLLAVVLSAGLPGNMANRCKKAQVKSCTECIRV
                     DKSCAYCTDELFKERRCNTQAELLAAGCRGESVLVMESSLEITENIQIDTSLHRSQVS
                     PQGLQVRLRPGEERNFVFKVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKIL
                     RQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWD
                     KLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANV
                     LAGIMNRNDEKCHLDATGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYE
                     KLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQK
                     TETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQMAKEDQRGNIHLKPSFSDGLRMDAS
                     VICDVCACELQKEVQSARCHYRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREG
                     EDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCE
                     PGWTGRSCDCPLSNATCIDSNGGICNGLGFCECGRCHCNQRSSLYTDTTCEINYSAIR
                     LGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKKAEEVVEYCSFRDEDDDC
                     TYSYTVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLVLLLLLCWKYCAC
                     CKACLGLLPCCNQGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITN
                     NVQRPGFATHAASISPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEV
                     YRQVNGVHKLQQTKFRQQPNAGKKQDHTIVDTVLLAPRSAKQSLLKLTEKQVEQGSFH
                     ELKVAPGYYTLTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVG
                     TATLGRRLVNITIIKEQASGIVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYST
                     QDNTAHGHRDYVPVEGELLFYPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNP
                     KFGARLGQPNTATVIIGEQDETDRSLINEISASPPLPRGDLGAPQNPNAKAAGSRKIH
                     FNWLPPPGKPMGYRVKYWVQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAH
                     GEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLV
                     NEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLAT
                     QPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGR
                     MDFAYPGSANSLHRMTAANVAYGTHLSPHQTHRMLSTSSTLTRDYHSLTRTDHSQSGT
                     LPRDYSTLTSLSSQGLPPIWEDGRSRLPLSWTLGSWSRAQMKGVPASRGSPDSIILAG
                     QSAAPSWGTDSRGAMGVPDTPTRLVFSALGPTSLKVSWQEPQCDRALLGYSVEYQLLN
                     GGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQS
                     PLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGG
                     GPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPF
                     PQLGSHSGLFQNPLQSEYSTVTSTHSTTTTEPFLIDGLTLGTQRLEAGGSLTRHVTQE
                     FVSRTLTTSGSLSTHMDQQFFQT"
     exon            425..507
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            508..609
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            610..814
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            815..911
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1083
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1347
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1437
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1560
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1725
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1802
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..2005
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2109
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2211
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2341
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2464
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2571
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2605
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2797
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2901
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2960
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..2984
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3133
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3313
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3462
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3667
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3825
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..4006
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4144
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4327
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4459
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4696
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4855
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4856..5005
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5006..5194
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5195..5350
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5351..5515
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5516..5629
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5630..6042
                     /gene="Itgb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggggatcc gatccaggag cctgtggctc ctcctccagc cccctccggg gcggctcgga
       61 gctcggggcc ggcgccggtt gagccgcagc cctttccggg gggcgggcct ggaggctggg
      121 acgacacccc agctcctgcc ccgacaggtg cgcgcagcgc acaggaatgc agcccgcctg
      181 actcaccagc gcctccttcc tacctgcgcc gcccgtccat aaagcactgc tggctcccgc
      241 ccgccgccgc ccgacaagct gtccggccgg gctcgcccgc gcactcagct cgacccaacg
      301 cagcccaagt ccgaggtagt cccactcagg aggaggaaga ggaggatggc agggctatgt
      361 tccagcccgt gggtgaagct gctactggca gtagtgctga gtgccggtct ccctggaaac
      421 atggccaacc gctgtaagaa ggctcaggtg aagagctgta cggagtgcat ccgagtggac
      481 aagagctgtg cctactgcac agacgagctg ttcaaggagc gacgctgcaa cacccaggcg
      541 gagcttctgg ctgcaggctg ccggggagag agcgtgttgg tcatggagag cagccttgag
      601 atcacagaga acatccagat tgacaccagc ctgcaccgca gccaggtatc tccccaaggc
      661 ctgcaagtgc ggctgcggcc gggtgaggag cgcaactttg tgttcaaggt gtttgagccc
      721 ctggagagcc ccgtggatct gtatatcctc atggactttt ccaactccat gtctgatgat
      781 ctggacaacc tcaagcagat ggggcagaac ctggccaaga tcctgcgcca gctcaccagt
      841 gactacacta ttggattcgg aaagtttgtg gacaaagtca gtgtccctca gacggacatg
      901 aggcccgaga agctgaagga gccgtggccc aacagcgacc ccccattctc cttcaagaat
      961 gttatcagct taacagagaa tgtggaggaa ttctgggaca aactgcaagg agaacgcatc
     1021 tcaggcaacc tggacgctcc tgaaggaggc ttcgacgcca tcctgcagac agccgtgtgc
     1081 acaagggaca ttggctggag agcggacagc acccacctgc tggtgttctc caccgagtct
     1141 gccttccact atgaggctga tggtgccaac gtgctggccg gcatcatgaa ccgcaatgat
     1201 gagaagtgcc acctggatgc cacaggcgcc tacacccagt ataagaccca ggactaccca
     1261 tctgtgccca cactggttcg cctgcttgcc aaacacaaca ttatccccat ctttgccgtc
     1321 accaactact cttacagtta ctacgagaag ctccataaat atttccctgt ctcctctctg
     1381 ggagtcctgc aggaagattc atccaacatc gtggagctgc tggaggaggc tttctatcga
     1441 attcgctcca acctggacat ccgggctctg gacagcccga gaggcctgag gacagaggtc
     1501 acctccgata ccctccagaa gacagagact gggtcctttc acatcaagcg gggggaagtg
     1561 ggcacataca atgtgcatct tcgggcagtg gaggacatag atgggacaca cgtgtgccag
     1621 atggccaaag aagaccaaag aggtaacatc cacctgaaac cctccttctc cgatggcctc
     1681 cggatggacg cgagcgtcat ctgtgacgtg tgcgcctgcg agctgcaaaa ggaagttcag
     1741 tcagctcgct gtcactacag aggagacttc atgtgtggac actgtgtgtg caacgagggc
     1801 tggagtggca aaacctgcaa ttgctccacg ggttccctga gtgacacgca gccctgcctg
     1861 cgtgagggtg aggacaaacc atgctcgggc catggcgagt gccagtgcgg acgttgtgtg
     1921 tgctacggtg aaggccgcta cgagggtcac ttctgcgagt atgacaactt ccagtgtccc
     1981 cgcacctctg gattcctttg caatgaccgg ggacgctgct ccatgggaga gtgtgtgtgt
     2041 gagcctggtt ggaccggccg cagctgtgac tgtcccctca gcaatgccac ctgtatcgat
     2101 agcaatgggg gcatctgcaa tggactaggc ttctgtgagt gtggccgttg tcactgcaac
     2161 cagcggtctt cgctctacac ggacaccacc tgtgagatca actactcggc gatacgcctg
     2221 ggcctctgtg aggacctccg ctcctgtgta cagtgccagg cctggggcac tggggagaag
     2281 aaagggcgca cgtgtgagga atgcaacttt aaggtcaaga tggtagacga gcttaagaaa
     2341 gcggaagagg tggtggagta ctgctccttc cgggacgagg atgacgactg cacttacagc
     2401 tacaccgtgg agggcgacgg cagccctggg cccaacagca ccgtcctggt ccacaagaag
     2461 aaagactgcc ctcccggctc cttctggtgg ctcattcccc tgctcatctt cctcctgttg
     2521 ctcctggtgt tgcttctgct gctctgctgg aaatactgtg cctgctgcaa agcctgcctg
     2581 ggacttcttc cttgctgcaa ccaaggtcac atggtgggct ttaaggaaga tcactatatg
     2641 ctgcgggaga acctgatggc ctctgaccac ctggacacgc ccatgctgag aagtgggaac
     2701 ctcaagggac gagacacagt ccgctggaag atcaccaaca atgtgcaacg gcctggcttt
     2761 gccacccatg ctgccagcat cagccccaca gagctcgtac cctatgggct atccctgcgc
     2821 cttggccgcc tctgcactga gaacctcatg aagcctggca cccgagagtg tgaccagcta
     2881 cgccaggagg tggaggaaaa tctgaatgag gtatacagac aagtcaacgg cgtacacaag
     2941 ctccagcaga cgaagttccg acagcaaccc aacgctggga aaaagcaaga ccacaccatt
     3001 gtggacacag tgttgctggc gccccgctct gccaagcagt cgctgctgaa gctgacagag
     3061 aagcaggtgg agcaggggtc cttccatgaa ctcaaggtgg cccctggtta ctacaccctc
     3121 acagcagagc aggatgcccg gggcatggtg gagttccagg agggggtaga gctggtggac
     3181 gtgcgtgtgc ccctcttcat ccggcctgag gatgatgatg agaaacagct gctggtggag
     3241 gccattgatg tccccgtggg cactgccacc cttggtcgac gcctggtaaa catcaccatc
     3301 attaaggagc aagctagcgg gatagtgtcc tttgagcagc ctgaatactc agtgagtcgt
     3361 ggagaccagg tggcccgcat ccctgtcatc cggcacatcc tggacaacgg caagtcccag
     3421 gtctcctata gcacacagga taatacagca catggacacc gggattatgt ccctgtggaa
     3481 ggggagctgt tgttctaccc cggagagacc tggaaggaac tgcaggtgaa gctcctggag
     3541 ctgcaggaag tcgactccct ccttcgtggc cgccaggtcc gacgcttcca agttcaactc
     3601 agcaacccca agtttggagc ccgcctgggc cagcccaaca cagccactgt tatcatcggg
     3661 gaacaagatg aaacggacag aagtctcata aatgagatat ccgcatcgcc gccactaccc
     3721 cgtggagacc tgggtgcccc gcagaacccc aatgccaagg ctgccggatc caggaagatc
     3781 catttcaact ggctgccccc tcctggcaag ccaatggggt atagggtgaa atactgggtc
     3841 cagggcgact ctgagtccga agcccacctg ctggacagca aggtgccctc agtggagctc
     3901 accaacctgt atccctattg cgactacgaa atgaaggtgt gcgcctacgg ggcacacggg
     3961 gaggggccct atagctcact ggtgtcctgc cgcacccacc aggaagtgcc cagtgagcca
     4021 ggaaggctgg ctttcaatgt agtttcttct acggtgaccc agctgagctg ggcagaacca
     4081 gctgaaacca acggggagat cacagcctat gaggtctgct atggactggt caacgaggac
     4141 aaccgaccca ttggacctat gaagaaggtg cttgtggaca accccaagaa ccggatgctg
     4201 ctcattgaga atcttcgaga gtcccagcca taccgataca cggtgaaggc gcgaaacggg
     4261 gcaggatggg gacccgagag agaggctatc atcaacctgg ccacacagcc caagcggccc
     4321 atgtccattc ctatcatccc agacatcccc atagtggacg cccagggtgg agaagactac
     4381 gaaaacttcc tcatgtacag tgacgacgtt ctgcgctccc cagccagcag ccagaggccc
     4441 agcgtttcag atgacactga gcacctggtg aatggccgga tggactttgc ctatccaggc
     4501 agtgccaact ccctgcatag gatgactgct gccaacgtgg cctatggcac acatctaagc
     4561 ccacaccaga cccaccgaat gctgagcacg tcttctaccc ttacccggga ctaccactct
     4621 ctgacgcgca cagaccactc tcagtcaggc acacttcccc gggactactc cactctcact
     4681 tccctttcct cccaaggcct ccctcctatc tgggaagatg ggaggagcag gcttccgctg
     4741 tcctggaccc ttgggtcctg gagccgggct cagatgaagg gtgtgcccgc atccaggggc
     4801 tcaccagact ctataatcct ggccgggcag tcagcagcgc cctcctgggg tacagattcc
     4861 cgtggggcta tgggtgtgcc cgacacaccc actcggctgg tgttctccgc cctggggccc
     4921 acatctctga aggtgagctg gcaggagcca cagtgtgatc gagcactgct gggctacagc
     4981 gtggaatacc agctactcaa cggcggcgag atgcatcggc tcaacatccc taaccctggc
     5041 caaacctctg tggtggtaga ggatctcctg cctaaccact cctatgtgtt ccgggtgcgg
     5101 gcacaaagcc aggagggctg gggccgggag cgagagggtg tcatcaccat cgagtcccag
     5161 gtgcacccgc agagccctct ctgccccctg ccaggctccg ccttcacctt gagcaccccc
     5221 agcgccccag gccccctggt gttcactgcc ctaagcccag actctctgca gctgagctgg
     5281 gagcgcccaa gaaggcccaa cggagatatc cttggctacc tggtgacctg tgagatggcc
     5341 caaggaggag gaccagccag aaccttccgg gtggatgggg acaaccctga gagccggctg
     5401 acggttcctg gcctcagtga gaacgttcct tacaagttca aggtgcaggc ccggacaaca
     5461 gagggctttg ggcccgagcg tgagggtatc atcaccatcg agtctcagga tggaggcccc
     5521 ttcccacagc tgggcagcca ttctgggctt ttccagaacc cactgcaaag tgagtacagc
     5581 actgtcacca gcactcacag cactaccacc accgagccct tccttataga tggactaacc
     5641 ctggggaccc agcgcctgga agcagggggc tccctcaccc ggcatgtgac ccaggaattt
     5701 gtgagccgga ccctgaccac cagtggctct ctcagcactc atatggacca acagttcttc
     5761 caaacctgaa tcccccagga acctgggccc ctccttgcct cctcgccctg gcgccttctt
     5821 cctctgctgt tgtacccacc tgcatgctga tcacagagcc agcacctgta gtcagagagc
     5881 gggggtaggt gctgtctggg aggcatgaag tgggtagagg tgacacaaga cctctgactg
     5941 catcctgccc tgggtccaaa cccacatgta accaaaaagc tggagccgac acaaggaccc
     6001 agcctttgtt ctgcacttaa taaaagactt tgctactgcg ta
//
