LOCUS       NM_153720               2377 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus integrin subunit beta 3 (Itgb3), mRNA.
ACCESSION   NM_153720
VERSION     NM_153720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2377)
  AUTHORS   Changaei,M., Javidan,M., Ramezani Tehrani,F., Mosaffa,N.,
            Noroozzadeh,M., Hosseinzadeh,R. and Rajaei,S.
  TITLE     Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo
            implantation site of rat model with prenatal androgen-induced
            polycystic ovary syndrome
  JOURNAL   Am J Reprod Immunol 90 (1), e13702 (2023)
   PUBMED   37062956
  REMARK    GeneRIF: Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in
            the embryo implantation site of rat model with prenatal
            androgen-induced polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 2377)
  AUTHORS   Li,L., Rongfang,Z., Junhai,Z., Changqin,C. and Jing,Y.
  TITLE     Integrin alphanubeta3 modulates lipopolysaccharide-induced
            hyperpermeability in cardiac microvascular endothelial cells
  JOURNAL   Biosci Biotechnol Biochem 84 (8), 1614-1620 (2020)
   PUBMED   32351169
  REMARK    GeneRIF: Integrin alphanubeta3 modulates lipopolysaccharide-induced
            hyperpermeability in cardiac microvascular endothelial cells.
REFERENCE   3  (bases 1 to 2377)
  AUTHORS   Bye,A.P., Gibbins,J.M. and Mahaut-Smith,M.P.
  TITLE     Ca2+ waves coordinate purinergic receptor-evoked integrin
            activation and polarization
  JOURNAL   Sci Signal 13 (615) (2020)
   PUBMED   31964805
  REMARK    GeneRIF: Ca(2+) waves coordinate purinergic receptor-evoked
            integrin activation and polarization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2377)
  AUTHORS   Takada,Y.K., Yu,J., Shimoda,M. and Takada,Y.
  TITLE     Integrin Binding to the Trimeric Interface of CD40L Plays a
            Critical Role in CD40/CD40L Signaling
  JOURNAL   J Immunol 203 (5), 1383-1391 (2019)
   PUBMED   31331973
REFERENCE   5  (bases 1 to 2377)
  AUTHORS   Liu,A., Liu,Y., Li,B., Yang,M., Liu,Y. and Su,J.
  TITLE     Role of miR-223-3p in pulmonary arterial hypertension via targeting
            ITGB3 in the ECM pathway
  JOURNAL   Cell Prolif 52 (2), e12550 (2019)
   PUBMED   30507047
  REMARK    GeneRIF: MiR-223-3p alleviated the progression of pulmonary
            arterial hypertension by suppressing the expression of ITGB3, a
            finding which provides novel targets for clinical treatment.
REFERENCE   6  (bases 1 to 2377)
  AUTHORS   Peretz,H., Rosenberg,N., Usher,S., Graff,E., Newman,P.J.,
            Coller,B.S. and Seligsohn,U.
  TITLE     Glanzmann's thrombasthenia associated with deletion-insertion and
            alternative splicing in the glycoprotein IIb gene
  JOURNAL   Blood 85 (2), 414-420 (1995)
   PUBMED   7529063
REFERENCE   7  (bases 1 to 2377)
  AUTHORS   Brooks,P.C., Montgomery,A.M., Rosenfeld,M., Reisfeld,R.A., Hu,T.,
            Klier,G. and Cheresh,D.A.
  TITLE     Integrin alpha v beta 3 antagonists promote tumor regression by
            inducing apoptosis of angiogenic blood vessels
  JOURNAL   Cell 79 (7), 1157-1164 (1994)
   PUBMED   7528107
REFERENCE   8  (bases 1 to 2377)
  AUTHORS   Nishimura,S.L., Sheppard,D. and Pytela,R.
  TITLE     Integrin alpha v beta 8. Interaction with vitronectin and
            functional divergence of the beta 8 cytoplasmic domain
  JOURNAL   J Biol Chem 269 (46), 28708-28715 (1994)
   PUBMED   7525578
REFERENCE   9  (bases 1 to 2377)
  AUTHORS   Helfrich,M.H., Nesbitt,S.A. and Horton,M.A.
  TITLE     Integrins on rat osteoclasts: characterization of two monoclonal
            antibodies (F4 and F11) to rat beta 3
  JOURNAL   J Bone Miner Res 7 (3), 345-351 (1992)
   PUBMED   1585837
REFERENCE   10 (bases 1 to 2377)
  AUTHORS   Bray,P.F. and Shuman,M.A.
  TITLE     Identification of an abnormal gene for the GPIIIa subunit of the
            platelet fibrinogen receptor resulting in Glanzmann's
            thrombasthenia
  JOURNAL   Blood 75 (4), 881-888 (1990)
   PUBMED   1967954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153720.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ440952.1, SRR26643429.39351.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000010.1  90009927-90010012
            87-172              JAXUCZ010000010.1  90026312-90026397
            173-368             JAXUCZ010000010.1  90035976-90036171
            369-621             JAXUCZ010000010.1  90037308-90037560
            622-784             JAXUCZ010000010.1  90040584-90040746
            785-946             JAXUCZ010000010.1  90041347-90041508
            947-1042            JAXUCZ010000010.1  90043601-90043696
            1043-1132           JAXUCZ010000010.1  90044290-90044379
            1133-1267           JAXUCZ010000010.1  90045420-90045554
            1268-1697           JAXUCZ010000010.1  90046809-90047238
            1698-1920           JAXUCZ010000010.1  90055709-90055931
            1921-2021           JAXUCZ010000010.1  90057143-90057243
            2022-2141           JAXUCZ010000010.1  90059459-90059578
            2142-2308           JAXUCZ010000010.1  90062505-90062671
            2309-2377           JAXUCZ010000010.1  90064533-90064601
FEATURES             Location/Qualifiers
     source          1..2377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2377
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /note="integrin subunit beta 3"
                     /db_xref="GeneID:29302"
                     /db_xref="RGD:628868"
     exon            1..86
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2374
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /note="integrin beta 3 (Cd61); integrin, beta 3; platelet
                     membrane glycoprotein IIIa"
                     /codon_start=1
                     /product="integrin beta-3 precursor"
                     /protein_id="NP_714942.1"
                     /db_xref="GeneID:29302"
                     /db_xref="RGD:628868"
                     /translation="MRTRRPGQLWATLLALGALAGVVVGESNICTTRGVNSCQQCLAV
                     SPVCAWCSDESLPQNSPRCNLKKNLLKDKCSPESIEFPVSEAQILEALPLSSKGSGDS
                     AQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDLSFSMKDDLSSIQTLG
                     TKLASQMRKLTSNLRIGFGAFVDKPVSPYMFISPPQAIKNPCYTMKSTCLPMFGYKHV
                     LTLTDQVTRFNDEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTD
                     AKTHIALDGRLAGIVLPNDGRCHIGPDNHYSASTTMDYPSLGLMTEKLSQKNINLIFA
                     VTENVVSLYQNYSELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELS
                     LSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPQQKEQSFTIKPVGFKDSL
                     TVQVTFDCDCDCQAFAQPLSPRCNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQ
                     EECSPKEGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQ
                     CNCGDCVCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCE
                     KCPTCPDACSFKKDCVECKKFNRGKLHEENNCNRFCRDDIELVKELTDTGKNAVNCTY
                     KNEDDCVVRFQYYEDSSGRAVLYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIW
                     KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT"
     exon            87..172
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            173..368
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            369..621
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            622..784
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            785..946
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1042
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1132
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1267
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1697
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1920
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2021
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2141
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2308
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2377
                     /gene="Itgb3"
                     /gene_synonym="GPIIIa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggacagg atgcgaacgc ggcggccggg acagctctgg gccactctgc tggcgctggg
       61 ggcgctggcg ggcgttgtcg tcggagagtc caacatctgt accacgagag gcgtgaactc
      121 ctgccagcag tgtctggccg taagtcccgt gtgtgcctgg tgctcagatg agtctctgcc
      181 tcagaactcg ccccgctgta acctgaaaaa gaacctgctg aaggataagt gctccccaga
      241 gtctattgag ttcccagtca gcgaggccca gatcctggaa gctcttccgc tcagcagcaa
      301 gggctcagga gacagcgccc agatcactca ggtcagcccc cagaggatcg cccttcggct
      361 gcggccagat gattcgaaga tcttttcact ccaagtgcgg caggtggagg attaccctgt
      421 agacatctac tacttgatgg atctgtcttt ctccatgaag gatgatctgt ccagcatcca
      481 gaccctgggt accaagttgg cctctcagat gcgcaagctt accagcaacc ttcggattgg
      541 ctttggggcc tttgtggaca agcccgtgtc tccatacatg ttcatctccc caccacaggc
      601 gatcaaaaac ccctgttaca ctatgaagag tacctgcttg cccatgtttg gctacaaaca
      661 tgtgctaaca ctaaccgacc aggtgacccg cttcaatgac gaagtgaaga agcagagtgt
      721 gtcacgtaac cgagatgccc cagagggcgg ctttgacgcc atcatgcagg ctacagtctg
      781 tgatgaaaaa attggctgga ggaatgatgc atcccatttg ctggtgttta ccactgatgc
      841 caagacccat attgccctgg acggaaggct ggcaggcatt gtcttgccca atgatgggcg
      901 ctgccacatt ggcccggaca accactactc tgcttccact actatggatt acccatctct
      961 ggggctgatg actgagaaac tatcccagaa gaacattaac ttgatctttg cagtgaccga
     1021 aaatgtcgtc agcctttacc agaattacag tgagctcatc ccggggacca cagtgggagt
     1081 cctgtctgat gactcaagca atgtccttca gctcatcgtt gatgcttacg ggaaaatccg
     1141 ttctaaagtg gagctggaag tgcgtgatct ccccgaagag ctgtcgctgt ccttcaatgc
     1201 cacctgcctc aacaacgagg tcatcccagg cctcaagtct tgtgtgggcc tcaagattgg
     1261 agacacggtg agcttcagca tcgaggccaa ggtgcgtggc tgcccccagc agaaggagca
     1321 atctttcact attaagcctg tgggctttaa ggacagcctt acagtccagg tgaccttcga
     1381 ctgtgactgt gactgccagg cctttgccca gcctctcagc ccacgctgca acaatggtaa
     1441 cggaaccttt gagtgtgggg tgtgccgctg tgatcagggc tggctgggct ccatgtgtga
     1501 gtgctccgag gaggactatc gaccctctca gcaggaagag tgcagcccca aggaaggcca
     1561 gcccatctgc agccagcggg gcgagtgcct ctgtggccag tgcgtctgcc acagcagtga
     1621 ctttggcaag atcaccggca agtactgtga gtgtgatgac ttctcctgtg tccgctacaa
     1681 aggggagatg tgctctggcc atggccagtg caactgtggg gactgcgtgt gtgactcgga
     1741 ctggactggc tactactgca actgcacaac acgcaccgac acctgcatgt ccaccaacgg
     1801 gctgctgtgc agcggccggg gcaactgtga gtgtggcagc tgtgtgtgcg tccagccagg
     1861 ctcctatgga gacacctgtg agaagtgtcc cacctgccca gatgcctgct catttaagaa
     1921 ggactgtgtg gagtgtaaga agttcaaccg gggaaagcta catgaagaaa acaactgcaa
     1981 ccgtttctgc cgagatgaca tcgagctggt gaaagaactg acggatactg gcaaaaacgc
     2041 ggtgaactgt acctacaaga atgaggacga ctgtgtcgtc agattccagt actatgaaga
     2101 ctccagtgga agggctgtcc tgtatgtggt agaagagcct gagtgtccta agggtcctga
     2161 tatcctggtg gtcctgctgt cagtgatggg ggcgattctg ctcattggcc ttgctactct
     2221 gctcatctgg aagctactca tcaccattca tgaccggaag gaatttgcta aatttgagga
     2281 agaacgagcc agagccaaat gggacacagc aaacaaccca ttgtataaag aggccacctc
     2341 caccttcacc aatatcacct accgggggac ttaatga
//
