LOCUS       NM_001037780            3161 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus integrin subunit beta 2 (Itgb2), mRNA.
ACCESSION   NM_001037780 XM_228072
VERSION     NM_001037780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3161)
  AUTHORS   Zhou H, Yang Z, Mu L and Shi Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3161)
  AUTHORS   Bai M, Grieshaber-Bouyer R, Wang J, Schmider AB, Wilson ZS, Zeng L,
            Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT,
            Soberman RJ and Nigrovic PA.
  TITLE     CD177 modulates human neutrophil migration through
            activation-mediated integrin and chemoreceptor regulation
  JOURNAL   Blood 130 (19), 2092-2100 (2017)
   PUBMED   28807980
REFERENCE   3  (bases 1 to 3161)
  AUTHORS   Oksala N, Parssinen J, Seppala I, Klopp N, Illig T, Laaksonen R,
            Levula M, Raitoharju E, Kholova I, Sioris T, Kahonen M, Lehtimaki T
            and Hytonen VP.
  TITLE     Kindlin 3 (FERMT3) is associated with unstable atherosclerotic
            plaques, anti-inflammatory type II macrophages and upregulation of
            beta-2 integrins in all major arterial beds
  JOURNAL   Atherosclerosis 242 (1), 145-154 (2015)
   PUBMED   26188538
REFERENCE   4  (bases 1 to 3161)
  AUTHORS   Baert K, Sonck E, Goddeeris BM, Devriendt B and Cox E.
  TITLE     Cell type-specific differences in beta-glucan recognition and
            signalling in porcine innate immune cells
  JOURNAL   Dev Comp Immunol 48 (1), 192-203 (2015)
   PUBMED   25453580
REFERENCE   5  (bases 1 to 3161)
  AUTHORS   Morales O, Mrizak D, Francois V, Mustapha R, Miroux C, Depil S,
            Decouvelaere AV, Lionne-Huyghe P, Auriault C, de Launoit Y, Pancre
            V and Delhem N.
  TITLE     Epstein-Barr virus infection induces an increase of T regulatory
            type 1 cells in Hodgkin lymphoma patients
  JOURNAL   Br J Haematol 166 (6), 875-890 (2014)
   PUBMED   25041527
REFERENCE   6  (bases 1 to 3161)
  AUTHORS   Wada J, Shikata K, Makino H, Morioka S, Hirata K, Ota K, Tamatani
            T, Miyasaka M, Horiuchi T, Noji S, Nishikawa K, Myokai F, Taniguchi
            S, Kanwar Y and Ota Z.
  TITLE     The critical role of intercellular adhesion molecule-1 in Masugi
            nephritis in rats
  JOURNAL   Nephron 73 (2), 264-272 (1996)
   PUBMED   8773354
REFERENCE   7  (bases 1 to 3161)
  AUTHORS   Chu HW, Wang JM, Boutet M, Boulet LP and Laviolette M.
  TITLE     Increased expression of intercellular adhesion molecule-1 (ICAM-1)
            in a murine model of pulmonary eosinophilia and high IgE level
  JOURNAL   Clin Exp Immunol 100 (2), 319-324 (1995)
   PUBMED   7743671
REFERENCE   8  (bases 1 to 3161)
  AUTHORS   Mulligan MS, Warren JS, Smith CW, Anderson DC, Yeh CG, Rudolph AR
            and Ward PA.
  TITLE     Lung injury after deposition of IgA immune complexes. Requirements
            for CD18 and L-arginine
  JOURNAL   J Immunol 148 (10), 3086-3092 (1992)
   PUBMED   1374449
REFERENCE   9  (bases 1 to 3161)
  AUTHORS   Tamatani T, Kotani M and Miyasaka M.
  TITLE     Characterization of the rat leukocyte integrin, CD11/CD18, by the
            use of LFA-1 subunit-specific monoclonal antibodies
  JOURNAL   Eur J Immunol 21 (3), 627-633 (1991)
   PUBMED   1672643
REFERENCE   10 (bases 1 to 3161)
  AUTHORS   Arnaout MA, Dana N, Gupta SK, Tenen DG and Fathallah DM.
  TITLE     Point mutations impairing cell surface expression of the common
            beta subunit (CD18) in a patient with leukocyte adhesion molecule
            (Leu-CAM) deficiency
  JOURNAL   J Clin Invest 85 (3), 977-981 (1990)
   PUBMED   1968911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085817.1.
            
            On Dec 27, 2007 this sequence version replaced NM_001037780.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132272,
                                           SAMD00132286 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              BC085817.1         1-1150
            1151-3161           BC085817.1         1978-3988
FEATURES             Location/Qualifiers
     source          1..3161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3161
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /note="integrin subunit beta 2"
                     /db_xref="GeneID:309684"
                     /db_xref="RGD:1305581"
     exon            1..90
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            91..311
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..2560
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /note="integrin, beta 2 (antigen CD18 (p95), lymphocyte
                     function-associated antigen 1; macrophage antigen 1
                     (mac-1) beta subunit); CD18 leukocyte adhesion molecule;
                     integrin beta-2"
                     /codon_start=1
                     /product="integrin beta-2 precursor"
                     /protein_id="NP_001032869.2"
                     /db_xref="GeneID:309684"
                     /db_xref="RGD:1305581"
                     /translation="MLGPHTLLLILAGLLFLGSALSEECTKYKVSNCRDCIQSGPGCS
                     WCQKLNFTGPGEPDSLRCDTRAQLLLKGCPADDIMDPKSFADLHPQYQVQRSQLSPQK
                     VTLNLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEI
                     TESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQ
                     TEVGKQLISGNLDAPEGGLDAIMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLG
                     AILTPNDGRCHLEDNMYKRSNEFDYPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLT
                     EIIPKSAVGELSDDSSNVVQLIKKAYYKLSSRVFLDHTTIPDTLKVTYDSFCNNRVSS
                     IGKSRGDCDGVQINNPVTFQVKVTASECIQEQSFVIRALGFTDTVTVQVHPQCECQCR
                     DQSRMRNLCGGKGVMECGICRCESGYIGKNCECQTQGRSSQELEGNCRKDNSSIVCSG
                     LGDCICGQCVCHTSDIPNKVIFGQYCECDNFNCERYDGQVCGGLKRGSCSCGQCNCKE
                     GFEGSACQCQRSTTGCLNARLVECSGRGRCQCNRCICEKGYQPPLCEECPGCPLPCST
                     YVFCAECLKFDKGPFQKNCSVQCANVTLQTVPFKKKPCKERDSEGCWITYTLQQKDGN
                     AYNIHVDDDRECVKGPNVAAIIGGTVAGVVLIGVLLLVIWKALTHLTDLNEYRRFEKE
                     KLKSQWNNDNPLFKSATTTVMNPKFAES"
     exon            312..400
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            401..581
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            582..752
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            753..994
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1150
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1246
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1336
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1477
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1665
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1910
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2130
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2330
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2497
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..3161
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccaccaca gagccagctg gtgagaagca ggcagagaca tctccagtca gtcagattca
       61 cggattggag gcttcctggg accaagaggg gtacttgacc acctgagcca gcccccccac
      121 atccctccct gaggtagctg agtgacatct gtgctggccc tctctgatcc tcgtaccctg
      181 tggcagcaag cctgcaagga ggaactcctt gggtgatcag cctggagtca tctggccctt
      241 ctctccacag gacatgctgg gcccacacac actgctactc atcctagctg gactactctt
      301 cctgggatct gccctgtccg aggaatgcac caagtacaaa gtcagcaact gccgggactg
      361 tatccagtcg gggcctggct gctcgtggtg ccagaagctg aacttcaccg gaccagggga
      421 gcctgactcc ttgcgctgtg acacgcgggc acagctgctc ctcaagggtt gcccagccga
      481 tgatataatg gaccccaaga gctttgctga tctccacccc caatatcagg tgcaacggag
      541 tcaactgtct ccacaaaaag tgacccttaa cttgcgacca gggcaggctg ctgcattcaa
      601 tgtgactttc cgacgggcca agggctaccc cattgatctg tactacctca tggacctctc
      661 ctactctatg ctcgatgacc tgaacaatgt caagaagttg ggtggtgatt tgctgcaggc
      721 cctcaacgag atcacagagt ccggccgcat cggcttcggg tccttcgtgg acaagacggt
      781 gctgcctttt gtcaacaccc atcccgagaa gctgaggaac ccatgcccca acaaggagaa
      841 agcctgccag cctccgtttg cctttcgcca cgtgctcaag ctaaccgaca actccaacca
      901 gtttcagaca gaggtcggca agcaactgat ttccggaaac ctggacgccc ctgagggcgg
      961 gctggatgcc ataatgcaag tggctgcctg tccggaggaa attggctggc gcaatgtcac
     1021 gaggctgctg gtgtttgcca cagacgacgg cttccacttt gccggtgatg ggaaactggg
     1081 tgccatcctg acccccaacg atggccgctg ccacctggag gataacatgt acaagaggag
     1141 caatgagttc gactacccgt cagtgggcca gctggcccac aaactttccg agagcaacat
     1201 ccagcccatc tttgcagtga caaagaagat ggtgaaaacc tatgagaaac tgacagagat
     1261 tatccccaag tcagcggtgg gcgagctgtc tgacgattcc agtaacgtag tccagcttat
     1321 caagaaagcc tactacaaac tctcctctag agtcttcctg gaccacacca ccatcccgga
     1381 caccctgaaa gtcacctatg actccttctg taataacaga gtatcgagta taggcaaatc
     1441 ccgaggggac tgtgacggtg tgcagatcaa caacccggtc accttccagg taaaggtcac
     1501 ggcttcggag tgtatccagg agcagtcctt tgtcatccgg gcgctgggct tcaccgacac
     1561 agtgacggta caggtccatc cccagtgcga gtgccagtgc cgggaccaga gtcggatgag
     1621 gaatctctgt ggaggcaagg gagtcatgga gtgtggcatc tgcaggtgtg agtctggcta
     1681 cattgggaaa aactgtgagt gtcagacgca gggccggagc agccaggagc tggaggggaa
     1741 ctgccggaag gacaatagtt ccattgtgtg ctcggggctg ggggactgca tctgcgggca
     1801 gtgcgtgtgc cacacgagtg acatccccaa caaagtgatc tttgggcaat actgcgagtg
     1861 tgacaacttc aactgtgaga gatatgatgg ccaagtctgc ggtggcctaa agagaggctc
     1921 ctgctcctgt ggccagtgta attgcaagga gggtttcgag ggttctgctt gccagtgtca
     1981 gaggtctacc acgggctgtc tgaacgcacg gctggtggag tgcagtggcc gtggccggtg
     2041 ccaatgcaac agatgcatct gtgagaaagg ttaccagcca cctctgtgtg aagagtgtcc
     2101 cggctgcccc ttgccctgca gcacctacgt cttctgtgcc gagtgcctga aatttgataa
     2161 gggccccttt cagaagaatt gtagtgttca gtgtgccaat gtgacgctgc agactgtccc
     2221 tttcaagaaa aagccctgca aggagaggga ctcggagggc tgctggataa cctacacttt
     2281 gcagcagaag gacggaaacg cttacaacat ccatgtggac gacgatcgag agtgtgtgaa
     2341 aggccccaac gtggctgcca tcataggggg cactgtggcc ggcgttgtac tgattggtgt
     2401 cctcctcctg gtcatctgga aggctcttac ccacctgact gacctcaatg aatacagacg
     2461 ctttgagaag gagaaactca agtcccagtg gaacaacgac aaccccctct tcaagagcgc
     2521 cacgacaacg gtcatgaacc ctaagtttgc tgagagctag agaaggagtc agaggagacc
     2581 cctccagacc atgcctcctc ccctctgcaa atagaatgta gcttacagct agccccagtg
     2641 ctgccaagga tccaaaagcc tactttgttt ctttccgcca ttatatcaag gctgccaggg
     2701 tttccacaga ctcatcttcc gacctataca atcttgccac agagcctgca gattgttccg
     2761 gagtcccaag aggttccaca cacgttttcg tgcataaagg gaagacaggg gtctcagtaa
     2821 aggtggcccc agcttattta tatttaaact tgttagcgta taaaactact attatattgt
     2881 taacatcctg tccgttgtat tatatgtgag tgtaaaacta tatcccacat atatcagaat
     2941 catgtgtgta aaaataataa agcttccatt cagggctgca gagatggctc agtggttaag
     3001 agcactgact gctcttccag aggtcctgag ttcaattccc agcatccaca tggtggctca
     3061 caaccatctg taatgggatc tgatgccctt gtctggtgtg gctgaagata gcaacagtgt
     3121 actcacatac ataaaataaa taaagccttt taataaaaaa a
//
