LOCUS       NM_001108245            1285 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus integrin subunit beta 1 binding protein 2
            (Itgb1bp2), mRNA.
ACCESSION   NM_001108245 XM_001069915 XM_228553
VERSION     NM_001108245.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1285)
  AUTHORS   Sun,X., Wang,Y., Xia,B., Li,Z., Dai,J., Qiu,P., Ma,A., Lin,Z.,
            Huang,J., Wang,J., Xie,W.B. and Wang,J.
  TITLE     Methamphetamine produces cardiac damage and apoptosis by decreasing
            melusin
  JOURNAL   Toxicol Appl Pharmacol 378, 114543 (2019)
   PUBMED   30904475
  REMARK    GeneRIF: METH can produce cardiac damage and apoptosis by
            decreasing melusin.
REFERENCE   2  (bases 1 to 1285)
  AUTHORS   Aro,J., Tokola,H., Ronkainen,V.P., Koivisto,E., Tenhunen,O.,
            Ilves,M., Szokodi,I., Ruskoaho,H. and Rysa,J.
  TITLE     Regulation of cardiac melusin gene expression by hypertrophic
            stimuli in the rat
  JOURNAL   Acta Physiol (Oxf) 207 (3), 470-484 (2013)
   PUBMED   23198998
  REMARK    GeneRIF: Multiple hypertrophic stimuli regulate melusin expression
            predominately in the atria, which may represent a necessary initial
            step in early adaptive remodelling processes in left ventricular
            hypertrophy.
REFERENCE   3  (bases 1 to 1285)
  AUTHORS   Waardenberg,A.J., Bernardo,B.C., Ng,D.C.H., Shepherd,P.R.,
            Cemerlang,N., Sbroggio,M., Wells,C.A., Dalrymple,B.P.,
            Brancaccio,M., Lin,R.C.Y. and McMullen,J.R.
  TITLE     Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key
            components of the Z-disc and cardiac structure
  JOURNAL   J Biol Chem 286 (35), 30837-30846 (2011)
   PUBMED   21757757
  REMARK    GeneRIF: PI3K regulates the expression of genes essential for
            cardiac structure and Z-disc signaling, interacts with melusin, and
            is critical for Z-disc alignment
REFERENCE   4  (bases 1 to 1285)
  AUTHORS   Brancaccio,M., Menini,N., Bongioanni,D., Ferretti,R., De Acetis,M.,
            Silengo,L. and Tarone,G.
  TITLE     Chp-1 and melusin, two CHORD containing proteins in vertebrates
  JOURNAL   FEBS Lett 551 (1-3), 47-52 (2003)
   PUBMED   12965203
REFERENCE   5  (bases 1 to 1285)
  AUTHORS   Brancaccio,M., Fratta,L., Notte,A., Hirsch,E., Poulet,R.,
            Guazzone,S., De Acetis,M., Vecchione,C., Marino,G., Altruda,F.,
            Silengo,L., Tarone,G. and Lembo,G.
  TITLE     Melusin, a muscle-specific integrin beta1-interacting protein, is
            required to prevent cardiac failure in response to chronic pressure
            overload
  JOURNAL   Nat Med 9 (1), 68-75 (2003)
   PUBMED   12496958
REFERENCE   6  (bases 1 to 1285)
  AUTHORS   Brancaccio,M., Guazzone,S., Menini,N., Sibona,E., Hirsch,E., De
            Andrea,M., Rocchi,M., Altruda,F., Tarone,G. and Silengo,L.
  TITLE     Melusin is a new muscle-specific interactor for beta(1) integrin
            cytoplasmic domain
  JOURNAL   J Biol Chem 274 (41), 29282-29288 (1999)
   PUBMED   10506186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1, FM116382.1 and FM118664.1.
            
            On Mar 22, 2013 this sequence version replaced NM_001108245.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215476.1, FQ216100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000021.1  70612521-70612561
            42-464              FM116382.1         1-423
            465-709             FM118664.1         449-693
            710-811             JAXUCZ010000021.1  70616063-70616164
            812-874             JAXUCZ010000021.1  70616397-70616459
            875-1285            JAXUCZ010000021.1  70616748-70617158
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1285
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /note="integrin subunit beta 1 binding protein 2"
                     /db_xref="GeneID:317258"
                     /db_xref="RGD:1565015"
     exon            1..122
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1108
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /note="melusin"
                     /codon_start=1
                     /product="integrin beta-1-binding protein 2"
                     /protein_id="NP_001101715.1"
                     /db_xref="GeneID:317258"
                     /db_xref="RGD:1565015"
                     /translation="MSLLCYNKGCGQHFDPNTNLPDSCRYHPGVPIFHDALKGWSCCR
                     KRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPATSSLQEQKPLNTIPKSAETLLRE
                     RPKSEMPPKLLPLLISQALGVALEQKELDQEPGAGLDNSLIWTGSSCQNPGCDAVYQG
                     PESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWAKQLPASC
                     RHDWHQTDSLVVLTVYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVINV
                     EQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEDSDDDLS
                     WTEEEDEDEEEAMGE"
     exon            123..172
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            173..229
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            230..372
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            373..467
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            468..526
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            527..597
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            598..697
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            698..811
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            812..874
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1285
                     /gene="Itgb1bp2"
                     /gene_synonym="RGD1565015"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccacactgc agccagactc cttgaaatac cctttgagta agctcggtca gtgcctccat
       61 gtctctgctc tgctataaca aaggctgtgg gcaacacttt gaccccaata ccaatctccc
      121 tgattcctgc cgttatcacc ctggggtccc aatctttcat gatgcactta agggttggtc
      181 ctgctgccga aagcgaactg tagatttctc tgagttctta aacatcaagg gctgtactgt
      241 gggaccacac tgtgctgaga agcttcctga ggtccctcag cctgagggcc ctgccacaag
      301 ttcacttcag gagcaaaaac ctctgaatac aattccaaag tcagcagaga ctttgctccg
      361 agaaaggcct aagtctgaga tgcctccgaa actgctacca cttcttatat ctcaagccct
      421 gggagtggcg ttggaacaga aagaattaga ccaggaacct ggagcaggac ttgacaatag
      481 tctgatctgg actggttcca gctgccagaa cccaggatgt gatgctgttt accaaggtcc
      541 tgagagtgat gctactccgt gtacctatca tccaggtgca cctcggtttc atgagggaat
      601 gaagtcttgg agctgttgtg gtatccagac tctggatttt ggggcattcc tggcacagcc
      661 aggatgtaga gttggtagac acgattgggc aaagcagctg ccagcatctt gccgccatga
      721 ttggcaccag acagattctt tggtagtgct cacggtctat ggccagattc cacttcctgc
      781 attcaactgg gtgaaggcca gtcaaactga gcttcatgtc cacattgtct ttgatggtaa
      841 ccgtgtgttc caagcacaga tgaagctctg gggggtcata aacgtggagc agagctctgt
      901 ctctttgatg ccatcacggg ttgaaatctc cctggtcaag gctgacccag gatcctgggc
      961 ccagctggag caccccgatt cactagctga gaaggctagg gcaggggttt tactagagat
     1021 ggatgaggaa gaatctgagg attcagatga tgacctgagc tggacagaag aggaagatga
     1081 agacgaggaa gaagctatgg gggaatagga acagcagaca gttgagtttc taggcaggcc
     1141 ctcagtgact gccttagaat ctcagagacc aggatagggt tgactatgtg gtgtcattga
     1201 gcagcaggag gctgaaggaa gagataacaa aatgtccaaa ctgctgctgc cccctaataa
     1261 accttacatt ctgcagtctc accca
//
