LOCUS       NM_001419757            4565 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus integrin subunit alpha X (Itgax), mRNA.
ACCESSION   NM_001419757 XM_574569
VERSION     NM_001419757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4565)
  AUTHORS   Wang,J., Yang,L., Liang,F., Chen,Y. and Yang,G.
  TITLE     Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt
            signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel
            endothelial cells
  JOURNAL   J Cell Biochem 120 (2), 1807-1818 (2019)
   PUBMED   30873824
REFERENCE   2  (bases 1 to 4565)
  AUTHORS   Wlodarczyk,A., Holtman,I.R., Krueger,M., Yogev,N., Bruttger,J.,
            Khorooshi,R., Benmamar-Badel,A., de Boer-Bergsma,J.J., Martin,N.A.,
            Karram,K., Kramer,I., Boddeke,E.W., Waisman,A., Eggen,B.J. and
            Owens,T.
  TITLE     A novel microglial subset plays a key role in myelinogenesis in
            developing brain
  JOURNAL   EMBO J 36 (22), 3292-3308 (2017)
   PUBMED   28963396
REFERENCE   3  (bases 1 to 4565)
  AUTHORS   Roberts,L.L. and Robinson,C.M.
  TITLE     Mycobacterium tuberculosis infection of human dendritic cells
            decreases integrin expression, adhesion and migration to chemokines
  JOURNAL   Immunology 141 (1), 39-51 (2014)
   PUBMED   23981064
REFERENCE   4  (bases 1 to 4565)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   5  (bases 1 to 4565)
  AUTHORS   Semon,J.A., Nagy,L.H., Llamas,C.B., Tucker,H.A., Lee,R.H. and
            Prockop,D.J.
  TITLE     Integrin expression and integrin-mediated adhesion in vitro of
            human multipotent stromal cells (MSCs) to endothelial cells from
            various blood vessels
  JOURNAL   Cell Tissue Res 341 (1), 147-158 (2010)
   PUBMED   20563599
REFERENCE   6  (bases 1 to 4565)
  AUTHORS   Yada,A., Ebihara,S., Matsumura,K., Endo,S., Maeda,T., Nakamura,A.,
            Akiyama,K., Aiba,S. and Takai,T.
  TITLE     Accelerated antigen presentation and elicitation of humoral
            response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune
            complex uptake
  JOURNAL   Cell Immunol 225 (1), 21-32 (2003)
   PUBMED   14643301
REFERENCE   7  (bases 1 to 4565)
  AUTHORS   Matsuzaki,J., Tsuji,T., Chamoto,K., Takeshima,T., Sendo,F. and
            Nishimura,T.
  TITLE     Successful elimination of memory-type CD8+ T cell subsets by the
            administration of anti-Gr-1 monoclonal antibody in vivo
  JOURNAL   Cell Immunol 224 (2), 98-105 (2003)
   PUBMED   14609575
REFERENCE   8  (bases 1 to 4565)
  AUTHORS   Yokota,A., Oikawa,A., Matsuda,C., Shinohara,N. and Eshima,K.
  TITLE     Cell-mediated fas-based lysis of dendritic cells which are
            apparently resistant to anti-Fas antibody
  JOURNAL   Microbiol Immunol 47 (4), 285-293 (2003)
   PUBMED   12801066
REFERENCE   9  (bases 1 to 4565)
  AUTHORS   Guerriero,A., Langmuir,P.B., Spain,L.M. and Scott,E.W.
  TITLE     PU.1 is required for myeloid-derived but not lymphoid-derived
            dendritic cells
  JOURNAL   Blood 95 (3), 879-885 (2000)
   PUBMED   10648399
REFERENCE   10 (bases 1 to 4565)
  AUTHORS   Liu,Y., Jones,B., Brady,W., Janeway,C.A. Jr. and Linsley,P.S.
  TITLE     Co-stimulation of murine CD4 T cell growth: cooperation between B7
            and heat-stable antigen
  JOURNAL   Eur J Immunol 22 (11), 2855-2859 (1992)
   PUBMED   1385153
  REMARK    Erratum:[Eur J Immunol 1993 Mar;23(3):780. Linley PS [corrected to
            Linsley PS]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2023 this sequence version replaced XM_574569.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.3928.1,
                                           SRR26643284.1489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000001.1  192150049-192150159
            112-217             JAXUCZ010000001.1  192150760-192150865
            218-321             JAXUCZ010000001.1  192151138-192151241
            322-389             JAXUCZ010000001.1  192151533-192151600
            390-504             JAXUCZ010000001.1  192151751-192151865
            505-635             JAXUCZ010000001.1  192153348-192153478
            636-781             JAXUCZ010000001.1  192153639-192153784
            782-935             JAXUCZ010000001.1  192154028-192154181
            936-1086            JAXUCZ010000001.1  192155285-192155435
            1087-1160           JAXUCZ010000001.1  192155654-192155727
            1161-1290           JAXUCZ010000001.1  192155875-192156004
            1291-1433           JAXUCZ010000001.1  192156090-192156232
            1434-1574           JAXUCZ010000001.1  192156393-192156533
            1575-1784           JAXUCZ010000001.1  192156613-192156822
            1785-1915           JAXUCZ010000001.1  192159661-192159791
            1916-2073           JAXUCZ010000001.1  192159916-192160073
            2074-2228           JAXUCZ010000001.1  192160187-192160341
            2229-2360           JAXUCZ010000001.1  192160975-192161106
            2361-2434           JAXUCZ010000001.1  192161695-192161768
            2435-2597           JAXUCZ010000001.1  192161948-192162110
            2598-2726           JAXUCZ010000001.1  192164078-192164206
            2727-2806           JAXUCZ010000001.1  192164286-192164365
            2807-2890           JAXUCZ010000001.1  192164446-192164529
            2891-2969           JAXUCZ010000001.1  192167723-192167801
            2970-3074           JAXUCZ010000001.1  192167890-192167994
            3075-3158           JAXUCZ010000001.1  192168094-192168177
            3159-3272           JAXUCZ010000001.1  192168372-192168485
            3273-3374           JAXUCZ010000001.1  192168629-192168730
            3375-3485           JAXUCZ010000001.1  192168981-192169091
            3486-4565           JAXUCZ010000001.1  192170072-192171151
FEATURES             Location/Qualifiers
     source          1..4565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..4565
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /note="integrin subunit alpha X"
                     /db_xref="GeneID:499271"
                     /db_xref="RGD:1561123"
     exon            1..111
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..3623
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /note="integrin, alpha X"
                     /codon_start=1
                     /product="integrin alpha-X precursor"
                     /protein_id="NP_001406686.1"
                     /db_xref="GeneID:499271"
                     /db_xref="RGD:1561123"
                     /translation="MSCTWTAFLLLKVFASCLGFNLDAEKPTRFHMDGAEFGHSVVQY
                     GGSWVVVGAPKEIQATNQIGGLYKCGYHTGMCESISLQVPPEAVNMSLGLSLTATNPS
                     WLLACGPTVHHICRENTYLTGLCFLLDSSFRQNQNFPAAQQGCPRQDQDIVFLIDGSG
                     SITYTDFEKMLAFVKAVMSQLQQSSTRFSLMQFSHTFRTHFTFNDFISTSSPLRLLDF
                     VNQLRGSTRTASAIKHVITELFTTQKGARKDATKILIVITDGRKEGDRLDYGDVIPMA
                     EAAGIIRYAIGVGQAFYQAQSRQELKDIASSPSREYVFSVENFDALKDIQNQLKEKIF
                     AIEGTETPSSSSFELEMSQEGFSAVFTPDGPVLGAVGSFGWSGGAFLYPPNTRPTFIN
                     MSQENVDMRDSYLGYSTAVAFWKGVHSLILGAPRHQHTGKVVIFTQEARHWRPKSEVR
                     GTQIGSYFGASLCSVDMDRDDSTDLVLIGAPHYYEQTRGGQVSVCPVPGVGSRWQCEA
                     TLHGEQGHPWGRFGAALTVLGDVNGDDLADVAIGAPGEEESRGAVYIFHGASRLEISP
                     SPSQRISASRIFPRLQYFGQSLSGGQDLTGDGLVDLAVGSKGHLLLLRTRPILRMSST
                     IQFTPTEISRSVFECQGQVTREQTLGTATVCLRTYESSKTQRGDLQSIVTFDLALDPG
                     RLSPRAIFKETKTQALTKVRTLGLSSHCEPVTLLLPACVEDSVTPITLRLNFSLVGVP
                     IPSLQNLQPMLAVDEQTYFTASLPFEKNCGADHICQDDLGIIFGFPDLKTLVVGSNLE
                     LSVAVTVTNDGEDSYGTTITLFYPVGLSFRRVAEAQVFLRTEDTQQWQQQGRHSLHLM
                     CDSTPDRSQGIWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDRLLLRARVSSENG
                     VPETRKTTFQLELPVKYAVYTVISSHDQFTKYLNFSASEKSRVSVVEHRFQVNNLGQR
                     DLPVSINFRVPTELKGETVWTVMVSHPQNPSTQCYQNRLKPTQFDLLTHMQKSPVLDC
                     SIADCLHFRCDIPSLGIQDELDFILKGNLSFGWISQTLQKKVLLVSEAEISFDTSVYS
                     QLPGQEAFLRAQAKTTLEMYEVHNPVPLIVGSSVGGLLLLALITAVLYKAGFFKRQYK
                     EMLAEANGQFASGNGNPNPQVTQQELPSPSSLNLPS"
     exon            112..217
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            218..321
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            322..389
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            390..504
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            505..635
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            636..781
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            782..935
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1086
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1160
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1290
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1433
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1574
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1784
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1915
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2073
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2228
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2360
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2434
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2597
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2726
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2806
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2890
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2969
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3074
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3158
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3272
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3374
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3485
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..4565
                     /gene="Itgax"
                     /gene_synonym="RGD1561123"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catttgctcc ttcggtgact tggcagacgt ttccaagttg ctaactgctc aaagcctgct
       61 cctgttctcc agtcatgagc tgtacctgga cagcctttct tctgctgaag gtgtttgctt
      121 cttgtctcgg cttcaacttg gatgcggaga agccgacacg tttccacatg gacggcgctg
      181 agttcggaca cagtgtggtc cagtatggtg gctcctgggt ggtggttggc gcgccaaagg
      241 aaatacaagc caccaaccaa ataggtggcc tctacaaatg tggctatcat acaggcatgt
      301 gtgagtccat ctccctccag gtgcccccag aggctgtgaa catgtccctg ggtctgtccc
      361 tcactgccac caacccttcc tggctgttgg cttgtggtcc tactgtgcat cacatatgca
      421 gagagaatac atacttgaca gggctctgct ttctactgga ctcatcgttc aggcagaacc
      481 agaacttccc agctgcacag caggggtgtc caaggcaaga ccaggacatt gtgttcttga
      541 ttgatggctc gggtagcatc acttacacag attttgaaaa aatgctggcc tttgttaaag
      601 ctgtgatgag ccaacttcag caatctagca cacggttctc cctgatgcag ttctcccata
      661 ccttccggac acattttact ttcaacgact ttatctccac gtcaagccct ttaaggctgt
      721 tagattttgt taatcagctg agagggtcca caagaacagc ctcggctatc aagcatgtca
      781 taacagagct gttcaccact caaaaaggag ctcggaaaga tgccacgaag atcctcattg
      841 tcatcactga tgggaggaaa gaaggggaca ggttggacta tggtgatgtc atccccatgg
      901 cggaggctgc aggcatcatc cgttatgcaa ttggggtagg acaggccttt taccaagcac
      961 agtccaggca agaattaaag gacattgcgt cgtcgccttc ccgtgaatac gtgttcagcg
     1021 tggagaactt tgatgctttg aaggacattc agaatcagct gaaggagaag atctttgcca
     1081 tcgagggtac agagacgcca agcagcagtt cttttgaatt ggagatgtcc caggagggat
     1141 tcagtgctgt gttcacacct gatggacccg ttctgggggc cgtgggaagt ttcggctggt
     1201 caggaggcgc cttcttatat cccccaaata cgagacccac ctttatcaac atgtctcaag
     1261 agaatgtaga catgagagac tcctacctgg gttactccac cgcagtggcc ttttggaaag
     1321 gggttcacag cctgatcctg ggggccccgc gtcaccagca cacggggaag gttgtcatct
     1381 ttacccagga agccaggcat tggaggccca agtctgaagt cagagggaca cagatcggct
     1441 cctacttcgg ggcctctctc tgttctgtgg acatggatag agatgacagc actgacctgg
     1501 tcctgatcgg agccccccat tactatgagc agacccgagg ggggcaggtc tcagtgtgcc
     1561 ccgtgcccgg tgtggggagc aggtggcagt gtgaggccac cctccacggg gagcagggcc
     1621 atccttgggg ccgctttggg gcggctctga cagtgctggg ggacgtgaat ggggacgatc
     1681 tggcagatgt ggctattggt gctcctggag aggaggagag cagaggtgct gtctacatat
     1741 ttcatggagc ctcgagactg gagatctcgc cctcgcccag ccagaggatt tcagcatccc
     1801 ggatcttccc caggctccag tattttggac agtcactgag tggaggtcag gacctcaccg
     1861 gggatggact ggtggacctg gccgtggggt ccaagggaca cttgctgctg ctaaggacca
     1921 gaccgatcct tcgaatgtca tcaaccatac agttcacacc tacagagatt tccaggtctg
     1981 tgtttgagtg tcagggacag gtgacccgtg agcagacact gggaactgcc actgtctgcc
     2041 ttcgtactta tgaaagctcc aagacccaac gaggtgacct ccaaagtatt gtcaccttcg
     2101 acctggccct agatcctggc cgcctgagtc cccgggccat cttcaaggag acaaagacac
     2161 aggcgctgac taaagttaga accctcggtc tgagcagtca ctgtgaacct gtgacgctgc
     2221 tcctcccggc ctgtgtggag gactcagtga ctcctatcac tttgcgtctc aacttctctc
     2281 ttgttggagt gcccatccct tccttacaaa acctccaacc catgctggct gtagatgagc
     2341 aaacatactt cacggcctct cttccctttg agaagaattg cggagctgac cacatctgtc
     2401 aggatgacct tggcatcata tttggcttcc cagacctgaa gaccctggtg gtaggaagta
     2461 acctggagct gagtgtagct gtgacagtga ctaacgatgg ggaagattcc tatggaacca
     2521 caatcactct gttctaccca gtcggtctgt ccttcagacg agtcgcagaa gcccaagtgt
     2581 tccttcggac ggaagatacc cagcagtggc agcagcaggg ccggcactcc ctgcacctca
     2641 tgtgtgacag caccccagac aggagtcagg gcatctggag caccagctgc agcagccgac
     2701 acgtcatttt ccggggaggc tcacagatga ctttcttggt aacttttgat gtctccccca
     2761 aagctgagct gggagacagg ctgctgctaa gagccagagt gagcagtgag aacggcgtac
     2821 ctgagaccag gaaaaccacc ttccagttgg agctcccagt aaagtatgct gtgtacactg
     2881 tcatcagcag ccacgaccaa tttaccaagt atcttaactt ctcagcctca gaaaagtcga
     2941 gggtcagtgt ggtggaacat agattccagg tgaataatct ggggcagaga gacttgccag
     3001 tcagcatcaa ctttcgggtg cccacagagc tgaagggaga aacggtgtgg acagtgatgg
     3061 tctcccaccc tcagaacccg tccacccaat gctatcagaa tagactcaag ccaacacaat
     3121 ttgacctcct gactcacatg cagaagagtc ccgtgctgga ctgctccatt gctgactgcc
     3181 tgcacttccg ctgtgacatc ccctccttgg gcatccagga cgaacttgac ttcattctga
     3241 agggcaacct cagcttcggc tggatcagtc agacattgca gaaaaaggtg ttgctcgtga
     3301 gtgaggctga aatctctttc gacacatctg tgtactccca gctgccagga caggaggcat
     3361 ttctgagagc ccaggcaaag acaacgctgg agatgtatga agttcacaac cccgtccctc
     3421 tcatcgtggg cagctcagtg ggaggtctgc tgctgctagc tctcatcaca gccgtacttt
     3481 acaaggctgg tttcttcaaa cgtcagtaca aagaaatgtt ggcggaagca aatggccagt
     3541 ttgcctctgg aaacgggaac ccaaaccccc aggttaccca gcaagaactt ccctctccat
     3601 cttctttgaa cctgccctcc tgagaggtgt cccaggactt gtactttctc taagtcagcc
     3661 ctaacagcaa agaagcgttg cagcaggaat gctgggaccg ggccgacttt gctctttgtg
     3721 tcttacctgg gaagggtcac tgtctggtca aaactttacc tggaaactca gagcacagag
     3781 tctctgctat ggccaaagaa cttctgtagg aatttctacc tcgggataca taggcagctc
     3841 agtggcccct tgccttgctg gccactaatg agctttctgg gatggaagta gccatcattg
     3901 ttgtctattt ccagtgcctc ccgtctgctt tcaggatgtc agaactgagt tctatctcaa
     3961 ggaggcgagc gcaggcaccc tgggatgccc tgtgagtcta tgttatcctc gtttctagtg
     4021 aagtgttaac accaggttgt agcttttctt ggaaacacct aatcccagct ccctcaaact
     4081 gaattagcaa ggaaacatct gggcaatgta gttgatggga ttggatttta gccacagtgt
     4141 tgctagctgg gaagaaccat cctgttgtcg taggagggac actgctctag aacagttcta
     4201 ggtcagagaa ggcctatgcc actttgcccc atgacccttt ttgggaagac gtaaacaaac
     4261 atctgtttgc ccatgataga ccaaagaaac tattccaccc aaggcttatc tagaaagcaa
     4321 atgagggagc ttgcagctca gttccagctt ggttccccat gttttacagc cttcgtgtgg
     4381 tatcttcagc agtagaaact tcccattcag ctctaacatg caactaaggc agtagaaata
     4441 gattttatgc ctttggggca gcagggagct ccttgactag taactcataa ggaagtaaac
     4501 cattttacgg atccctggag tgtcttttcc aataaatgta gtgtgtcttc attcaaactc
     4561 tttaa
//
