LOCUS       NM_001398692            6961 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus integrin subunit alpha V (Itgav), transcript
            variant 1, mRNA.
ACCESSION   NM_001398692 XM_039106445
VERSION     NM_001398692.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6961)
  AUTHORS   Brito,V.G.B., Patrocinio,M.S., de Sousa,M.C.L., Barreto,A.E.A.,
            Frasnelli,S.C.T., Lara,V.S., Santos,C.F. and Oliveira,S.H.P.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6961)
  AUTHORS   Takada,Y.K., Yu,J., Shimoda,M. and Takada,Y.
  TITLE     Integrin Binding to the Trimeric Interface of CD40L Plays a
            Critical Role in CD40/CD40L Signaling
  JOURNAL   J Immunol 203 (5), 1383-1391 (2019)
   PUBMED   31331973
REFERENCE   3  (bases 1 to 6961)
  AUTHORS   Zhang,Q., Yu,J., Guo,T., Tian,L., Quan,J., Lin,W., Niu,X.E. and
            Liu,J.
  TITLE     High glucose/ox-LDL induced hepatic sinusoidal capillarization via
            alphavbeta5/FAK/ERK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 513 (4), 1055-1062 (2019)
   PUBMED   31010681
  REMARK    GeneRIF: Integrin alphavbeta5 which induces LSECs dysfunction,
            promoting hepatic sinusoidal capillarization regulates VN
            expression via ERK/FAK pathway under high glucose/ox-LDL
REFERENCE   4  (bases 1 to 6961)
  AUTHORS   Perrucci,G.L., Barbagallo,V.A., Corliano,M., Tosi,D., Santoro,R.,
            Nigro,P., Poggio,P., Bulfamante,G., Lombardi,F. and Pompilio,G.
  TITLE     Integrin alphanubeta5 in vitro inhibition limits pro-fibrotic
            response in cardiac fibroblasts of spontaneously hypertensive rats
  JOURNAL   J Transl Med 16 (1), 352 (2018)
   PUBMED   30541573
  REMARK    GeneRIF: the effects on cardiac fibroblasts , isolated by
            spontaneously hypertensive rats (SHR), of integrin alphanubeta5
            inhibition in myofibroblast differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6961)
  AUTHORS   Zhang,J., Wang,J., Zheng,L., Wang,M., Lu,Y., Li,Z., Lian,C.,
            Mao,S., Hou,X., Li,S., Xu,J., Tian,H., Jin,C., Gao,F., Zhang,J.,
            Wang,F., Li,W., Lu,L. and Xu,G.T.
  TITLE     miR-25 Mediates Retinal Degeneration Via Inhibiting ITGAV and PEDF
            in Rat
  JOURNAL   Curr Mol Med 17 (5), 359-374 (2017)
   PUBMED   29210651
  REMARK    GeneRIF: findings demonstrate that, in SI-treated rats, oxidative
            stress activates STAT3 signaling which up-regulates miR-25
            expression, in a very early stage. The increased miR-25 then
            inhibits ITGAV and PEDF expressions, resulting in RPE phagocytosis
            dysfunction and then RPE apoptosis and visual impairment as
            observed in patients with AMD.
REFERENCE   6  (bases 1 to 6961)
  AUTHORS   Baudoin,C., Goumans,M.J., Mummery,C. and Sonnenberg,A.
  TITLE     Knockout and knockin of the beta1 exon D define distinct roles for
            integrin splice variants in heart function and embryonic
            development
  JOURNAL   Genes Dev 12 (8), 1202-1216 (1998)
   PUBMED   9553049
REFERENCE   7  (bases 1 to 6961)
  AUTHORS   Ruppert,M., Aigner,S., Hubbe,M., Yagita,H. and Altevogt,P.
  TITLE     The L1 adhesion molecule is a cellular ligand for VLA-5
  JOURNAL   J Cell Biol 131 (6 Pt 2), 1881-1891 (1995)
   PUBMED   8557754
REFERENCE   8  (bases 1 to 6961)
  AUTHORS   Nishimura,S.L., Sheppard,D. and Pytela,R.
  TITLE     Integrin alpha v beta 8. Interaction with vitronectin and
            functional divergence of the beta 8 cytoplasmic domain
  JOURNAL   J Biol Chem 269 (46), 28708-28715 (1994)
   PUBMED   7525578
REFERENCE   9  (bases 1 to 6961)
  AUTHORS   Helfrich,M.H., Nesbitt,S.A. and Horton,M.A.
  TITLE     Integrins on rat osteoclasts: characterization of two monoclonal
            antibodies (F4 and F11) to rat beta 3
  JOURNAL   J Bone Miner Res 7 (3), 345-351 (1992)
   PUBMED   1585837
REFERENCE   10 (bases 1 to 6961)
  AUTHORS   Moyle,M., Napier,M.A. and McLean,J.W.
  TITLE     Cloning and expression of a divergent integrin subunit beta 8
  JOURNAL   J Biol Chem 266 (29), 19650-19658 (1991)
   PUBMED   1918072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 21, 2021 this sequence version replaced XM_039106445.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.11862.1,
                                           SRR26643292.13062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               JAXUCZ010000003.1  89245382-89245848
            468-598             JAXUCZ010000003.1  89256676-89256806
            599-690             JAXUCZ010000003.1  89266090-89266181
            691-805             JAXUCZ010000003.1  89270315-89270429
            806-867             JAXUCZ010000003.1  89274736-89274797
            868-913             JAXUCZ010000003.1  89277067-89277112
            914-1039            JAXUCZ010000003.1  89279244-89279369
            1040-1084           JAXUCZ010000003.1  89280105-89280149
            1085-1128           JAXUCZ010000003.1  89280979-89281022
            1129-1185           JAXUCZ010000003.1  89281437-89281493
            1186-1238           JAXUCZ010000003.1  89282789-89282841
            1239-1441           JAXUCZ010000003.1  89283746-89283948
            1442-1633           JAXUCZ010000003.1  89288161-89288352
            1634-1679           JAXUCZ010000003.1  89291161-89291206
            1680-1787           JAXUCZ010000003.1  89293470-89293577
            1788-1846           JAXUCZ010000003.1  89295322-89295380
            1847-2001           JAXUCZ010000003.1  89297566-89297720
            2002-2139           JAXUCZ010000003.1  89300290-89300427
            2140-2207           JAXUCZ010000003.1  89315940-89316007
            2208-2355           JAXUCZ010000003.1  89316754-89316901
            2356-2448           JAXUCZ010000003.1  89317410-89317502
            2449-2528           JAXUCZ010000003.1  89319805-89319884
            2529-2609           JAXUCZ010000003.1  89320511-89320591
            2610-2715           JAXUCZ010000003.1  89320991-89321096
            2716-2874           JAXUCZ010000003.1  89321602-89321760
            2875-2973           JAXUCZ010000003.1  89322862-89322960
            2974-3087           JAXUCZ010000003.1  89328417-89328530
            3088-3195           JAXUCZ010000003.1  89328626-89328733
            3196-3318           JAXUCZ010000003.1  89329508-89329630
            3319-6961           JAXUCZ010000003.1  89329870-89333512
FEATURES             Location/Qualifiers
     source          1..6961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..6961
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /note="integrin subunit alpha V"
                     /db_xref="GeneID:296456"
                     /db_xref="RGD:1310613"
     exon            1..467
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..3414
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; integrin alpha-V; Dnmt3l-ps1 pseudogene"
                     /codon_start=1
                     /product="integrin alpha-V isoform 1 precursor"
                     /protein_id="NP_001385621.1"
                     /db_xref="GeneID:296456"
                     /db_xref="RGD:1310613"
                     /translation="MADPGRLLLRPRPGGLLLLLLGLLLPFAGSFNLDVESPAEYAGP
                     EGSYFGFAVDFFVPSTSSRMFLLVGAPKANTTQPGIIEGGQVLKCDCSSSRRCQPIEF
                     DSTGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFL
                     QDGTKTVEYAPCRSKNIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQV
                     AEIISKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIEDFVSGVPRA
                     ARTLGMVYIYDGKNMSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRG
                     SDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAA
                     PYGGEDKKGLVYIFNGRSTGLNSVPSQILQGQWAAQSMPPSFGYSMKGATDVDRNGYP
                     DLVVGAFGVDRAVLYRARPVVTVNAGLEVYPSILNQDNKICPLPGTALKVSCFNVRFC
                     LKADGKGTLPRKLNFQVELLLDKLKQKGAIRRALFLHNRSPGHSKDMTVFRGGQTQCE
                     ELVAYLRDESEFRDKLTPITIFMEYRLDQRTAADATGLQPILNQFTPANVSRQAHILL
                     DCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLTVKAQNQGEGAYEAELIVSIPPQAD
                     FIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTS
                     VKFDLKIQSSNSFDNVSPVVSYKVDLAVLAAVEIRGVSSPDHIFLPIPNWEYKETPET
                     EEDVGPVVQHIYELRNNGPSSFSKAILNLQWPYKYNNNTLLYILHYDIDGPMNCTADT
                     EINPLRIKTPEKNDTAAEQGGRNHLITKRDLSLSEGDVHTLGCGTAQCLQITCQVGRL
                     DRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNIIEFPYKNLPIEDLFNSTLV
                     TTNITWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQ
                     LQPHENGEGNSET"
     exon            468..598
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            599..690
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            691..805
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            806..867
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            868..913
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1039
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1084
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1128
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1185
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1238
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1441
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1633
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1679
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1787
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1846
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2001
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2139
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2207
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2355
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2448
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2528
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2609
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2715
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2874
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2973
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3087
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3195
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3318
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..6961
                     /gene="Itgav"
                     /gene_synonym="Cd51"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccggggca gctcagggcc ccgaggtacg gcgctcgccc cgccacttct cagagccagg
       61 caccgcggga gccagcgaca gagccggagt cccgcgtccg acactgcgcc tcctgggtgg
      121 ctgcccggct cagcctcgcg cctccctgcc gccccgccgc ccttgaccgc aagcgcaccg
      181 catagcacgg cagttcgggc gcggaggcgg cgggccgcgg ccacggtgca ctgggacagg
      241 gattgtagac tttccgctcc gcgccccgcg ctcgccccgg cgatggctga tcccgggcgg
      301 ctgctgctac gccctcgccc cggtggcctc ctgctcctgc tgctcggcct cctactgccc
      361 ttcgccggct ccttcaacct ggacgtcgaa agccccgccg agtacgccgg ccccgaggga
      421 agttacttcg gattcgccgt ggacttcttc gtgcccagca cgtcctccag gatgttcctc
      481 ctggtgggag ccccaaaagc aaacacaacc cagcctggga ttatagaagg agggcaagtt
      541 ctcaaatgtg actgctcatc cagccgccgg tgccagccca ttgaatttga ttcaacaggc
      601 aatcgagatt atgccaaaga tgacccactg gagtttaaat cccaccagtg gtttggagcc
      661 tccgtgaggt caaagcagga taaaatcttg gcctgtgctc cattgtacca ctggaggact
      721 gagatgaagc aggagagaga gccagttgga acctgctttc ttcaggatgg cacaaagacc
      781 gttgagtatg ctccatgcag gtcaaaaaat attgatgctg atggacaggg attttgtcaa
      841 ggaggattca gcattgattt tactaaagcc gacagagtac ttcttggagg tcccggcagc
      901 ttttattggc agggtcagct catttcagat caagtggcag aaatcatatc taaatatgac
      961 ccaaatgtct acagcatcaa atataataac caactagcca cacggactgc acaagcaatt
     1021 tttgatgaca gttatttggg ttactctgtg gccgtgggag acttcaatgg tgacggcatt
     1081 gaagattttg tttctggagt tccaagagca gcaaggactt tgggaatggt ttatatttat
     1141 gatgggaaaa acatgtcttc attacacaat tttactggtg aacagatggc tgcatatttt
     1201 ggattttctg tagctgctac tgacattaat ggggatgatt atgcagatgt gtttattgga
     1261 gcccctctgt tcatggaccg aggttctgat ggaaaactcc aggaggtcgg ccaggtctca
     1321 gtgtctctac agagagcgtc gggagacttc cagactacaa agctgaacgg gtttgaggtt
     1381 tttgccagat ttggaagtgc catagctcct ttgggagacc tggaccagga tggcttcaat
     1441 gacattgcaa ttgctgctcc atatggtggc gaagataaaa agggacttgt ttatatcttc
     1501 aatggaagat ccacaggctt gaattcggtg ccatctcaaa tcctgcaggg gcagtgggcc
     1561 gctcagagca tgcccccaag ctttggctat tcaatgaagg gagctacaga tgtagataga
     1621 aatggatatc cagacttagt tgtcggagct tttggtgtgg accgagctgt cttatacaga
     1681 gccagacctg ttgtcaccgt aaatgctggc cttgaagtgt accctagcat tttaaatcaa
     1741 gacaataaaa tctgcccatt gcctgggaca gctctcaagg tttcctgttt taatgtcagg
     1801 ttctgcttaa aggcggatgg caaagggaca cttccgagga aactcaactt ccaggtggag
     1861 cttcttttgg ataaactcaa gcagaaggga gccatccggc gagcactgtt tctccataac
     1921 aggtccccgg ggcactctaa ggacatgact gttttcaggg ggggacagac gcagtgtgag
     1981 gaactggtcg cctatcttcg ggatgaatct gagtttagag acaagctcac tcccatcact
     2041 atttttatgg agtatcggct ggaccagaga acggctgctg atgccacagg cttgcagccc
     2101 atcctgaacc agttcactcc ggccaacgtc agtcggcagg ctcacatttt acttgactgt
     2161 ggcgaagaca atgtctgtaa acctaaactg gaagtttctg tagatagtga tcaaaagaag
     2221 atctatattg gggatgacaa ccctctgacc ctgaccgtga aggcgcagaa tcaaggagaa
     2281 ggcgcctatg aagctgagct catcgtttct atcccaccac aggctgactt catcggggtt
     2341 gtccggaaca acgaagcctt agcaagactg tcctgtgcat ttaagacaga aaaccaaacc
     2401 cggcaggtgg tgtgtgacct tgggaacccg atgaaggctg gaactcaact gcttgctggc
     2461 cttcgtttca gcgtgcacca gcaatcagag atggatactt ctgtgaagtt tgacttgaaa
     2521 atccaaagct ctaattcttt tgacaatgtc agcccagtcg tgtcttacaa ggtcgacctt
     2581 gccgttttgg ctgccgttga gataagagga gtttcaagcc cagatcacat ctttcttcca
     2641 attccaaact gggagtacaa ggaaacccct gagactgaag aagacgttgg gcctgttgtt
     2701 cagcacatct atgagctgag aaacaatggt ccaagttcat tcagcaaggc aatcctgaac
     2761 ctccagtggc cttacaaata caacaacaat actttgctgt acattctcca ttacgacatt
     2821 gatgggccga tgaactgtac tgccgacaca gagatcaacc ctctgagaat taagacgccc
     2881 gaaaagaatg acacagcagc tgagcaagga ggaagaaatc atctcatcac caagcgggat
     2941 ctcagcctca gtgagggaga tgttcacact ttgggctgtg gaactgctca gtgcttgcag
     3001 atcacctgcc aggtcggtcg actggataga gggaagagcg ccatcctgta cgtgaaatcc
     3061 ctgctgtgga ccgagacgtt tatgaacaag gagaaccaga accattccta ttccctgaag
     3121 tcatccgctt catttaatat catagaattc ccttacaaga atcttccgat tgaggatctc
     3181 ttcaactcta cgctagtcac cacgaacatc acctggggca ttcagccagc acccatgcct
     3241 gtgcctgtgt gggtgatcat cttggcggtt ctcgcagggc tgctgttact ggccgtgttg
     3301 gtatttgtaa tgtacaggat gggctttttc aaacgtgtcc gaccacctca agaagagcaa
     3361 gaaagagaac agcttcagcc tcatgagaac ggcgaaggaa actctgaaac ctaactgggt
     3421 ttcttaagct gtggtacttc cgcgccctcc gaatttacca ccccgatggc ggatttaaat
     3481 ctctctcctg aagaataaaa tcccgggact gtattgctga gggcacccag cagcctcagt
     3541 ttacccacaa aatcgaaatg ggtatttgtt gacttctctt tataaataag ttcagatcat
     3601 ttacttcaca ttacactgac gtgtttttag gcctttaagt ggtggaattt cagtgtacat
     3661 aagacagata gcacccgagt taccacgttg tatagcatag taccttttca cttactgctt
     3721 ctaatttact gtgtggggct tctctctgcg gtgttacgtt agggcaggta ggattgtaaa
     3781 gcagttcaga cttagacctt aactcagtaa gtttgcacag gtacttagaa caggtacaca
     3841 tcacactaca gttgagttca taagctactg aagactttgc aattgcatgg acttagattt
     3901 taatatcatt tacacagcgg gacttttaaa acaaataata ccatcaaaat tctttcctgg
     3961 gactatagct cacttcgaag cacatgcaac tctctgggtt taatcctcca cacggggagg
     4021 aaaaacagta gcttcctgta ttaacagcgg tacagtattt ttatatgaaa attaggtttt
     4081 tatttatgtg tagttggcat tgtattttat tgtattttaa cttttgtaat ttaaattcta
     4141 tatcagatcc tttaagccat ttcatgcaga aaattttata attaaaaata cccattatgt
     4201 aatagcgtgg tctcagctga tgatgatgac tgaagccatt ggagttggaa gttgtttcta
     4261 gtacatctgt ttccttcgtt tgggtgcctg caacgtataa aagctcgaga gactctctgt
     4321 agatgtctct accccacctg ctcaccaaaa atccgctctt taattgtacc tgagctttta
     4381 attggtagta atttattttc ctcctgtctt catattttcc ttccacttcc aaaatggaga
     4441 ctggctcaag actgtcttca taacctatag gaacctggat atatcctccc ccccccctta
     4501 ccccatgaga aatggctggg attagcatcc caaaggtggc tattgatttg tttctagcga
     4561 tagcatgggt agtaccttag gttaaacaag gcaatgtata aaaccttccc ccgcagtcag
     4621 aataaaaact aaaaaggtgt aagcagttct tgttactgag acctcctaaa gctgtcttac
     4681 agttttaaat tcaaattact tttctggggc tttaatagag gcagcagagg aaggacggta
     4741 tggtcttaag tgttggtgat ttattcacag ttcctcaagg cccccgggat aactattaat
     4801 tatagctatt tttgtgcaat tacatcatgt tatgcattgg aagctgagaa ttttaatagc
     4861 ttttaaaact gctgtcctca ttaagcggtg aaaaatattt ctcttaaata ttgaatattt
     4921 ttcctacatt ttaacaataa ttaaagtttg tcccaccata tcttacatta attccatgtg
     4981 cgtggatgag ctaatctgga ggataatata ttttcatacc ttgaagcgca tttatgtgag
     5041 tacaaattag actatagaca gaaccctata tctagcttta atgaaatttt aaatgaatga
     5101 gttttggcct gaaagatcat aatcatatat acaataataa ttatttttta aaccaataga
     5161 tttaaattct ttgaaggaac attttttttt tgtcttacgg ccaaatgcca cttggccagc
     5221 taggaccact gcacagtcac taagttggcc gtacaaactc ttgccttcct tgtctttcag
     5281 cataataact gcctgaaaac caacgaaact cattcctgaa aaccaatgaa actcattctc
     5341 tggcagtcga atcaatattg gtttttacag ctctatgcca aggagtagct ttctgttaga
     5401 gatagaaaga tgttgtaact gggaaaactg acatgatgtg taggtttcac atacaacagt
     5461 atggattttc ttttttaaaa aaaatataaa tctgtacctc tgtaaaatta ggaattgtaa
     5521 tttgaatgtt aactctgaaa agatgttgag attctcttta tgctataaca gcgtaggcat
     5581 atagctaatg aaacaacagg agattatttt agattgatat tttttattta ctgaaaattg
     5641 aaatttattt ccaagtatga aattttcata atctagtttg attaaagaaa tggattggtc
     5701 cggaggacat ttgacacaca tgagggatat taacactgat actgatttct tacagagata
     5761 tttattttag agtcgatact ttaaaacatc tgtgtgaggg ttactttgcc cccttatgtt
     5821 taattatcat cataattctg attatgttct caatgactat gaaaggtgac acagtcaaga
     5881 tattattgtc ttaaatctac ctgtatcgca aaattacttg ctaataatta atcctcgtga
     5941 atacattact tctataatga ggaaaatcac taagagcaga cagagagttt tgttgctacc
     6001 ttacgagaac agtgagtgtc tgtagtgagt ctaaccctaa ggagggaatt tggtggcagc
     6061 atttatgtaa gcagctggtt ctatccccat gtgggggagc ctcatggaga agaaaagcaa
     6121 gtggttctag agtatctgtg tgtggccact gactatccta atgtcacttg tgggtggctt
     6181 gtatatttaa tttgatgagt aagggaaccc ggcaaaaatg tattatggga tctaaaaagg
     6241 caaaaaaaaa ttaactcaat gcctagtgat ttgtaaaagg tttctttgaa cttactcctt
     6301 ttatttgaac catgaacctg tgggtatgcc atctacagta tacactggca ttcactgtga
     6361 tttctgacat gtcatggact tcctgtgcgg tactgaatcc ttgcattctg ttgtcattgt
     6421 tctcaagtgc aatataacaa tgtaacgaaa cttaaatatg agtcactatt aatttagtaa
     6481 gaaattatta atttgtcact attaatctga gtagaaattt attagtattt tttattagca
     6541 gaaaagaaca attctgctgt agttgtagat atacaggtga agtttttttg ttttttgctt
     6601 tttttgtttc gttttggtct tttttttttt tttttttttt ttacctctaa accatccaat
     6661 ctgcatttta ttttaggtgg aagacaaact attccctacc agttttaaga catcttcagt
     6721 atattaagat aacttggaag ctgtgtgtat caaattactt tgctctctaa gtaacatgga
     6781 agatattttt tttttttggc ttctcttgtg atcgcccaca ttgggtgaga cataaaacga
     6841 gtctcttctg aaacctgtca ttggctagct tgttttgagt tagtaaaagc aggttccatg
     6901 ctctgcttgg tttccaatgt gtaacttgtg actgtataat aaacttgaac atctggtgcc
     6961 a
//
